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Volumn 1, Issue 1, 2015, Pages

A dual role for Caspase8 and NF-κB interactions in regulating apoptosis and necroptosis of ovarian cancer, with correlation to patient survival

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EID: 85018220487     PISSN: None     EISSN: 20587716     Source Type: Journal    
DOI: 10.1038/cddiscovery.2015.53     Document Type: Article
Times cited : (35)

References (48)
  • 2
    • 32944481884 scopus 로고    scopus 로고
    • Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance
    • COI: 1:CAS:528:DC%2BD28XhtFeitb4%3D
    • Wamunyokoli FW, Bonome T, Lee JY, Feltmate CM, Welch WR, Radonovich M et al. Expression profiling of mucinous tumors of the ovary identifies genes of clinicopathologic importance. Clin Cancer Res 2006; 12 (3 Pt 1): 690–700.
    • (2006) Clin Cancer Res , vol.12 , Issue.3 , pp. 690-700
    • Wamunyokoli, F.W.1    Bonome, T.2    Lee, J.Y.3    Feltmate, C.M.4    Welch, W.R.5    Radonovich, M.6
  • 3
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • COI: 1:CAS:528:DC%2BC3MXotlCks7w%3D
    • Bell D, Berchuck A, Birrer M, Chien J, Cramer DW, Dao F et al. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474: 609–615.
    • (2011) Nature , vol.474 , pp. 609-615
    • Bell, D.1    Berchuck, A.2    Birrer, M.3    Chien, J.4    Cramer, D.W.5    Dao, F.6
  • 4
    • 52649085237 scopus 로고    scopus 로고
    • Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome
    • COI: 1:CAS:528:DC%2BD1cXpslKgu70%3D
    • Tothill RW, Tinker AV, George J, Brown R, Fox SB, Lade S et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 2008; 14: 5198–5208.
    • (2008) Clin Cancer Res , vol.14 , pp. 5198-5208
    • Tothill, R.W.1    Tinker, A.V.2    George, J.3    Brown, R.4    Fox, S.B.5    Lade, S.6
  • 5
    • 77957946398 scopus 로고    scopus 로고
    • ARID1A mutations in endometriosis-associated ovarian carcinomas
    • COI: 1:CAS:528:DC%2BC3cXht12ltrbL
    • Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med 2010; 363: 1532–1543.
    • (2010) N Engl J Med , vol.363 , pp. 1532-1543
    • Wiegand, K.C.1    Shah, S.P.2    Al-Agha, O.M.3    Zhao, Y.4    Tse, K.5    Zeng, T.6
  • 6
    • 84858718448 scopus 로고    scopus 로고
    • NF-kappaB and the link between inflammation and cancer
    • DiDonato JA, Mercurio F, Karin M. NF-kappaB and the link between inflammation and cancer. Immunol Rev 2012; 246: 379–400.
    • (2012) Immunol Rev , vol.246 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 7
    • 84901022839 scopus 로고    scopus 로고
    • Basal NF-kappaB controls IL-7 responsiveness of quiescent naive T cells
    • COI: 1:CAS:528:DC%2BC2cXnsVWrtb0%3D
    • Miller ML, Mashayekhi M, Chen L, Zhou P, Liu X, Michelotti M et al. Basal NF-kappaB controls IL-7 responsiveness of quiescent naive T cells. Proc Natl Acad Sci USA 2014; 111: 7397–7402.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 7397-7402
    • Miller, M.L.1    Mashayekhi, M.2    Chen, L.3    Zhou, P.4    Liu, X.5    Michelotti, M.6
  • 8
    • 77954297744 scopus 로고    scopus 로고
    • Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer
    • COI: 1:CAS:528:DC%2BC3cXptlWqu7k%3D
    • Annunziata CM, Stavnes HT, Kleinberg L, Berner A, Hernandez LF, Birrer MJ et al. Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer 2010; 116: 3276–3284.
