Kidney injury from alternative medicines

Advances in Chronic Kidney Disease

Volumn 12, Issue 3, 2005, Pages 261-275

  Colson, Conny R D ^a   De Broe, Marc E ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Acute; Alternative medicines; Chronic; Kidney; Kidney injury; Toxicity

Indexed keywords

ALOERESIN A; ALOERESIN B; ANTIINFLAMMATORY AGENT; ANTIPYRETIC AGENT; ATRACTYLIS GUMMIFERA EXTRACT; ATRACTYLOSIDE; ATROPINE; CARBENOXOLONE; DIURETIC AGENT; EPHEDRA EXTRACT; FLAVONOID; GLYCYRRHIZIC ACID; GUMMIFERIN; HERBACEOUS AGENT; HYDRAZINE SULFATE; HYOSCYAMINE; LAXATIVE; MENTHA SPICATA EXTRACT; NIU HUANG CHIEH TU PIEN; PARACETAMOL; PLANT EXTRACT; POTASSIUM ATRACTYLIC ACID; PYRROLIZIDINE ALKALOID; SALICYLIC ACID METHYL ESTER; SALIX EXTRACT; SAPONIN; SCIADOPITYSIN; SCOPOLAMINE; TAXUS CELEBRICA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE KIDNEY FAILURE; ACUTE KIDNEY TUBULE NECROSIS; ACUTE TOXICITY; ALLERGIC REACTION; ALOE CAPENSIS; ALTERNATIVE MEDICINE; ANALGESIC NEPHROPATHY; ATRACTYLIS GUMMIFERA; BILE; BRAIN EDEMA; CALLILEPSIS LAUREOLA; CARP; CASSIA AURICULATA; CHOLESTATIC HEPATITIS; CHRONIC TOXICITY; CLINICAL TRIAL; COMA; CONSTIPATION; CRANBERRY; CROTALARIA JUNCEA; CROTALARIA VERRUCOSA; DELIRIUM; DIABETES MELLITUS; DIARRHEA; DISORIENTATION; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG FEVER; DRY SKIN; EPHEDRA SINICA; EPILEPSY; EUPHORBIA MATABALENSIS; FANCONI RENOTUBULAR SYNDROME; GALLBLADDER; GASTRITIS; GASTROINTESTINAL DISEASE; GINGIVITIS; GLYCYRRHIZA GLABRA; GONORRHEA; GYNECOLOGIC CANCER; HALLUCINATION; HEADACHE; HEART ARREST; HEART FAILURE; HEMATURIA; HEMOLYSIS; HEPATITIS; HEPATORENAL SYNDROME; HOLARRHENA ANTIDYSENTERICA; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; HYPOGLYCEMIA; HYPOKALEMIA; IMPOTENCE; INFERTILITY; INTERSTITIAL NEPHRITIS; JAUNDICE; KIDNEY FAILURE; KIDNEY GRAFT REJECTION; KIDNEY INJURY; KIDNEY TUBULE NECROSIS; LETHARGY; LIVER CIRRHOSIS; LIVER FAILURE; LIVER NECROSIS; LIVER TOXICITY; LIVER VEIN OBSTRUCTION; LIVER VENOOCCLUSIVE DISEASE; MEDICINAL PLANT; MENTHA PIPERITA; MENTHA SPICATA; METABOLIC ACIDOSIS; MYDRIASIS; NEPHROSIS; NEPHROTOXICITY; NONHUMAN; OLIGURIA; PEPTIC ULCER; PRIORITY JOURNAL; PROTEINURIA; PYURIA; RENIN ANGIOTENSIN DISORDER; REVIEW; RHEUMATIC DISEASE; SECURIDACA LONGEPEDUNCULATA; SHEEP; SIDE EFFECT; STOMACH DISEASE; TACHYCARDIA; TAPEWORM INFECTION; TAXUS CELEBRICA; TERMINALIA CHEBULA; THIRST; UNO DEGATTA; URINE COLOR; URINE RETENTION; VOMITING; WATER RETENTION; WILLOW; WITHANIA SOMNIFERA;

EID: 21544442032     PISSN: 15485595     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ackd.2005.03.006     Document Type: Article

References (124)

1. Traditional medicine. Available at: http://www.who.int/mediacentre/ factsheets/fs134/en. Accessed January 15, 2005
2. N.V. Dahl Herbs and supplements in dialysis patients Panacea or poison? Semin Dial 14 2001 186 192
3. V. Jha, K.S. Chugh Nephropathy associated with animal, plant and chemical toxines in the tropics Semin Nephrol 23 2003 49 65
4. B. Roemheld-Hamm, N.V. Dahl Herbs, menopause, and dialysis Semin Dial 15 2002 53 59
5. C.I. Bagnis, G. Deray, A. Baumelou Herbs and the kidney Am J Kidney Dis 44 2004 1 11
6. D.M. Marcus, A.P. Grollman Botanical medicines-The need for new regulations N Engl J Med 347 2002 2073 2076
