A NOTCH-sensitive uPAR-regulated oncolytic adenovirus effectively suppresses pancreatic tumor growth and triggers synergistic anticancer effects with gemcitabine and nab-paclitaxel

Oncotarget

Volumn 8, Issue 14, 2017, Pages 22700-22715

  Mato Berciano, Ana ^a,b   Raimondi, Giulia ^a,b   Maliandi, Maria Victoria ^a,b   Alemany, Ramon ^c   Montoliu, Lluis ^b,d   Fillat, Cristina ^a,b  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^d CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

Cancer stem cells; Gemcitabine; Nab paclitaxel; Oncolytic adenovirus; Pancreatic cancer

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; E1A PROTEIN; GEMCITABINE; NOTCH RECEPTOR; ONCOLYTIC ADENOVIRUS; PACLITAXEL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CSL; UNCLASSIFIED DRUG; UROKINASE RECEPTOR; 130-NM ALBUMIN-BOUND PACLITAXEL; ALBUMINOID; ANTINEOPLASTIC AGENT; DOXECITINE; TUMOR MARKER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; CANCER COMBINATION CHEMOTHERAPY; CANCER STEM CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG SELECTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER TOXICITY; MALE; MOUSE; MOUSE MODEL; NONHUMAN; ONCOLYTIC VIROTHERAPY; PANCREAS ADENOCARCINOMA; PANCREATIC CANCER CELL LINE; SINGLE DRUG DOSE; TUMOR REGRESSION; TUMOR XENOGRAFT; UPREGULATION; ADENOVIRIDAE; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CELL PROLIFERATION; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; MULTIMODALITY CANCER THERAPY; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL CULTURE; VIROLOGY;

ADENOVIRIDAE; ALBUMINS; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BIOMARKERS, TUMOR; CELL PROLIFERATION; COMBINED MODALITY THERAPY; DEOXYCYTIDINE; DRUG SYNERGISM; GEMCITABINE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASTIC STEM CELLS; ONCOLYTIC VIROTHERAPY; PACLITAXEL; PANCREATIC NEOPLASMS; RECEPTORS, NOTCH; RECEPTORS, UROKINASE PLASMINOGEN ACTIVATOR; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85017001077     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15169     Document Type: Article

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