Role of NeuroD1 on the negative regulation of Pomc expression by glucocorticoid

PLoS ONE

Volumn 12, Issue 4, 2017, Pages

  Parvin, Rehana ^a   Saito Hakoda, Akiko ^a   Shimada, Hiroki ^a   Shimizu, Kyoko ^a   Noro, Erika ^a   Iwasaki, Yasumasa ^b   Fujiwara, Ken ^c   Yokoyama, Atsushi ^a   Sugawara, Akira ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KOCHI UNIVERSITY   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DEXAMETHASONE; MESSENGER RNA; NEUROGENIC DIFFERENTIATION FACTOR; NUCLEAR RECEPTOR NUR77; NUCLEAR RECEPTOR RELATED FACTOR 1; PROOPIOMELANOCORTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E BOX; TRANSCRIPTION FACTOR PITX1; TRANSCRIPTION FACTOR TPIT; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GLUCOCORTICOID; NEUROD1 PROTEIN, MOUSE; RNA; TUMOR PROTEIN;

ACTH SECRETING CELL; ANIMAL CELL; ARTICLE; CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE DELETION; GENE OVEREXPRESSION; INHIBITION KINETICS; LUCIFERASE ASSAY; MOUSE; NONHUMAN; POINT MUTATION; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; ACTH SECRETING ADENOMA; ADENOMA; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; RAT; TUMOR CELL LINE;

ACTH-SECRETING PITUITARY ADENOMA; ADENOMA; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCOCORTICOIDS; MICE; NEOPLASM PROTEINS; PRO-OPIOMELANOCORTIN; PROMOTER REGIONS, GENETIC; RATS; RNA, MESSENGER; RNA, NEOPLASM;

EID: 85017571684     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0175435     Document Type: Article

References (55)

1. Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20:429-440. PMID: 10611221
2. Bell GI, Polonsky KS (2001) Diabetes mellitus and genetically programmed defects in beta-cell function. Nature 414:788-791. https://doi.org/10.1038/414788a PMID: 11742410
3. Cerf ME (2006) Transcription factors regulating beta-cell function. Eur J Endocrinol 155:671-679. https://doi.org/10.1530/eje.1.02277 PMID: 17062882
4. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H (1995) Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268:836-844. PMID: 7754368
5. Miyata T, Maeda T, Lee JE (1999) NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev 13:1647-1652. PMID: 10398678
6. Liu M, Pereira FA, Price SD, Chu MJ, Shope C, Himes D, et al. (2000) Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev 14:2839-2854. PMID: 11090132
7. Poulin G, Turgeon B, Drouin J (1997) NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol Cell Biol 17:6673-6682. PMID: 9343431
8. Lamolet B, Poulin G, Chu K, Guillemot F, Tsai MJ, Drouin J (2004) Tpit-independent function of NeuroD1 (BETA2) in pituitary corticotroph differentiation. Mol Endocrinol 18:995-1003. https://doi.org/10. 1210/me.2003-0127 PMID: 14726486
9. Poulin G, Lebel M, Chamberland M, Paradis FW, Drouin J (2000) Specific protein-protein interaction between basic helix-loop-helix transcription factors and homeoproteins of the Pitx family. Mol Cell Biol 20:4826-4837. PMID: 10848608
10. Bertagna X (1994) Proopiomelanocortin-derived peptides. Endocrinol Metab Clin North Am 23:467-485. PMID: 7805649
11. Castro MG, Morrison E (1997) Post-translational processing of proopiomelanocortin in the pituitary and in the brain. Crit Rev Neurobiol 11:35-57. PMID: 9093813
12. Smith EM, Blalock JE (1981) Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon. Proc Natl Acad Sci U S A 78:7530-7534. PMID: 6174975
13. Zhou A, Bloomquist BT, Mains RE (1993) The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in a strict temporal order during proopiomelanocortin biosynthetic processing. J Biol Chem 268:1763-1769. PMID: 8380577
14. Bloomquist BT, Eipper BA, Mains RE (1991) Prohormone-converting enzymes: regulation and evaluation of function using antisense RNA. Mol Endocrinol 5:2014-2024. https://doi.org/10.1210/mend-5-12-2014 PMID: 1791845
15. Axelrod J, Reisine TD (1984) Stress hormones: their interaction and regulation. Science 224:452-459. PMID: 6143403
16. Jeannotte L, Trifiro MA, Plante RK, Chamberland M, Drouin J (1987) Tissue-specific activity of the proopiomelanocortin gene promoter. Mol Cell Biol 7:4058-4064. PMID: 3431549
17. Wardlaw SL, McCarthy KC, Conwell IM (1998) Glucocorticoid regulation of hypothalamic proopiomelanocortin. Neuroendocrinology 67:51-57. PMID: 9485169
18. Drouin J, Trifiro MA, Plante RK, Nemer M, Eriksson P, Wrange O (1989) Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol Cell Biol 9:5305-5314. PMID: 2586521
19. Eberwine JH, Roberts JL (1984) Glucocorticoid regulation of pro-opiomelanocortin gene transcription in the rat pituitary. J Biol Chem 259:2166-2170. PMID: 6546571
20. Gagner JP, Drouin J (1985) Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol Cell Endocrinol 40:25-32. PMID: 3873366
21. Dostert A, Heinzel T (2004) Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 10:2807-2816. PMID: 15379669
22. Cadepond F, Schweizer-Groyer G, Segard-Maurel I, Jibard N, Hollenberg SM, Giguere V, et al. (1991) Heat shock protein 90 as a critical factor in maintaining glucocorticosteroid receptor in a nonfunctional state. J Biol Chem 266:5834-5841. PMID: 2005120
23. Picard D, Yamamoto KR (1987) Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6:3333-3340. PMID: 3123217
24. Kumar R, Thompson EB (2005) Gene regulation by the glucocorticoid receptor: structure: function relationship. J Steroid Biochem Mol Biol 94:383-394. https://doi.org/10.1016/j.jsbmb.2004.12.046 PMID: 15876404
25. Drouin J, Sun YL, Chamberland M, Gauthier Y, De Lean A, Nemer M, et al. (1993) Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J 12:145-156. PMID: 8428574
26. Bilodeau S, Vallette-Kasic S, Gauthier Y, Figarella-Branger D, Brue T, Berthelet F, et al. (2006) Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes Dev 20:2871-2886. https://doi.org/10.1101/gad.1444606 PMID: 17043312
27. Murakami I, Takeuchi S, Kudo T, Sutou S, Takahashi S (2007) Corticotropin-releasing hormone or dexamethasone regulates rat proopiomelanocortin transcription through Tpit/Pitx-responsive element in its promoter. J Endocrinol 193:279-290. https://doi.org/10.1677/JOE-06-0143 PMID: 17470519
28. Saito-Hakoda A, Uruno A, Yokoyama A, Shimizu K, Parvin R, Kudo M, et al. (2015) Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression. PLoS One 10:e0141960. https://doi.org/10.1371/journal.pone.0141960 PMID: 26714014
29. Uruno A, Saito-Hakoda A, Yokoyama A, Kogure N, Matsuda K, Parvin R, et al. (2014) Retinoic acid receptor-alpha up-regulates proopiomelanocortin gene expression in AtT20 corticotroph cells. Endocr J 61:1105-1114. PMID: 25132258
30. Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, et al. (2009) Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem 284:31236-31248. https://doi.org/10.1074/jbc. M109.048694 PMID: 19759004
