Traditional Medicines and Kidney Disease in Low- and Middle-Income Countries: Opportunities and Challenges

Seminars in Nephrology

Volumn 37, Issue 3, 2017, Pages 245-259

  Stanifer, John W ^a,b   Kilonzo, Kajiru ^c   Wang, Daphne ^a   Su, Guobin ^d,e,f   Mao, Wei ^d,f   Zhang, Lei ^d,f   Zhang, La ^d,f,g   Nayak Rao, Shobhana ^h   Miranda, J Jaime ^i,j  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c KILIMANJARO CHRISTIAN MEDICAL UNIVERSITY COLLEGE   (Tanzania)

^d GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^e KAROLINSKA INSTITUTE   (Sweden)

^f GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^g RMIT UNIVERSITY   (Australia)

^h Medical Sciences Complex   (India)

ⁱ CRONICAS CENTER OF EXCELLENCE IN CHRONIC DISEASES   (Peru)

^j UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

more..

Author keywords

Ayurveda; kidney disease; low and middle income countries; traditional Chinese medicine; Traditional medicines

Indexed keywords

ACONITUM EXTRACT; ALOE VERA EXTRACT; ARISTOLOCHIA FANGCHI EXTRACT; ARRABIDAEA BRACHYPODA EXTRACT; ASTRAGALUS EXTRACT; BOERHAAVIA DIFFUSA EXTRACT; CALLILEPSIS LAUREOLA EXTRACT; CECROPIA OBTUSIFOLIA EXTRACT; CECROPIA PACHYSTACHYA EXTRACT; COLEUS AROMATICUS EXTRACT; CORDYCEPS SINENSIS EXTRACT; CROTALARIA LABUMIFOLI EXTRACT; CUCULIGO ORCHIODES EXTRACT; CYMBOPOGON CITRATUS EXTRACT; CYNODON DACTYLON EXTRACT; DOLICHOS BIFLORUS EXTRACT; EMBLICA OFFICINALIS EXTRACT; EUPHORBIA MATABALENSIS EXTRACT; HIBISCUS SABDARIFFA EXTRACT; PLANT EXTRACT; RHEUM PALPATUM EXTRACT; SECURIDACA LONGEPEDUNCULATA EXTRACT; SMALLANTHUS SONCHIFOLIUS EXTRACT; TRIPTERYGIUM WILFORDII EXTRACT; UNCARIA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG; VITEX POLYGAMA EXTRACT;

ACUPUNCTURE; ACUTE KIDNEY TUBULE NECROSIS; AFRICA SOUTH OF THE SAHARA; ARTHRALGIA; ARTHRITIS; ASTHMA; AYURVEDA; BIOMEDICINE; BRONCHITIS; CHINESE MEDICINE; CHRONIC KIDNEY FAILURE; CLINICAL EXAMINATION; CONJUNCTIVITIS; CONSTIPATION; CULTURAL FACTOR; CYSTITIS; DERMATITIS; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DIARRHEA; DIET THERAPY; DISEASE EXACERBATION; DYSMENORRHEA; DYSPEPSIA; ECZEMA; EDEMA; ELECTROLYTE DISTURBANCE; EPILEPSY; FATIGUE; FEVER; FLATULENCE; GENERAL PRACTITIONER; GLOMERULONEPHRITIS; GLOMERULOPATHY; HEALTH CARE ACCESS; HEMATURIA; HEMORRHOID; HEPATORENAL SYNDROME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERKALEMIA; HYPERTENSION; HYPOTENSION; HYPOVOLEMIA; IMMUNOGLOBULIN A NEPHROPATHY; IMPOTENCE; INDIA; INFERTILITY; INFLAMMATION; INTERSTITIAL NEPHRITIS; ISCHEMIC HEART DISEASE; JAUNDICE; KIDNEY DISEASE; KIDNEY FIBROSIS; KIDNEY ISCHEMIA; KIDNEY TUBULE NECROSIS; LIBIDO DISORDER; LIVER CIRRHOSIS; LOW INCOME COUNTRY; LUPUS VULGARIS; MALARIA; MALIGNANT NEOPLASM; MEDICAL RESEARCH; MENORRHAGIA; MIDDLE INCOME COUNTRY; MYALGIA; NEPHRITIS; NEPHROLITHIASIS; NEPHROTIC SYNDROME; NEPHROTOXICITY; NONHUMAN; OLIGOMENORRHEA; PATIENT SAFETY; POLYPHARMACY; PRIORITY JOURNAL; PSORIASIS; PUBLIC HEALTH SERVICE; QIGONG; REVIEW; RHEUMATIC HEART DISEASE; RHEUMATOID ARTHRITIS; RISK BENEFIT ANALYSIS; SEIZURE; SEXUALLY TRANSMITTED DISEASE; SHOCK; SKIN DISEASE; SKIN INJURY; SNAKEBITE; SOCIAL ASPECT; SOUTH AND CENTRAL AMERICA; THRUSH; TRADITIONAL MEDICINE; TRANSITIONAL CELL CARCINOMA; URINARY TRACT DISEASE; URINARY TRACT INFECTION; DEVELOPING COUNTRY; ECONOMICS; GLOBAL HEALTH; HEALTH SERVICE; NEPHROLOGY; PROCEDURES; UTILIZATION;

