Gut microbiota and bacterial translocation in digestive surgery: the impact of probiotics

Langenbeck's Archives of Surgery

Volumn 402, Issue 3, 2017, Pages 401-416

  Komatsu, Shunichiro ^a   Yokoyama, Yukihiro ^b   Nagino, Masato ^b  

^a AICHI MEDICAL UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bacterial translocation; Dysbiosis; Infectious complication; Probiotics; Synbiotics

Indexed keywords

BACTERIOCIN; DEFENSIN; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; LECTIN; OCCLUDIN; POLYPEPTIDE ANTIBIOTIC AGENT; PROBIOTIC AGENT; SHORT CHAIN FATTY ACID; SYNBIOTIC AGENT;

BACTEREMIA; BACTERIAL COLONIZATION; BACTERIAL TRANSLOCATION; COLORECTAL SURGERY; CYTOKINE PRODUCTION; ENTEROCOLITIS; EPITHELIUM CELL; ESOPHAGUS SURGERY; GASTROINTESTINAL SURGERY; GASTROINTESTINAL TRACT; GENE EXPRESSION; GENETIC HETEROGENEITY; GENOTYPE PHENOTYPE CORRELATION; HEPATOBILIARY PARAMETERS; HUMAN; INTERVENTION STUDY; INTESTINE FLORA; INTESTINE INFECTION; MESENTERIC LYMPH NODE LYMPHOCYTE; MOLECULAR PATHOLOGY; PANCREATICODUODENECTOMY; PARENTERAL NUTRITION; PNEUMONIA; PRIORITY JOURNAL; PUBLICATION; QUALITY OF LIFE ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SEPTICEMIA; URINARY TRACT INFECTION; ABDOMINAL SURGERY; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; PREMEDICATION;

BACTERIAL TRANSLOCATION; DIGESTIVE SYSTEM SURGICAL PROCEDURES; GASTROINTESTINAL MICROBIOME; HUMANS; POSTOPERATIVE COMPLICATIONS; PREMEDICATION; PROBIOTICS;

EID: 85018257086     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-017-1577-6     Document Type: Review

References (88)

