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Volumn 6, Issue 3, 2017, Pages 1018-1028

Mesenchymal stem cell-derived extracellular vesicles as mediators of anti-inflammatory effects: Endorsement of macrophage polarization

Author keywords

Cell hypoxia; Extracellular vesicles; Inflammation; Macrophages; Mesenchymal stem cells; Regenerative medicine

Indexed keywords

CARDIOTOXIN; ANTIINFLAMMATORY AGENT;

EID: 85017552825     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.1002/sctm.16-0363     Document Type: Article
Times cited : (432)

References (50)
  • 1
    • 84969791632 scopus 로고    scopus 로고
    • Current understanding of the pathways involved in adult stem and progenitor cell migration for tissue homeostasis and repair
    • Goichberg P. Current understanding of the pathways involved in adult stem and progenitor cell migration for tissue homeostasis and repair. Stem Cell Rev 2016; 12:421–437.
    • (2016) Stem Cell Rev , vol.12 , pp. 421-437
    • Goichberg, P.1
  • 2
    • 43749088730 scopus 로고    scopus 로고
    • Wound repair and regeneration
    • Gurtner GC, Werner S, Barrandon Y et al. Wound repair and regeneration. Nature 2008; 453:314–321.
    • (2008) Nature , vol.453 , pp. 314-321
    • Gurtner, G.C.1    Werner, S.2    Barrandon, Y.3
  • 3
    • 70449659580 scopus 로고    scopus 로고
    • The wound healing process: An overview of the cellular and molecular mechanisms
    • Velnar T, Bailey T, Smrkolj V. The wound healing process: An overview of the cellular and molecular mechanisms. J Int Med Res 2009;37: 1528–1542.
    • (2009) J Int Med Res , vol.37 , pp. 1528-1542
    • Velnar, T.1    Bailey, T.2    Smrkolj, V.3
  • 4
    • 33847020833 scopus 로고    scopus 로고
    • Inflammation in wound repair: Molecular and cellular mechanisms
    • Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: Molecular and cellular mechanisms. J Invest Dermatol 2007;127: 514–525.
    • (2007) J Invest Dermatol , vol.127 , pp. 514-525
    • Eming, S.A.1    Krieg, T.2    Davidson, J.M.3
  • 5
    • 33144468586 scopus 로고    scopus 로고
    • Monocytes/macrophages cooperate with progenitor cells During neovascularization and tissue repair: Conversion of cell columns into fibrovascular bundles
    • Anghelina M, Krishnan P, Moldovan L et al. Monocytes/macrophages cooperate with progenitor cells During neovascularization and tissue repair: Conversion of cell columns into fibrovascular bundles. Am J Pathol 2006;168:529–541.
    • (2006) Am J Pathol , vol.168 , pp. 529-541
    • Anghelina, M.1    Krishnan, P.2    Moldovan, L.3
  • 6
    • 65549151760 scopus 로고    scopus 로고
    • Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways
    • Lolmede K, Campana L, Vezzoli M et al. Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways. J Leukoc Biol 2009;85:779–787.
    • (2009) J Leukoc Biol , vol.85 , pp. 779-787
    • Lolmede, K.1    Campana, L.2    Vezzoli, M.3
  • 7
    • 84943594573 scopus 로고    scopus 로고
    • Monocyte and macrophage plasticity in tissue repair and regeneration
    • Das A, Sinha M, Datta S et al. Monocyte and macrophage plasticity in tissue repair and regeneration. Am J Pathol 2015;185:2596–2606.
    • (2015) Am J Pathol , vol.185 , pp. 2596-2606
    • Das, A.1    Sinha, M.2    Datta, S.3
  • 8
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair--current views
    • Phinney DG, Prockop DJ. Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair--current views. STEM CELLS 2007; 25:2896–2902.