DEVELOPING COUNTRIES; GLOBAL HEALTH; HEALTH SERVICES; HUMANS; MEDICINE, TRADITIONAL; NEPHROLOGY; RENAL INSUFFICIENCY, CHRONIC;

EID: 85017569997     PISSN: 02709295     EISSN: 15584488     Source Type: Journal    
DOI: 10.1016/j.semnephrol.2017.02.005     Document Type: Review

References (116)

1. Ordunez, P., Campbell, N.R., Beyond the opportunities of SDG 3: the risk for the NCDs agenda. Lancet Diabetes Endocrinol 4 (2016), 15–17.
2. World Health Organization. Traditional medicine strategy 2014-2023. 2013, World Health Organization, Geneva.
3. Fuster, V., Cardiovascular disease and the United Nation Millennium Development Goals: a serious concern. Nat Clin Pract Cardiovasc Med, 3, 2006, 401.
4. Zhong, Y., Menon, M.C., Deng, Y., Chen, Y., He, J.C., Recent advances in traditional Chinese medicine for kidney disease. Am J Kidney Dis 66 (2015), 513–522.
5. Lameire, N.H., Bagga, A., Cruz, D., et al. Acute kidney injury: an increasing global concern. Lancet 382:9887 (2013), 170–179.
6. Mehta RL, Burdmann EA, Cerda J, Feehally J, Finkelstein F, Garcia-Garcia G, et al. Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study. Lancet (London, England). 2016;387(10032):2017-25.
7. World Health Organization. National policy on traditional medicine and regulation of herbal medicines. Report of a WHO global survey, 2005, World Health Organization, Geneva.
8. Napier, A.D., Ancarno, C., Butler, B., Calabrese, J., Chater, A., Chatterjee, H., et al. Culture and health. Lancet 384 (2014), 1607–1639.
9. Herbal Supplements and Remedies: A Global Strategic Business Report. Global Analysts, Inc. San Jose: 2015. Accessible: http://www.strategyr.com/PressMCP-1081.asp.
10. Growing threat from counterfeit medicines. Bull World Health Organ. 2010;88(4):247-8.
11. The World Bank. World development indicators. [cited 2016 June 30]. Available from: http://data.worldbank.org/region/SSA.
12. Population Division of the Department of Economic and Social Affairs of the United Nations Secretariat. World population prospects: the 2007 revision and world urbanization prospects. [cited 2016 June 30]. Available from: http://www.un.org/esa/population/unpop.htm.
13. Stanifer, J.W., Patel, U.D., Karia, F., Thielman, N., Maro, V., Shimbi, D., et al. The determinants of traditional medicine use in Northern Tanzania: a mixed-methods study. PLoS One, 10, 2015, e0122638.
14. Mhame, P.P., Busia, K., Kasilo, M.J., World Health Organization: clinical practices of African traditional medicine. 2010, African Health Monitor, Dar es Salaam.
15. Semenya, S.S., Potgieter, M.J., Bapedi traditional healers in the Limpopo Province, South Africa: their socio-cultural profile and traditional healing practice. J Ethnobiol Ethnomed, 10, 2014, 4.
16. Abdullahi, A.A., Trends and challenges of traditional medicine in Africa. Afr J Tradit Complement Altern Med 8:Suppl (2011), 115–123.
17. Luyckx, V.A., Nephrotoxicity of alternative medicine practice. Adv Chronic Kidney Dis 19 (2012), 129–141.
18. Stanifer, J.W., Jing, B., Tolan, S., Helmke, N., Mukerjee, R., Naicker, S., et al. The epidemiology of chronic kidney disease in sub-Saharan Africa: a systematic review and meta-analysis. Lancet Glob Health 2 (2014), e174–e181.
19. Stanifer, J.W., Lunyera, J., Boyd, D., Karia, F., Maro, V., Omolo, J., et al. Traditional medicine practices among community members with chronic kidney disease in northern Tanzania: an ethnomedical survey. BMC Nephrol, 16, 2015, 170.