    • (2010) Cancer , vol.116 , pp. 3276-3284
    • Annunziata, C.M.1    Stavnes, H.T.2    Kleinberg, L.3    Berner, A.4    Hernandez, L.F.5    Birrer, M.J.6
  • 9
    • 77952808420 scopus 로고    scopus 로고
    • Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer
    • COI: 1:CAS:528:DC%2BC3cXlvFyru70%3D
    • Hernandez L, Hsu SC, Davidson B, Birrer MJ, Kohn EC, Annunziata CM. Activation of NF-kappaB signaling by inhibitor of NF-kappaB kinase beta increases aggressiveness of ovarian cancer. Cancer Res 2010; 70: 4005–4014.
    • (2010) Cancer Res , vol.70 , pp. 4005-4014
    • Hernandez, L.1    Hsu, S.C.2    Davidson, B.3    Birrer, M.J.4    Kohn, E.C.5    Annunziata, C.M.6
  • 10
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • COI: 1:CAS:528:DC%2BD2cXnslelsrc%3D
    • Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 2004; 431: 461–466.
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 11
    • 84893858504 scopus 로고    scopus 로고
    • Positive feedback between NF-kappaB and TNF-alpha promotes leukemia-initiating cell capacity
    • COI: 1:CAS:528:DC%2BC2cXis1ersb8%3D
    • Kagoya Y, Yoshimi A, Kataoka K, Nakagawa M, Kumano K, Arai S et al. Positive feedback between NF-kappaB and TNF-alpha promotes leukemia-initiating cell capacity. J Clin Invest 2014; 124: 528–542.
    • (2014) J Clin Invest , vol.124 , pp. 528-542
    • Kagoya, Y.1    Yoshimi, A.2    Kataoka, K.3    Nakagawa, M.4    Kumano, K.5    Arai, S.6
  • 12
    • 84870383878 scopus 로고    scopus 로고
    • Tumor necrosis factor
    • COI: 1:CAS:528:DC%2BC38Xhs1agsr7K
    • Chu WM. Tumor necrosis factor. Cancer Lett 2013; 328: 222–225.
    • (2013) Cancer Lett , vol.328 , pp. 222-225
    • Chu, W.M.1
  • 13
    • 79953906762 scopus 로고    scopus 로고
    • In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
    • COI: 1:CAS:528:DC%2BC3MXksVKmtL0%3D
    • Gentle IE, Wong WW, Evans JM, Bankovacki A, Cook WD, Khan NR et al. In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8. J Biol Chem 2011; 286: 13282–13291.
    • (2011) J Biol Chem , vol.286 , pp. 13282-13291
    • Gentle, I.E.1    Wong, W.W.2    Evans, J.M.3    Bankovacki, A.4    Cook, W.D.5    Khan, N.R.6
  • 14
    • 84904047854 scopus 로고    scopus 로고
    • Functions of caspase 8: the identified and the mysterious
    • COI: 1:CAS:528:DC%2BC2cXoslCnurw%3D
    • Salvesen GS, Walsh CM. Functions of caspase 8: the identified and the mysterious. Semin Immunol 2014; 26: 246–252.
    • (2014) Semin Immunol , vol.26 , pp. 246-252
    • Salvesen, G.S.1    Walsh, C.M.2
  • 15
    • 44949240664 scopus 로고    scopus 로고
    • cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
    • COI: 1:CAS:528:DC%2BD1cXnvFWnt74%3D
    • Bertrand MJ, Milutinovic S, Dickson KM, Ho WC, Boudreault A, Durkin J et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689–700.
    • (2008) Mol Cell , vol.30 , pp. 689-700
    • Bertrand, M.J.1    Milutinovic, S.2    Dickson, K.M.3    Ho, W.C.4    Boudreault, A.5    Durkin, J.6
  • 16
    • 84900447769 scopus 로고    scopus 로고
    • Characterization of TNF-induced caspase-independent necroptosis
    • COI: 1:CAS:528:DC%2BC2cXnsVWmurc%3D
    • Sawai H. Characterization of TNF-induced caspase-independent necroptosis. Leuk Res 2014; 38: 706–713.
    • (2014) Leuk Res , vol.38 , pp. 706-713
    • Sawai, H.1
  • 17
    • 0033214236 scopus 로고    scopus 로고
    • Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis
    • COI: 1:CAS:528:DyaK1MXmvFOit78%3D
    • Lin Y, Devin A, Rodriguez Y, Liu ZG. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev 1999; 13: 2514–2526.
