The role of bFGF on the ability of MSC to activate endogenous regenerative mechanisms in an ectopic bone formation model

Biomaterials

Volumn 33, Issue 7, 2012, Pages 2086-2096

  Tasso, Roberta ^a,b   Gaetani, Massimiliano ^a,c   Molino, Erica ^a,b   Cattaneo, Angela ^d   Monticone, Massimiliano ^b   Bachi, Angela ^d   Cancedda, Ranieri ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c MEDITERRANEAN INSTITUTE FOR TRANSPLANTATION AND ADVANCED SPECIALIZED THERAPIES ISMETT   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Bone regeneration; Cell signaling; Fibroblast growth factor; Mesenchymal stem cells

Indexed keywords

BIOACTIVE MOLECULES; BIOLOGICAL PROCESS; BONE MARROW; BONE REGENERATION; CELL SIGNALING; CULTURE MEDIA; CULTURE MEDIUM; ECTOPIC BONES; FIBROBLAST GROWTH FACTOR; GENE EXPRESSION PROFILING; HETEROGENEOUS POPULATIONS; IMMUNE RESPONSE; IN-VITRO; INFLAMMATORY RESPONSE; KEY FACTORS; MESENCHYMAL STEM CELL; MICROENVIRONMENTS; NOVEL STRATEGIES; QUANTITATIVE PROTEOMICS;

BIOACTIVITY; BONE; ENZYME ACTIVITY; GENE EXPRESSION; MOLECULAR BIOLOGY; STEM CELLS; TISSUE;

CELL CULTURE;

CD146 ANTIGEN; CD31 ANTIGEN; CD34 ANTIBODY; CD44V ANTIGEN; CD45 ANTIGEN; FIBROBLAST GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; THY 1 ANTIGEN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CELL DIFFERENTIATION; CHEMOTAXIS; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HISTOLOGY; IMMUNE RESPONSE; IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; REGENERATIVE ABILITY; UPREGULATION; WOUND;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CHROMATOGRAPHY, LIQUID; CULTURE MEDIA, CONDITIONED; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION PROFILING; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROARRAY ANALYSIS; OSTEOGENESIS; REGENERATION; TANDEM MASS SPECTROMETRY; TISSUE SCAFFOLDS;

EID: 84855740326     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.043     Document Type: Article

References (37)

