Caffeine bitterness is related to daily caffeine intake and bitter receptor mRNA abundance in human taste tissue

Perception

Volumn 46, Issue 3-4, 2017, Pages 245-256

  Lipchock, Sarah V ^a   Spielman, Andrew I ^b   Mennella, Julie A ^a   Mansfield, Corrine J ^a   Hwang, Liang Dar ^a   Douglas, Jennifer E ^a   Reed, Danielle R ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

^b NEW YORK UNIVERSITY COLLEGE OF DENTISTRY   (United States)

Author keywords

Bitter taste; Copy number variation; Human; MRNA expression; Psychophysics; TAS2R

Indexed keywords

CAFFEINE; DENATONIUM BENZOATE; G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; PROPYLTHIOURACIL; QUATERNARY AMMONIUM DERIVATIVE; QUININE; TASTE RECEPTORS, TYPE 2; UREA;

ADULT; COMPARATIVE STUDY; COPY NUMBER VARIATION; DRUG EFFECTS; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION; HUMAN; MALE; METABOLISM; PHYSIOLOGY; TASTE; TASTE BUD; YOUNG ADULT;

ADULT; CAFFEINE; DNA COPY NUMBER VARIATIONS; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION; HUMANS; MALE; PROPYLTHIOURACIL; QUATERNARY AMMONIUM COMPOUNDS; QUININE; RECEPTORS, G-PROTEIN-COUPLED; RNA, MESSENGER; TASTE BUDS; TASTE PERCEPTION; UREA; YOUNG ADULT;

EID: 85018337678     PISSN: 03010066     EISSN: 14684233     Source Type: Journal    
DOI: 10.1177/0301006616686098     Document Type: Article

References (42)