1. Jeppsson B, Mangell P, Thorlacius H (2011) Use of probiotics as prophylaxis for postoperative infections. Nutrients 3:604–612
2. Correia MI, Liboredo JC, Consoli ML (2012) The role of probiotics in gastrointestinal surgery. Nutrition 28:230–234
3. He D, Wang HY, Feng JY et al (2013) Use of pro-/synbiotics as prophylaxis in patients undergoing colorectal resection for cancer: a meta-analysis of randomized controlled trials. Clin Res Hepatol Gastroenterol 37:406–415
4. Wang W, Xu S, Ren Z et al (2015) Gut microbiota and allogeneic transplantation. J Transl Med 13:275
5. Gerritsen J, Smidt H, Rijkers GT et al (2011) Intestinal microbiota in human health and disease: the impact of probiotics. Genes Nutr 6:209–240
6. Arumugam S, Lau CS, Chamberlain RS (2016) Probiotics and synbiotics decrease postoperative sepsis in elective gastrointestinal surgical patients: a meta-analysis. J Gastrointest Surg 20:1123–1131
7. Lytvyn L, Quach K, Banfield L et al (2016) Probiotics and synbiotics for the prevention of postoperative infections following abdominal surgery: a systematic review and meta-analysis of randomized controlled trials. J Hosp Infect 92:130–139
8. Wu XD, Liu MM, Liang X, et al (2016) Effects of perioperative supplementation with pro-/synbiotics on clinical outcomes in surgical patients: a meta-analysis with trial sequential analysis of randomized controlled trials. Clin Nutr http://www.ncbi.nlm.nih.gov/pubmed/27836310
9. Yang Z, Wu Q, Liu Y, et al (2016a) Effect of perioperative probiotics and synbiotics on postoperative infections after gastrointestinal surgery: a systematic review with meta-analysis. JPEN J Parenter Enteral Nutr http://www.ncbi.nlm.nih.gov/pubmed/26950947
10. Geuking MB, Koller Y, Rupp S et al (2014) The interplay between the gut microbiota and the immune system. Gut Microbes 5:411–418
11. Sassone-Corsi M, Raffatellu M (2015) No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens. J Immunol 194:4081–4087
12. Velasquez-Manoff M (2015) Gut microbiome: the peacekeepers. Nature 518:S3–11
13. Britton RA, Young VB (2014) Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology 146:1547–1553
14. Buffie CG, Pamer EG (2013) Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 13:790–801
15. Lawley TD, Walker AW (2013) Intestinal colonization resistance. Immunology 138:1–11
16. Ammori BJ, Leeder PC, King RF et al (1999) Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality. J Gastrointest Surg 3:252–262
17. Deitch EA (1990) The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 125:403–404
18. Deitch EA (2012) Gut-origin sepsis: evolution of a concept. Surgeon 10:350–356
19. Brenchley JM, Douek DC (2012) Microbial translocation across the GI tract. Annu Rev Immunol 30:149–173
20. MacFie J, O’Boyle C, Mitchell CJ et al (1999) Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity. Gut 45:223–228
21. Hotchkiss RS, Karl IE (2003) The pathophysiology and treatment of sepsis. N Engl J Med 348:138–150
22. MacFie J, Reddy BS, Gatt M et al (2006) Bacterial translocation studied in 927 patients over 13 years. Br J Surg 93:87–93
23. Britton RA, Young VB (2012) Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol 20:313–319
24. Marteyn B, Scorza FB, Sansonetti PJ et al (2011) Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol 13:171–176
25. Duncan SH, Louis P, Thomson JM et al (2009) The role of pH in determining the species composition of the human colonic microbiota. Environ Microbiol 11:2112–2122
26. Kamiya S, Nagino M, Kanazawa H et al (2004) The value of bile replacement during external biliary drainage: an analysis of intestinal permeability, integrity, and microflora. Ann Surg 239:510–517
27. Deitch EA (1989) Simple intestinal obstruction causes bacterial translocation in man. Arch Surg 124:699–701
28. Shiomi H, Shimizu T, Endo Y et al (2007) Relations among circulating monocytes, dendritic cells, and bacterial translocation in patients with intestinal obstruction. World J Surg 31:1806–1812
29. Komatsu S, Panes J, Grisham MB et al (1997) Effects of intestinal stasis on intercellular adhesion molecule 1 expression in the rat: role of enteric bacteria. Gastroenterology 112:1971–1978
30. Stavrou G, Kotzampassi K (2017) Gut microbiome, surgical complications and probiotics. Ann Gastroenterol 30:45–53
31. Guttman JA, Finlay BB (2009) Tight junctions as targets of infectious agents. Biochim Biophys Acta 1788:832–841
32. Gordon JI, Hermiston ML (1994) Differentiation and self-renewal in the mouse gastrointestinal epithelium. Curr Opin Cell Biol 6:795–803
33. Johansson ME (2012) Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins. PLoS One 7:e41009
34. Louis P, Young P, Holtrop G et al (2010) Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyryl-CoA:acetate CoA-transferase gene. Environ Microbiol 12:304–314
