Ghrelin improves vascular autophagy in rats with vascular calcification

Life Sciences

Volumn 179, Issue , 2017, Pages 23-29

  Xu, Mingming ^a   Liu, Lin ^a   Song, Chenfang ^a   Chen, Wei ^a   Gui, Shuyan ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

3 methyladenine; AMPK; Autophagy; Compound C; Ghrelin; Vascular calcification

Indexed keywords

3 METHYLADENINE; BECLIN 1; CALCIUM; COLECALCIFEROL; GHRELIN; GLYCEROL 2 PHOSPHATE; LC3 PROTEIN; NICOTINE; PHOSPHATE; PROTEIN; UNCLASSIFIED DRUG; BETA-GLYCEROPHOSPHORIC ACID; GLYCEROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTIC TISSUE; ARTICLE; AUTOPHAGY; BLOOD VESSEL CALCIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; UPREGULATION; VASCULAR SMOOTH MUSCLE CELL; WESTERN BLOTTING; ANIMAL; AORTA; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; VASCULAR CALCIFICATION; VASCULAR SMOOTH MUSCLE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AORTA; AUTOPHAGY; CALCIUM; CHOLECALCIFEROL; DISEASE MODELS, ANIMAL; GHRELIN; GLYCEROPHOSPHATES; MALE; MUSCLE, SMOOTH, VASCULAR; NICOTINE; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR CALCIFICATION;

EID: 85018276541     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2016.11.025     Document Type: Article

References (41)