    • (1999) Genes Dev , vol.13 , pp. 2514-2526
    • Lin, Y.1    Devin, A.2    Rodriguez, Y.3    Liu, Z.G.4
  • 18
    • 0034648648 scopus 로고    scopus 로고
    • Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP
    • COI: 1:CAS:528:DC%2BD3cXntlGnur0%3D
    • Kim JW, Choi EJ, Joe CO. Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP. Oncogene 2000; 19: 4491–4499.
    • (2000) Oncogene , vol.19 , pp. 4491-4499
    • Kim, J.W.1    Choi, E.J.2    Joe, C.O.3
  • 19
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
    • COI: 1:CAS:528:DC%2BC38XmtVequ7o%3D
    • Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012; 483: 603–607.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4    Margolin, A.A.5    Kim, S.6
  • 20
    • 0029027995 scopus 로고
    • Serum levels of tumor necrosis factor (TNF), soluble receptors for TNF (55- and 75-kDa sTNFr), and soluble CD14 (sCD14) in epithelial ovarian cancer
    • COI: 1:CAS:528:DyaK2MXntlamtrs%3D
    • Gadducci A, Ferdeghini M, Castellani C, Annicchiarico C, Gagetti O, Prontera C et al. Serum levels of tumor necrosis factor (TNF), soluble receptors for TNF (55- and 75-kDa sTNFr), and soluble CD14 (sCD14) in epithelial ovarian cancer. Gynecol Oncol 1995; 58: 184–188.
    • (1995) Gynecol Oncol , vol.58 , pp. 184-188
    • Gadducci, A.1    Ferdeghini, M.2    Castellani, C.3    Annicchiarico, C.4    Gagetti, O.5    Prontera, C.6
  • 21
    • 77955716864 scopus 로고    scopus 로고
    • Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism
    • COI: 1:CAS:528:DC%2BC3cXhtVSmurzK
    • Hamoudi RA, Appert A, Ye H, Ruskone-Fourmestraux A, Streubel B, Chott A et al. Differential expression of NF-kappaB target genes in MALT lymphoma with and without chromosome translocation: insights into molecular mechanism. Leukemia 2010; 24: 1487–1497.
    • (2010) Leukemia , vol.24 , pp. 1487-1497
    • Hamoudi, R.A.1    Appert, A.2    Ye, H.3    Ruskone-Fourmestraux, A.4    Streubel, B.5    Chott, A.6
  • 22
    • 48549092983 scopus 로고    scopus 로고
    • A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer
    • COI: 1:CAS:528:DC%2BD1cXnvFyju74%3D
    • Bonome T, Levine DA, Shih J, Randonovich M, Pise-Masison CA, Bogomolniy F et al. A gene signature predicting for survival in suboptimally debulked patients with ovarian cancer. Cancer Res 2008; 68: 5478–5486.
    • (2008) Cancer Res , vol.68 , pp. 5478-5486
    • Bonome, T.1    Levine, D.A.2    Shih, J.3    Randonovich, M.4    Pise-Masison, C.A.5    Bogomolniy, F.6
  • 23
    • 13544258066 scopus 로고    scopus 로고
    • Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans
    • COI: 1:CAS:528:DC%2BD2MXivFKnsg%3D%3D
    • Gupta S, Bi R, Kim C, Chiplunkar S, Yel L, Gollapudi S. Role of NF-kappaB signaling pathway in increased tumor necrosis factor-alpha-induced apoptosis of lymphocytes in aged humans. Cell Death Differ 2005; 12: 177–183.
    • (2005) Cell Death Differ , vol.12 , pp. 177-183
    • Gupta, S.1    Bi, R.2    Kim, C.3    Chiplunkar, S.4    Yel, L.5    Gollapudi, S.6
  • 24
    • 0030702084 scopus 로고    scopus 로고
    • Caspases: intracellular signaling by proteolysis
    • COI: 1:CAS:528:DyaK2sXnsFGmtLg%3D
    • Salvesen GS, Dixit VM. Caspases: intracellular signaling by proteolysis. Cell 1997; 91: 443–446.
