The effects of lysine analogs during pelvic surgery: A systematic review and meta-analysis

Transfusion Medicine Reviews

Volumn 28, Issue 3, 2014, Pages 145-155

  Breau, Rodney H ^a,b,c   Kokolo, Madzouka B ^a   Punjani, Nahid ^c   Cagiannos, Ilias ^b,c   Beck, Andrew ^a   Niznick, Naomi ^a   Buenaventura, Chieny ^a   Cowan, Juthaporn ^b   Knoll, Gregory ^a,b,c   Momoli, Franco ^a,c   Morash, Chris ^b,c   Ruzicka, Marcel ^b   Schachkina, Svetlana ^b   Tinmouth, Alan ^b   Xie, Hai Yan ^b   Fergusson, Dean A ^a,c  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

Author keywords

Aminocaproic acid; Pelvis; Surgery; Tranexamic acid

Indexed keywords

4 AMINOMETHYLBENZOIC ACID; AMINOCAPROIC ACID; LYSINE DERIVATIVE; PLACEBO; LYSINE; TRANEXAMIC ACID;

ABDOMINAL HYSTERECTOMY; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; CESAREAN SECTION; DEATH; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; ERYTHROCYTE TRANSFUSION; GYNECOLOGIC SURGERY; HEART INFARCTION; HUMAN; HYSTEROSCOPIC RESECTOSCOPY; LUNG EMBOLISM; META ANALYSIS; MYOMECTOMY; OPERATIVE BLOOD LOSS; PELVIS SURGERY; PROSTATECTOMY; RESPIRATORY DISTRESS; SYSTEMATIC REVIEW; THROMBOEMBOLISM; TRANSURETHRAL RESECTION; URETER REIMPLANTATION; UTERINE CERVIX CONIZATION; ANALOGS AND DERIVATIVES; BLOOD LOSS, SURGICAL; CHEMISTRY; HEMORRHAGE; MALE GENITAL SYSTEM SURGERY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK; SURGERY; THROMBOSIS; TREATMENT OUTCOME;

AMINOCAPROIC ACID; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; GYNECOLOGIC SURGICAL PROCEDURES; HEMORRHAGE; HUMANS; LYSINE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK; SURGICAL PROCEDURES, OPERATIVE; THROMBOSIS; TRANEXAMIC ACID; TREATMENT OUTCOME; UROLOGIC SURGICAL PROCEDURES, MALE;

EID: 84903482385     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2014.05.002     Document Type: Article

References (72)