1. Ehninger A., Trumpp A. The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. JExp Med 2011, 208:421-428.
2. Kucia M., Reca R., Jala V.R., Dawn B., Ratajczak J., Ratajczak M.Z. Bone marrow as a home of heterogenous populations of nonhematopoietic stem cells. Leukemia 2005, 19:1118-1127.
3. Ratajczak M.Z., Zuba-Surma E.K., Wojakowski W., Ratajczak J., Kucia M. Bone marrow - home of versatile stem cells. Transfus Med Hemother 2008, 35:248-259.
4. Picinich S.C., Mishra P.J., Glod J., Banerjee D. The therapeutic potential of mesenchymal stem cells. Cell- & tissue-based therapy. Expert Opin Biol Ther 2007, 7:965-973.
5. Prockop D.J. Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther 2009, 17:939-946.
6. Zipori D. The hemopoietic stem cell niche versus the microenvironment of the multiple myeloma-tumor initiating cell. Cancer Microenviron 2010, 3:15-28.
7. Wagner W., Ho A.D., Zenke M. Different facets of aging in human mesenchymal stem cells. Tissue Eng Part B Rev 2010, 16:445-453.
8. Auletta J.J., Zale E.A., Welter J.F., Solchaga L.A. Fibroblast growth factor-2 enhances expansion of human bone marrow-derived mesenchymal stromal cells without diminishing their immunosuppressive potential. Stem Cells Int 2011, 2011:235176.
9. Bianchi G., Banfi A., Mastrogiacomo M., Notaro R., Luzzatto L., Cancedda R., et al. Exvivo enrichment of mesenchymal cell progenitors by fibroblast growth factor 2. Exp Cell Res 2003, 287:98-105.
10. Gotoh N. Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Curr Stem Cell Res Ther 2009, 4:9-15.
11. Martin I., Muraglia A., Campanile G., Cancedda R., Quarto R. Fibroblast growth factor-2 supports exvivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology 1997, 138:4456-4462.
12. Caplan A.I., Correa D. The MSC: an injury drugstore. Cell Stem Cell 2011, 9:11-15.
13. Tasso R., Augello A., Boccardo S., Salvi S., Carida M., Postiglione F., et al. Recruitment of a host's osteoprogenitor cells using exogenous mesenchymal stem cells seeded on porous ceramic. Tissue Eng Part A 2009, 15:2203-2212.
14. Tasso R., Fais F., Reverberi D., Tortelli F., Cancedda R. The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model. Biomaterials 2010, 31:2121-2129.
15. Tolar J., Le Blanc K., Keating A., Blazar B.R. Concise review: hitting the right spot with mesenchymal stromal cells. Stem Cells 2010, 28:1446-1455.
16. Yagi H., Soto-Gutierrez A., Parekkadan B., Kitagawa Y., Tompkins R.G., Kobayashi N., et al. Mesenchymal stem cells: mechanisms of immunomodulation and homing. Cell Transplant 2010, 19:667-679.
17. Olsen J.V., de Godoy L.M., Li G., Macek B., Mortensen P., Pesch R., et al. Parts per million mass accuracy on an Orbitrap mass spectrometer via lock mass injection into a C-trap. Mol Cell Proteomics 2005, 4:2010-2021.
18. Cox J., Neuhauser N., Michalski A., Scheltema R.A., Olsen J.V., Mann M. Andromeda: a peptide search engine integrated into the MaxQuant environment. JProteome Res 2011, 10:1794-1805.
19. Saeed A.I., Sharov V., White J., Li J., Liang W., Bhagabati N., et al. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003, 34:374-378.
20. Muraglia A., Martin I., Cancedda R., Quarto R. Anude mouse model for human bone formation in unloaded conditions. Bone 1998, 22:131S-134S.
21. Tortelli F., Tasso R., Loiacono F., Cancedda R. The development of tissue-engineered bone of different origin through endochondral and intramembranous ossification following the implantation of mesenchymal stem cells and osteoblasts in a murine model. Biomaterials 2010, 31:242-249.
22. Bachi A., Bonaldi T. Quantitative proteomics as a new piece of the systems biology puzzle. JProteomics 2008, 71:357-367.
23. Mann M. Functional and quantitative proteomics using SILAC. Nat Rev Mol Cell Biol 2006, 7:952-958.
24. Cox J., Mann M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 2008 Dec, 26(12):1367-1372.
25. Chien K.R., Moretti A., Laugwitz K.L. Development. ES cells to the rescue. Science 2004, 306:239-240.
26. Heng B.C., Liu H., Cao T. Utilising human embryonic stem cells as "catalysts" for biological repair and regeneration. Challenges and some possible strategies. Clin Exp Med 2005, 5:37-39.
27. Fraidenraich D., Stillwell E., Romero E., Wilkes D., Manova K., Basson C.T., et al. Rescue of cardiac defects in id knockout embryos by injection of embryonic stem cells. Science 2004, 306:247-252.
28. Caplan A.I., Dennis J.E. Mesenchymal stem cells as trophic mediators. JCell Biochem 2006, 98:1076-1084.
29. Uccelli A., Moretta L., Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 2006, 36:2566-2573.
30. Bi Y., Stuelten C.H., Kilts T., Wadhwa S., Iozzo R.V., Robey P.G., et al. Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. JBiol Chem 2005, 280:30481-30489.
31. Sacchetti B., Funari A., Michienzi S., Di Cesare S., Piersanti S., Saggio I., et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007, 131:324-336.
32. Copland I., Sharma K., Lejeune L., Eliopoulos N., Stewart D., Liu P., et al. CD34 expression on murine marrow-derived mesenchymal stromal cells: impact on neovascularization. Exp Hematol 2008, 36:93-103.
33. Peister A., Mellad J.A., Larson B.L., Hall B.M., Gibson L.F., Prockop D.J. Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potential. Blood 2004, 103:1662-1668.
34. Lolmede K., Campana L., Vezzoli M., Bosurgi L., Tonlorenzi R., Clementi E., et al. Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways. JLeukoc Biol 2009, 85:779-787.
35. Lyons F.G., Al-Munajjed A.A., Kieran S.M., Toner M.E., Murphy C.M., Duffy G.P., et al. The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs. Biomaterials 2010, 31:9232-9243.
36. Liu Z.J., Zhuge Y., Velazquez O.C. Trafficking and differentiation of mesenchymal stem cells. JCell Biochem 2009, 106:984-991.
37. Meirelles Lda S., Fontes A.M., Covas D.T., Caplan A.I. Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 2009, 20:419-427.