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Volumn 7, Issue 1, 2017, Pages

Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CA9 PROTEIN, HUMAN; CARBONATE DEHYDRATASE IX; DITERPENE; EPOXIDE; IMMUNOLOGICAL ANTINEOPLASTIC AGENT; LIPOSOME; MONOCLONAL ANTIBODY; PHENANTHRENE DERIVATIVE; TRIPTOLIDE; TUMOR ANTIGEN;

EID: 85018167343     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/s41598-017-00957-4     Document Type: Article
Times cited : (86)

References (50)
  • 2
    • 77953766334 scopus 로고    scopus 로고
    • Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides assuppressors of cellular resistance
    • Garbuzenko, O. B., et al. Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides assuppressors of cellular resistance. Proceedings of the National Academy of Sciences of the United States of America 107, 10737-10742, doi:10.1073/pnas.1004604107 (2010).
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , pp. 10737-10742
    • Garbuzenko, O.B.1
  • 3
    • 79955006086 scopus 로고    scopus 로고
    • Lung Cancer: New biological insights and recent therapeutic advances
    • Ramalingam, S. S., Owonikoko, T. K., Khuri, F. R. Lung Cancer: New Biological Insights and Recent Therapeutic Advances. Ca-Cancer J Clin 61, 91-112, doi:10.3322/caac.20102 (2011).
    • (2011) Ca-Cancer J Clin , vol.61 , pp. 91-112
    • Ramalingam, S.S.1    Owonikoko, T.K.2    Khuri, F.R.3
  • 4
    • 84886292840 scopus 로고    scopus 로고
    • Stimuli-responsive nanocarriers for drug delivery
    • Mura, S., Nicolas, J., Couvreur, P. Stimuli-responsive nanocarriers for drug delivery. Nature materials 12, 991-1003, doi:10.1038/NMAT3776 (2013).
    • (2013) Nature Materials , vol.12 , pp. 991-1003
    • Mura, S.1    Nicolas, J.2    Couvreur, P.3
  • 5
    • 78650954706 scopus 로고    scopus 로고
    • Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting
    • doi:ARTN 64ra210.1126/scitranslmed.3001385
    • Murakami, M., et al. Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting. Sci Transl Med 3, doi:ARTN 64ra210.1126/scitranslmed.3001385 (2011).
    • (2011) Sci Transl Med , vol.3
    • Murakami, M.1
  • 6
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen, T. M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2, 750-763, doi:10.1038/nrc903 (2002).
    • (2002) Nat Rev Cancer , vol.2 , pp. 750-763
    • Allen, T.M.1
  • 7
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-Inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis throughthe regulation of the intracellular pH
    • Chiche, J., et al. Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis throughthe Regulation of the Intracellular pH. Cancer research 69, 358-368, doi:10.1158/0008-5472.CAN-08-2470 (2009).
    • (2009) Cancer Research , vol.69 , pp. 358-368
    • Chiche, J.1
  • 8
    • 0032755017 scopus 로고    scopus 로고
    • Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lungcarcinoma
    • Vermylen, P., et al. Carbonic anhydrase IX antigen differentiates between preneoplastic malignant lesions in non-small cell lungcarcinoma. European Respiratory Journal 14, 806-811, doi:10.1034/j.1399-3003.1999.14d14.x (1999).
    • (1999) European Respiratory Journal , vol.14 , pp. 806-811
    • Vermylen, P.1
  • 9
    • 0037315252 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poorprognosis in non-small-cell lung cancer
    • Swinson, D. E. B., et al. Carbonic anhydrase IX expression, a novel surrogate marker of tumor hypoxia, is associated with a poorprognosis in non-small-cell lung cancer. J Clin Oncol 21, 473-482, doi:10.1200/Jco.2003.11.132 (2003).