7. R.J. Huxtable The harmful potential of herbal and other plant products Drug Safety 5 suppl 1 1990 126 136
8. B. Tomlinson, T.Y.K. Chan, J.C.N. Chan Toxicity of complementary therapies An Eastern perspective J Clin Pharmacol 40 2000 451 456
9. P.A.G.M. De Smet Herbal remedies N Engl J Med 347 2002 2046 2056
10. Y.K. Seedat Acute renal failure among blacks and Indians in South Africa S Afr Med J 54 1978 427 431
11. T.A. Adelkum, T.R. Ekwere, A. Akinsola The pattern of acute toxic nephropathy in Ife, Nigeria West Afr J Med 18 1999 60 63
12. L.I. Ojogwu, C. Anah Renal failure and hypertension in tropical Africa-A pre-dialysis experience from Nigeria East Afr Med J 60 1983 478 484
13. I.G. Randeree, A. Czarnocki, J. Moodley Acute renal failure in pregnancy I South Africa Renal Failure 17 1995 147 153
14. S. Kadiri, A. Ogunlesi, K. Osinfade The causes and course of acute tubular necrosis in Nigerians Afr J Med Sci 21 1992 91 96
15. C.H. Gold Acute renal failure from herbal and patent remedies in blacks Clin Nephrol 14 1980 28 34
16. D.C. Dukes, H.M. Dukes, J.A. Gordon Acute renal failure in Central Africa. The toxic effects of traditional African medicine Centr Afr J Med 15 1969 71 78
17. L.S. Otieno, S.O. McLigeyo, M. Luta Acute renal failure following the use of herbal remedies East Afr Med J 68 1991 993 998
18. Y.K. Seedat Acute renal failure in the black population of South Africa Int J Artif Organs 16 1993 801 802
19. M.N. Lowenthal, I.G. Jones, V. Mohelsky Acute renal failure in Zambian women using traditional herbal remedies J Trop Med Hyg 77 1974 190 192
20. N.Z. Nyazema Poisoning due to traditional remedies Centr Afr J Med 30 1984 80 83
21. D. Larry Hepatoxicity of herbal remedies J Hepatol 26 1997 47 51
22. C. Swanepoel, S. Naicker, R. Moosa Nephrotoxins in Africa M.E. De Broe G.A. Porter W.M. Bennett Clinical Nephrotoxins (ed 2) 2003 Kluwer Academic Publishers The Netherlands 603 611
23. M.E. De Broe Acute renal failure and toxic nephropathies M. El-Nahas R. Barsoum J. Dirks Kidney Diseases in Ethnic Minorities and the Developing World 2005 Marcel Dekker Inc New York, NY (in press)
24. A.R. Watson, H.M. Coodivia, K.D. Bhoola The clinical syndrome of Impilla (Callilepsis laureola) poisoning in children S Afr Med J 55 1979 290 292
25. J. Wainwright, M.M. Schonland, H.A. Candy Toxicity of Callilepsis laureola S Afr Med J 52 1977 313 315
26. Y.K. Seedat, P.J. Hitchcock Acute renal failure from callilepsis laureola S Afr Med J 45 1971 832 833
27. A. Popat, N.H. Shear, I. Malkiewicz The toxicity of Callipepsis laureola, a South African traditional medicine Clin Biochem 34 2001 229 236
28. M. Zoratti, I. Szabo The mitochondrial permeability transition Biochem Biophys Acta 1241 1995 139 176
29. K. Vancompernolle, F. Van Herreweghe, G. Pynaert Atractyloside-induced release of cathepsin B, a protease with caspase-processing activity FEBS Lett 438 1998 150 158
30. S. Nogue, P. Sanz, A. Botey Insuffisance rénale aiguë due a une intoxication par le charbon à glu (Atractylis gummifera-L) Presse Med 21 1992 130
31. V.A. Luyckx, R. Ballantine, M. Claeys Herbal remedy-associated acute renal failure secondary to Cape aloes Am J Kidney Dis 39 2002 1 5