    • (2007) STEM CELLS , vol.25 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 10
    • 84905670049 scopus 로고    scopus 로고
    • Mesenchymal stem cell paracrine activity is modulated by platelet lysate: Induction of an inflammatory response and secretion of factors maintaining macrophages in a proinflammatory phenotype
    • Ulivi V, Tasso R, Cancedda R et al. Mesenchymal stem cell paracrine activity is modulated by platelet lysate: Induction of an inflammatory response and secretion of factors maintaining macrophages in a proinflammatory phenotype. Stem Cells Dev 2014;00: 1–12.
    • (2014) Stem Cells Dev , vol.1 , pp. 1-12
    • Ulivi, V.1    Tasso, R.2    Cancedda, R.3
  • 11
    • 84903705293 scopus 로고    scopus 로고
    • The regenerative role of the fetal and adult stem cell secretome
    • Bollini S, Gentili C, Tasso R et al. The regenerative role of the fetal and adult stem cell secretome. J Clin Med 2013;2:302–327.
    • (2013) J Clin Med , vol.2 , pp. 302-327
    • Bollini, S.1    Gentili, C.2    Tasso, R.3
  • 12
    • 84861999021 scopus 로고    scopus 로고
    • Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: Can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    • Ratajczak MZ, Kucia M, Jadczyk T et al. Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: Can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies? Leukemia 2012;26:1166–1173.
    • (2012) Leukemia , vol.26 , pp. 1166-1173
    • Ratajczak, M.Z.1    Kucia, M.2    Jadczyk, T.3
  • 13
    • 84889641452 scopus 로고    scopus 로고
    • In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche
    • Tasso R, Ulivi V, Reverberi D et al. In vivo implanted bone marrow-derived mesenchymal stem cells trigger a cascade of cellular events leading to the formation of an ectopic bone regenerative niche. Stem Cells Dev 2013; 22:3178–3191.
    • (2013) Stem Cells Dev , vol.22 , pp. 3178-3191
    • Tasso, R.1    Ulivi, V.2    Reverberi, D.3
  • 14
    • 84865482681 scopus 로고    scopus 로고
    • Exosomes: New players in cell-cell communication
    • Bang C, Thum T. Exosomes: New players in cell-cell communication. Int J Biochem Cell Biol 2012;44:2060–2064.
    • (2012) Int J Biochem Cell Biol , vol.44 , pp. 2060-2064
    • Bang, C.1    Thum, T.2
  • 15
    • 77958098024 scopus 로고    scopus 로고
    • Exosomes/microvesicles as a mechanism of cell-to-cell communication
    • Camussi G, Deregibus MC, Bruno S et al. Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int 2010; 78:838–848.
    • (2010) Kidney Int , vol.78 , pp. 838-848
    • Camussi, G.1    Deregibus, M.C.2    Bruno, S.3
  • 16
    • 85016448020 scopus 로고    scopus 로고
    • Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles
    • Lötvall J, Hill AF, Hochberg F et al. Minimal experimental requirements for definition of extracellular vesicles and their functions: A position statement from the International Society for Extracellular Vesicles. J Extracell Vesicles 2014;3:26913.
    • (2014) J Extracell Vesicles , vol.3 , pp. 26913
    • Lötvall, J.1    Hill, A.F.2    Hochberg, F.3
  • 17
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath SH, Levy O, Inamdar MS et al. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012;10:244–258.
    • (2012) Cell Stem Cell , vol.10 , pp. 244-258
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3
  • 18
    • 84919483752 scopus 로고    scopus 로고
    • Extracellular vesicles: Potential roles in regenerative medicine
    • De Jong OG, Van Balkom BWM, Schiffelers RM et al. Extracellular vesicles: Potential roles in regenerative medicine. Front Immunol 2014;5:608.
    • (2014) Front Immunol , vol.5 , pp. 608
    • De Jong, O.G.1    Van Balkom, B.2    Schiffelers, R.M.3
  • 19
    • 34249113091 scopus 로고    scopus 로고
    • Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells
    • Grayson WL, Zhao F, Bunnell B et al. Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells. Biochem Biophys Res Commun 2007;358:948–953.
