Paraprotein-related kidney disease: Kidney injury from paraproteins—What determines the site of injury?

Clinical Journal of the American Society of Nephrology

Volumn 11, Issue 12, 2016, Pages 2288-2294

  Doshi, Mona ^a   Lahoti, Amit ^b   Danesh, Farhad R ^b   Batuman, Vecihi ^c,d   Sanders, Paul W ^e,f,g  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e University of Alabama at Birmingham   (United States)

^f UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^g BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Amyloidosis; Glomerular disease; Immunoglobulin free light chains; Immunoglobulins; Kidney; Kidney Diseases; Multiple myeloma; Multiple myeloma M proteins; Myeloma Proteins; Paraproteins; Tubular epithelium

Indexed keywords

AMYLOID; APOLIPOPROTEIN E; CLUSTERIN; MATRIX METALLOPROTEINASE; PARAPROTEIN; SERUM AMYLOID P; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN;

AL AMYLOIDOSIS; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CRYOGLOBULINEMIA; FANCONI RENOTUBULAR SYNDROME; FIBROSING ALVEOLITIS; GLOMERULOPATHY; GLYCOSYLATION; HUMAN; IMMUNE COMPLEX DISEASE; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN DEPOSITION; KIDNEY BIOPSY; KIDNEY INJURY; KIDNEY TUBULE DISORDER; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PARAPROTEINEMIA; PATHOGENESIS; PROLIFERATIVE GLOMERULONEPHRITIS; AMYLOIDOSIS; COMPLICATION; GLOMERULONEPHRITIS; GLOMERULUS; KIDNEY DISEASE; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; METABOLISM; PATHOLOGY;

AMYLOIDOSIS; GLOMERULONEPHRITIS; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; KIDNEY TUBULES, PROXIMAL; PARAPROTEINEMIAS; PARAPROTEINS;

EID: 85017945568     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.02560316     Document Type: Article

References (53)