32. H.D. Nuewinger Afrikanische Arzneiflanzen und Jagdgifte 1994 Wissenschaftliche Verlaggesellschaft mbH Stutgart 489 494
33. J.N. Hilepo, A.G. Belluci, R.T. Mossey Acute renal failure caused by "cat's claw" herbal remedy in a patient with systemic lupus erythematosus Nephron 77 1997 361
34. S.N. Arseculeratne, A.A.L. Gunatilaka, R.G. Panabokke Studies on medicinal plants of Sri Lanka, part 14 Toxicity of some traditional medicinal herbs J Ethnopharmacol 13 1985 323 335
35. Y.K. Sakuja, K. Sud Acute renal failure in the tropics Saudi J Kidney Dis Tansplant 9 1998 247 260
36. Y.F. Lin, S.H. Lin Simultaneous acute renal and hepatic failure after ingesting raw carp gall bladder Nephrol Dial Transplant 14 1999 2011 2012
37. R.N. Sahoo, M.K. Mohapatra, B. Sahoo Acute renal failure associated with freshwater fish toxin Trop Geograph Med 47 1995 94 95
38. S.K. Park, D.G. Kim, S.K. Kang toxic acute renal failure and hepatitis after ingestion of raw carp bile Nephron 56 1990 188 193
39. K. Choi, S.W. Park, K.J. Lee Grass carp (Ctenopharyngodon idellus) bile may inhibit the release of renal dipeptidase from the proximal tubules by nitric oxide generation Kidney Blood Press Res 23 2000 113 118
40. Hepatic and renal toxicity among patients ingesting sheep bile as an unconventional remedy for diabetes mellitus-Saudi Arabia, 1995 MMWR Morb Mortal Wkly Rep 45 1996 941 943
41. J.L. Lin, Y.S. Ho Flavanoid-induced acute nephropathy Am J Kidney Dis 23 1994 433 440
42. A. Jaeger, M. Walti, K. Neftel Side effects of flavanoids in medical practice Prog Clin Biol Res 280 1988 379 394
43. J.A. Molhuysen, J. Gerbrandy, L.A. De Vries A liquorice extract with deoxycortone-like action Lancet 2 1950 381 386
44. P.M. Stewart, A.M. Wallace, R. Valentine Mineralocorticoid activity of liquorice 11β-hydroxysteroid dehydrogenase deficiency comes of age Lancet 2 1987 821 824
45. J.W. Funder, P.T. Pearce, R. Smith Mineralocorticoid action target tissue specificity is enzyme, not receptor mediated Science 243 1988 583 585
46. C. Delcroix, E. Poncin, O. Pourrat Proximal tubulopathy in licorice poisoning Presse Med 14 1985 2346 2347
47. G.J. De Klerk, M.G. Nieuwenhuis, J. Beutler Lesson of the week Hypokalaemia and hypertension associated with the use of liquorice flavored chewing gum BMJ 314 1997 731 735
48. B.R. Walker, C.R.W. Edwards Licorice-induced hypertension and syndromes of apparent mineralocorticoid excess Endocrinol Metab Clin North Am 23 1994 359 377
49. L.C. Winslow, D.J. Kroll Herbs as medicines Arch Intern Med 158 1998 2192 2199
50. B. Tomlinson, T.Y. Chan, J.C. Chan Toxicity of complementary therapies an Eastern perspective J Clin Pharmacol 40 2000 451 456
51. T. Izumotani, E. Ishimura, K. Tsumura An adult case of Fanconi syndrome due to a mixture of Chinese crude drugs Nephron 65 1993 137 140
52. The Review of Natural Products 1997 Facts and Comparisons St Louis, MO
53. US Food and Drug Administration. Illnesses and injuries associated with the use of selected dietary supplements. Unsubstanciated claims and documented health hazards in the dietary supplement marketplace. Available at: www.cfsan.fda.gov/∼dms/ds-ill.htm. Accessed January 15, 2005
54. T. Powell, F. Hsu, J. Turk Ma-huang strikes again Ephedrine nephrolithiasis Am J Kidney Dis 32 1998 153 159