20. Liwa, A.C., Smart, L.R., Frumkin, A., Epstein, H.A., Fitzgerald, D.W., Peck, R.N., Traditional herbal medicine use among hypertensive patients in sub-Saharan Africa: a systematic review. Curr Hypertens Rep, 16, 2014, 437.
21. Stanifer, J.W., Maro, V., Egger, J., Karia, F., Thielman, N., Turner, E.L., et al. The epidemiology of chronic kidney disease in Northern Tanzania: a population-based survey. PLoS One, 10, 2015, e0124506.
22. Stanifer, J.W., Turner, E.L., Egger, J.R., Thielman, N., Karia, F., Maro, V., et al. Knowledge, attitudes, and practices associated with chronic kidney disease in northern Tanzania: a community-based study. PLoS One, 11, 2016, e0156336.
23. Seck, S.M., Diop, E.A., Doupa, D., Cisse, M.M., Ka, E.F., Niang, A., et al. Efficacy of Kinkeliba in non-complicated hypertensive patients: a randomized controlled trial (abstr). 2015, International Society of Nephrology, World Congress, Cape Town.
24. Stanifer, J.W., Muiru, A., Jafar, T.H., Patel, U.D., Chronic kidney disease in low- and middle-income countries. Nephrol Dial Transplant 31 (2016), 868–874.
25. Hove, M., Ngwerume, E.T., Muchemwa, C., The urban crisis in sub-Saharan Africa. Stability 2 (2013), 1–14.
26. Colson, C.R., De Broe, M.E., Kidney injury from alternative medicines. Adv Chronic Kidney Dis 12 (2005), 261–275.
27. Isnard Bagnis, C., Deray, G., Baumelou, A., Le Quintrec, M., Vanherweghem, J.L., Herbs and the kidney. Am J Kidney Dis 44 (2004), 1–11.
28. Muller, A.C., Kanfer, I., Potential pharmacokinetic interactions between antiretrovirals and medicinal plants used as complementary and African traditional medicines. Biopharm Drug Dispos 32 (2011), 458–470.
29. Kanungo, S., Bhowmik, K., Mahapatra, T., Mahapatra, S., Bhadra, U.K., Sarkar, K., Perceived morbidity, healthcare-seeking behavior and their determinants in a poor-resource setting: observation from India. PLoS One, 10, 2015, e0125865.
30. Unschuld, P.U., The past 1000 years of Chinese medicine. Lancet, 354(Suppl), 1999, SIV9.
31. Cheung, F., TCM: made in China. Nature 480:7378 (2011), S82–83.
32. Health Statistic Yearbook 2011: Chinese Traditional Medicine (1987-2010). The State Administration of Traditional Chinese Medicine. Beijing: Ministry of Health, China; 2011.
33. Tang, J.L., Liu, B.Y., Ma, K.W., Traditional Chinese medicine. Lancet 372 (2008), 1938–1940.
34. Zhong, Y., Deng, Y., Chen, Y., Chuang, P.Y., Cijiang He, J., Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases. Kidney Int 84 (2013), 1108–1118.
35. Zhang, L., Wang, F., Wang, L., Wang, W., Liu, B., Liu, J., et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet 379 (2012), 815–822.
36. Yang, L., Xing, G., Wang, L., Wu, Y., Li, S., Xu, G., et al. Acute kidney injury in China: a cross-sectional survey. Lancet 386 (2015), 1465–1471.
37. Xie, Z., Liang, A., [New theoretical study on the biological origins of Chinese medicinal herbs]. Zhongguo Zhong Yao Za Zhi 20 (1995), 259–261 318.
38. Wojcikowski, K., Johnson, D.W., Gobe, G., Herbs or natural substances as complementary therapies for chronic kidney disease: ideas for future studies. J Lab Clin Med 147 (2006), 160–166.
39. You, Z., Xin, Y., Liu, Y., Han, B., Zhang, L., Chen, Y., et al. Protective effect of Salvia miltiorrhizae injection on N(G)-nitro-D-arginine induced nitric oxide deficient and oxidative damage in rat kidney. Exp Toxicol Pathol 64 (2012), 453–458.
40. Li, L.T., Shi, M.Y., Wei, S.Y., Li, T., Li, B., Huai Qi Huang ameliorates proteinuria and hematuria in mild IgA nephropathy patients: a prospective randomized controlled study. J Formos Med Assoc 112 (2013), 766–772.
