The notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Abel, Ethan V ^a   Kim, Edward J ^b   Wu, Jingjiang ^a   Hynes, Mark ^a   Bednar, Filip ^a   Proctor, Erica ^a   Wang, Lidong ^a   Dziubinski, Michele L ^a   Simeone, Diane M ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE; MK 0752; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; NOTCH RECEPTOR; SHORT HAIRPIN RNA; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HES1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; LIGAND; PROTEINASE INHIBITOR; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CELL POPULATION; CONTROLLED STUDY; GENE; GENE TARGETING; HES1 GENE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NOTCH GENE; PANCREAS CANCER; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTICELLULAR SPHEROID; NONOBESE DIABETIC MOUSE; PANCREAS TUMOR; PATHOLOGY; SCID MOUSE; TUMOR CELL CULTURE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; LIGANDS; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; PROTEASE INHIBITORS; RECEPTORS, NOTCH; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84898653686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091983     Document Type: Article

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