55. C. Haller, N. Benowitz Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids N Engl J Med 343 2000 1833 1838
56. A. Djibo, S.B. Bouzou Intoxication aiguë au "sobi-lobi" (Datura). A propos de quatre cas au Niger Bull Soc Pathol Exot 93 2000 294 297
57. J.C.N. Chan, T.Y.K. Chan, K.L. Chan Anticholinergic poisoning from Chinese herbal medicines Aust N Z J Med 24 1994 317 318
58. K.J. Harkins What's the use of cranberry juice? Age Ageing 29 2000 9 12
59. P.T. Bodel, R. Cotran, E. Kass Cranberry juice and the antibacterial action of hippuric acid J Lab Clin Med 54 1959 881 888
60. M.S. Jackson, L. Hicks Effect of cranberry juice on urinary pH in older adults Home Health Nurs 15 1997 199 202
61. D. Zafiri, I. Ofek, R. Adar Inhibitory activity of cranberry juice on adherence of type I and type P fimbriated Escherichia coli to eukaryotic cells Antimicrob Agents Chemother 33 1989 92 98
62. I. Ofek, J. Goldhar, D. Zafiri Anti-Escherichia coli adhesin activity of cranberry and blueberry juices N Engl J Med 324 1991 1599
63. R.G. Jepson, L. Mihaljevic, J. Craig Cranberries for preventing urinary tract infection (Cochrane Review) Cochrane Database Syst Rev 1 2004 CD001321
64. J.I. Van Der Spoel, B.H.C. Stricker, M.E.I. Schipper Toxische beschadiging van nier, lever en spier toegeschreven aan het gebruik van germanium-lactaat-citraat Ned Tijdschr Geneeskd 135 1991 1134 1137
65. M.I. Hainer, N. Tsai, S.T. Komura Fatal hepatorenal failure associated with hydrazine sulfate Ann Int Med 133 2000 877 880
66. E. Sotaniemi, J. Hirovonen, H. Isomaki Hydrazine toxicity in the human. Report of a fatal case Ann Clin Res 3 1971 30 33
67. M. Akdogan, I. Kilinç, M. Oncu Investigation of biochemical and histopathological effects of Mentha piperata L. and Mentha spicata L. on kidney tissue in rats Hum Exp Toxicol 22 2003 213 219
68. J.S. Till, B.N. Majmudar Cantharidin poisoning South Med J 74 1982 444 447
69. D.J. Karras, S.E. Farrell, R.A. Harrigan Poisoning from "Spanish fly" (cantharidin) Am J Emerg Med 14 1996 478 483
70. WHO Cadmium Environmental Health Criteria 1992 WHO Geneva 280
71. L. Friberg Cadmium and health A toxicological and epidemiologic appraisal L. Friberg C.G. Elinder T. Kjellström Cadmium and Health A Toxicological and Epidemiologic Appraisal vol 2 1986 CRC Press Boca Raton, FL
72. T.R. Van Vleet, R.G. Schnellmann Toxic nephropathy Environmental chemicals Semin Nephrol 23 2003 500 508
73. L. Friberg Health hazards in the manufacture of alkaline accumulators with special reference to chronic cadmium poisoning Acta Med Scand 240 suppl 1950 1 124
74. L. Järup, C.G. Elinder Incidence of renal stones among cadmium exposed battery workers Br J Ind Med 50 1993 598 602
75. P.W. Mueller, S.J. Smith, K.K. Steinberg Chronic renal tubular effects in relation to urine cadmium levels Nephron 52 1989 45 54
76. G. Kanzantzis Renal tubular dysfunction and abnormalities of cadmium metabolism in cadmium workers Environ Health Perspect 28 1979 155 159
77. D.J. Atherton, M.H. Rustin, J. Brostoff Need for correct identification of herbs in herbal poisoning Lancet 341 1993 637 638
78. M.S. Wu, J.J. Hong, C.W. Lin Multiple tubular dysfunction induced by mixed Chinese herbal medicines containing cadmium Nephrol Dial Transplant 11 1996 867 870