    • (2003) J Clin Oncol , vol.21 , pp. 473-482
    • Swinson, D.E.B.1
  • 10
    • 33645079888 scopus 로고    scopus 로고
    • An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers
    • Le, Q. T., et al. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers.Clinical Cancer Research 12, 1507-1514, doi:10.1158/1078-0432.CCR-05-2049 (2006).
    • (2006) Clinical Cancer Research , vol.12 , pp. 1507-1514
    • Le, Q.T.1
  • 11
    • 0030835515 scopus 로고    scopus 로고
    • Identification of the MN/CA9 protein as a reliable diagnosticbiomarker of clear cell carcinoma of the kidney
    • Liao, S. Y., Aurelio, O. N., Jan, K., Zavada, J., Stanbridge, E. J. Identification of the MN/CA9 protein as a reliable diagnosticbiomarker of clear cell carcinoma of the kidney. Cancer research 57, 2827-2831 (1997).
    • (1997) Cancer Research , vol.57 , pp. 2827-2831
    • Liao, S.Y.1    Aurelio, O.N.2    Jan, K.3    Zavada, J.4    Stanbridge, E.J.5
  • 12
    • 0031819881 scopus 로고    scopus 로고
    • Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation
    • Saarnio, J., et al. Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 153, 279-285, doi:10.1016/S0002-9440(10)65569-1(1998).
    • (1998) Am J Pathol , vol.153 , pp. 279-285
    • Saarnio, J.1
  • 13
    • 0035105565 scopus 로고    scopus 로고
    • Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of thebreast
    • Wykoff, C. C., et al. Expression of the hypoxia-inducible and tumor-associated carbonic anhydrases in ductal carcinoma in situ of thebreast. Am J Pathol 158, 1011-1019, doi:10.1016/S0002-9440(10)64048-5 (2001).
    • (2001) Am J Pathol , vol.158 , pp. 1011-1019
    • Wykoff, C.C.1
  • 14
    • 33644756432 scopus 로고    scopus 로고
    • Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer
    • Simi, L., et al. Quantitative analysis of carbonic anhydrase IX mRNA in human non-small cell lung cancer. Lung Cancer 52, 59-66, doi:10.1016/j.lungcan.2005.11.017 (2006).
    • (2006) Lung Cancer , vol.52 , pp. 59-66
    • Simi, L.1
  • 15
    • 0031040821 scopus 로고    scopus 로고
    • Carbonic anhydrase IX MN/CA IX: Analysis of stomach complementary DNA sequence and expression inhuman and rat alimentary tracts
    • Pastorekova, S., et al. Carbonic anhydrase IX, MN/CA IX: Analysis of stomach complementary DNA sequence and expression inhuman and rat alimentary tracts. Gastroenterology 112, 398-408, doi:10.1053/gast.1997.v112.pm9024293 (1997).
    • (1997) Gastroenterology , vol.112 , pp. 398-408
    • Pastorekova, S.1
  • 16
    • 74449091486 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumortarget
    • De Simone, G., Supuran, C. T. Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumortarget. Bba-Proteins Proteom 1804, 404-409, doi:10.1016/j.bbapap.2009.07.027 (2010).
    • (2010) Bba-Proteins Proteom , vol.1804 , pp. 404-409
    • De Simone, G.1    Supuran, C.T.2
  • 17
    • 84863501358 scopus 로고    scopus 로고
    • Multiple binding modes of inhibitors to carbonicanhydrases: How to design specific drugs targeting 15 different isoforms
    • Alterio, V., Di Fiore, A., D'Ambrosio, K., Supuran, C. T., De Simone, G. Multiple binding modes of inhibitors to carbonicanhydrases: How to design specific drugs targeting 15 different isoforms Chem Rev 112, 4421-4468, doi:10.1021/cr200176r (2012).
