Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

ACS Medicinal Chemistry Letters

Volumn 8, Issue 4, 2017, Pages 438-442

  Maetani, Micah ^a,b   Kato, Nobutaka ^b   Jabor, Valquiria A P ^c   Calil, Felipe A ^c   Nonato, Maria Cristina ^c   Scherer, Christina A ^b   Schreiber, Stuart L ^a,b,d  

^a HARVARD UNIVERSITY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

BRD7539; BRD9185; DHODH; diversity oriented synthesis; malaria; Plasmodium falciparum

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; AZETIDINE DERIVATIVE; BRD 9185; CYANIDE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLIC STABILITY; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 85017567672     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.7b00030     Document Type: Article

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