The effect of perioperative probiotics treatment for colorectal cancer: Short-term outcomes of a randomized controlled trial

Oncotarget

Volumn 7, Issue 7, 2016, Pages 8432-8440

  Yang, Yongzhi ^a   Xia, Yang ^b   Chen, Hongqi ^b   Hong, Leiming ^a   Feng, Junlan ^b   Yang, Jun ^a   Yang, Zhe ^b   Shi, Chenzhang ^a   Wu, Wen ^a   Gao, Renyuan ^a   Wei, Qing ^c   Qin, Huanlong ^a   Ma, Yanlei ^a  

^a TONGJI UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^c TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

Author keywords

Colorectal cancer; Perioperative probiotics treatment; Post operative outcome; Randomised clinical trial

Indexed keywords

PLACEBO; PROBIOTIC AGENT;

ABDOMINAL DISTENSION; ABDOMINAL DRAINAGE; ABSENCE OF SIDE EFFECTS; ADULT; ANASTOMOSIS LEAKAGE; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BIFIDOBACTERIUM LONGUM; COLORECTAL CANCER; COLORECTAL SURGERY; CONTROLLED STUDY; DEFECATION; DIARRHEA; DRUG EFFECT; ENTEROCOCCUS FAECALIS; FEMALE; FEVER; FLATULENCE; FLUID INTAKE; HEART RATE; HUMAN; INTESTINE FUNCTION; LACTOBACILLUS ACIDOPHILUS; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; OPERATIVE BLOOD LOSS; PERIOPERATIVE PERIOD; PNEUMONIA; POSTOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; SURGICAL INFECTION; TREATMENT DURATION; TREATMENT OUTCOME; URINARY TRACT INFECTION; ABDOMINAL SURGERY; ADVERSE EFFECTS; AGED; CANCER STAGING; CASE CONTROL STUDY; COLORECTAL NEOPLASMS; FOLLOW UP; PROGNOSIS; SURVIVAL RATE; TIME FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BACTEREMIA; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; NEOPLASM STAGING; PERIOPERATIVE CARE; PROBIOTICS; PROGNOSIS; SURVIVAL RATE; TIME FACTORS;

EID: 84958824692     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7045     Document Type: Article

References (33)