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 948-953
    • Grayson, W.L.1    Zhao, F.2    Bunnell, B.3
  • 20
    • 84962092232 scopus 로고    scopus 로고
    • A relativity concept in mesenchymal stromal cell manufacturing
    • Martin I, De Boer J, Sensebe L. A relativity concept in mesenchymal stromal cell manufacturing. Cytotherapy 2016;16:613–620.
    • (2016) Cytotherapy , vol.16 , pp. 613-620
    • Martin, I.1    De Boer, J.2    Sensebe, L.3
  • 21
    • 84962129237 scopus 로고    scopus 로고
    • Extracellular vesicles as new players in angiogenesis
    • S1537–1891
    • Kholia S, Ranghino A, Garnieri P et al. Extracellular vesicles as new players in angiogenesis. Vasc Pharmacol 2016;S1537–1891: 30105–30101.
    • (2016) Vasc Pharmacol , pp. 30105
    • Kholia, S.1    Ranghino, A.2    Garnieri, P.3
  • 22
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H, Ekström K, Bossios A et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007;9: 654–659.
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3
  • 23
    • 84867118648 scopus 로고    scopus 로고
    • Exosomes and microvesicles: Extracellular vesicles for genetic information transfer and gene therapy
    • Lee Y, El Andaloussi S, Wood MJA. Exosomes and microvesicles: Extracellular vesicles for genetic information transfer and gene therapy. Hum Mol Genet 2012;21:125–134.
    • (2012) Hum Mol Genet , vol.21 , pp. 125-134
    • Lee, Y.1    El Andaloussi, S.2    Wood, M.J.A.3
  • 24
    • 84862150859 scopus 로고    scopus 로고
    • A novel regulator of macrophage activation: MiR-223 in obesity-associated adipose tissue inflammation
    • Zhuang G, Meng C, Guo X et al. A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation 2012;125:2892–2903.
    • (2012) Circulation , vol.125 , pp. 2892-2903
    • Zhuang, G.1    Meng, C.2    Guo, X.3
  • 25
    • 84879973586 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b
    • Curtale G, Mirolo M, Renzi TA et al. Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b. Proc Natl Acad Sci USA 2013;110: 11499–11504.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 11499-11504
    • Curtale, G.1    Mirolo, M.2    Renzi, T.A.3
  • 26
    • 71449107946 scopus 로고    scopus 로고
    • MicroRNAs in inflammation
    • Sonkoly E, Pivarcsi A. microRNAs in inflammation. Int Rev Immunol 2009;28:535–561.
    • (2009) Int Rev Immunol , vol.28 , pp. 535-561
    • Sonkoly, E.1
  • 27
    • 48549106378 scopus 로고    scopus 로고
    • The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
    • Wang S, Aurora AB, Johnson BA et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell 2008;15:261–271.
    • (2008) Dev Cell , vol.15 , pp. 261-271
    • Wang, S.1    Aurora, A.B.2    Johnson, B.A.3
  • 28
    • 84908514073 scopus 로고    scopus 로고
    • MiRNA-199a- 3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway
    • Jia L, Li Y-F, Wu G-F et al. MiRNA-199a- 3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway. Int J Mol Sci 2014;15:296–308.
    • (2014) Int J Mol Sci , vol.15 , pp. 296-308
    • Jia, L.1    Li, Y.-F.2    Wu, G.-F.3
  • 29
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A, Biswas SK, Galdiero MR et al. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol 2013;229:176–185.
    • (2013) J Pathol , vol.229 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3
  • 30
    • 84878419732 scopus 로고    scopus 로고
    • Macrophage phenotypes during tissue repair
    • Novak ML, Koh TJ. Macrophage phenotypes during tissue repair. J Leukoc Biol 2013; 93:875–881.