    • (2012) Chem Rev , vol.112 , pp. 4421-4468
    • Alterio, V.1    Di Fiore, A.2    D'Ambrosio, K.3    Supuran, C.T.4    De Simone, G.5
  • 18
  • 19
    • 84964285573 scopus 로고    scopus 로고
    • Targeting carbonic anhydrase IX activity and expression
    • Mahon, B. P., Pinard, M. A., McKenna, R. Targeting carbonic anhydrase IX activity and expression. Molecules 20, 2323-2348, doi:10.3390/molecules20022323 (2015).
    • (2015) Molecules , vol.20 , pp. 2323-2348
    • Mahon, B.P.1    Pinard, M.A.2    McKenna, R.3
  • 20
    • 78751650361 scopus 로고    scopus 로고
    • A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(A (R))) and interferon-alpha-2a inmetastatic renal cell carcinoma patients
    • Siebels, M., et al. A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX(A (R))) and interferon-alpha-2a inmetastatic renal cell carcinoma patients. World J Urol 29, 121-126, doi:10.1007/s00345-010-0570-2 (2011).
    • (2011) World J Urol , vol.29 , pp. 121-126
    • Siebels, M.1
  • 21
    • 84888227525 scopus 로고    scopus 로고
    • ARISER: A randomized double blind phase III study to evaluate adjuvant cG250 treatment versus placebo inpatients with high-risk ccRCC-Results and implications for adjuvant clinical trials
    • Belldegrun, A. S., et al. ARISER: A randomized double blind phase III study to evaluate adjuvant cG250 treatment versus placebo inpatients with high-risk ccRCC-Results and implications for adjuvant clinical trials. J Clin Oncol 31 (2013).
    • (2013) J Clin Oncol , vol.31
    • Belldegrun, A.S.1
  • 22
    • 27944500753 scopus 로고    scopus 로고
    • Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent processregulated by TACE/ADAM17
    • Zatovicova, M., et al. Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent processregulated by TACE/ADAM17. Br J Cancer 93, 1267-1276, doi:10.1038/sj.bjc.6602861 (2005).
    • (2005) Br J Cancer , vol.93 , pp. 1267-1276
    • Zatovicova, M.1
  • 23
    • 84971342197 scopus 로고    scopus 로고
    • Triptolide inhibits Wnt signaling due to DNA methylation alteration that is determined bydynamic histone 3 K79 lysine methylation in NSCLC
    • Li, Y. Q., Shen, B. H., Kim, J., Raz, D. Triptolide inhibits Wnt signaling due to DNA methylation alteration that is determined bydynamic histone 3 K79 lysine methylation in NSCLC. Cancer research 75, doi:10.1158/1538-7445.AM2015-4777 (2015).
    • (2015) Cancer Research , pp. 75
    • Li, Y.Q.1    Shen, B.H.2    Kim, J.3    Raz, D.4
  • 24
    • 84958726241 scopus 로고    scopus 로고
    • Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN bytargeting miR-21
    • Li, X. F., et al. Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN bytargeting miR-21. Mol Med Rep 13, 2763-2768, doi:10.3892/mmr.2016.4844 (2016).
    • (2016) Mol Med Rep , vol.13 , pp. 2763-2768
    • Li, X.F.1
  • 25
    • 84946474228 scopus 로고    scopus 로고
    • Triptolide inhibits lung cancer cell migration invasion metastasis
    • Reno, T. A., Kim, J. Y., Raz, D. J. Triptolide Inhibits Lung Cancer Cell Migration, Invasion, Metastasis. Annals Of ThoracicSurgery 100, 1817-1825, doi:10.1016/j.athoracsur.2015.05.074 (2015).
    • (2015) Annals of ThoracicSurgery , vol.100 , pp. 1817-1825
    • Reno, T.A.1    Kim, J.Y.2    Raz, D.J.3
  • 26
    • 84861144099 scopus 로고    scopus 로고
    • Triptolide: Structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms
    • Zhou, Z. L., Yang, Y. X., Ding, J., Li, Y. C., Miao, Z. H. Triptolide: Structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep 29, 457-475, doi:10.1039/c2np00088a (2012).