1. Wochner RD, Strober W, Waldmann TA: The role of the kidney in the catabolism of Bence Jones proteins and immunoglobulin fragments. J Exp Med 126: 207-221, 1967
2. Basnayake K, Stringer SJ, Hutchison CA, Cockwell P: The biology of immunoglobulin free light chains and kidney injury. Kidney Int 79: 1289-1301, 2011
3. Solomon A, Weiss DT, Kattine AA: Nephrotoxic potential of Bence Jones proteins. N Engl J Med 324: 1845-1851, 1991
4. Paueksakon P, Fogo AB: More light shed on light chains. Nephrol Dial Transplant 29: 1799-1801, 2014
5. Teng J, Turbat-Herrera EA, Herrera GA: An animal model of glomerular light-chain-associated amyloidogenesis depicts the crucial role of lysosomes. Kidney Int 86: 738-746, 2014
6. Merlini G, Stone MJ: Dangerous small B-cell clones. Blood 108: 2520-2530, 2006
7. Kyle RA, Linos A, Beard CM, Linke RP, Gertz MA, O’Fallon WM, Kurland LT: Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989. Blood 79: 1817-1822, 1992
8. Merlini G, Bellotti V: Molecular mechanisms of amyloidosis. N Engl J Med 349: 583-596, 2003
9. Comenzo RL, Zhang Y, Martinez C, Osman K, Herrera GA: The tropism of organ involvement in primary systemic amyloidosis: Contributions of Ig V(L) germline gene use and clonal plasma cell burden. Blood 98: 714-720, 2001
10. Diomede L, Rognoni P, Lavatelli F, Romeo M, del Favero E, Cantù L, Ghibaudi E, di Fonzo A, Corbelli A, Fiordaliso F, Palladini G, Valentini V, Perfetti V, Salmona M, Merlini G: A Caenorhabditis elegans-based assay recognizes immunoglobulin light chains causing heart amyloidosis. Blood 123: 3543-3552, 2014
11. Keeling J, Teng J, Herrera GA: AL-amyloidosis and light-chain deposition disease light chains induce divergent phenotypic transformations of human mesangial cells. Lab Invest 84: 1322-1338, 2004
12. Charitaki E, Kastritis E, Petraki C, Liapis K, Adamidis K, Apostolou T, Christodoulidou C, Nikolopoulou N, Terpos E, Nakopoulou L, Dimopoulos MA: Glomerular expression of matrix metalloproteinases in AL-amyloidosis and association with renal function at the time of kidney biopsy. Clin Nephrol 85: 44-54, 2016
13. Tennent GA, Lovat LB, Pepys MB: Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc Natl Acad Sci U S A 92: 4299-4303, 1995
14. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB: Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature 468: 93-97, 2010
15. Novak L, Cook WJ, Herrera GA, Sanders PW: AL-amyloidosis is underdiagnosed in renal biopsies. Nephrol Dial Transplant 19: 3050-3053, 2004
16. Leung N, Nasr SH, Sethi S: How I treat amyloidosis: The importance of accurate diagnosis and amyloid typing. Blood 120: 3206-3213, 2012
17. Denoroy L, Déret S, Aucouturier P: Overrepresentation of the V kappa IV subgroup in light chain deposition disease. Immunol Lett 42: 63-66, 1994
18. James LC, Jones PC, McCoy A, Tennent GA, Pepys MB, Famm K, Winter G: Beta-edge interactions in a pentadecameric human antibody V kappa domain. J Mol Biol 367: 603-608, 2007
19. CognéM, Preud’homme JL, Bauwens M, Touchard G, Aucouturier P: Structure of a monoclonal kappa chain of the V kappa IV subgroup in the kidney and plasma cells in light chain deposition disease. J Clin Invest 87: 2186-2190, 1991
20. Vidal R, Goñi F, Stevens F, Aucouturier P, Kumar A, Frangione B, Ghiso J, Gallo G: Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: Potential effects on aberrant protein conformation and deposition. Am J Pathol 155: 2009-2017, 1999
21. Moulin B, Deret S, Mariette X, Kourilsky O, Imai H, Dupouet L, Marcellin L, Kolb I, Aucouturier P, Brouet JC, Ronco PM, Mougenot B: Nodular glomerulosclerosis with deposition of monoclonal immunoglobulin heavy chains lacking C(H)1. J Am Soc Nephrol 10: 519-528, 1999
22. Herrera GA: Renal manifestations of plasma cell dyscrasias: An appraisal from the patients’ bedside to the research laboratory. Ann Diagn Pathol 4: 174-200, 2000
23. Zhu L, Herrera GA, Murphy-Ullrich JE, Huang ZQ, Sanders PW: Pathogenesis of glomerulosclerosis in light chain deposition disease. Role for transforming growth factor-beta. Am J Pathol 147: 375-385, 1995
24. Teng J, Zhang PL, Russell WJ, Zheng LP, Jones ML, Herrera GA: Insights into mechanisms responsible for mesangial alterations associated with fibrogenic glomerulopathic light chains. Nephron, Physiol 94: 28-38, 2003
25. Herrera GA, Shultz JJ, Soong SJ, Sanders PW: Growth factors in monoclonal light-chain-related renal diseases. Hum Pathol 25: 883-892, 1994
26. Ronco P, Plaisier E, Mougenot B, Aucouturier P: Immunoglobulin light (heavy)-chain deposition disease: From molecularmedicine to pathophysiology-driven therapy. Clin J Am Soc Nephrol 1: 1342-1350, 2006
27. Sethi S, Zand L, Leung N, Smith RJ, Jevremonic D, Herrmann SS, Fervenza FC: Membranoproliferative glomerulonephritis secondary to monoclonal gammopathy. Clin J Am Soc Nephrol 5: 770-782, 2010