    • (1997) Cell , vol.91 , pp. 443-446
    • Salvesen, G.S.1    Dixit, V.M.2
  • 25
    • 84900333477 scopus 로고    scopus 로고
    • Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-kappaB activation, and is active in patient-derived xenograft models
    • COI: 1:CAS:528:DC%2BC2cXls1Gjuro%3D
    • Benetatos CA, Mitsuuchi Y, Burns JM, Neiman EM, Condon SM, Yu G et al. Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-kappaB activation, and is active in patient-derived xenograft models. Mol Cancer Ther 2014; 13: 867–879.
    • (2014) Mol Cancer Ther , vol.13 , pp. 867-879
    • Benetatos, C.A.1    Mitsuuchi, Y.2    Burns, J.M.3    Neiman, E.M.4    Condon, S.M.5    Yu, G.6
  • 26
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • COI: 1:CAS:528:DC%2BD2MXls1OmsLg%3D
    • Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 2005; 1: 112–119.
    • (2005) Nat Chem Biol , vol.1 , pp. 112-119
    • Degterev, A.1    Huang, Z.2    Boyce, M.3    Li, Y.4    Jagtap, P.5    Mizushima, N.6
  • 27
    • 84880265865 scopus 로고    scopus 로고
    • RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex
    • COI: 1:CAS:528:DC%2BC38XhtFOrsbvE
    • Abhari BA, Cristofanon S, Kappler R, von Schweinitz D, Humphreys R, Fulda S. RIP1 is required for IAP inhibitor-mediated sensitization for TRAIL-induced apoptosis via a RIP1/FADD/caspase-8 cell death complex. Oncogene 2013; 32: 3263–3273.
    • (2013) Oncogene , vol.32 , pp. 3263-3273
    • Abhari, B.A.1    Cristofanon, S.2    Kappler, R.3    von Schweinitz, D.4    Humphreys, R.5    Fulda, S.6
  • 28
    • 80054817975 scopus 로고    scopus 로고
    • Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor alpha-induced necroptosis
    • COI: 1:CAS:528:DC%2BC3MXhsF2isbjK
    • Laukens B, Jennewein C, Schenk B, Vanlangenakker N, Schier A, Cristofanon S et al. Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor alpha-induced necroptosis. Neoplasia 2011; 13: 971–979.
    • (2011) Neoplasia , vol.13 , pp. 971-979
    • Laukens, B.1    Jennewein, C.2    Schenk, B.3    Vanlangenakker, N.4    Schier, A.5    Cristofanon, S.6
  • 29
    • 33344476184 scopus 로고    scopus 로고
    • cFLIP regulation of lymphocyte activation and development
    • COI: 1:CAS:528:DC%2BD28Xhsleltb0%3D
    • Budd RC, Yeh WC, Tschopp J. cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 2006; 6: 196–204.
    • (2006) Nat Rev Immunol , vol.6 , pp. 196-204
    • Budd, R.C.1    Yeh, W.C.2    Tschopp, J.3
  • 30
    • 84872764927 scopus 로고    scopus 로고
    • Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome
    • COI: 1:CAS:528:DC%2BC38XhvVOqsL3F
    • Kang TB, Yang SH, Toth B, Kovalenko A, Wallach D. Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome. Immunity 2013; 38: 27–40.
    • (2013) Immunity , vol.38 , pp. 27-40
    • Kang, T.B.1    Yang, S.H.2    Toth, B.3    Kovalenko, A.4    Wallach, D.5
  • 31
    • 84885015530 scopus 로고    scopus 로고
    • Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
    • COI: 1:CAS:528:DC%2BC3sXhsVWru7nO
    • Steinhart L, Belz K, Fulda S. Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis. Cell Death Dis 2013; 4: e802.
    • (2013) Cell Death Dis , vol.4
    • Steinhart, L.1    Belz, K.2    Fulda, S.3
  • 32
    • 84923674191 scopus 로고    scopus 로고
    • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL
    • COI: 1:CAS:528:DC%2BC2MXhtF2itLrK
    • Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA et al. RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL. Nat Commun 2015; 6: 6282.
