The Safety and Efficacy of Lysine Analogues in Cancer Patients: A Systematic Review and Meta-Analysis

Transfusion Medicine Reviews

Volumn 31, Issue 3, 2017, Pages 141-148

  Montroy, Joshua ^a,b   Fergusson, Nicholas A ^a,b   Hutton, Brian ^a   Lavallée, Luke T ^a,c   Morash, Chris ^c   Cagiannos, Ilias ^c   Cnossen, Sonya ^a   Fergusson, Dean A ^a   Breau, Rodney H ^a,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Blood transfusion; Cancer; Lysine analogue; Surgery; Venous thromboembolism

Indexed keywords

AMINOCAPROIC ACID; LYSINE DERIVATIVE; PLACEBO; TRANEXAMIC ACID; LYSINE;

ADULT; BLOOD TRANSFUSION; CANCER PATIENT; DRUG EFFICACY; DRUG SAFETY; HUMAN; INFECTION RISK; META ANALYSIS; MORTALITY RISK; OPERATIVE BLOOD LOSS; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK REDUCTION; SIDE EFFECT; SYSTEMATIC REVIEW; VENOUS THROMBOEMBOLISM; ANALOGS AND DERIVATIVES; COMPLICATION; ERYTHROCYTE TRANSFUSION; NEOPLASM; PATIENT SAFETY; THROMBOCYTE TRANSFUSION; TREATMENT OUTCOME; VEIN THROMBOSIS;

ADULT; AMINOCAPROIC ACID; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; ERYTHROCYTE TRANSFUSION; HUMANS; LYSINE; NEOPLASMS; PATIENT SAFETY; PLATELET TRANSFUSION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TRANEXAMIC ACID; TREATMENT OUTCOME; VENOUS THROMBOSIS;

EID: 85016637934     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2017.03.002     Document Type: Review

References (53)