1. [1] Choi, A.M., Ryter, S.W., Levine, B., Autophagy in human health and disease. N. Engl. J. Med. 368 (2013), 1845–1846.
2. [2] Kaushik, S., Cuervo, A.M., Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 22 (2012), 407–417.
3. [3] Mijaljica, D., Prescott, M., Devenish, R.J., Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 7 (2011), 673–682.
4. [4] Nussenzweig, S.C., Verma, S., Finkel, T., The role of autophagy in vascular biology. Circ. Res. 116 (2015), 480–488.
5. [5] Demer, L.L., Tintut, Y., Inflammatory, metabolic, and genetic mechanisms of vascular calcification. Arterioscler. Thromb. Vasc. Biol. 34 (2014), 715–723.
6. [6] Campean, V., Neureiter, D., Varga, I., Runk, F., Reiman, A., Garlichs, C., Achenbach, S., Nonnast-Daniel, B., Amann, K., Atherosclerosis and vascular calcification in chronic renal failure. Kidney Blood Press. Res. 28 (2005), 280–289.
7. [7] Neven, E., D'Haese, P.C., Vascular calcification in chronic renal failure: what have we learned from animal studies?. Circ. Res. 108 (2011), 249–264.
8. [8] Steitz, S.A., Speer, M.Y., Curinga, G., Yang, H.Y., Haynes, P., Aebersold, R., Schinke, T., Karsenty, G., Giachelli, C.M., Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ. Res. 89 (2001), 1147–1154.
9. [9] Neven, E., Dauwe, S., De Broe, M.E., D'Haese, P.C., Persy, V., Endochondral bone formation is involved in media calcification in rats and in men. Kidney Int. 72 (2007), 574–581.
10. [10] Dai, X.Y., Zhao, M.M., Cai, Y., Guan, Q.C., Zhao, Y., Guan, Y., Kong, W., Zhu, W.G., Xu, M.J., Wang, X., Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release. Kidney Int. 83 (2013), 1042–1051.
11. [11] Liu, D., Cui, W., Liu, B., Hu, H., Liu, J., Xie, R., Yang, X., Gu, G., Zhang, J., Zheng, H., Atorvastatin protects vascular smooth muscle cells from TGF-β1-stimulated calcification by inducing autophagy via suppression of the β-catenin pathway. Cell. Physiol. Biochem. 33 (2014), 129–141.
12. [12] Zhao, Y., Zhao, M.M., Cai, Y., Zheng, M.F., Sun, W.L., Zhang, S.Y., Kong, W., Gu, J., Wang, X., Xu, M.J., Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation. Kidney Int. 88 (2015), 711–721.
13. [13] Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., Kangawa, K., Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402 (1999), 656–660.
14. [14] Date, Y., Kojima, M., Hosoda, H., Sawaguchi, A., Mondal, M.S., Suganuma, T., Matsukura, S., Kangawa, K., Nakazato, M., Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141 (2000), 4255–4261.
15. [15] Yang, J., Brown, M.S., Liang, G., Grishin, N.V., Goldstein, J.L., Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132 (2008), 387–396.
16. [16] Granata, R., Baragli, A., Settanni, F., Scarlatti, F., Ghigo, E., Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J. Mol. Endocrinol. 45 (2010), 107–118.
17. [17] Zhang, G., Yin, X., Qi, Y., Pendyala, L., Chen, J., Hou, D., Tang, C., Ghrelin and cardiovascular diseases. Curr. Cardiol. Rev. 6 (2010), 62–70.
18. [18] Mao, Y., Tokudome, T., Kishimoto, I., Ghrelin as a treatment for cardiovascular diseases. Hypertension 64 (2014), 450–454.
19. [19] Virdis, A., Lerman, L.O., Regoli, F., Ghiadoni, L., Lerman, A., Taddei, S., Human ghrelin: a gastric hormone with cardiovascular properties. Curr. Pharm. Des. 22 (2016), 52–58.
20. [20] Li, G.Z., Jiang, W., Zhao, J., Pan, C.S., Cao, J., Tang, C.S., Chang, L., Ghrelin blunted vascular calcification in vivo and in vitro in rats. Regul. Pept. 129 (2005), 167–176.
21. [21] Liu, Y., Zhou, Y.B., Zhang, G.G., Cai, Y., Duan, X.H., Teng, X., Song, J.Q., Shi, Y., Tang, C.S., Yin, X.H., Qi, Y.F., Cortistatin attenuates vascular calcification in rats. Regul. Pept. 159 (2010), 35–43.
22. [22] Liang, Q.H., Jiang, Y., Zhu, X., Cui, R.R., Liu, G.Y., Liu, Y., Wu, S.S., Liao, X.B., Xie, H., Zhou, H.D., Wu, X.P., Yuan, L.Q., Liao, E.Y., Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. PLoS One, 7, 2012, e33126.