    • (2015) Nat Commun , vol.6 , pp. 6282
    • Lawlor, K.E.1    Khan, N.2    Mildenhall, A.3    Gerlic, M.4    Croker, B.A.5    D'Cruz, A.A.6
  • 33
    • 58549104540 scopus 로고    scopus 로고
    • Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen
    • COI: 1:CAS:528:DC%2BD1MXksV2ntg%3D%3D
    • Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W et al. Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. Proc Natl Acad Sci USA 2008; 105: 20798–20803.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20798-20803
    • Lam, L.T.1    Davis, R.E.2    Ngo, V.N.3    Lenz, G.4    Wright, G.5    Xu, W.6
  • 34
    • 84891935347 scopus 로고    scopus 로고
    • The c-FLIPL cleavage product p43FLIP promotes activation of ERK, NF-kappaB, caspase-8 and T cell survival
    • COI: 1:CAS:528:DC%2BC2cXns1Wnsw%3D%3D
    • Koenig A, Buskiewicz IA, Fortner KA, Russell JQ, Asaoka T, He YW et al. The c-FLIPL cleavage product p43FLIP promotes activation of ERK, NF-kappaB, caspase-8 and T cell survival. J Biol Chem 2014; 289: 1183–1191.
    • (2014) J Biol Chem , vol.289 , pp. 1183-1191
    • Koenig, A.1    Buskiewicz, I.A.2    Fortner, K.A.3    Russell, J.Q.4    Asaoka, T.5    He, Y.W.6
  • 35
    • 77954930632 scopus 로고    scopus 로고
    • IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer
    • COI: 1:CAS:528:DC%2BC3cXpt1Gjtbw%3D
    • Gyrd-Hansen M, Meier P. IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer. Nat Rev Cancer 2010; 10: 561–574.
    • (2010) Nat Rev Cancer , vol.10 , pp. 561-574
    • Gyrd-Hansen, M.1    Meier, P.2
  • 36
    • 19944428834 scopus 로고    scopus 로고
    • Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling
    • COI: 1:CAS:528:DC%2BD2MXhtVehtbo%3D
    • Lam LT, Davis RE, Pierce J, Hepperle M, Xu Y, Hottelet M et al. Small molecule inhibitors of IkappaB kinase are selectively toxic for subgroups of diffuse large B-cell lymphoma defined by gene expression profiling. Clin Cancer Res 2005; 11: 28–40.
    • (2005) Clin Cancer Res , vol.11 , pp. 28-40
    • Lam, L.T.1    Davis, R.E.2    Pierce, J.3    Hepperle, M.4    Xu, Y.5    Hottelet, M.6
  • 37
    • 84876388556 scopus 로고    scopus 로고
    • Control of autophagic cell death by caspase-10 in multiple myeloma
    • COI: 1:CAS:528:DC%2BC3sXltVemsL0%3D
    • Lamy L, Ngo VN, Emre NC, Shaffer AL 3rd, Yang Y, Tian E et al. Control of autophagic cell death by caspase-10 in multiple myeloma. Cancer Cell 2013; 23: 435–449.
    • (2013) Cancer Cell , vol.23 , pp. 435-449
    • Lamy, L.1    Ngo, V.N.2    Emre, N.C.3    Shaffer, A.L.4    Yang, Y.5    Tian, E.6
  • 39
    • 84901487898 scopus 로고    scopus 로고
    • A phase I study of birinapant (TL32711) combined with multiple chemotherapies evaluating tolerability and clinical activity for solid tumor patients
    • Suppl; abstract 2504
    • Ravi K, Amaravadi NNS, Martin LP, Russell JS, LoRusso P, Papadopoulos KP et al. A phase I study of birinapant (TL32711) combined with multiple chemotherapies evaluating tolerability and clinical activity for solid tumor patients. J Clin Oncol 2013; 31 (Suppl; abstract 2504).
    • (2013) J Clin Oncol , vol.31
    • Ravi, K.1    Amaravadi, N.N.S.2    Martin, L.P.3    Russell, J.S.4    Lorusso, P.5    Papadopoulos, K.P.6
  • 40
    • 84899917603 scopus 로고    scopus 로고
    • Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer
    • Suppl; abstract 3621
    • Neil N, Senzer PL, Martin LP, Schilder RJ, Amaravadi RK, Papadopoulos KP et al. Phase II clinical activity and tolerability of the SMAC-mimetic birinapant (TL32711) plus irinotecan in irinotecan-relapsed/refractory metastatic colorectal cancer. J Clin Oncol 2013; 31 (Suppl; abstract 3621).