1. Alter, H.J., Klein, H.G., The hazards of blood transfusion in historical perspective. Blood 112:7 (2008), 2617–2626.
2. Mannucci, P.M., Levi, M., Prevention and treatment of major blood loss. N Engl J Med 356:22 (2007), 2301–2311.
3. Wright, J.D., Ananth, C.V., Lewin, S.N., Burke, W.M., Siddiq, Z., Neugut, A.I., et al. Patterns of use of hemostatic agents in patients undergoing major surgery. J Surg Res 186:1 (2014), 458–466.
4. CRASH-2 trial collaborators, Shakur, H., Roberts, I., Bautista, R., Caballero, J., Coats, T., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376:9734 (2010), 23–32.
5. Breau, R.H., Kokolo, M.B., Punjani, N., Cagioannos, I., Beck, A., Niznick, N., et al. The effects of lysine analogues during pelvic surgery: a systematic review and meta-analysis. Transfus Med Rev 28:3 (2014), 145–155.
6. Bennett, C., Klingenberg, S.L., Langholz, E., Gluud, L.L., Tranexamic acid for upper gastrointestinal bleeding. Cochrane Database Syst Rev, 11, 2014, CD006640.
7. Nilsson, I.M., Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol), 14, 1980, 41.
8. Henry, D.A., Carless, P.A., Moxey, A.J., O'Connell, D., Stokes, B.J., Fergusson, D.A., et al. Anti-fibrinolytic use for minimising perioperative allogenic blood transfusion. Cochrane Database Syst Rev, 16(3), 2011, CD001886.
9. Hutton, B., Joseph, L., Fergusson, D., Mazer, C.D., Shapiro, S., Tinmouth, A., Risks of harms using antifibrinolytics in cardiac surgery: systematic review and network meta-analysis of randomised and observational studies. BMJ, 345, 2012, e5798.
10. Li, Z.J., Fu, X., Xing, D., Zhang, H.F., Zang, J.C., Ma, X.L., Is tranexamic acid effective and safe in spinal surgery? A meta-analysis of randomized controlled trials. Eur Spine J 22:9 (2013), 1950–1957.
11. Kagoma, Y.K., Crowther, M.A., Douketis, J., Bhandari, M., Eikelboom, J., Lim, W., Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res 123:5 (2009), 68–696.
12. WHO, 19th WHO model list of essential medicines (April 2015). 2015 [Retrieved March 4, 2016].
13. Thiagarajamurthy, S., Levine, A., Dunning, J., Does prophylactic tranexamic acid safely reduce bleeding without increasing thrombotic complications in patients undergoing cardiac surgery?. Interact Cardiovasc Thorac Surg, 2(7975), 2004, 49.
14. Woo, K.S., Tse, L.K., Woo, J.L., Vallance-Owen, J., Massive pulmonary thromboembolism after tranexamic acid antifibrinolytic therapy. Br J Clin Pract 43:12 (1989), 456–466.
15. Mandal, A.K.J., Missouris, C.G., Tranexamic acid and acute myocardial infarction. Br J Cardiol 12:4 (2005), 306–307.
16. Ross, J., Al-Shahi Salman, R., The frequency of thrombotic events among adults given antifibrinolytic drugs for spontaneous bleeding: systematic review and meta-analysis of observational studies and randomized trials. Curr Drug Saf 7:1 (2012), 44–54.
17. Pereira, J., Phan, T., Management of bleeding in patients with advanced cancer. Oncologist 9:5 (2004), 561–570.
18. Baron, J.A., Gridley, G., Weiderpass, E., Nyrén, O., Linet, M., Venous thromboembolism and cancer. Lancet 351:9109 (1998), 1077–1080.
19. Silverstein, R.L., Nachman, R.L., Cancer and cloting—Trousseau's warning. N Engl J Med 327:16 (1992), 1163–1164.
20. Gore, J.M., Applebaum, J.S., Greene, H.L., Dexter, L., Dalen, J.E., Occult cancer in patients with acute pulmonary embolism. Ann Intern Med 95 (1982), 556–560.
21. Lee, A.Y., Levine, M.N., Venous thromboembolism and cancer: risks and outcomes. Circulation 208 (2003), 117–121.
22. Molenaar, I.Q., Warnaar, N., Groen, H., Tenvergert, E.M., Sloof, M.J., Porte, R.J., Efficacy and safety of antifibrinolytic drugs in liver transplantation: a systematic review and meta-analysis. Am J Transplant 7:1 (2007), 185–194.
23. Basta, M.N., Stricker, P.A., Taylor, J.A., A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. Pediatr Surg Int 28:11 (2012), 1059–1069.
24. Olsen, J.J., Skov, J., Ingerslev, J., Thorn, J.J., Pinholt, E.M., Prevention of bleeding in orthognathic surgery-a systematic review and meta-analysis of randomized controlled trials. J Oral Maxillofac Surg 74:1 (2016), 139–150.
25. Zehtabchi, S., Abdel Baki, S.G., Falzon, L., Nishijima, D.K., Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis. Am J Emerg Med 32:12 (2014), 1503–1509.
26. Estcourt, L.J., Desborough, M., Brunskill, S.J., Doree, C., Hopewell, S., Murphy, M.F., et al. Antifibrinolytics (lysine analogues) for the prevention of bleeding in people with haematological disorders. Cochrane Database Syst Rev, 3, 2016, CD009733.
27. Kietpeerakool, C., Supoken, A., Laopaiboon, M., Lumbiganon, P., Effectiveness of tranexamic acid in reducing blood loss during cytoreductive surgery for advanced ovarian cancer. Cochrane Database Syst Rev, 1, 2016, CD011732.
28. Martin-Hirsch, P.P.L., Bryant, A., Interventions for preventing blood loss during the treatment of cervical intraepithelial neoplasia. Cochrane Database Syst Rev, 12, 2013, CD001421.
29. Seto, A.H., Dunlap, D.S., Tranexamic acid in oncology. Ann Pharmacother 30:7–8 (1996), 868–870.
30. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 151:4 (2009), 264–269.
31. Higgins, J., Altman, D.G., Chapter 8: assessing risk of bias in included studies. http://handbook.cochrane.org/chapter_8/8_assessing_risk_of_bias_in_included_studies.html accessed 15.10.16.
32. Higgins, J.P., Thompson, S.G., Quantifying heterogeneity in a meta-analysis. Stat Med 21 (2002), 1539–1558.
33. Schünemann HJ, Oxman AD, Vist GE, Higgins JPT, Deeks JJ, Glasziou P, et al. Chapter 12: Interpreting results and drawing conclusions. In: Higgins JPT, Green S (editors). Cochrane handbook for systematic reviews of interventions version 5.1.0, 2011.
34. Avvisati, G., ten Cate, J.W., Buller, H.R., Mandelli, F., Tranexamic acid for control of haemorrhage in acute promyelocytic leukaemia. Lancet 2:9655 (1989), 122–124.
35. Shpilberg, O., Blumenthal, R., Sofer, O., Katz, Y., Chetrit, A., Ramot, B., et al. A controlled trial of tranexamic acid therapy for the reduction of bleeding during treatment of acute myeloid leukemia. Leuk Lymphoma 19:1–2 (1995), 141–144.
36. Amar, D., Grant, F.M., Zhang, H., Boland, P.J., Leung, D.H., Healey, J.A., Antifibrinolytic therapy and perioperative blood loss in cancer patients undergoing major orthopedic surgery. Anesthesiology 98:2 (2003), 337–342.
37. Celebi, N., Celebioglu, B., Selcuk, M., Canbay, O., Karagoz, A.H., Aypar, U., The role of antifibrinolytic agents in gynecologic cancer surgery. Saudi Med J 27:5 (2006), 637–641.
38. Rybo, G., Westerberg, H., The effect of tranexamic acid (AMCA) on postoperative bleeding after conisation. Acta Obstet Gynecol Scand 51:4 (1972), 347–350.
39. Wu, C.C., Ho, W.M., Cheng, S.B., Yeh, D.C., Wen, M.C., Liu, T.J., et al. Perioperative parenteral tranexamic acid in live tumor resection: a prospective randomized trial toward a “blood transfusion”-free hepatectomy. Ann Surg 243:2 (2006), 173–180.
40. Crescenti, A., Borghi, G., Bignami, E., Bertarelli, G., Landoni, G., Casiraghi, G.M., et al. Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial. BMJ, 343, 2011, d5701.
41. Lundin, E.S., Johansson, T., Zachrisson, H., Leandersson, U., Bäckman, F., Falknäs, L., et al. Single-dose tranexamic acid in advanced ovarian cancer surgery reduces blood loss and transfusions: double-blind placebo-controlled randomized multicenter study. Acta Obstet Gynecol Scan 93:4 (2014), 335–344.
42. Vel, R., Udupi, B.P., Satya Prakash, M.V., Adinarayanan, S., Mishra, S., Babu, L., Effect of low dose tranexamic acid on intra-operative blood loss in neurosurgical patients. Saudi J Anaesth 9:1 (2015), 42–48.
43. Das, A., Chattopadhyay, S., Mandal, D., Chhaule, S., Mitra, T., Mukherjee, A., et al. Does the preoperative administration of tranexamic acid reduce perioperative blood loss and transfusion requirements after head neck cancer surgery? A randomized, controlled trial. Anesth Essays Res 9:3 (2015), 384–390.
44. Kulkarni, A.P., Chaukar, D.A., Patil, V.P., Metgudmath, R.B., Hawaldar, R.W., Divatia, J.V., Does tranexamic acid reduce blood loss during head and neck cancer surgery?. Indian J Anaesth 60:1 (2016), 19–24.
45. Simonazzi, G., Bisulli, M., Saccone, G., Moro, E., Marshall, A., Berghella, V., Tranexamic acid for preventing postpartum blood loss after caesarean delivery: a systematic review and meta-analysis of randomized controlled trials. Acta Obstet Gynecol Scand 95:1 (2016), 28–37.
46. Wang, M., Zheng, X.F., Jiang, L.S., Efficacy and safety of antifibrinolytic agents in reducing perioperative blood loss and transfusion requirements in scoliosis surgery: a systematic review and meta-analysis. PLoS One, 10(9), 2015, e0137886.
47. Ker, K., Edwards, P., Perel, P., Shakur, H., Roberts, I., Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ, 344, 2012, e3054.
48. Keus, F., Wetterlev, J., Gluud, C., Gooszen, H.G., van Laarhoven, C.J., Robustness assessments are needed to reduce bias in meta-analyses that include zero-event randomized trials. Am J Gastroenterol 104:3 (2009), 546–551.
49. Bradburn, M.J., Deeks, J.J., Berlin, J.A., Russell, Localio A., Much ado about nothing: a comparison of the performance of meta-analytical methods with rare events. Stat Med 26:1 (2007), 53–77.
50. Sweeting, M.J., Sutton, A.J., Lambert, P.C., What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med 23:9 (2004), 1351–1375.
51. Dwan, K., Altman, D.G., Clarke, M., Gamble, C., Higgins, J.P., Sterne, J.A., et al. Evidence for the selective reporting of analyses and discrepancies in clinical trials: a systematic review of cohort studies of clinical trials. PLoS Med, 11(6), 2014, e1001666.
52. Williamson, P.R., Gamble, C., Altman, D.G., Hutton, J.L., Outcome selection bias in meta-analysis. Stat Methods Med Res 14:5 (2005), 515–524.
53. Meghelli, L., Narducci, F., Mariette, C., Piessen, G., Vanseymortier, M., Leblanc, E., et al. Reporting adverse events in cancer surgery randomized trials: a systematic review of published trials in oesophago-gastric and gynecological cancer patients. Crit Rev Hematol 104 (2016), 108–114.