41. Zhang, G., el Nahas, A.M., The effect of rhubarb extract on experimental renal fibrosis. Nephrol Dial Transplant 11 (1996), 186–190.
42. Yan, M., Wen, Y., Yang, L., Wu, X., Lu, X., Zhang, B., et al. Chinese herbal medicine Tangshen Formula treatment of patients with type 2 diabetic kidney disease with macroalbuminuria: study protocol for a randomized controlled trial. Trials, 17, 2016, 259.
43. Li, M., Wang, W., Xue, J., Gu, Y., Lin, S., Meta-analysis of the clinical value of Astragalus membranaceus in diabetic nephropathy. J Ethnopharmacol 133 (2011), 412–419.
44. Mao, W., Zhang, L., Zou, C., Li, C., Wu, Y., Su, G., et al. Rationale and design of the Helping Ease Renal failure with Bupi Yishen compared with the Angiotensin II Antagonist Losartan (HERBAAL) trial: a randomized controlled trial in non-diabetes stage 4 chronic kidney disease. BMC Complement Altern Med, 15, 2015, 316.
45. Wang, Y.J., He, L.Q., Sun, W., Lu, Y., Wang, X.Q., Zhang, P.Q., et al. Optimized project of traditional Chinese medicine in treating chronic kidney disease stage 3: a multicenter double-blinded randomized controlled trial. J Ethnopharmacol 139 (2012), 757–764.
46. Yoshikawa, N., Ito, H., Sakai, T., Takekoshi, Y., Honda, M., Awazu, M., et al. [A prospective controlled study of sairei-to in childhood IgA nephropathy with focal/minimal mesangial proliferation. Japanese Pediatric IgA Nephropathy Treatment Study Group]. Nihon Jinzo Gakkai Shi 39 (1997), 503–506.
47. Gökmen, M., Cosyns, J., Arlt, V., Stiborová, M., Phillips, D., Schmeiser, H., et al. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review. Ann Intern Med 158 (2013), 469–477.
48. IARC Working Group on the Evaluation of Carcinogenic Risk to Humans. Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC monographs on the evaluation of carcinogenic risks to humans, no. 82. B, Aristolochia species and aristolochic acids. 2002, International Agency for Research on Cancer, Lyon Available from http://www.ncbi.nlm.nih.gov/books/NBK326609/.
49. Liu, Q., Triptolide and its expanding multiple pharmacological functions. Int Immunopharmacol 11 (2011), 377–383 [accessed 06.07.16].
50. Ming, L.Q., Cheng, N., Nephrotoxicity study of aristolochia fangchi and it's compatible with astragali radix in rats by metabonomics. J Zhejiang Univ Tradit Chinese Med, 1, 2010, 026.
51. Su, G.B., Liu, X.S., Weng, J.X., [A survey and analysis of Chinese patent medicine for outpatients with chronic kidney disease]. Zhongguo Zhong Xi Yi Jie He Za Zhi 31 (2011), 1074–1079.
52. Samal, J., Dehury, R.K., an evaluation on medical education, research and development of AYUSH systems of medicine through five year plans of India. J Clin Diagn Res, 10, 2016, Ie01–Ie05.
53. Department of AYUSH Annual Report 2014-2015. New Dehli: Department of AYUSH, Ministry of Health and Family Welfare; 2016.
54. Gogtay, N.J., Bhatt, H.A., Dalvi, S.S., Kshirsagar, N.A., The use and safety of non-allopathic Indian medicines. Drug Saf 25 (2002), 1005–1019.
55. Singh, A.K., Farag, Y.M., Mittal, B.V., Subramanian, K.K., Reddy, S.R., Acharya, V.N., et al. Epidemiology and risk factors of chronic kidney disease in India - results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC Nephrol, 14, 2013, 114.
56. Arjuna Rao, A.S., Phaneendra, D., Pavani Ch, D., Soundararajan, P., Rani, N.V., Thennarasu, P., et al. Usage of complementary and alternative medicine among patients with chronic kidney disease on maintenance hemodialysis. J Pharm Bioallied Sci 8 (2016), 52–57.