23. [23] Tong, X.X., Wu, D., Wang, X., Chen, H.L., Chen, J.X., Wang, X.X., Wang, X.L., Gan, L., Guo, Z.Y., Shi, G.X., Zhang, Y.Z., Jiang, W., Ghrelin protects against cobalt chloride-induced hypoxic injury in cardiac H9c2 cells by inhibiting oxidative stress and inducing autophagy. Peptides 38 (2012), 217–227.
24. [24] Pei, X.M., Yung, B.Y., Yip, S.P., Chan, L.W., Wong, C.S., Ying, M., Siu, P.M., Protective effects of desacyl ghrelin on diabetic cardiomyopathy. Acta Diabetol. 52 (2015), 293–306.
25. [25] Yu, A.P., Pei, X.M., Sin, T.K., Yip, S.P., Yung, B.Y., Chan, L.W., Wong, C.S., Siu, P.M., Acylated and unacylated ghrelin inhibit doxorubicin-induced apoptosis in skeletal muscle. Acta Physiol (Oxford) 211 (2014), 201–213.
26. [26] Tam, B.T., Pei, X.M., Yung, B.Y., Yip, S.P., Chan, L.W., Wong, C.S., Siu, P.M., Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice. Pflugers Arch. 467 (2015), 2555–2569.
27. [27] Mao, Y., Cheng, J., Yu, F., Li, H., Guo, C., Fan, X., Ghrelin attenuated lipotoxicity via autophagy induction and nuclear factor-κB inhibition. Cell. Physiol. Biochem. 37 (2015), 563–576.
28. [28] Zhang, Y., Fang, F., Goldstein, J.L., Brown, M.S., Zhao, T.J., Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone. Proc. Natl. Acad. Sci. U. S. A. 112 (2015), 1226–1231.
29. [29] Niederhoffer, N., Bobryshev, Y.V., Lartaud-Idjouadiene, I., Giummelly, P., Atkinson, J., Aortic calcification produced by vitamin D3 plus nicotine. J. Vasc. Res. 34 (1997), 386–398.
30. [30] Shioi, A., Nishizawa, Y., Jono, S., Koyama, H., Hosoi, M., Morii, H., Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 15:11 (1995), 2003–2009.
31. [31] Parhami, F., Morrow, A., Balucan, J., Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation: a possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler. Thromb. Vasc. Biol. 17 (1997), 680–687.
32. [32] Zhou, Y.B., Gao, Q., Li, P., Han, Y., Zhang, F., Qi, Y.F., Tang, C.S., Gao, X.Y., Zhu, G.Q., Adrenomedullin attenuates vascular calcification in fructose-induced insulin resistance rats. Acta Physiol (Oxford) 207 (2013), 437–446.
33. [33] Chang, J.R., Duan, X.H., Zhang, B.H., Teng, X., Zhou, Y.B., Liu, Y., Yu, Y.R., Zhu, Y., Tang, C.S., Qi, Y.F., Intermedin1-53 attenuates vascular smooth muscle cell calcification by inhibiting endoplasmic reticulum stress via cyclic adenosine monophosphate/protein kinase A pathway. Exp. Biol. Med. (Maywood) 238 (2013), 1136–1146.
34. [34] Han, X., Wang, L.Y., Diao, Z.L., Liu, W.H., Apelin: a novel inhibitor of vascular calcification in chronic kidney disease. Atherosclerosis 244 (2016), 1–8.
35. [35] Somers, P., Knaapen, M., Kockx, M., van Cauwelaert, P., Bortier, H., Mistiaen, W., Histological evaluation of autophagic cell death in calcified aortic valve stenosis. J. Heart Valve Dis. 15 (2006), 43–47.
36. [36] Zhang, D., Wang, W., Sun, X., Xu, D., Wang, C., Zhang, Q., Wang, H., Luo, W., Chen, Y., Chen, H., Liu, Z., AMPK regulates autophagy by phosphorylating BECN1 at threonine 388. Autophagy, 15, 2016 Jun (Epub ahead of print).
37. [37] Shin, H.J., Kim, H., Oh, S., Lee, J.G., Kee, M., Ko, H.J., Kweon, M.N., Won, K.J., Baek, S.H., AMPK-SKP2-CARM1 signalling cascade in transcriptional regulation of autophagy. Nature 534 (2016), 553–557.
38. [38] Pan, H., Zhong, X.P., Lee, S., Sustained activation of mTORC1 in macrophages increases AMPKα-dependent autophagy to maintain cellular homeostasis. BMC Biochem., 17, 2016, 14.
39. [39] Zhang, M., Fang, W.Y., Qu, X.K., Yuan, F., Wang, W.G., Fei, J., Wang, Z.G., AMPK activity is down-regulated in endothelial cells of GHS-R(−/−) mice. Int. J. Clin. Exp. Pathol. 6 (2013), 1770–1780.
40. [40] Wang, L., Chen, Q., Li, G., Ke, D., Ghrelin ameliorates impaired angiogenesis of ischemic myocardium through GHSR1a-mediated AMPK/eNOS signal pathway in diabetic rats. Peptides 73 (2015), 77–87.
41. [41] Yuan, M.J., Kong, B., Wang, T., Wang, X., Huang, H., Maghsoudi, T., Ghrelin protects infarcted myocardium by induction of autophagy and AMP-activated protein kinase pathway. Biochem. Biophys. Res. Commun. 476 (2016), 365–370.