    • (2012) Nat Prod Rep , vol.29 , pp. 457-475
    • Zhou, Z.L.1    Yang, Y.X.2    Ding, J.3    Li, Y.C.4    Miao, Z.H.5
  • 27
    • 0041333929 scopus 로고    scopus 로고
    • PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2
    • Frese, S., et al. PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2.Oncogene 22, 5427-5435, doi:10.1038/sj.onc.1206842 (2003).
    • (2003) Oncogene , vol.22 , pp. 5427-5435
    • Frese, S.1
  • 28
    • 0037207259 scopus 로고    scopus 로고
    • Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand(TRAIL)-induced apoptosis by inhibition of NF-kappa B activation
    • Lee, K. Y., Park, J. S., Jee, Y. K., Rosen, G. D. Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand(TRAIL)-induced apoptosis by inhibition of NF-kappa B activation. Experimental And Molecular Medicine 34, 462-468 (2002).
    • (2002) Experimental and Molecular Medicine , vol.34 , pp. 462-468
    • Lee, K.Y.1    Park, J.S.2    Jee, Y.K.3    Rosen, G.D.4
  • 29
    • 84949818263 scopus 로고    scopus 로고
    • Phosphonooxymethyl prodrug of triptolide: Synthesis, physicochemical characterization, efficacy in humancolon adenocarcinoma and ovarian cancer xenografts
    • Patil, S., et al. Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, Efficacy in HumanColon Adenocarcinoma and Ovarian Cancer Xenografts. Journal of medicinal chemistry 58, 9334-9344, doi:10.1021/acs.jmedchem.5b01329 (2015).
    • (2015) Journal of Medicinal Chemistry , vol.58 , pp. 9334-9344
    • Patil, S.1
  • 30
    • 79951944060 scopus 로고    scopus 로고
    • Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome totarget chemotherapeutics to tumor
    • Manjappa, A. S., et al. Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome totarget chemotherapeutics to tumor. J Control Release 150, 2-22, doi:10.1016/j.jconrel.2010.11.002 (2011).
    • (2011) J Control Release , vol.150 , pp. 2-22
    • Manjappa, A.S.1
  • 31
    • 84880086575 scopus 로고    scopus 로고
    • Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from producteffects
    • Hutterer, K. M., et al. Monoclonal antibody disulfide reduction during manufacturing: Untangling process effects from producteffects. mAbs 5, 608-613, doi:10.4161/mabs.24725 (2013).
    • (2013) MAbs , vol.5 , pp. 608-613
    • Hutterer, K.M.1
  • 32
    • 80155194385 scopus 로고    scopus 로고
    • Advanced procedures for labeling of antibodies with quantum dots
    • Mahmoud, W., et al. Advanced procedures for labeling of antibodies with quantum dots. Analytical biochemistry 416, 180-185, doi:10.1016/j.ab.2011.05.018 (2011).
    • (2011) Analytical Biochemistry , vol.416 , pp. 180-185
    • Mahmoud, W.1
  • 33
    • 84930660625 scopus 로고    scopus 로고
    • Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dualtherapeutic/prophylactic antimalarial strategy
    • Moles, E., et al. Immunoliposome-mediated drug delivery to Plasmodium-infected and non-infected red blood cells as a dualtherapeutic/prophylactic antimalarial strategy. J Control Release 210, 217-229, doi:10.1016/j.jconrel.2015.05.284 (2015).
    • (2015) J Control Release , vol.210 , pp. 217-229
    • Moles, E.1
  • 34
    • 84861762712 scopus 로고    scopus 로고
    • Carbonic anhydrase IX promotes tumor growth and necrosis in vivo and inhibition enhances Anti-VEGF therapy
    • McIntyre, A., et al. Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGFTherapy. Clinical Cancer Research 18, 3100-3111, doi:10.1158/1078-0432.CCR-11-1877 (2012).