35. Mortensen PB, Clausen MR (1996) Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol Suppl 216:132–148
36. Gantois I, Ducatelle R, Pasmans F et al (2006) Butyrate specifically down-regulates salmonella pathogenicity island 1 gene expression. Appl Environ Microbiol 72:946–949
37. Valenzano MC, DiGuilio K, Mercado J et al (2015) Remodeling of tight junctions and enhancement of barrier integrity of the CACO-2 intestinal epithelial cell layer by micronutrients. PLoS One 10:e0133926
38. Furusawa Y, Obata Y, Fukuda S et al (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 504:446–450
39. Inan MS, Rasoulpour RJ, Yin L et al (2000) The luminal short-chain fatty acid butyrate modulates NF-kappaB activity in a human colonic epithelial cell line. Gastroenterology 118:724–734
40. Kankainen M, Paulin L, Tynkkynen S et al (2009) Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein. Proc Natl Acad Sci U S A 106:17193–17198
41. Panda S, El khader I, Casellas F et al (2014) Short-term effect of antibiotics on human gut microbiota. PLoS One 9:e95476
42. Watanabe M, Murakami M, Nakao K et al (2010) Randomized clinical trial of the influence of mechanical bowel preparation on faecal microflora in patients undergoing colonic cancer resection. Br J Surg 97:1791–1797
43. Jalanka J, Salonen A, Salojarvi J et al (2015) Effects of bowel cleansing on the intestinal microbiota. Gut 64:1562–1568
44. Reddy BS, Gatt M, Sowdi R et al (2006) Surgical manipulation of the large intestine increases bacterial translocation in patients undergoing elective colorectal surgery. Color Dis 8:596–600
45. Ozban M, Aydin C, Cevahir N et al (2015) The effect of melatonin on bacterial translocation following ischemia/reperfusion injury in a rat model of superior mesenteric artery occlusion. BMC Surg 15:18
46. Karabeyoglu M, Unal B, Bozkurt B et al (2008) The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury. J Surg Res 144:59–63
47. Su Y, Pan H, Guo Z et al (2015) Bacterial translocation and endotoxemia after pringle maneuver in cirrhotic rats. Dig Dis Sci 60:414–419
48. Kasravi FB, Wang L, Wang XD et al (1996) Bacterial translocation in acute liver injury induced by D-galactosamine. Hepatology 23:97–103
49. Morowitz MJ, Babrowski T, Carlisle EM et al (2011) The human microbiome and surgical disease. Ann Surg 253:1094–1101
50. Alverdy J, Holbrook C, Rocha F et al (2000) Gut-derived sepsis occurs when the right pathogen with the right virulence genes meets the right host: evidence for in vivo virulence expression in Pseudomonas aeruginosa. Ann Surg 232:480–489
51. Kanazawa H, Nagino M, Kamiya S et al (2005) Synbiotics reduce postoperative infectious complications: a randomized controlled trial in biliary cancer patients undergoing hepatectomy. Langenbeck’s Arch Surg 390:104–113
52. Reddy BS, Macfie J, Gatt M et al (2007) Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br J Surg 94:546–554
53. Liu Z, Qin H, Yang Z et al (2011) Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery—a double-blind study. Aliment Pharmacol Ther 33:50–63
54. Usami M, Miyoshi M, Kanbara Y et al (2011) Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. JPEN J Parenter Enteral Nutr 35:317–328
55. Tanaka K, Yano M, Motoori M et al (2012) Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: a prospective randomized controlled trial. Surgery 152:832–842
56. Zhang JW, Du P, Gao J et al (2012) Preoperative probiotics decrease postoperative infectious complications of colorectal cancer. Am J Med Sci 343:199–205
57. Sadahiro S, Suzuki T, Tanaka A et al (2014) Comparison between oral antibiotics and probiotics as bowel preparation for elective colon cancer surgery to prevent infection: prospective randomized trial. Surgery 155:493–503
58. Yokoyama Y, Nishigaki E, Abe T et al (2014) Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy. Br J Surg 101:189–199
59. Komatsu S, Sakamoto E, Norimizu S et al (2016) Efficacy of perioperative synbiotics treatment for the prevention of surgical site infection after laparoscopic colorectal surgery: a randomized controlled trial. Surg Today 46:479–490
60. Mizuno T, Yokoyama Y, Nishio H et al (2010) Intraoperative bacterial translocation detected by bacterium-specific ribosomal rna-targeted reverse-transcriptase polymerase chain reaction for the mesenteric lymph node strongly predicts postoperative infectious complications after major hepatectomy for biliary malignancies. Ann Surg 252:1013–1019
61. Nishigaki E, Abe T, Yokoyama Y et al (2014) The detection of intraoperative bacterial translocation in the mesenteric lymph nodes is useful in predicting patients at high risk for postoperative infectious complications after esophagectomy. Ann Surg 259:477–484
62. Rayes N, Seehofer D, Hansen S et al (2002) Early enteral supply of lactobacillus and fiber versus selective bowel decontamination: a controlled trial in liver transplant recipients. Transplantation 74:123–127