1. Sommer F and Backhed F. The gut microbiota-masters of host development and physiology. Nature reviews Microbiology. 2013; 11:227-238.
2. Ursell LK, Metcalf JL, Parfrey LW and Knight R. Defining the human microbiome. Nutrition reviews. 2012; 70 Suppl 1:S38-44.
3. Tjalsma H, Boleij A, Marchesi JR and Dutilh BE. A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects. Nature reviews Microbiology. 2012; 10:575-582.
4. Worthley DL, Le Leu RK, Whitehall VL, Conlon M, Christophersen C, Belobrajdic D, Mallitt KA, Hu Y, Irahara N, Ogino S, Leggett BA and Young GP. A human, double-blind, placebo-controlled, crossover trial of prebiotic, probiotic, and synbiotic supplementation: effects on luminal, inflammatory, epigenetic, and epithelial biomarkers of colorectal cancer. The American journal of clinical nutrition. 2009; 90:578-586.
5. Hold GL and Garrett WS. Gut microbiota: Microbiota organisation-a key to understanding CRC development. Nature reviews Gastroenterology & hepatology. 2015.
6. Leung A, Tsoi H and Yu J. Fusobacterium and Escherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening. Expert review of gastroenterology & hepatology. 2015:1-7.
7. Lokody I. Tumour microenvironment: bacterial balance affects cancer treatment. Nature reviews Cancer. 2014; 14:10.
8. Sears CL and Garrett WS. Microbes, Microbiota, and Colon Cancer. Cell host & microbe. 2014; 15:317-328.
9. Salvans S, Mayol X, Alonso S, Messeguer R, Pascual M, Mojal S, Grande L and Pera M. Postoperative peritoneal infection enhances migration and invasion capacities of tumor cells in vitro: an insight into the association between anastomotic leak and recurrence after surgery for colorectal cancer. Annals of surgery. 2014; 260:939-943; discussion 943-934.
10. Deitch EA. Gut-origin sepsis: evolution of a concept. Surgeon. 2012; 10:350-356.
11. Jalanka J, Salonen A, Salojarvi J, Ritari J, Immonen O, Marciani L, Gowland P, Hoad C, Garsed K, Lam C, Palva A, Spiller RC and de Vos WM. Effects of bowel cleansing on the intestinal microbiota. Gut. 2014.
12. Serban DE. Gastrointestinal cancers: influence of gut microbiota, probiotics and prebiotics. Cancer letters. 2014; 345:258-270.
13. Raman M, Ambalam P, Kondepudi KK, Pithva S, Kothari C, Patel AT, Purama RK, Dave JM and Vyas BR. Potential of probiotics, prebiotics and synbiotics for management of colorectal cancer. Gut microbes. 2013; 4:181-192.
14. Azcarate-Peril MA, Sikes M and Bruno-Barcena JM. The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? American journal of physiology Gastrointestinal and liver physiology. 2011; 301:G401-424.
15. Redman MG, Ward EJ and Phillips RS. The efficacy and safety of probiotics in people with cancer: a systematic review. Ann Oncol. 2014; 25:1919-1929.
16. Sanders ME, Guarner F, Guerrant R, Holt PR, Quigley EM, Sartor RB, Sherman PM and Mayer EA. An update on the use and investigation of probiotics in health and disease. Gut. 2013; 62:787-796.
17. He D, Wang HY, Feng JY, Zhang MM, Zhou Y and Wu XT. Use of pro-/synbiotics as prophylaxis in patients undergoing colorectal resection for cancer: a meta-analysis of randomized controlled trials. Clinics and research in hepatology and gastroenterology. 2013; 37:406-415.
18. Okazaki M, Matsukuma S, Suto R, Miyazaki K, Hidaka M, Matsuo M, Noshima S, Zempo N, Asahara T and Nomoto K. Perioperative synbiotic therapy in elderly patients undergoing gastroenterological surgery: a prospective, randomized control trial. Nutrition. 2013; 29:1224-1230.
19. Peitsidou K, Karantanos T and Theodoropoulos GE. Probiotics, prebiotics, synbiotics: is there enough evidence to support their use in colorectal cancer surgery? Digestive surgery. 2012; 29:426-438.
20. Johnson DA, Barkun AN, Cohen LB, Dominitz JA, Kaltenbach T, Martel M, Robertson DJ, Boland CR, Giardello FM, Lieberman DA, Levin TR, Rex DK and Cancer USM-STFoC. Optimizing adequacy of bowel cleansing for colonoscopy: recommendations from the US multi-society task force on colorectal cancer. Gastroenterology. 2014; 147:903-924.
21. Blencowe NS, Chana P, Whistance RN, Stevens D, Wong NA, Falk SJ and Blazeby JM. Outcome reporting in neoadjuvant surgical trials: a systematic review of the literature and proposals for new standards. Journal of the National Cancer Institute. 2014; 106.
22. Shi CZ, Chen HQ, Liang Y, Xia Y, Yang YZ, Yang J, Zhang JD, Wang SH, Liu J and Qin HL. Combined probiotic bacteria promotes intestinal epithelial barrier function in interleukin-10-gene-deficient mice. World J Gastroenterol. 2014; 20:4636-4647.
23. Pitsouni E, Alexiou V, Saridakis V, Peppas G and Falagas ME. Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials. European journal of clinical pharmacology. 2009; 65:561-570.
24. Kim EK, Sheetz KH, Bonn J, DeRoo S, Lee C, Stein I, Zarinsefat A, Cai S, Campbell DA, Jr. and Englesbe MJ. A statewide colectomy experience: the role of full bowel preparation in preventing surgical site infection. Annals of surgery. 2014; 259:310-314.
25. Sugawara G, Nagino M, Nishio H, Ebata T, Takagi K, Asahara T, Nomoto K and Nimura Y. Perioperative synbiotic treatment to prevent postoperative infectious complications in biliary cancer surgery: a randomized controlled trial. Annals of surgery. 2006; 244:706-714.
26. Nomura T, Tsuchiya Y, Nashimoto A, Yabusaki H, Takii Y, Nakagawa S, Sato N, Kanbayashi C and Tanaka O. Probiotics reduce infectious complications after pancreaticoduodenectomy. Hepato-gastroenterology. 2007; 54:661-663.
27. Rayes N, Seehofer D, Theruvath T, Schiller RA, Langrehr JM, Jonas S, Bengmark S and Neuhaus P. Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation-a randomized, double-blind trial. American journal of transplantation: official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2005; 5:125-130.
28. Sommacal HM, Bersch VP, Vitola SP and Osvaldt AB. Perioperative synbiotics decrease postoperative complications in periampullary neoplasms: a randomized, double-blind clinical trial. Nutrition and cancer. 2015; 67:457-462.
29. Liu Z, Li C, Huang M, Tong C, Zhang X, Wang L, Peng H, Lan P, Zhang P, Huang N, Peng J, Wu X, Luo Y, Qin H, Kang L and Wang J. Positive regulatory effects of perioperative probiotic treatment on postoperative liver complications after colorectal liver metastases surgery: a double-center and double-blind randomized clinical trial. BMC gastroenterology. 2015; 15:34.
30. Bellows CF, Mills KT, Kelly TN and Gagliardi G. Combination of oral non-absorbable and intravenous antibiotics versus intravenous antibiotics alone in the prevention of surgical site infections after colorectal surgery: a meta-analysis of randomized controlled trials. Techniques in coloproctology. 2011; 15:385-395.
31. Liu ZH, Huang MJ, Zhang XW, Wang L, Huang NQ, Peng H, Lan P, Peng JS, Yang Z, Xia Y, Liu WJ, Yang J, Qin HL and Wang JP. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. The American journal of clinical nutrition. 2013; 97:117-126.
32. Usami M, Miyoshi M, Kanbara Y, Aoyama M, Sakaki H, Shuno K, Hirata K, Takahashi M, Ueno K, Tabata S, Asahara T and Nomoto K. Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. JPEN Journal of parenteral and enteral nutrition. 2011; 35:317-328.
33. Liu Z, Qin H, Yang Z, Xia Y, Liu W, Yang J, Jiang Y, Zhang H, Yang Z, Wang Y and Zheng Q. Randomised clinical trial: the effects of perioperative probiotic treatment on barrier function and post-operative infectious complications in colorectal cancer surgery - a double-blind study. Alimentary pharmacology & therapeutics. 2011; 33:50-63.