A humanized mouse-based HIV-1 viral outgrowth assay with higher sensitivity than in vitro qVOA in detecting latently infected cells from individuals on ART with undetectable viral loads

Virology

Volumn 507, Issue , 2017, Pages 135-139

  Charlins, Paige ^a   Schmitt, Kimberly ^a   Remling Mulder, Leila ^a   Hogan, Louise E ^b,c   Hanhauser, Emily ^b,c   Hobbs, Kristen S ^b,c   Hecht, Frederick ^b   Deeks, Steven G ^b   Henrich, Timothy J ^b,c   Akkina, Ramesh ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Comparison of HIV qVOA and in vivo hu mouse VOA; Humanized mouse based latent HIV 1 viral outgrowth assay; In vivo latent HIV 1 viral outgrowth assay; Latent HIV 1 detection by hu mouse based VOA; Ultra Sensitive latent HIV 1 detection in patient cells

Indexed keywords

ABACAVIR; ATAZANAVIR; COBICISTAT; DOLUTEGRAVIR; ELVITEGRAVIR; EMTRICITABINE; LAMIVUDINE; RALTEGRAVIR; RILPIVIRINE; RITONAVIR; TENOFOVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIRETROVIRAL THERAPY; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; COMPARATIVE STUDY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMANIZED MOUSE VIRAL OUTGROWTH ASSAY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NEWBORN; NONHUMAN; QUANTITATIVE VIRAL OUTGROWTH ASSAY; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS; VIRUS DETECTION; VIRUS LOAD; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HIV INFECTIONS; PHYSIOLOGY; VIROLOGY; VIRUS LATENCY;

ANIMALS; ANTI-HIV AGENTS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MICE; MICE, INBRED BALB C; VIRAL LOAD; VIRUS LATENCY;

EID: 85017583966     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2017.04.011     Document Type: Article

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