63. Rayes N, Seehofer D, Theruvath T et al (2005) Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial. Am J Transplant 5:125–130
64. Sugawara G, Nagino M, Nishio H et al (2006) Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Ann Surg 244:706–714
65. Nomura T, Tsuchiya Y, Nashimoto A et al (2007) Probiotics reduce infectious complications after pancreaticoduodenectomy. Hepato-Gastroenterology 54:661–663
66. Rayes N, Seehofer D, Theruvath T et al (2007) Effect of enteral nutrition and synbiotics on bacterial infection rates after pylorus-preserving pancreatoduodenectomy: a randomized, double-blind trial. Ann Surg 246:36–41
67. Diepenhorst GM, van Ruler O, Besselink MG et al (2011) Influence of prophylactic probiotics and selective decontamination on bacterial translocation in patients undergoing pancreatic surgery: a randomized controlled trial. Shock 35:9–16
68. Eguchi S, Takatsuki M, Hidaka M et al (2011) Perioperative synbiotic treatment to prevent infectious complications in patients after elective living donor liver transplantation: a prospective randomized study. Am J Surg 201:498–502
69. Rammohan A, Sathyanesan J, Rajendran K et al (2015) Synbiotics in surgery for chronic pancreatitis: are they truly effective? A single-blind prospective randomized control trial. Ann Surg 262:31–37
70. Sommacal HM, Bersch VP, Vitola SP et al (2015) Perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial. Nutr Cancer 67:457–462
71. Yokoyama Y, Miyake T, Kokuryo T et al (2016) Effect of perioperative synbiotic treatment on bacterial translocation and postoperative infectious complications after pancreatoduodenectomy. Dig Surg 33:220–229
72. Backhed F, Ley RE, Sonnenburg JL et al (2005) Host-bacterial mutualism in the human intestine. Science 307:1915–1920
73. Gianotti L, Morelli L, Galbiati F et al (2010) A randomized double-blind trial on perioperative administration of probiotics in colorectal cancer patients. World J Gastroenterol 16:167–175
74. Horvat M, Krebs B, Potrc S et al (2010) Preoperative synbiotic bowel conditioning for elective colorectal surgery. Wien Klin Wochenschr 122(Suppl 2):26–30
75. Mangell P, Thorlacius H, Syk I et al (2012) Lactobacillus plantarum 299v does not reduce enteric bacteria or bacterial translocation in patients undergoing colon resection. Dig Dis Sci 57:1915–1924
76. Liu ZH, Huang MJ, Zhang XW et al (2013) The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr 97:117–126
77. Pellino G, Sciaudone G, Candilio G et al (2013) Early postoperative administration of probiotics versus placebo in elderly patients undergoing elective colorectal surgery: a double-blind randomized controlled trial. BMC Surg 13(Suppl 2):S57
78. Kotzampassi K, Stavrou G, Damoraki G et al (2015) A four-probiotics regimen reduces postoperative complications after colorectal surgery: a randomized, double-blind, placebo-controlled study. World J Surg 39:2776–2783
79. Liu Z, Li C, Huang M et al (2015) Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC Gastroenterol 15:34
80. Consoli ML, da Silva RS, Nicoli JR et al (2016) Randomized clinical trial: impact of oral administration of Saccharomyces boulardii on gene expression of intestinal cytokines in patients undergoing colon resection. JPEN J Parenter Enteral Nutr 40:1114–1121
81. Theodoropoulos GE, Memos NA, Peitsidou K et al (2016) Synbiotics and gastrointestinal function-related quality of life after elective colorectal cancer resection. Ann Gastroenterol 29:56–62
82. Yang Y, Xia Y, Chen H et al (2016b) The effect of perioperative probiotics treatment for colorectal cancer: short-term outcomes of a randomized controlled trial. Oncotarget 7:8432–8440
83. Watt DG, McSorley ST, Horgan PG et al (2015) Enhanced recovery after surgery: which components, if any, impact on the systemic inflammatory response following colorectal surgery?: a systematic review. Medicine (Baltimore) 94:e1286
84. Besselink MG, van Santvoort HC, Renooij W et al (2009) Intestinal barrier dysfunction in a randomized trial of a specific probiotic composition in acute pancreatitis. Ann Surg 250:712–719
85. Bongaerts GP, Severijnen RS (2016) A reassessment of the PROPATRIA study and its implications for probiotic therapy. Nat Biotechnol 34:55–63
86. Meini S, Laureano R, Fani L et al (2015) Breakthrough Lactobacillus rhamnosus GG bacteremia associated with probiotic use in an adult patient with severe active ulcerative colitis: case report and review of the literature. Infection 43:777–781
87. Thygesen JB, Glerup H, Tarp B (2012) Saccharomyces boulardii fungemia caused by treatment with a probioticum. BMJ Case Rep 2012
88. Vahabnezhad E, Mochon AB, Wozniak LJ et al (2013) Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol 47:437–439