57. Patel, M.V., Gupta, S.N., Patel, N.G., Effects of Ayurvedic treatment on 100 patients of chronic renal failure (other than diabetic nephropathy). Ayu 32 (2011), 483–486.
58. Ramteke, R.S., Thakar, A.B., Trivedi, A.H., Patil, P.D., Clinical efficacy of Gokshura-Punarnava Basti in the management of microalbuminuria in diabetes mellitus. Ayu 33 (2012), 537–541.
59. Prakash, J., Singh, T.B., Ghosh, B., Malhotra, V., Rathore, S.S., Vohra, R., et al. Changing epidemiology of community-acquired acute kidney injury in developing countries: analysis of 2405 cases in 26 years from eastern India. Clin Kidney J 6 (2013), 150–155.
60. Lunyera, J., Mohottige, D., Von Isenburg, M., Jeuland, M., Patel, U.D., Stanifer, J.W., CKD of uncertain etiology: a systematic review. Clin J Am Soc Nephrol 11 (2016), 379–385.
61. Siddarth, M., Datta, S.K., Ahmed, R.S., Banerjee, B.D., Kalra, O.P., Tripathi, A.K., Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study. Environ Toxicol Pharmacol 36 (2013), 164–170.
62. Rajapurkar, M.M., John, G.T., Kirpalani, A.L., Abraham, G., Agarwal, S.K., Almeida, A.F., et al. What do we know about chronic kidney disease in India: first report of the Indian CKD registry. BMC Nephrol, 13, 2012, 10.
63. Sakhuja, V., Sud, K., End-stage renal disease in India and Pakistan: burden of disease and management issues. Kidney Int Suppl 83 (2003), S115–S118.
64. Saper, R.B., Kales, S.N., Paquin, J., Burns, M.J., Eisenberg, D.M., Davis, R.B., et al. Heavy metal content of Ayurvedic herbal medicine products. JAMA 292 (2004), 2868–2873.
65. Ernst, E., Heavy metals in traditional Indian remedies. Eur J Clin Pharmacol 57 (2002), 891–896.
66. Lead poisoning associated with Ayurvedic medications–five states, 2000-2003. MMWR Morbid Mortal Wkly Rep 53 (2004), 582–584.
67. Sathe, K., Ali, U., Ohri, A., Acute renal failure secondary to ingestion of Ayurvedic medicine containing mercury. Ind J Nephrol 23 (2013), 301–303.
68. Pedersen, D., Baruffati, V., Health and traditional medicine cultures in Latin America and the Caribbean. Social Sci Med 21 (1985), 5–12.
69. Miranda, J.J., Nunez, H., Alca, A., Traditional healers, still part of the community health systems in the Andes. J Epidemiol Commun Health, 56, 2002, 733.
70. Montenegro, R.A., Stephens, C., Indigenous health in Latin America and the Caribbean. Lancet 367 (2006), 1859–1869.
71. Anderson, I., Robson, B., Connolly, M., Al-Yaman, F., Bjertness, E., King, A., et al. Indigenous and tribal peoples’ health (The Lancet-Lowitja Institute Global Collaboration): a population study. Lancet 388 (2016), 131–157.
72. Cano, J.H., Volpato, G., Herbal mixtures in the traditional medicine of eastern Cuba. J Ethnopharmacol 90 (2004), 293–316.
73. Cechinel-Filho, V., Plant bioactives and drug discovery: principles, practice, and perspectives. 2012, John Wiley & Sons, Hoboken, NJ.
74. Gonzalez-Coloma, A., Reina, M., Saenz, C., Lacret, R., Ruiz-Mesia, L., Aran, V.J., et al. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants. Parasitol Res 110 (2012), 1381–1392.
75. Catalogue Floristico De Plantas Medicinales Peruanas. Lima: Centro Nacional De Salud Intercultural, Instituto Nacional De Salud; 2013. [cited 2016 August 4]. Available from: http://www.bvs.ins.gob.pe/insprint/CENSI/catalogo_floristico_plantas_medicinales.pdf.
