Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer's disease

Alzheimer's and Dementia

Volumn 13, Issue 10, 2017, Pages 1143-1153

  Nielsen, Rune B ^a   Egefjord, Lærke ^a   Angleys, Hugo ^a   Mouridsen, Kim ^a   Gejl, Michael ^a,b   Møller, Arne ^b   Brock, Birgitte ^a,b   Brændgaard, Hans ^b   Gottrup, Hanne ^b   Rungby, Jørgen ^c   Eskildsen, Simon F ^a   Østergaard, Leif ^a,b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c BISPEBJERG HOSPITAL   (Denmark)

Author keywords

Alzheimer's disease; Capillary dysfunction; Capillary transit time heterogeneity (CTH); Cerebral blood flow (CBF); Cerebral blood volume (CBV); Cortical thinning; Hypoxia; Magnetic resonance imaging (MRI); Microvascular dysfunction; Neurodegeneration; Neurovascular dysfunction; Perfusion imaging; Relative transit time heterogeneity (RTH); Tissue oxygen tension (PtO2)

Indexed keywords

GADOBUTROL; LIRAGLUTIDE; PITTSBURGH COMPOUND B; PLACEBO;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VOLUME; BRAIN CORTEX; BRIEF COGNITIVE STATUS EXAMINATION; CAPILLARY TRANSIT TIME HETEROGENEITY; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CORTICAL THICKNESS (BRAIN); DENMARK; DISEASE SEVERITY; ECHO PLANAR IMAGING; ELECTRON SPIN RESONANCE; ESTIMATED GLOMERULAR FILTRATION RATE; FEMALE; HEMODYNAMICS; HUMAN; HUMAN TISSUE; ICD-10; MALE; MEAN TRANSIT TIME; MENTAL DISEASE ASSESSMENT; NERVE DEGENERATION; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OXYGEN TISSUE LEVEL; PERFUSION WEIGHTED IMAGING; POSITRON EMISSION TOMOGRAPHY; POSTERIOR CINGULATE; PRIORITY JOURNAL; TISSUE OXYGENATION; VERY ELDERLY; WECHSLER MEMORY SCALE; BRAIN CIRCULATION; COGNITIVE DEFECT; COMPLICATION; DEGENERATIVE DISEASE; DIAGNOSTIC IMAGING; IMAGE PROCESSING; MICROVASCULATURE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; PATHOLOGY; PATHOPHYSIOLOGY; PERFUSION; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; COGNITIVE DYSFUNCTION; FEMALE; HEMODYNAMICS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MICROVESSELS; MIDDLE AGED; NEURODEGENERATIVE DISEASES; NEUROPSYCHOLOGICAL TESTS; PERFUSION;

EID: 85017188013     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2017.02.007     Document Type: Article

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