Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 8, 2012, Pages 1589-1599

  Wierenga, Christina E ^a,b,c   Dev, Sheena I ^a   Shin, David D ^d   Clark, Lindsay R ^e   Bangen, Katherine J ^b   Jak, Amy J ^a,b   Rissman, Robert A ^f   Liu, Thomas T ^d   Salmon, David P ^f   Bondi, Mark W ^a,b  

^a VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAN DIEGO STATE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

apolipoprotein E; arterial spin labeling; cognition; mild cognitive impairment

Indexed keywords

APOLIPOPROTEIN E;

AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; CLINICAL ARTICLE; COGNITION; DISEASE ASSOCIATION; FEMALE; FRONTAL GYRUS; FUSIFORM GYRUS; GENOTYPE; HUMAN; MALE; MILD COGNITIVE IMPAIRMENT; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAHIPPOCAMPAL GYRUS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESTING CEREBRAL BLOOD FLOW; VERBAL MEMORY;

AGED; ALLELES; APOLIPOPROTEIN E4; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; COGNITION; FEMALE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; MILD COGNITIVE IMPAIRMENT; NEUROPSYCHOLOGICAL TESTS;

EID: 84864553756     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.58     Document Type: Article

References (47)

1. Alsop DC, Detre JA, Grossman M (2000) Assessment of cerebral blood flow in Alzheimer's disease by spinlabeled magnetic resonance imaging. Ann Neurol 47: 93-100
2. Braak H, Braak E (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol (Berl) 82: 239-59
3. Brown GG, Clark C, Liu TT (2007) Measurement of cerebral perfusion with arterial spin labeling: Part 2. Applications. J Int Neuropsychol Soc 13:526-38
4. Brown GG, Eyler Zorrilla LT, Georgy B, Kindermann SS, Wong EC, Buxton RB (2003) BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion. J Cereb Blood Flow Metab 23:829-37
5. Brumm KP, Perthen JE, Liu TT, Haist F, Ayalon L, Love T (2010) An arterial spin labeling investigation of cerebral blood flow deficits in chronic stroke survivors. Neuroimage 51:995-1005
6. Buxton RB (2009) Introduction to functional magnetic resonance imaging: principles and techniques. Cambridge: University Press
7. Buxton RB, Uludag K, Dubowitz DJ, Liu TT (2004) Modeling the hemodynamic response to brain activation. Neuroimage 23(Suppl 1):S220-33
8. Cabeza R, Anderson ND, Locantore JK, McIntosh AR (2002) Aging gracefully: compensatory brain activity in highperforming older adults. Neuroimage 17:1394-402
9. Chalela JA, Alsop DC, Gonzalez-Atavales JB, Maldjian JA, Kasner SE, Detre JA (2000) Magnetic resonance perfusion imaging in acute ischemic stroke using continuous arterial spin labeling. Stroke 31:680-7
10. Chao LL, Buckley ST, Kornak J, Schuff N, Madison C, Yaffe K, Miller BL, Kramer JH, Weiner MW (2010) ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer Dis Assoc Disord 24:19-27
11. D'Agostino RB, Wolf PA, Belanger AJ, Kannel WB (1994) Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke 25:40-3
12. Dai W, Lopez OL, Carmichael OT, Becker JT, Kuller LH, Gach HM (2009) Mild cognitive impairment and Alzheimer's disease: patterns of altered cerebral blood flow at MR imaging. Radiology 250:856-66
13. Daselaar SM, Fleck MS, Dobbins IG, Madden DJ, Cabeza R (2006) Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study. Cereb Cortex 16:1771-82
14. D'Esposito M, Deouell LY, Gazzaley A (2003) Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging. Nat Rev Neurosci 4:863-72
15. Detre JA, Alsop DC (1999) Perfusion magnetic resonance imaging with continuous arterial spin labeling: methods and clinical applications in the central nervous system. Eur J Radiol 30:115-24
16. Devanand DP, Pelton GH, Zamora D, Liu X, Tabert MH, Goodkind M, Scarmeas N, Braun I, Stern Y, Mayeux R (2005) Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment. Arch Neurol 62:975-80
17. Ewing JR, Cao Y, Knight RA, Fenstermacher JD (2005) Arterial spin labeling: validity testing and comparison studies. J Magn Reson Imaging 22:737-40
18. Fennema-Notestine C, Ozyurt IB, Clark CP, Morris S, Bischoff-Grethe A, Bondi MW, Jernigan TL, Fischl B, Segonne F, Shattuck DW, Leahy RM, Rex DE, Toga AW, Zou KH, Brown GG (2006) Quantitative evaluation of automated skull-stripping methods applied to contemporary and legacy images: effects of diagnosis, bias correction, and slice location. Hum Brain Mapp 27: 99-113
19. Heaton RK, Grant I, Matthews CG (1991) Comprehensive norms for an extended Halstead-Reitan neuropsychological battery: demographic corrections, research findings, and clinical applications. Odessa, FL: Psychological Assessment Resources, Inc.
20. Hermes M, Hagemann D, Britz P, Lieser S, Rock J, Naumann E, Walter C (2007) Reproducibility of continuous arterial spin labeling perfusion MRI after 7 weeks. MAGMA 20:103-15