    • (2013) J Clin Oncol , vol.31
    • Neil, N.1    Senzer, P.L.2    Martin, L.P.3    Schilder, R.J.4    Amaravadi, R.K.5    Papadopoulos, K.P.6
  • 41
    • 84865856759 scopus 로고    scopus 로고
    • A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells
    • COI: 1:CAS:528:DC%2BC38XntFWltrs%3D
    • Petrucci E, Pasquini L, Bernabei M, Saulle E, Biffoni M, Accarpio F et al. A small molecule SMAC mimic LBW242 potentiates TRAIL- and anticancer drug-mediated cell death of ovarian cancer cells. PLoS One 2012; 7: e35073.
    • (2012) PLoS One , vol.7
    • Petrucci, E.1    Pasquini, L.2    Bernabei, M.3    Saulle, E.4    Biffoni, M.5    Accarpio, F.6
  • 42
    • 84872790310 scopus 로고    scopus 로고
    • Smac peptide potentiates TRAIL- or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo
    • COI: 1:CAS:528:DC%2BC3sXis1CnsL8%3D
    • Mao HL, Pang Y, Zhang X, Yang F, Zheng J, Wang Y et al. Smac peptide potentiates TRAIL- or paclitaxel-mediated ovarian cancer cell death in vitro and in vivo. Oncol Rep 2013; 29: 515–522.
    • (2013) Oncol Rep , vol.29 , pp. 515-522
    • Mao, H.L.1    Pang, Y.2    Zhang, X.3    Yang, F.4    Zheng, J.5    Wang, Y.6
  • 43
    • 84879384319 scopus 로고    scopus 로고
    • Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode
    • COI: 1:CAS:528:DC%2BC3sXhtVyku7nI
    • Gillissen B, Richter A, Overkamp T, Essmann F, Hemmati PG, Preissner R et al. Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode. Cell Death Dis 2013; 4: e643.
    • (2013) Cell Death Dis , vol.4
    • Gillissen, B.1    Richter, A.2    Overkamp, T.3    Essmann, F.4    Hemmati, P.G.5    Preissner, R.6
  • 44
    • 0037184113 scopus 로고    scopus 로고
    • Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro
    • COI: 1:CAS:528:DC%2BD38XnsVCis78%3D
    • MacFarlane M, Merrison W, Bratton SB, Cohen GM. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 2002; 277: 36611–36616.
    • (2002) J Biol Chem , vol.277 , pp. 36611-36616
    • MacFarlane, M.1    Merrison, W.2    Bratton, S.B.3    Cohen, G.M.4
  • 45
    • 70350509121 scopus 로고    scopus 로고
    • Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells
    • COI: 1:CAS:528:DC%2BD1MXhtlSqs7rM
    • Berges C, Haberstock H, Fuchs D, Sadeghi M, Opelz G, Daniel V et al. Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells. J Cell Biochem 2009; 108: 935–946.
    • (2009) J Cell Biochem , vol.108 , pp. 935-946
    • Berges, C.1    Haberstock, H.2    Fuchs, D.3    Sadeghi, M.4    Opelz, G.5    Daniel, V.6
  • 46
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • COI: 1:CAS:528:DC%2BC3cXhvFCitw%3D%3D
    • Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB et al. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 2010; 463: 88–92.
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1    Ngo, V.N.2    Lenz, G.3    Tolar, P.4    Young, R.M.5    Romesser, P.B.6
  • 47
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • COI: 1:CAS:528:DC%2BD28XktVGlt74%3D
    • Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006; 441: 106–110.
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1    Davis, R.E.2    Lamy, L.3    Yu, X.4    Zhao, H.5    Lenz, G.6
  • 48
    • 0023792919 scopus 로고
    • Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
    • COI: 1:CAS:528:DyaL1cXls1arsrk%3D, PID: 3409223
    • Scudiero DA, Shoemaker RH, Paull KD, Monks A, Tierney S, Nofziger TH et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988; 48: 4827–4833.
    • (1988) Cancer Res , vol.48 , pp. 4827-4833
    • Scudiero, D.A.1    Shoemaker, R.H.2    Paull, K.D.3    Monks, A.4    Tierney, S.5    Nofziger, T.H.6


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