76. Cusumano, A.M., Gonzalez Bedat, M.C., Chronic kidney disease in Latin America: time to improve screening and detection. Clin J Am Soc Nephrol 3 (2008), 594–600.
77. De Maio, F.G., Understanding chronic non-communicable diseases in Latin America: towards an equity-based research agenda. Global Health, 7, 2011, 36.
78. Francis, E.R., Allen, A.K., Herrera-Anazco, P., Kuo, C.C., Cardenas, M.K., Feldman, H.I., et al. Establishing a higher priority for chronic kidney disease in Peru. Lancet Glob Health 4 (2016), e17–e18.
79. Bussmann, R.W., Sharon, D., Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture. J Ethnobiol Ethnomed, 2, 2006, 47.
80. Bussmann, R.W., The globalization of traditional medicine in northern Peru: from shamanism to molecules. Evid Based Complement Alternat Med, 2013, 2013, 291903.
81. Hilepo, J.N., Bellucci, A.G., Mossey, R.T., Acute renal failure caused by ‘cat's claw’ herbal remedy in a patient with systemic lupus erythematosus. Nephron, 77, 1997, 361.
82. Valerio, L.G. Jr, Gonzales, G.F., Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis. Toxicol Rev 24 (2005), 11–35.
83. de Oliveira, R.B., de Paula, D.A., Rocha, B.A., Franco, J.J., Gobbo-Neto, L., Uyemura, S.A., et al. Renal toxicity caused by oral use of medicinal plants: the yacon example. J Ethnopharmacol 133 (2011), 434–441.
84. Rodrıguez, M.I., Sounding the alarm on chronic kidney disease in farming communities. Minister of health, El Salvador. Interview by Conner Gorry. MEDICC Rev 15 (2013), 8–10.
85. Luyckx, V.A., Ballantine, R., Claeys, M., Cuyckens, F., Van den Heuvel, H., Cimanga, R.K., et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis, 39, 2002, E13.
86. Eshun, K., He, Q., Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industries–a review. Crit Rev Food Sci Nutr 44 (2004), 91–96.
87. Mahomoodally, M.F., Traditional medicines in Africa: an appraisal of ten potent African medicinal plants. Evid Based Complement Alternat Med, 2013, 2013, 617459.
88. Chen, W., Van Wyk, B.-E., Vermaak, I., Viljoen, A.M., Cape aloes—a review of the phytochemistry, pharmacology and commercialisation of aloe ferox. Phytochem Lett 5 (2012), 1–12.
89. Vogler, B.K., Ernst, E., Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 49 (1999), 823–828.
90. Naicker, S., Aboud, O., Gharbi, M.B., Epidemiology of acute kidney injury in Africa. Semin Nephrol 28 (2008), 348–353.
91. Lowenthal, M.N., Jones, I.G., Mohelsky, V., Acute renal failure in Zambian women using traditional herbal remedies. J Trop Med Hygiene 77 (1974), 190–192.
92. Jha, V., Rathi, M., Natural medicines causing acute kidney injury. Semin Nephrol 28 (2008), 416–428.
93. Ekpenyong, C.E., Daniel, N.E., Antai, A.B., Effect of lemongrass tea consumption on estimated glomerular filtration rate and creatinine clearance rate. J Renal Nutr 25 (2015), 57–66.
94. Carlini, E.A., Contar, Jd.D.P., Silva-Filho, A.R., da Silveira-Filho, N.G., Frochtengarten, M.L., Bueno, O.F., Pharmacology of lemongrass (Cymbopogon citratus Stapf). I. Effects of teas prepared from the leaves on laboratory animals. J Ethnopharmacol 17 (1986), 37–64.
95. Shah, G., Shri, R., Panchal, V., Sharma, N., Singh, B., Mann, A.S., Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass). J Adv Pharm Technol Res 2 (2011), 3–8.
96. Boaduo, N.K., Katerere, D., Eloff, J.N., Naidoo, V., Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in South Africa using in vitro methods. Pharm Biol 52 (2014), 756–761.
97. Dike, I.P., Obembe, O.O., Adebiyi, F.E., Ethnobotanical survey for potential anti-malarial plants in south-western Nigeria. J Ethnopharmacol 144 (2012), 618–626.