    • (2012) Clinical Cancer Research , vol.18 , pp. 3100-3111
    • McIntyre, A.1
  • 35
    • 84859870939 scopus 로고    scopus 로고
    • Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
    • McDonald, P. C., Winum, J. Y., Supuran, C. T., Dedhar, S. Recent Developments in Targeting Carbonic Anhydrase IX for CancerTherapeutics. Oncotarget 3, 84-97 (2012).
    • (2012) Oncotarget , vol.3 , pp. 84-97
    • McDonald, P.C.1    Winum, J.Y.2    Supuran, C.T.3    Dedhar, S.4
  • 36
    • 84869495994 scopus 로고    scopus 로고
    • Opportunities and challenges for use of tumor spheroids as modelsto test drug delivery and efficacy
    • Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., Takayama, S. Opportunities and challenges for use of tumor spheroids as modelsto test drug delivery and efficacy. J Control Release 164, 192-204, doi:10.1016/j.jconrel.2012.04.045 (2012).
    • (2012) J Control Release , vol.164 , pp. 192-204
    • Mehta, G.1    Hsiao, A.Y.2    Ingram, M.3    Luker, G.D.4    Takayama, S.5
  • 37
    • 0028245129 scopus 로고
    • Modulation of Tumor-Cell response to chemotherapy by the organ environment
    • Fidler, I. J., et al. Modulation Of Tumor-Cell Response To Chemotherapy by the Organ Environment. Cancer Metast Rev 13, 209-222, doi:10.1007/Bf00689637 (1994).
    • (1994) Cancer Metast Rev , vol.13 , pp. 209-222
    • Fidler, I.J.1
  • 38
    • 0026706954 scopus 로고
    • Orthotopic and ectopic organ environments differentiallyinfluence the sensitivity of murine Colon-Carcinoma cells to doxorubicin and 5-Fluorouracil
    • Wilmanns, C., Fan, D., Obrian, C. A., Bucana, C. D., Fidler, I. J. Orthotopic And Ectopic Organ Environments DifferentiallyInfluence the Sensitivity Of Murine Colon-Carcinoma Cells To Doxorubicin And 5-Fluorouracil. Int J Cancer 52, 98-104, doi:10.1002/ijc.2910520118 (1992).
    • (1992) Int J Cancer , vol.52 , pp. 98-104
    • Wilmanns, C.1    Fan, D.2    Obrian, C.A.3    Bucana, C.D.4    Fidler, I.J.5
  • 39
    • 0345060457 scopus 로고    scopus 로고
    • Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice
    • Onn, A., et al. Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.Clinical Cancer Research 9, 5532-5539 (2003).
    • (2003) Clinical Cancer Research , vol.9 , pp. 5532-5539
    • Onn, A.1
  • 40
    • 84983604718 scopus 로고    scopus 로고
    • PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mousemodel of lung carcinoma
    • Luo, T., et al. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mousemodel of lung carcinoma. J Control Release 239, 62-71, doi:10.1016/j.jconrel.2016.08.008 (2016).
    • (2016) J Control Release , vol.239 , pp. 62-71
    • Luo, T.1
  • 41
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization biodistribution, pharmacokinetics of polymeric nanoparticles
    • Owens, D. E., Peppas, N. A. Opsonization, biodistribution, pharmacokinetics of polymeric nanoparticles. Int J Pharm 307, 93-102, doi:10.1016/j.ijpharm.2005.10.010 (2006).
    • (2006) Int J Pharm , vol.307 , pp. 93-102
    • Owens, D.E.1    Peppas, N.A.2
  • 42
    • 84860600084 scopus 로고    scopus 로고
    • Opsonization, biodistribution, cellular uptake and apoptosis study of PE Gylated PBCA nanoparticle aspotential drug delivery carrier
    • Chaudhari, K. R., et al. Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle asPotential Drug Delivery Carrier. Pharmaceutical research 29, 53-68, doi:10.1007/s11095-011-0510-x (2012).
