Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1

British Journal of Haematology

Volumn 122, Issue 6, 2003, Pages 915-917

  Van Der Helm Van Mil, Annette H M ^a   Smith, Alice C ^b   Pouria, Shideh ^c   Tarelli, Edward ^d   Brunskill, Nigel J ^b   Eikenboom, Heroen C J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Henoch Sch nlein purpura; IgA multiple myeloma; Mass spectrometry; O glycosylation; Sialylation

Indexed keywords

DEXAMETHASONE; DOXORUBICIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN A1; LECTIN; MELPHALAN; PEANUT AGGLUTININ; VINCRISTINE;

ABDOMINAL PAIN; ADULT; ANAPHYLACTOID PURPURA; ANEMIA; ARTHRALGIA; ARTICLE; CASE REPORT; CLINICAL FEATURE; GLYCOSYLATION; HUMAN; LEUKOCYTE COUNT; MALE; MASS SPECTROMETRY; MULTIPLE MYELOMA; PRIORITY JOURNAL; PROTEIN BINDING; SIALYLATION; THROMBOCYTE COUNT;

GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN A; MALE; MIDDLE AGED; MULTIPLE MYELOMA; PURPURA, SCHOENLEIN-HENOCH;

EID: 0141763653     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2003.04539.x     Document Type: Article

References (10)

1. Birchmore, D., Sweeney, C., Choudhury, D., Konwinski, M.F., Carnevale, K. & D'Agati, V. (1996) IgA multiple myeloma presenting as Henoch-Schönlein purpura/polyarteritis nodosa overlap syndrome. Arthritis and Rheumatism, 39, 698-703.
2. Dosa, S., Cairns, S.A., Mallick, N.P., Lawler, W. & Williams, G. (1980) Relapsing Henoch-Schönlein syndrome with renal involvement in a patient with an IgA monoclonal gammapathy. Nephron, 26, 145-148.
3. Hiki, Y., Kokubo, T., Iwase, H., Masaki, Y., Sano, T., Tanaka, A., Toma, K., Hotta, K. & Kobayashi, Y. (1999) Underglycosylation of IgA1 hinge plays a certain role for its glomerular deposition of IgA nephropathy. Journal of the American Society of Nephrology, 10, 760-769.
4. Hiki, Y., Odani, H., Takahashi, M., Yusuda, Y., Nishimoto, A., Iwase, H., Shinzato, T., Kombayashi, Y. & Maeda, K. (2001) Mass spectrometry proves under-O-glycosylation of glomerular IgA1 in IgA nephropathy. Kidney International, 59, 1077-1085.
5. Nikolova, E.B., Tomana, M. & Russell, M.W. (1994) The role of the carbohydrate chains in complement (C3) Fixation by solid-phase-bound human IgA. Immunology, 82, 321-327.
6. Osawa, T. & Tsuji, T. (1987) Fractionation and structural assessment of oligosaccharides and glycopeptides by use of immobilized lectins. Annual Reviews in Biochemistry, 56, 21-42.
7. Saulsbury, F.T. (1997) Alterations in the O-linked glycosylation of IgA1 in children with Henoch-Schönlein purpura. Journal of Rheumatology, 24, 2246-2249.
8. Saulsbury, F.T. (2001) Henoch-Schönlein purpura. Current Opinion in Rheumatology, 13, 35-40.
9. Tomino, Y., Ohmuro, H., Takahashi, Y., Suzuki, Y., Saka, S., Tashiro, K., Shirato, I. & Koide, H. (1995) Binding capacity of serum IgA to jacalin in patients with IgA nephropathy using jacalin-coated microplates. Nephron, 70, 329-333.
10. Zickerman, A.M., Allen, A.C., Talwar, V., Olczak, S.A., Brownlee, A., Holland, M., Furness, P.N., Brunskill, N.J. & Feehally, J. (2000) IgA-myeloma presenting as Henoch-Schönlein purpura with nephritis. American Journal of Kidney Diseases, 36, 1-5.