Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling

Cell

Volumn 169, Issue 2, 2017, Pages 338-349.e11

  Paek, Jaeho ^a   Kalocsay, Marian ^a   Staus, Dean P ^b   Wingler, Laura ^b   Pascolutti, Roberta ^a   Paulo, Joao A ^a   Gygi, Steven P ^a   Kruse, Andrew C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

APEX; G protein coupled receptor; GPCR; isobaric tagging; mass spectrometry; proximity labeling; signal transduction

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; ADENYLATE CYCLASE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; AP 2 PROTEIN; BETA 2 ADRENERGIC RECEPTOR; BETA ARRESTIN 2; CLATHRIN; FCHO PROTEIN; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; HYDROGEN PEROXIDE; INTERSECTIN; LMBRD2 PROTEIN; MEMBRANE PROTEIN; PEROXIDASE; PROTEIN; RAB PROTEIN; RAB7 PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG; ASCORBATE PEROXIDASE; BETA ARRESTIN; BIOTIN; OLIGOPEPTIDE; SARCOSINE-ARGINYL-VALYL-TYROSYL-ISOLEUCYL-HISTIDYL-PROLYL-ALANINE;

ARTICLE; BIOTINYLATION; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENDOCYTOSIS; KINETICS; LIPID RAFT; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; AGONISTS; CHEMISTRY; HEK293 CELL LINE; HUMAN; METABOLISM; PROCEDURES; PROTEIN ENGINEERING; STAINING;

ASCORBATE PEROXIDASES; BETA-ARRESTINS; BIOTIN; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; OLIGOPEPTIDES; PROTEIN ENGINEERING; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION; STAINING AND LABELING;

EID: 85017183446     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.03.028     Document Type: Article

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