Effects of Hypercapnia and Hypercapnic Acidosis on Hospital Mortality in Mechanically Ventilated Patients

Critical Care Medicine

Volumn 45, Issue 7, 2017, Pages e649-e656

  Tiruvoipati, Ravindranath ^a,b   Pilcher, David ^b   Buscher, Hergen ^c,d   Botha, John ^a,b   Bailey, Michael ^b  

^a FRANKSTON HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c ST VINCENT S HOSPITAL   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

hypercapnia; respiratory acidosis; respiratory failure

Indexed keywords

CARBON DIOXIDE;

ACIDOSIS; ADULT; ARTICLE; ARTIFICIAL VENTILATION; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; COMORBIDITY; FEMALE; HEART RATE; HOSPITAL ADMISSION; HOSPITAL MORTALITY; HUMAN; HYPERCAPNIA; INTENSIVE CARE UNIT; KIDNEY DISEASE; KIDNEY FUNCTION; LENGTH OF STAY; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PH; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; TEMPERATURE; VENTILATED PATIENT; ACIDOSIS, RESPIRATORY; ADVERSE EFFECTS; AGE; AGED; BLOOD; CLINICAL TRIAL; MIDDLE AGED; MORTALITY; STATISTICAL MODEL; VERY ELDERLY;

ACIDOSIS, RESPIRATORY; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CARBON DIOXIDE; COMORBIDITY; FEMALE; HOSPITAL MORTALITY; HUMANS; HYDROGEN-ION CONCENTRATION; HYPERCAPNIA; INTENSIVE CARE UNITS; LOGISTIC MODELS; MALE; MIDDLE AGED; RESPIRATION, ARTIFICIAL; RETROSPECTIVE STUDIES;

EID: 85017571441     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002332     Document Type: Article

References (39)

1. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000; 342: 1301 1308
2. Amato MB Meade MO Slutsky AS. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med 2015; 372: 747 755
3. Terragni PP Del Sorbo L Mascia L. Tidal volume lower than 6 ml/kg enhances lung protection: Role of extracorporeal carbon dioxide removal. Anesthesiology 2009; 111: 826 835
4. Kavanagh BP Laffey JG. Hypercapnia: Permissive and therapeutic. Minerva Anestesiol 2006; 72: 567 576
5. Laffey JG Kavanagh BP. Carbon dioxide and the critically ill-too little of a good thing? Lancet 1999; 354: 1283 1286
6. Laffey JG Tanaka M Engelberts D. Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000; 162: 2287 2294
7. Laffey JG Engelberts D Kavanagh BP. Buffering hypercapnic acidosis worsens acute lung injury. Am J Respir Crit Care Med 2000; 161: 141 146
8. Stewart TE Meade MO Cook DJ. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure-and Volume-Limited Ventilation Strategy Group. N Engl J Med 1998; 338: 355 361
9. Paul E Bailey M Pilcher D. Risk prediction of hospital mortality for adult patients admitted to Australian and New Zealand intensive care units: Development and validation of the Australian and New Zealand Risk of Death model. J Crit Care 2013; 28: 935 941
10. Laserna E Sibila O Aguilar PR. Hypocapnia and hypercapnia are predictors for ICU admission and mortality in hospitalized patients with community-acquired pneumonia. Chest 2012; 142: 1193 1199
11. Sin DD Man SF Marrie TJ. Arterial carbon dioxide tension on admission as a marker of in-hospital mortality in community-acquired pneumonia. Am J Med 2005; 118: 145 150
12. Tiruvoipati R Botha JA Pilcher D. Carbon dioxide clearance in critical care. Anaesth Intensive Care 2013; 41: 157 162
13. Cullen DJ Eger EI 2nd. Cardiovascular effects of carbon dioxide in man. Anesthesiology 1974; 41: 345 349
14. Curley G Laffey JG Kavanagh BP. Bench-to-bedside review: Carbon dioxide. Crit Care 2010; 14: 220
15. Pedoto A Caruso JE Nandi J. Acidosis stimulates nitric oxide production and lung damage in rats. Am J Respir Crit Care Med 1999; 159: 397 402
16. Lang JD Jr Chumley P Eiserich JP. Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway. Am J Physiol Lung Cell Mol Physiol 2000; 279: L994 1002
17. Doerr CH Gajic O Berrios JC. Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungs. Am J Respir Crit Care Med 2005; 171: 1371 1377
18. 2 modulates intracellular pH, intracellular oxidant generation, and interleukin-8 secretion in human neutrophils. J Leukoc Biol 2002; 71: 603 610
19. Curley G Contreras MM Nichol AD. Hypercapnia and acidosis in sepsis: A double-edged sword? Anesthesiology 2010; 112: 462 472
20. Pugin J Dunn-Siegrist I Dufour J. Cyclic stretch of human lung cells induces an acidification and promotes bacterial growth. Am J Respir Cell Mol Biol 2008; 38: 362 370
21. Casalino-Matsuda SM Nair A Beitel GJ. Hypercapnia inhibits autophagy and bacterial killing in human macrophages by increasing expression of Bcl-2 and Bcl-xL. J Immunol 2015; 194: 5388 5396
22. Bersentes TJ Simmons DH. Effects of acute acidosis on renal hemodynamics. Am J Physiol 1967; 212: 633 640
23. Ahmadi Z Bornefalk-Hermansson A Franklin KA. Hypo-and hypercapnia predict mortality in oxygen-dependent chronic obstructive pulmonary disease: A population-based prospective study. Respir Res 2014; 15: 30
24. Chailleux E Fauroux B Binet F. Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation. A 10-year analysis of ANTADIR Observatory. Chest 1996; 109: 741 749
25. Oga T Taniguchi H Kita H. Analysis of the relationship between health status and mortality in hypercapnic patients with noninvasive ventilation. Clin Respir J 2015 Nov 25. [Epub ahead of print]
26. Apanasenko GL Shchegolev VS Kuleshov VI. [Tolerance for controlled physical loading in chronic hypercapnia in man]. Kosm Biol Aviakosm Med 1978; 12: 49 52
27. Beekley MD Cullom DL Brechue WF. Hypercapnic impairment of neuromuscular function is related to afferent depression. Eur J Appl Physiol 2004; 91: 105 110
28. Juan G Calverley P Talamo C. Effect of carbon dioxide on diaphragmatic function in human beings. N Engl J Med 1984; 310: 874 879
29. Shiota S Okada T Naitoh H. Hypoxia and hypercapnia affect contractile and histological properties of rat diaphragm and hind limb muscles. Pathophysiology 2004; 11: 23 30
30. 2 in rat diaphragmatic arterioles: Role of the endothelium. Am J Physiol 1997; 272 (3 Pt 2): H1419 H1425
31. Costello J Higgins B Contreras M. Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis. Crit Care Med 2009; 37: 2412 2420
32. Sinclair SE Kregenow DA Lamm WJ. Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med 2002; 166: 403 408
33. Takeshita K Suzuki Y Nishio K. Hypercapnic acidosis attenuates endotoxin-induced nuclear factor-[kappa]B activation. Am J Respir Cell Mol Biol 2003; 29: 124 132
34. Vohwinkel CU Lecuona E Sun H. Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. J Biol Chem 2011; 286: 37067 37076
35. Brochard L Roudot-Thoraval F Roupie E. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on tidal volume reduction in ARDS. Am J Respir Crit Care Med 1998; 158: 1831 1838
36. Brower RG Shanholtz CB Fessler HE. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999; 27: 1492 1498
37. Amato MB Barbas CS Medeiros DM. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338: 347 354
38. Kaukonen KM Bailey M Pilcher D. Systemic inflammatory response syndrome criteria in defining severe sepsis. N Engl J Med 2015; 372: 1629 1638
39. Kaukonen KM Bailey M Suzuki S. Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012. JAMA 2014; 311: 1308 1316