A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

Immunity

Volumn 46, Issue 4, 2017, Pages 609-620

  Oyler Yaniv, Alon ^a,b,c   Oyler Yaniv, Jennifer ^b,c,d   Whitlock, Benjamin M ^c,e   Liu, Zhiduo ^f   Germain, Ronald N ^f   Huse, Morgan ^c   Altan Bonnet, Grégoire ^b,c   Krichevsky, Oleg ^a,c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d Weill Cornell Medical Center   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Cell to cell communications; Cell to cell variability; Cytokine niches; Cytokines; Diffusion Consumption; Interleukin 2; Quantitative Immunology; STAT5; Theoretical Modeling

Indexed keywords

CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; STAT5 PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL LYMPHOMA CELL; B16-F10 CELL LINE; CELL COMMUNICATION; CELL DENSITY; CELL DIFFERENTIATION; CELL PLASTICITY; CELL SIZE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; DIFFUSION; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INGUINAL LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FLOW CYTOMETRY; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CELL COMMUNICATION; CELL LINE, TUMOR; CELLS, CULTURED; CYTOKINES; DIFFUSION; FLOW CYTOMETRY; HUMANS; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, IMMUNOLOGICAL; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 85017404528     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.03.011     Document Type: Article

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