79. M. S̈ubat-Dez̈ulović, I. Slavić, V. Roz̈manić Drug-induced acute tubulointerstitial nephritis A case with elevated urinary cadmium Pediatr Nephrol 17 2002 382 385
80. J. Cunha, L. Pereira, M.I. Pun Arsenic and acute lethal intoxication Hong Kong Pharm J 7 1998 50 53
81. E.O. Espinoza, M.J. Mann, B. Blaesdell Arsenic and mercury in traditional Chinese herbal balls N Engl J Med 333 1995 803 804 (letter)
82. R. Wood, P.B. Mills, G.J. Knobel Acute dichromate poisoning after use of traditional purgatives S Afr Med J 77 1990 640 642
83. M. Geraghty Herbal supplements for renal patients What do we know? Nephrol News Issues 14 2000 12 13 42-43, 54
84. J. Diamond, T. Pallone Acute interstitial nephritis following use of Tung Shueh pills Am J Kidney Dis 24 1994 219 221
85. M. Segasothy, S. Samad Illicit herbal preparation containing phenylbutazone causing analgesic nephropathy Nephron 59 1991 166 167
86. M.I. Hamdouk, S.M. Suleiman, H. Kallel Paraphenylene diamine hair dye poisoning M.E. De Broe G.A. Porter W.M. Bennett G.A. Verpooten Clinical Nephrotoxins-Renal Injury from Drugs and Chemicals (2nd edition) 2003 Kluwer Academic Publishers Dordrecht 611 618
87. M. Sir Hashim, Y.O. Hamza, B. Yahia Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum Ann Trop Paediatr 12 1992 3 6
88. A. Bourquia, A.J. Jabrane, B. Ramdani Systemic toxicity of paraphenylenediamine 4 cases Presse Med 17 1998 1798 1800
89. Z. Averbukh, D. Modai, Y. Leonov Rhabdomyolysis and acute renal failure induced by paraphenylenediamine Hum Toxicol 8 1989 345 348
90. I.Y. Shemesh, Y. Mishal, A.M. Baruchin Rhabdomyolysis in paraphenylenediamine intoxication Vet Hum Toxicol 37 1995 244 245
91. K. Saito, T. Murai, K. Yabe [Rhabdomyolysis due to paraphenylenediamine (hair dye)-Report of an autopsy case] Nippon Hoigaku Zasshi 44 1990 469 474
92. H.W. Nott Systemic poisoning by hair dye Br Med J 1 1924 421 422
93. A.K. Mathur, B.N. Gupta, S. Narang Biochemical and histopathological changes following dermal exposure to paraphenylene diamine in guinea pigs J Appl Toxicol 10 1990 383 386
94. M. Hamdouk PPD nephrotoxicity, in paraphenylene diamine (hair dye) acute systemic toxicity 2001 Sheffield Kidney Institute Sheffield, UK (thesis)
95. J. Prakash Acute renal failure in epidemic dropsy Renal Failure 21 1999 707 711
96. C.L. Pasricha, S. Lal, K.S. Malik An outbreak of epidemic dropsy in a close community Ind Med Gaz 74 1939 133 136
97. Y.M. Bhende Vascular changes produced by Argemone oil II-changes in rats given injection of the oil J Post Grad Med 2 1956 185
98. N.N. Sood, M.S. Sachdev, M. Mohan Epidemic dropsy following transcutaneous absorption of Argemone mexicana oil Trans R Soc Med Hyg 79 1985 510 512
99. J.L. Vanherweghem, M. Depierreux, C. Tielemans Rapidly progressive interstitial renal fibrosis in young women Association with slimming regimen including Chinese herbs Lancet 341 1993 387 391
100. M. Depierreux, B. Van Damme, K. Vanden Houte Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs Am J Kidney Dis 24 1994 172 180
101. M. Vanhaelen, R. Vanhaelen-Fastre, P. But Identification of aristolochic acid in Chinese herbs Lancet 343 1994 174
102. J.L. Vanherweghem Misuse of herbal remedies The case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy) J Altern Complement Med 4 1998 9 13