28. Bhutani G, Nasr SH, Said SM, Sethi S, Fervenza FC, Morice WG, Kurtin PJ, Buadi FK, Dingli D, Dispenzieri A, Gertz MA, Lacy MQ, Kapoor P, Kumar S, Kyle RA, Rajkumar SV, Leung N: Hematologic characteristics of proliferative glomerulonephritides with nonorganized monoclonal immunoglobulin deposits. Mayo Clin Proc 90: 587-596, 2015
29. Zickerman AM, Allen AC, Talwar V, Olczak SA, Brownlee A, Holland M, Furness PN, Brunskill NJ, Feehally J: IgA myeloma presenting as Henoch-Schönlein purpura with nephritis. Am J Kidney Dis 36: E19, 2000
30. Birchmore D, Sweeney C, Choudhury D, Konwinski MF, Carnevale K, D’Agati V: IgA multiple myeloma presenting as Henoch-Schönlein purpura/polyarteritis nodosa overlap syndrome. Arthritis Rheum 39: 698-703, 1996
31. VanDerHelm-Van Mil AH, Smith AC, Pouria S, Tarelli E, Brunskill NJ, Eikenboom HC: Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1. Br J Haematol 122: 915-917, 2003
32. Allen AC, Willis FR, Beattie TJ, Feehally J: Abnormal IgA glycosylation in Henoch-Schönlein purpura restricted to patients with clinical nephritis. Nephrol Dial Transplant 13: 930-934, 1998
33. Tomana M, Novak J, Julian BA, Matousovic K, Konecny K, Mestecky J: Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies. J Clin Invest 104: 73-81, 1999
34. Angioi A, Fervenza FC, Sethi S, Zhang Y, Smith RJ, Murray D, Van Praet J, Pani A, De Vriese AS: Diagnosis of complement alternative pathway disorders. Kidney Int 89: 278-288, 2016
35. Sethi S, Sukov WR, Zhang Y, Fervenza FC, Lager DJ, Miller DV, Cornell LD, Krishnan SG, Smith RJ: Dense deposit disease associated with monoclonal gammopathy of undetermined significance. Am J Kidney Dis 56: 977-982, 2010
36. Bridoux F, Desport E, Frémeaux-Bacchi V, Chong CF, Gombert JM, Lacombe C, Quellard N, Touchard G: Glomerulonephritis with isolated C3 deposits and monoclonal gammopathy: A fortuitous association? Clin J Am Soc Nephrol 6: 2165-2174, 2011
37. Meri S, Koistinen V, Miettinen A, Törnroth T, Seppälä IJ: Activation of the alternative pathway of complement by monoclonal lambda light chains in membranoproliferative glomerulonephritis. J Exp Med 175: 939-950, 1992
38. Alpers CE, Kowalewska J: Fibrillary glomerulonephritis and immunotactoid glomerulopathy. JAmSoc Nephrol 19: 34-37, 2008
39. Sanders PW: Mechanisms of light chain injury along the tubular nephron. J Am Soc Nephrol 23: 1777-1781, 2012
40. Batuman V: Proximal tubular injury in myeloma. Contrib Nephrol 153: 87-104, 2007
41. Batuman V: The pathogenesis of acute kidney impairment in patients with multiplemyeloma. Adv Chronic KidneyDis 19: 282-286, 2012
42. Ecotière L, Thierry A, Debiais-Delpech C, Chevret S, Javaugue V, Desport E, Belmouaz S, Quellard N, Kaaki S, Goujon JM, Fermand JP, Touchard G, Bridoux F: Prognostic value of kidney biopsy in myeloma cast nephropathy: A retrospective study of 70 patients. Nephrol Dial Transplant 31: 64-72, 2016
43. Herrera GA: Proximal tubulopathies associated with monoclonal light chains: The spectrum of clinicopathologic manifestations and molecular pathogenesis. Arch Pathol Lab Med 138: 1365-1380, 2014
44. Hutchison CA, Batuman V, Behrens J, Bridoux F, Sirac C, Dispenzieri A, Herrera GA, Lachmann H, Sanders PW; International Kidney and Monoclonal Gammopathy Research Group: The pathogenesis and diagnosis of acute kidney injury in multiple myeloma. Nat Rev Nephrol 8: 43-51, 2011
45. Stokes MB, Valeri AM, Herlitz L, Khan AM, Siegel DS, Markowitz GS, D’Agati VD: Light chain proximal tubulopathy: Clinical and pathologic characteristics in the modern treatment era. J Am Soc Nephrol 27: 1555-1565, 2016
46. Sirac C, Bridoux F, Carrion C, Devuyst O, Fernandez B, Goujon JM, El Hamel C, Aldigier JC, Touchard G, CognéM: Role of the monoclonal kappa chain V domain and reversibility of renal damage in a transgenic model of acquired Fanconi syndrome. Blood 108: 536-543, 2006
47. Khan AM, Li M, Balamuthusamy S, Maderdrut JL, Simon EE, Batuman V: Myeloma light chain-induced renal injury in mice. Nephron Exp Nephrol 116: e32-e41, 2010
48. Sengul S, Erturk S, Khan AM, Batuman V: Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells. PLoS One 8: e70276, 2013
49. Weiss JH, Williams RH, Galla JH, Gottschall JL, Rees ED, Bhathena D, Luke RG: Pathophysiology of acute Bence-Jones protein nephrotoxicity in the rat. Kidney Int 20: 198-210, 1981
50. Sanders PW, Booker BB: Pathobiology of cast nephropathy from human Bence Jones proteins. J Clin Invest 89: 630-639, 1992
51. Huang Z-Q, Sanders PW: Localization of a single binding site for immunoglobulin light chains on human Tamm-Horsfall glycoprotein. J Clin Invest 99: 732-736, 1997
52. Ying WZ, Allen CE, Curtis LM, Aaron KJ, Sanders PW: Mechanism and prevention of acute kidney injury from cast nephropathy in a rodent model. J Clin Invest 122: 1777-1785, 2012
53. Sanders PW, Booker BB, Bishop JB, Cheung HC: Mechanisms of intranephronal proteinaceous cast formation by low molecular weight proteins. J Clin Invest 85: 570-576, 1990