1. Adler, E., Hoon, M. A., Mueller, K. L., Chandrashekar, J., Ryba, N. J. P., & Zuker, C. S. (2000). A novel family of mammalian taste receptors. Cell, 100, 693–702.
2. Behrens, M., Gunn, H. C., Ramos, P. C., Meyerhof, W., & Wooding, S. P. (2013). Genetic, functional, and phenotypic diversity in TAS2R38-mediated bitter taste perception. Chemical Senses, 38, 475–484.
3. Bufe, B., Breslin, P. A., Kuhn, C., Reed, D. R., Tharp, C. D., Slack, J. P., Meyerhof, W. (2005). The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Current Biology, 15, 322–327.
4. Campbell, M. C., Ranciaro, A., Froment, A., Hirbo, J., Omar, S., Bodo, J. M., Tishkoff, S. A. (2012). Evolution of functionally diverse alleles associated with PTC bitter taste sensitivity in Africa. Molecular Biology and Evolution, 29, 1141–1153.
5. Chandrashekar, J., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., & Ryba, N. J. (2000). T2Rs function as bitter taste receptors. Cell, 100, 703–711.
6. Cheled-Shoval, S. L., Behrens, M., Meyerhof, W., Niv, M. Y., & Uni, Z. (2014). Perinatal administration of a bitter tastant influences gene expression in chicken palate and duodenum. Journal of Agricultural and Food Chemistry, 62, 12512–12520.
7. Delwiche, J. F., Buletic, Z., & Breslin, P. A. (2001). Covariation in individuals’ sensitivities to bitter compounds: Evidence supporting multiple receptor/transduction mechanisms. Perception & Psychophysics, 63, 761–776.
8. Dsamou, M., Palicki, O., Septier, C., Chabanet, C., Lucchi, G., Ducoroy, P., Morzel, M. (2012). Salivary protein profiles and sensitivity to the bitter taste of caffeine. Chemical Senses, 37, 87–95.
9. Duffy, V. B., Davidson, A. C., Kidd, J. R., Kidd, K. K., Speed, W. C., Pakstis, A. J., Bartoshuk, L. M. (2004). Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcoholism: Clinical and Experimental Research, 28, 1629–1637.
10. Feskanich, D., Rimm, E. B., Giovannucci, E. L., Colditz, G. A., Stampfer, M. J., Litin, L. B., Willett, W. C. (1993). Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaire. Journal of the American Dietetic Association, 93, 790–796.
11. Genick, U. K., Kutalik, Z., Ledda, M., Souza Destito, M. C., Souza, M. M., Cirillo, C. A., le Coutre, J. (2011). Sensitivity of genome-wide-association signals to phenotyping strategy: The PROP-TAS2R38 taste association as a benchmark. PLoS One, 6, e27745.
12. Giacoia, G. P., Taylor-Zapata, P., & Zajicek, A. (2012). Eunice Kennedy Shriver National Institute of Child Health and Human Development pediatrics formulation initiative: Proceedings from the second workshop on pediatric formulations. Clinical Therapeutics, 34, S1–S10.
13. Jeon, T. I., Zhu, B., Larson, J. L., & Osborne, T. F. (2008).SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. The Journal of Clinical Investigation, 118, 3693–3700.
14. Kim, U. K., Jorgenson, E., Coon, H., Leppert, M., Risch, N., & Drayna, D. (2003). Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science, 299, 1221–1225.
15. Knaapila, A., Hwang, L. D., Lysenko, A., Duke, F. F., Fesi, B., Khoshnevisan, A., Reed, D. R. (2012). Genetic analysis of chemosensory traits in human twins. Chemical Senses, 37, 869–881.
16. Ledda, M., Kutalik, Z., Souza Destito, M. C., Souza, M. M., Cirillo, C. A., Zamboni, A., Genick, U. K. (2014). GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. Human Molecular Genetics, 23, 259–267.
17. Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B., Lysenko, A., Jiang, P., Cohen, N. A. (2012). T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. The Journal of Clinical Investigation, 122, 4145–4159.
18. Lipchock, S. V., Mennella, J. A., Spielman, A. I., & Reed, D. R. (2013). Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. American Journal of Clinical Nutrition, 98, 1136–1143.
19. Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402–408.
20. Matsunami, H., Montmayeur, J. P., & Buck, L. B. (2000). A family of candidate taste receptors in human and mouse. Nature, 404, 601–604.
21. Mela, D. J., Mattes, R. D., Tanimura, S., & Garcia-Medina, M. R. (1992). Relationships between ingestion and gustatory perception of caffeine. Pharmacology Biochemistry and Behavior, 43, 513–521.
22. Mennella, J. A., Pepino, M. Y., Duke, F. F., & Reed, D. R. (2010). Psychophysical dissection of genotype effects on human bitter perception. Chemical Senses, 36, 161–167.
23. Mennella, J. A., Pepino, M. Y., & Reed, D. R. (2005). Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics, 115, e216–e222.
24. Mennella, J. A., Spector, A. C., Reed, D. R., & Coldwell, S. E. (2013). The bad taste of medicines: Overview of basic research on bitter taste. Clinical Therapeutics, 35, 1225–1246.
25. Meyerhof, W., Batram, C., Kuhn, C., Brockhoff, A., Chudoba, E., Bufe, B., Behrens, M. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chemical Senses, 35, 157–170.
26. Miller, I. J. Jr, & Reedy, F. E. Jr (1990). Variations in human taste bud density and taste intensity perception. Physiology & Behavior, 47, 1213–1219.
27. Newcomb, R. D., Xia, M. B., & Reed, D. R. (2012). Heritable differences in chemosensory ability among humans. Flavour, 1, 9.
28. Nozawa, M., Kawahara, Y., & Nei, M. (2007). Genomic drift and copy number variation of sensory receptor genes in humans. Proceedings of the National Academy of Sciences USA, 104, 20421–20426.
29. Oka, Y., Butnaru, M., von Buchholtz, L., Ryba, N. J., & Zuker, C. S. (2013). High salt recruits aversive taste pathways. Nature, 494, 472–475.
30. Paul, D. R., Rhodes, D. G., Kramer, M., Baer, D. J., & Rumpler, W. V. (2005). Validation of a food frequency questionnaire by direct measurement of habitual ad libitum food intake. American Journal of Epidemiology, 162, 806–814.
31. Prodi, D. A., Drayna, D., Forabosco, P., Palmas, M. A., Maestrale, G. B., Piras, D., Angius, A. (2004). Bitter taste study in a Sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chemical Senses, 29, 697–702.
32. Pronin, A. N., Xu, H., Tang, H., Zhang, L., Li, Q., & Li, X. (2007). Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin. Current Biology, 17, 1403–1408.
33. Reed, D. R., Zhu, G., Breslin, P. A., Duke, F. F., Henders, A. K., Campbell, M. J., Wright, M. J. (2010). The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Human Molecular Genetics, 19, 4278–4285.
34. Roudnitzky, N., Behrens, M., Engel, A., Kohl, S., Thalmann, S., Hubner, S., Meyerhof, W. (2015). Receptor polymorphism and genomic structure interact to shape bitter taste perception. PLoS Genetics, 11, e1005530.
35. Roudnitzky, N., Bufe, B., Thalmann, S., Kuhn, C., Gunn, H. C., Xing, C., Wooding, S. P. (2011). Genomic, genetic, and functional dissection of bitter taste responses to artificial sweeteners. Human Molecular Genetics, 20, 3437–3449.
36. Roura, E., Aldayyani, A., Thavaraj, P., Prakash, S., Greenway, D., Thomas, W. G., Foster, S. R. (2015). Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation. Chemical Senses, 40, 427–435.
37. Spielman, A. I., Pepino, M. Y., Feldman, R., & Brand, J. G. (2010). Technique to collect fungiform (taste) papillae from human tongue. Journal of Visualized Experiment, 18, 2201.
38. Suitor, C. J., Gardner, J., & Willett, W. C. (1989). A comparison of food frequency and diet recall methods in studies of nutrient intake of low-income pregnant women. Journal of the American Dietetic Association, 89, 1786–1794.
39. Timpson, N. J., Heron, J., Day, I. N., Ring, S. M., Bartoshuk, L. M., Horwood, J., Davey-Smith, G. (2007). Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: Findings from the Avon Longitudinal Study of Parents and Children. BMC Genetics, 8, 51.
40. Tordoff, M. G., Ellis, H. T., Aleman, T. R., Downing, A., Marambaud, P., Foskett, J. K., McCaughey, S. A. (2014). Salty taste deficits in CALHM1 knockout mice. Chemical Senses, 39, 515–528.
41. Wong, K. K., deLeeuw, R. J., Dosanjh, N. S., Kimm, L. R., Cheng, Z., Horsman, D. E., Lam, W. L. (2007). A comprehensive analysis of common copy-number variations in the human genome. The American Journal of Human Genetics, 80, 91–104.
42. Wooding, S. P., Atanasova, S., Gunn, H. C., Staneva, R., Dimova, I., & Toncheva, D. (2012). Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN). BMC Medical Genetics, 13, 961.