103. J.P. Cosyns, J.P. Dehoux, Y. Guiot Chronic aristolochic acid toxicity in rabbits A model of Chinese herbs nephropathy? Kidney Int 59 2001 2164 2173
104. F.D. Debelle, J.L. Nortier, E.G. De Prez Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats J Am Soc Nephrol 13 2002 431 436
105. M.E. De Broe On a nephrotoxic and carcinogenic slimming regimen Am J Kidney Dis 33 1999 1171 1173
106. A. Tanaka, R. Nishida, T. Yoshida Outbreak of Chinese herb nephropathy in Japan Are there any differences from Belgium? Intern Med 40 2001 296 300
107. Y.Y. Ng, S. Yu, T.W. Chen Interstitial renal fibrosis in a young woman Association with a Chinese preparation given for irregular menses Nephrol Dial Transplant 13 1998 2115 2117
108. J. Farrell, E. Campbell, J.J. Walshe Renal failure associated with alternative medical therapies Renal Failure 17 1995 759 764
109. H. Woelk Comparison of St John's wort and imipramine for treating depression Randomized controlled trial BMJ 321 2000 536 539
110. E. Ernst The risk-benefit profile of commonly used herbal therapies Ginkgo, St John's wort, ginseng, echinacea, saw palmetto, and kava Ann Intern Med 136 2002 42 53
111. E. Ernst Second thoughts about safety of St John's wort Lancet 354 1999 2014 2016
112. A. Johne, J. Brockmoller, S. Bauer Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum) Clin Pharmacol Ther 66 1999 338 345
113. S.C. Piscitelli, A.H. Burstein, D. Chaitt Indinavir concentrations and St John's wort Lancet 355 2000 547 548
114. Q.Y. Yue, C. Bergquist, B. Gerden Safety of St John's wort (Hypericum perforatum) Lancet 355 2000 576 577
115. A. Nebel, B.J. Schneider, R.K. Baker Potential metabolic interaction between St. John's wort and theophylline Ann Pharmacother 33 1999 502
116. R. Bolley, C. Zulke, M. Kammerl Tacrolimus-induced nephrotoxicity unmasked by induction of the CYP3A4 system with St John's wort Transplantation 73 2002 1009
117. G.W. Barone, B.J. Gurley, B.L. Ketel Herbal supplements A potential for drug interactions in transplant recipients Transplantation 71 2001 239 241
118. C. Moshella, B.L. Jaber Interaction between cyclosporine and Hypericum perforatum (St John's wort) after organ transplantation Am J Kidney Dis 38 2001 1105 1107
119. T. Breidenbach, M.W. Hoffmann, T. Becker Drug interaction of St John's wort with cyclosporin Lancet 355 2000 1912 (letter)
120. I. Mai, E. Strömer, S. Bauer Impact of St John's wort treatment on the pharmacokinetics of tacrolimus and mycophenolic acid in renal transplant patients Nephrol Dial Transplant 18 2003 819 822
121. T. Breidenbach, V. Kliem, M. Burg Profound drop of cyclosporin A whole blood trough levels caused by St John's wort (Hypericum perforatum) Transplantation 69 2000 2229 2230 (letter)
122. D. Durr, B. Stieger, G.A. Kullak-Ublick St John's wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP 3A4 Clin Pharmacol Ther 68 2000 598 604
123. L.B. Moore, B. Goodwin, S.A. Jones St. John's wort induces hepatic drug metabolism through activation of the pregnane x receptor Proc Natl Acad Sci U S A 97 2000 7500 7502
124. T.D. Light, J.A. Light Acute renal transplant rejection possibly related to herbal medications Am J Transplant 3 2003 1608 1609