RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells

Molecular and Cellular Biochemistry

Volumn 435, Issue 1-2, 2017, Pages 15-24

  Chauhan, Anil Kumar ^a   Min, Kyoung jin ^a   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

Author keywords

Artesunate; Necroptosis; Renal cancer; RIP1; ROS

Indexed keywords

7 AMINODACTINOMYCIN; ACTIN; ARTESUNATE; CASPASE 3; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE ETHYL ESTER; NECROSTATIN 1; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN KINASE1; SMALL INTERFERING RNA; TROLOX C; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN; AGFG1 PROTEIN, HUMAN; ARTEMISININ DERIVATIVE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; NECROSTATIN-1; NUCLEOPORIN; PEPTIDE CHLOROMETHYL KETONE; RNA BINDING PROTEIN; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL KILLING; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; HCT 116 CELL LINE; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; MITOCHONDRION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; SKIN FIBROBLAST; WESTERN BLOTTING; CELL DEATH; DRUG EFFECT; GENETICS; KIDNEY TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AMINO ACID CHLOROMETHYL KETONES; ARTEMISININS; CELL DEATH; CELL LINE, TUMOR; HUMANS; IMIDAZOLES; INDOLES; KIDNEY NEOPLASMS; MITOCHONDRIA; NEOPLASM PROTEINS; NUCLEAR PORE COMPLEX PROTEINS; REACTIVE OXYGEN SPECIES; RNA-BINDING PROTEINS;

EID: 85018370502     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-017-3052-7     Document Type: Article

References (29)

1. Capitanio U, Montorsi F (2016) Renal cancer. Lancet 387:894–906
2. Jonasch E, Gao J, Rathmell WK (2014) Renal cell carcinoma. BMJ 349:g4797–g4808
3. Cohen HT, McGovern FJ (2005) Renal-cell carcinoma. N Engl J Med 353:2477–2490
4. Stukalin I, Alimohamed N, Heng DY (2016) Contemporary treatment of metastatic renal cell carcinoma. Oncol Rev 10:295–303
5. Su D, Stamatakis L, Singer EA, Srinivasan R (2014) Renal cell carcinoma: molecular biology and targeted therapy. Curr Opin Oncol 26:321–327
6. Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115–124
7. Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, Barrios CH, Salman P, Gladkov OA, Kavina A, Zarba JJ, Chen M, McCann L, Pandite L, Roychowdhury DF, Hawkins RE (2010) Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 28:1061–1068
8. Juengel E, Kim D, Makarevic J, Reiter M, Tsaur I, Bartsch G, Haferkamp A, Blaheta RA (2015) Molecular analysis of sunitinib resistant renal cell carcinoma cells after sequential treatment with RAD001 (everolimus) or sorafenib. J Cell Mol Med 19:430–441
9. Motzer RJ, Hutson TE, Cella D, Reeves J, Hawkins R, Guo J, Nathan P, Staehler M, de Souza P, Merchan JR, Boleti E, Fife K, Jin J, Jones R, Uemura H, De Giorgi U, Harmenberg U, Wang J, Sternberg CN, Deen K, McCann L, Hackshaw MD, Crescenzo R, Pandite LN, Choueiri TK (2013) Pazopanib versus sunitinib in metastatic renal-cell carcinoma. N Engl J Med 369:722–731
10. Zhang D, Lin J, Han J (2010) Receptor-interacting protein (RIP) kinase family. Cell Mol Immunol 7:243–249
11. Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81:513–523
12. Kim JY, Morgan M, Kim DG, Lee JY, Bai L, Lin Y, Liu ZG, Kim YS (2011) TNFalpha induced noncanonical NF-kappaB activation is attenuated by RIP1 through stabilization of TRAF2. J Cell Sci 124:647–656
13. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G (2010) Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 11:700–714
14. Papatriantafyllou M (2012) Cell signalling: a necrosome build-up. Nat Rev Mol Cell Biol 13:540
15. O’Neill PM, Barton VE, Ward SA (2010) The molecular mechanism of action of artemisinin—the debate continues. Molecules 15:1705–1721
16. Posner GH, O’Neill PM (2004) Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides. Acc Chem Res 37:397–404
17. Yang ND, Tan SH, Ng S, Shi Y, Zhou J, Tan KS, Wong WS, Shen HM (2014) Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem 289:33425–33441
18. Button RW, Lin F, Ercolano E, Vincent JH, Hu B, Hanemann CO, Luo S (2014) Artesunate induces necrotic cell death in schwannoma cells. Cell Death Dis 5:e1466
19. Hamacher-Brady A, Stein HA, Turschner S, Toegel I, Mora R, Jennewein N, Efferth T, Eils R, Brady NR (2011) Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. J Biol Chem 286:6587–6601
20. Eom SA, Kim DW, Shin MJ, Ahn EH, Chung SY, Sohn EJ, Jo HS, Jeon SJ, Kim DS, Kwon HY, Cho SW, Han KH, Park J, Eum WS, Choi SY (2015) Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson’s disease. BMB Rep 48:395–400
21. Kim HB, Yoo BS (2016) Propolis inhibits UVA-induced apoptosis of human keratinocyte HaCaT cells by scavenging ROS. Toxicol Res 32:345–351
22. Woerdenbag HJ, Moskal TA, Pras N, Malingre TM, El-Feraly FS, Kampinga HH, Konings AW (1993) Cytotoxicity of artemisinin-related endoperoxides to Ehrlich ascites tumor cells. J Nat Prod 56:849–856
23. Pang Y, Qin G, Wu L, Wang X, Chen T (2016) Artesunate induces ROS-dependent apoptosis via a Bax-mediated intrinsic pathway in Huh-7 and Hep3B cells. Exp Cell Res 347:251–260
24. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976–3985
25. Chaitanya GV, Steven AJ, Babu PP (2010) PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration. Cell Commun Signal 8:31–41
26. Pasparakis M, Vandenabeele P (2015) Necroptosis and its role in inflammation. Nature 517:311–320
27. Efferth T, Giaisi M, Merling A, Krammer PH, Li-Weber M (2007) Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PLoS ONE 2:e693
28. Ye YC, Wang HJ, Yu L, Tashiro S, Onodera S, Ikejima T (2012) RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy. Int Immunopharmacol 14:674–682
29. Schenk B, Fulda S (2015) Reactive oxygen species regulate Smac mimetic/TNFalpha-induced necroptotic signaling and cell death. Oncogene 34:5796–5806