    • (2013) J Leukoc Biol , vol.93 , pp. 875-881
    • Novak, M.L.1    Koh, T.J.2
  • 31
    • 84897826443 scopus 로고    scopus 로고
    • Altered macrophage phenotype transition impairs skeletal muscle regeneration
    • Wang H, Melton DW, Porter L et al. Altered macrophage phenotype transition impairs skeletal muscle regeneration. Am J Pathol 2014;184:1167–1184.
    • (2014) Am J Pathol , vol.184 , pp. 1167-1184
    • Wang, H.1    Melton, D.W.2    Porter, L.3
  • 32
    • 84983102649 scopus 로고    scopus 로고
    • Inflammation during skeletal muscle regeneration and tissue remodeling: Application to exercise-induced muscle damage management
    • Chazaud B. Inflammation during skeletal muscle regeneration and tissue remodeling: Application to exercise-induced muscle damage management. Immunol Cell Biol 2016;94:140–145.
    • (2016) Immunol Cell Biol , vol.94 , pp. 140-145
    • Chazaud, B.1
  • 33
    • 33744980849 scopus 로고    scopus 로고
    • MCP-1 parallels inflammatory and regenerative responses in ischemic muscle
    • Shireman PK, Contreras-Shannon V, Reyes-Reyna SM et al. MCP-1 parallels inflammatory and regenerative responses in ischemic muscle. J Surg Res 2006;134:145–157.
    • (2006) J Surg Res , vol.134 , pp. 145-157
    • Shireman, P.K.1    Contreras-Shannon, V.2    Reyes-Reyna, S.M.3
  • 34
    • 84891717595 scopus 로고    scopus 로고
    • Nuclear positioning in muscle development and disease
    • Folker ES, Baylies MK. Nuclear positioning in muscle development and disease. Front Physiol 2013;4:363.
    • (2013) Front Physiol , vol.4 , pp. 363
    • Folker, E.S.1    Baylies, M.K.2
  • 35
    • 85014619748 scopus 로고    scopus 로고
    • Biological properties of extracellular vesicles and their physiological functions
    • Yãnez-Mo M, Siljander PR-M, Andreu Z et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles 2015;4:27066.
    • (2015) J Extracell Vesicles , vol.4
    • Yãnez-Mo, M.1    Siljander, P.-M.2    Andreu, Z.3
  • 36
    • 84956943692 scopus 로고    scopus 로고
    • Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
    • Lener T, Gimona M, Aigner L et al. Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper. J Extracell Vesicles 2015;4:30087.
    • (2015) J Extracell Vesicles , vol.4
    • Lener, T.1    Gimona, M.2    Aigner, L.3
  • 37
    • 40149086501 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A promising candidate in regenerative medicine
    • Chen Y, Shao JZ, Xiang LX et al. Mesenchymal stem cells: A promising candidate in regenerative medicine. Int J Biochem Cell Biol 2008;40:815–820.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 815-820
    • Chen, Y.1    Shao, J.Z.2    Xiang, L.X.3
  • 38
    • 84855740326 scopus 로고    scopus 로고
    • The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model
    • Tasso R, Gaetani M, Molino E et al. The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model. Biomaterials 2012;33:2086–2096.
    • (2012) Biomaterials , vol.33 , pp. 2086-2096
    • Tasso, R.1    Gaetani, M.2    Molino, E.3
  • 39
    • 84871081424 scopus 로고    scopus 로고
    • Inflammation, wound repair, and fibrosis: Reassessing the spectrum of tissue injury and resolution
    • White ES, Mantovani AR. Inflammation, wound repair, and fibrosis: Reassessing the spectrum of tissue injury and resolution. J Pathol 2013;229:141–144.
    • (2013) J Pathol , vol.229 , pp. 141-144
    • White, E.S.1    Mantovani, A.R.2
  • 40
    • 84960437624 scopus 로고    scopus 로고
    • Macrophages in tissue repair, regeneration, and fibrosis
    • Wynn TA, Vanella KM. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 2016;44:450–462.