98. Seedat, Y.K., Hitchcock, P.J., Acute renal failure from Callilepsis laureola. S Afr Med J 45 (1971), 832–833.
99. Steenkamp, V., Stewart, M.J., Nephrotoxicity associated with exposure to plant toxins, with particular reference to Africa. Ther Drug Monit 27 (2005), 270–277.
100. Zhou, Z.L., Yang, Y.X., Ding, J., Li, Y.C., Miao, Z.H., Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms. Nat Prod Rep 29 (2012), 457–475.
101. Xu, X.L., Yang, L.J., Jiang, J.G., Renal toxic ingredients and their toxicology from traditional Chinese medicine. Exp Opin Drug Metab Toxicol 12 (2016), 149–159.
102. Nortier, J.L., Martinez, M.C., Schmeiser, H.H., Arlt, V.M., Bieler, C.A., Petein, M., et al. Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 342 (2000), 1686–1692.
103. Pena, J.M., Borras, M., Ramos, J., Montoliu, J., Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 11 (1996), 1359–1360.
104. Debelle, F.D., Vanherweghem, J.L., Nortier, J.L., Aristolochic acid nephropathy: a worldwide problem. Kidney Int 74 (2008), 158–169.
105. Pari, L., Amarnath Satheesh, M., Antidiabetic effect of Boerhavia diffusa: effect on serum and tissue lipids in experimental diabetes. J Med Food 7 (2004), 472–476.
106. Mahesh, A.R., Kumar, H., Ranganath, M., Devkar, R.A., Detail study on Boerhavia Diffusa plant for its medicinal importance-a review. Res J Pharm Sci 1 (2012), 28–36.
107. Dasaroju, S., Gottumukkala, K.M., Current trends in the research of Emblica officinalis (Amla): a pharmacological perspective. Int J Pharm Sci Rev Res 24 (2014), 150–159.
108. Khajavi Rad, A., Hadjzadeh, M.A., Rajaei, Z., Mohammadian, N., Valiollahi, S., Sonei, M., The beneficial effect of cynodon dactylon fractions on ethylene glycol-induced kidney calculi in rats. Urol J 8 (2011), 179–184.
109. Prachi, C.N., Kumar, D., Kasana, M.S., Medicinal plants of Muzaffarnagar district used in treatment of urinary tract and kidney stones. Ind J Trad Knowl 8 (2009), 191–195.
110. Hazra, B., Sarkar, R., Mandal, S., Biswas, S., Mandal, N., Studies on antioxidant and antiradical activities of Dolichos biflorus seed extract. Afr J Biotechnol 8:816 (2009), 3927–3933.
111. Atodariya, U., Barad, R., Upadhyay, S., Upadhyay, U., Anti-urolithiatic activity of Dolichos biflorus seeds. J Pharmacognosy Phytochem 2:2 (2013), 209–213.
112. Palani, S., Raja, S., Naresh, R., Kumar, B.S., Evaluation of nephroprotective, diuretic, and antioxidant activities of plectranthus amboinicus on acetaminophen-induced nephrotoxic rats. Toxicol Mech Methods 20 (2010), 213–221.
113. Nie, Y., Dong, X., He, Y., Yuan, T., Han, T., Rahman, K., et al. Medicinal plants of genus Curculigo: traditional uses and a phytochemical and ethnopharmacological review. J Ethnopharmacol 147 (2013), 547–563.
114. Gallo, M.B., Vieira, P.C., Fernandes, J.B., da Silva, M.F., Salimena-Pires, F.R., Compounds from Vitex polygama active against kidney diseases. J Ethnopharmacol 115 (2008), 320–322.
115. Maquiaveli, C.C., da Silva, E.R., Rosa, L.C., Francescato, H.D., Lucon Junior, J.F., Silva, C.G., et al. Cecropia pachystachya extract attenuated the renal lesion in 5/6 nephrectomized rats by reducing inflammation and renal arginase activity. J Ethnopharmacol 158 (2014), 49–57.
116. Alviz, A.A., Salas, R.D., Franco, L.A., [Acute diuretic effect of ethanolic and aqueous extracts of Ceratopteris pteridoides (Hook) in normal rats]. Biomedica 33 (2013), 115–121.