31. Dai A, Yan G, He Q, Jiang Y, Zhang Q, Fang T, et al. (2012) Orphan nuclear receptor Nur77 regulates androgen receptor gene expression in mouse ovary. PLoS One 7:e39950. https://doi.org/10.1371/journal.pone.0039950 PMID: 22761936
32. Spyroglou A, Manolopoulou J, Wagner S, Bidlingmaier M, Reincke M, Beuschlein F (2009) Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice. J Mol Endocrinol 42:407-413. https://doi.org/10.1677/JME-08-0167 PMID: 19221003
33. Mercau ME, Repetto EM, Perez MN, Martinez Calejman C, Sanchez Puch S, Finkielstein CV, et al. (2016) Moderate Exercise Prevents Functional Remodeling of the Anterior Pituitary Gland in Diet-Induced Insulin Resistance in Rats: Role of Oxidative Stress and Autophagy. Endocrinology 157:1135-1145. https://doi.org/10.1210/en. 2015-1777 PMID: 26672805
34. Zhang Y, Chen B, Hou XH, Guan GJ, Liu G, Liu HY, et al. (2007) Effects of mycophenolate mofetil, valsartan and their combined therapy on preventing podocyte loss in early stage of diabetic nephropathy in rats. Chin Med J (Engl) 120:988-995.
35. Maliza R, Fujiwara K, Tsukada T, Azuma M, Kikuchi M, Yashiro T (2016) Effects of retinoic acid on growth hormone-releasing hormone receptor, growth hormone secretagogue receptor gene expression and growth hormone secretion in rat anterior pituitary cells. Endocr J 63:555-561. https://doi.org/10. 1507/endocrj. EJ16-0086 PMID: 27052215
36. Pecori Giraldi F, Casarino MF, Pagliardini L, Cavagnini F (2011) On the Effect of CRH and Dexamethasone on POMC Synthesis and ACTH Secretion in Rat Pituitary Primary Cultures. The Endocrine Society's 93rd Annual Meeting. Boston, P1-272.
37. Philips A, Lesage S, Gingras R, Maira MH, Gauthier Y, Hugo P, et al. (1997) Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells. Mol Cell Biol 17:5946-5951. PMID: 9315652
38. Batsche E, Moschopoulos P, Desroches J, Bilodeau S, Drouin J (2005) Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription. J Biol Chem 280:16088-16095. https://doi.org/10.1074/jbc. M413427200 PMID: 15701640
39. Walsh D, Avashia J (1992) Glucocorticoids in clinical oncology. Cleve Clin J Med 59:505-515. PMID: 1281759
40. Jenks BG (2009) Regulation of proopiomelanocortin gene expression: an overview of the signaling cascades, transcription factors, and responsive elements involved. Ann N Y Acad Sci 1163:17-30. https://doi.org/10.1111/j.1749-6632.2008.03620.x PMID: 19456325
41. Therrien M, Drouin J (1991) Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Mol Cell Biol 11:3492-3503. PMID: 2046665
42. Wilson TE, Fahrner TJ, Johnston M, Milbrandt J (1991) Identification of the DNA binding site for NGFI-B by genetic selection in yeast. Science 252:1296-1300. PMID: 1925541
43. Maira M, Martens C, Philips A, Drouin J (1999) Heterodimerization between members of the Nur subfamily of orphan nuclear receptors as a novel mechanism for gene activation. Mol Cell Biol 19:7549-7557. PMID: 10523643
44. Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A, et al. (2001) A pituitary cellrestricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Cell 104:849-859. PMID: 11290323
45. Karalis KP, Venihaki M, Zhao J, Van Vlerken LE, Chandras C (2004) NF-kappaB participates in the corticotropinreleasing, hormone-induced regulation of the pituitary proopiomelanocortin gene. J Biol Chem 279:10837-10840. https://doi.org/10.1074/jbc. M313063200 PMID: 14711817
46. Therrien M, Drouin J (1993) Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanocortin gene. Mol Cell Biol 13:2342-2353. PMID: 8455616
47. Dumonteil E, Laser B, Constant I, Philippe J (1998) Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J Biol Chem 273:19945-19954. PMID: 9685329
48. Sharma A, Moore M, Marcora E, Lee JE, Qiu Y, Samaras S, et al. (1999) The NeuroD1/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300/CREB binding protein binding. Mol Cell Biol 19:704-713. PMID: 9858593
49. Moates JM, Nanda S, Cissell MA, Tsai MJ, Stein R (2003) BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells. Diabetes 52:403-408. PMID: 12540614
50. Mutoh H, Naya FJ, Tsai MJ, Leiter AB (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev 12:820-830. PMID: 9512516
51. Konishi Y, Ohkawa N, Makino Y, Ohkubo H, Kageyama R, Furuichi T, et al. (1999) Transcriptional regulation of mouse type 1 inositol 1, 4, 5-trisphosphate receptor gene by NeuroD-related factor. J Neurochem 72:1717-1724. PMID: 10098882
52. Pozzoli O, Bosetti A, Croci L, Consalez GG, Vetter ML (2001) Xebf3 is a regulator of neuronal differentiation during primary neurogenesis in Xenopus. Dev Biol 233:495-512. https://doi.org/10.1006/dbio. 2001.0230 PMID: 11336510
53. Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ (2000) Regulation of the pancreatic isletspecific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol 20:3292-3307. PMID: 10757813
54. Shinozuka Y, Okada M, Oki T, Sagane K, Mizui Y, Tanaka I, et al. (2001) Altered expression of HES-1, BETA2/NeuroD, and PDX-1 is involved in impaired insulin synthesis induced by glucocorticoids in HITT15 cells. Biochem Biophys Res Commun 287:229-235. https://doi.org/10.1006/bbrc.2001.5573 PMID: 11549279
55. Drouin J (2016) 60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression. J Mol Endocrinol 56:T99-T112. https://doi.org/10.1530/JME-15-0289 PMID: 26792828