    • (2012) Pharmaceutical Research , vol.29 , pp. 53-68
    • Chaudhari, K.R.1
  • 43
    • 58149187849 scopus 로고    scopus 로고
    • The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells
    • Zhang, Z. R., et al. The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells. Biomaterials30, 1372-1381, doi:10.1016/j.biomaterials.2008.11.035 (2009).
    • (2009) Biomaterials , vol.30 , pp. 1372-1381
    • Zhang, Z.R.1
  • 44
    • 0027217705 scopus 로고
    • Liposomes obtained by the ethanol injection method
    • Pons, M., Foradada, M., Estelrich, J. Liposomes Obtained by the Ethanol Injection Method. Int J Pharm 95, 51-56, doi:10.1016/0378-5173(93)90389-W (1993).
    • (1993) Int J Pharm , vol.95 , pp. 51-56
    • Pons, M.1    Foradada, M.2    Estelrich, J.3
  • 45
    • 84904978899 scopus 로고    scopus 로고
    • Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells invitro
    • Wong, B. C. K., et al. Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells invitro. Drug Des Dev Ther 8, 993-1001, doi:10.2147/Dddt.S63235 (2014).
    • (2014) Drug des Dev Ther , vol.8 , pp. 993-1001
    • Wong, B.C.K.1
  • 46
    • 0035817346 scopus 로고    scopus 로고
    • In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniqueswith those made by a new post-insertion approach
    • Iden, D. L., Allen, T. M. In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniqueswith those made by a new post-insertion approach. Bba-Biomembranes 1513, 207-216, doi:10.1016/S0005-2736(01)00357-1(2001).
    • (2001) Bba-Biomembranes , vol.1513 , pp. 207-216
    • Iden, D.L.1    Allen, T.M.2
  • 47
    • 79956155445 scopus 로고    scopus 로고
    • A nanovector with complete discrimination for targeted delivery toPlasmodium falciparum-infected versus non-infected red blood cells in vitro
    • Urban, P., Estelrich, J., Cortes, A., Fernandez-Busquets, X. A nanovector with complete discrimination for targeted delivery toPlasmodium falciparum-infected versus non-infected red blood cells in vitro. J Control Release 151, 202-211, doi:10.1016/j.jconrel.2011.01.001 (2011).
    • (2011) J Control Release , vol.151 , pp. 202-211
    • Urban, P.1    Estelrich, J.2    Cortes, A.3    Fernandez-Busquets, X.4
  • 48
    • 84879088542 scopus 로고    scopus 로고
    • Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo
    • Wei, T., et al. Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo. Nano Lett 13, 2528-2534, doi:10.1021/nl400586t (2013).
    • (2013) Nano Lett , vol.13 , pp. 2528-2534
    • Wei, T.1
  • 49
    • 84896493907 scopus 로고    scopus 로고
    • Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting
    • Liu, Y. Y., et al. Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting. Biomaterials 35, 4835-4847, doi:10.1016/j.biomaterials.2014.02.031 (2014).
    • (2014) Biomaterials , vol.35 , pp. 4835-4847
    • Liu, Y.Y.1
  • 50
    • 84900814598 scopus 로고    scopus 로고
    • Preclinical antileukemic activity, toxicology, toxicokinetics and formulationdevelopment of triptolide derivative MRx102
    • Fidler, J. M., An, J. H., Carter, B. Z., Andreeff, M. Preclinical antileukemic activity, toxicology, toxicokinetics and formulationdevelopment of triptolide derivative MRx102. Cancer Chemoth Pharm 73, 961-974, doi:10.1007/s00280-014-2428-6 (2014).
    • (2014) Cancer Chemoth Pharm , vol.73 , pp. 961-974
    • Fidler, J.M.1    An, J.H.2    Carter, B.Z.3    Andreeff, M.4


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