21. Jak AJ, Bondi MW, Delano-Wood L, Wierenga C, Corey-Bloom J, Salmon DP, Delis DC (2009) Quantification of five neuropsychological approaches to defining mild cognitive impairment. Am J Geriatr Psychiatry 17: 368-375
22. Jankowski P, Kawecka-Jaszcz K, Bryniarski L, Czarnecka D, Brzozowska-Kiszka M, Posnik-Urbanska A, Kpoec G, Dragan J, Klecha A, Dudek D (2004) Fractional diastolic and systolic pressure in the ascending aorta are related to the extent of coronary artery disease. Am J Hypertens 17:641-6
23. Johnson NA, Jahng GH, Weiner MW, Miller BL, Chui HC, Jagust WJ, Gorno-Tempini ML, Schuff N (2005) Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spinlabeling MR imaging: initial experience. Radiology 234: 851-9
24. Koziak AM, Winter J, Lee TY, Thompson RT, St Lawrence KS (2008) Validation study of a pulsed arterial spin labeling technique by comparison to perfusion computed tomography. Magn Reson Imaging 26:543-53
25. Liu TT, Brown GG (2007) Measurement of cerebral perfusion with arterial spin labeling: Part 1. Methods. J Int Neuropsychol Soc 13:517-25
26. Liu TT, Wong EC (2005) A signal processing model for arterial spin labeling functional MRI. Neuroimage 24: 207-15
27. Luckhaus C, Cohnen M, Flüss MO, Jänner M, Grass-Kapanke B, Teipel SJ, Grothe M, Hampel H, Peters O, Kornhuber J, MaierW, Supprian T, GaebelW, Mödder U, Wittsack HJ (2010) The relation of regional cerebral perfusion and atrophy in mild cognitive impairment (MCI) and early Alzheimer's dementia. Psychiatry Res 183:44-51
28. Mahley RW, Nathan BP, Pitas RE (1996) Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease. Ann N Y Acad Sci 777:139-45
29. Marra C, Ferraccioli M, Vita MG, Quaranta D, Gainotti G (2011) Patterns of cognitive decline and rates of conversion to dementia in patients with degenerative and vascular forms of MCI. Curr Alzheimer Res 8:24-31
30. Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA (2010) APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 67:122-31
31. Parkes LM, Rashid W, Chard DT, Tofts PS (2004) Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects. Magn Reson Med 51:736-43
32. Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P (1999) SENSE: sensitivity encoding for fast MRI. Magn Reson Med 42:952-62
33. Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D (1996) Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E. N Engl J Med 334:752-8
34. Ringman JM, Medina LD, Braskie M, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer S (2011) Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cereb Cortex 21:877-83
35. Sakamoto S, Matsuda H, Asada T, Ohnishi T, Nakano S, Kanetaka H, Takasaki M (2003) Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study. J Neuroimaging 13:113-23
36. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ et al (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467-72
37. Shattuck DW, Sandor-Leahy SR, Schaper KA, Rottenberg DA, Leahy RM (2001) Magnetic resonance image tissue classification using a partial volume model. Neuroimage 13:856-76
38. Shin DD, Liu TT, Wong EC, Shankaranarayanan A, Jung Y (2012) Pseudocontinuous arterial spin labeling with optimized tagging efficiency. Magn Reson Med doi: 10.1002/mrm.24113 (E-pub ahead of print 3 January 2012).
39. Thambisetty M, Beason-Held L, An Y, Kraut MA, Resnick SM (2010) APOE epsilon 4 genotype and longitudinal changes in cerebral blood flow in normal aging. Arch Neurol 67:93-8
40. Tiraboschi P, Hansen LA, Masliah E, Alford M, Thal LJ, Corey-Bloom J (2004) Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology 62:1977-83
41. Weiger M, Pruessmann KP, Osterbauer R, Bornert P, Boesiger P, Jezzard P (2002) Sensitivity-encoded single-shot spiral imaging for reduced susceptibility artifacts in BOLD fMRI. Magn Reson Med 48:860-866
42. Wierenga CE, Bondi MW (2007) Use of functional magnetic resonance imaging in the early identification of Alzheimer's disease. Neuropsychol Rev 17:127-43
43. Wolf H, Jelic V, Gertz HJ, Nordberg A, Julin P, Wahlund LO (2003) A critical discussion of the role of neuroimaging in mild cognitive impairment. Acta Neurol Scand Suppl 179:52-76
44. Wong EC (2005) Quantifying CBF with pulsed ASL: technical and pulse sequence factors. J Magn Reson Imaging 22:727-31
45. Wong EC, Buxton RB, Frank LR (1998) Quantitative imaging of perfusion using a single subtraction (QUIPSS and QUIPSS II). Magn Reson Med 39:702-8
46. Xu G, Antuono PG, Jones J, Xu Y, Wu G, Ward D, Li SJ (2007) Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology 69:1650-6
47. Yip AG, McKee AC, Green RC, Wells J, Young H, Cupples LA, Farrer LA (2005) APOE, vascular pathology, and the AD brain. Neurology 65:259-65