    • (2016) Immunity , vol.44 , pp. 450-462
    • Wynn, T.A.1    Vanella, K.M.2
  • 41
    • 84879103109 scopus 로고    scopus 로고
    • Macrophage activation and polarization as an adaptive component of innate immunity
    • Locati M, Mantovani A, Sica A. Macrophage activation and polarization as an adaptive component of innate immunity. Adv Immunol 2013;120:163–184.
    • (2013) Adv Immunol , vol.120 , pp. 163-184
    • Locati, M.1    Mantovani, A.2    Sica, A.3
  • 42
    • 84897556094 scopus 로고    scopus 로고
    • The M1 and M2 paradigm of macrophage activation: Time for reassessment
    • Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: Time for reassessment. F1000Prime Rep 2014;6:13.
    • (2014) F1000prime Rep , vol.6 , pp. 13
    • Martinez, F.O.1    Gordon, S.2
  • 43
    • 84938697816 scopus 로고    scopus 로고
    • Human bone marrow- and adiposemesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
    • Baglio SR, Rooijers K, Koppers-Lalic D et al. Human bone marrow- and adiposemesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res 2015;6:127.
    • (2015) Stem Cell Res , vol.6
    • Baglio, S.R.1    Rooijers, K.2    Koppers-Lalic, D.3
  • 44
    • 27744603002 scopus 로고    scopus 로고
    • Hypoxia regulates macrophage functions in inflammation
    • Murdoch C, Muthana M, Lewis CE. Hypoxia regulates macrophage functions in inflammation. J Immunol 2005;175:6257–6263.
    • (2005) J Immunol , vol.175 , pp. 6257-6263
    • Murdoch, C.1    Muthana, M.2    Lewis, C.E.3
  • 45
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • Bian S, Zhang L, Duan L et al. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med. 2014;92:387–397.
    • (2014) J Mol Med , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3
  • 46
    • 84875756145 scopus 로고    scopus 로고
    • Concise review: Role of mesenchymal stem cells in wound repair
    • Maxson S, Lopez EA, Yoo D et al. Concise review: Role of mesenchymal stem cells in wound repair. STEM CELLS TRANSL MED 2012;1: 142–149.
    • (2012) STEM CELLS TRANSL MED , vol.1 , pp. 142-149
    • Maxson, S.1    Lopez, E.A.2    Yoo, D.3
  • 47
    • 84941931780 scopus 로고    scopus 로고
    • LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosomeshuttled let-7b
    • Dongdong T, Haojie H, Chuan T et al. LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for resolution of chronic inflammation via exosomeshuttled let-7b. J Transl Med 2015;13:308–321.
    • (2015) J Transl Med , vol.13 , pp. 308-321
    • Dongdong, T.1    Haojie, H.2    Chuan, T.3
  • 48
    • 84874534408 scopus 로고    scopus 로고
    • Macrophage plasticity and the role of inflammation in skeletal muscle repair
    • Kharraz Y, Guerra J, Mann CJ et al. Macrophage plasticity and the role of inflammation in skeletal muscle repair. Mediators Inflamm 2013;2013:491497.
    • (2013) Mediators Inflamm , vol.2013
    • Kharraz, Y.1    Guerra, J.2    Mann, C.J.3
  • 49
    • 84942057633 scopus 로고    scopus 로고
    • IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration
    • Makita N, Hizukuri Y, Yamashiro K et al. IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration. Int Immunol. 2015;27:131–141.
    • (2015) Int Immunol , vol.27 , pp. 131-141
    • Makita, N.1    Hizukuri, Y.2    Yamashiro, K.3
  • 50
    • 84925858150 scopus 로고    scopus 로고
    • Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration
    • Gondin J, Théret M, Duhamel G et al. Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration. J Immunol 2015;194:3389–3399.
    • (2015) J Immunol , vol.194 , pp. 3389-3399
    • Gondin, J.1    Théret, M.2    Duhamel, G.3


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