1. Tomacruz R.S., Bristow R.E., Montz F.J. Management of pelvic hemorrhage. Surg Clin North Am 2001, 81:925-948.
2. Lee K., Freiha F., Presti J., Gill H. Gender differences in radical cystectomy: complications and blood loss. J Urol 2004, 63:1095-1099.
3. Chang S.S., Smith J.A., Wells N., Peterson M., Kovach B., Cookson M.S. Estimated blood loss and transfusion requirements of radical cystectomy. J Urol 2001, 166:2151-2154.
4. Lepor H., Nieder A.M., Ferrandino M.N. Intraoperative and postoperative complications of radical retropubic prostatectomy in a consecutive series of 1,000 cases. J Urol 2001, 166:1729-1733.
5. Augustin H., Hammerer P., Graefen M., et al. Intraoperative and perioperative morbidity of contemporary radical retropubic prostatectomy in a consecutive series of 1243 patients: results of a single center between 1999 and 2002. Eur Urol 2003, 43:113-118.
6. Nilsson I.M. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol) 1980, 14:41-47.
7. Henry D.A., Carless P.A., Moxey A.J., et al. Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. Cochrane Database Syst Rev 2011, 3:1-426.
8. Shakur H., Roberts I., et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010, 376:23-32. CRASH-2 trial collaborators.
9. Tyson M.D., Castle E.P., Humphreys M.R., Andrews P.E. Venous thromboembolism after urologic surgery. J Urol 2014, [Epub ahead of print, PubMed PMID: 24594402, pii: S0022-5347(14)00350-4].
10. Punjani N., Lavallée L.T., Momoli F., et al. Blood transfusion and hemostatic agents used during radical cystectomy. Can Urol Assoc J 2013, 7:E275-E280.
11. Dickersin K., Scherer R., Lefebvre C. Systematic reviews: identifying relevant studies for systematic reviews. Br Med J 1994, 309:1286-1291.
12. SIGN: Scottish Intercollegiate Guidelines Network [Accessed August 30, 2011]. http://www.sign.ac.uk/methodology/filters.html.
13. Jadad A.R., Moore R.A., Carroll D., et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary?. Control Clin Trials 1996, 17:1-12.
14. Fetter T.R., Tocantins L., Cottone R., Brosseau C., Bowman W. Effect of epsilon aminocaproic acid on bleeding after prostatectomy. J Urol 1961, 85:970-972.
15. Sack E., Spaet T.H., Gentile R.L., Hudson P.B. Reduction of postprostatectomy bleeding by episilon-aminocaproic acid. N Engl J Med 1962, 266:541-543.
16. Aboulker P., Lassner J., Samama M., Casubolo Action of epsilon-amino caproic acid on bleeding in urinary surgery. Anesth Analg (Paris) 1963, 581-595. French.
17. Ladehoff A., Otte E. Inhibitory effect of epsilon aminocaproic acid on fibrinolytic activity and bleeding in transvesical prostatectomy. Scand J Clin Lab Invest 1963, 15:239-247.
18. Rouffilange F., Picard P., Radiguet dlB Apropos of the use of epsilon-aminocaproic acid in urology. Hemostase 1965, 5:405-409. French.
19. Albert L. On the hemostatic effect of the epsilon-amino-capronic acid after suprapubic transvesical prostatectomy. Z Urol Nephrol 1966, 59:425-428. German.
20. Madsen P.O., Strauch A. The effect of aminocaproic acid on bleeding following transurethral prostatectomy. J Urol 1966, 96:255-256.
21. Oswald K., Morl F.K., Matis P. Postoperative hemostasis by epsilon aminocaproic acid with precautionary inhibition of blood coagulation. Med Welt 1966, 15:816-817. German.
22. Schmutzler R., Furstenberg H. The effect of epsilon-aminocaproic acid and trasylol on fibrinolysis and blood loss after operations on the prostate. Ger Med Mon 1966, 11:391-396.
23. Schmutzler R., Furstenberg H. Epsilon-aminocaproic acid and trasylol as hemostyptic agents in prostatic surgery. Helv Chir Acta 1966, 33:478-483. German.
24. Vinnicombe J., Shuttleworth K.E. Aminocaproic acid in the control of haemorrhage after prostatectomy. A controlled trial. Lancet 1966, 1:230-232.
25. Vinnicombe J., Shuttleworth K.E. Aminocaproic acid in the control of haemorrhage after prostatectomy. Safety of aminocaproic acid-a controlled trial. Lancet 1966, 1:232-234.
26. Kirkman N.F. Post-prostatectomy haematuria. Treatment with epsilon-amino-caproic acid. Br J Surg 1967, 54:1026-1029.
27. Ludvik W., Pecherstorfer M. Modification of hemorrhage after suprapubic prostatectomy with epsilon-aminocaproic acid. Wien Klin Wochenschr 1967, 79:384-389. German.
28. Neef H., Preusser K.P. The epsilonaminocaproic acid prophylaxis in prostatectomy. Chirurg 1967, 38:69-72. German.
29. Kullander M. L'utilisation de l'acide epsilon amino capoique comme hemostatique dans les conisations du col uterin. Grenoble Med Chir 1968, 6:505-508.
30. Utikalova A., Prochazka J., Podivinsky R. Effect of epsilon-aminocaproic acid of hemorrhage following enucleatin of prostatic adenoma. Rozhl Chir 1968, 47:694-701. Czech.
31. Anger G., Preusser K.P., Neef H. Antifibrinolytic prophylaxis and postoperative after care in prostatectomy. Z Urol Nephrol 1969, 62:345-349. German.
32. Hedlund P.O. Antifibrinolytic therapy with Cyklokapron in connection with prostatectomy. A double blind study. Scand J Urol Nephrol 1969, 3:177-182.
33. Kaufmann J., Siefker K. Reduction of post-prostatectomy bleeding by medication (experience with the antifibrinolytic agent AMCA). Urologe 1969, 8:57-59. German.
34. Warren J.W., Stanley K.E. New anti-hemorrhagic agent, epsilon aminocaproic acid for control of hemorrhage after transurethral prostatic resection: a control study. J Kans Med Soc 1969, 70:173-176.
35. Borgstrom S., Becker J., Saltzman G.F. Combined treatment with aminocaproic acid and subcutaneous heparin in the prevention of thrombosis following prostatectomy. Zentralbl Phlebol 1970, 9:105-111.
36. Lee P., Pompeius R. Antifibrinolytic treatment and forced osmotic diuresis after transurethral prostatectomy. Nord Med 1970, 84:1624-1626. Swedish.
37. Rö J.S., Knutrud O., Stormorken H. Antifibrinolytic treatment with tranexamic acid (AMCA) in pediatric urinary tract surgery. J Pediatr Surg 1970, 5:315-320.
38. Gordon-Smith I.C., Hickman J.A., el Masri S.H. The effect of the fibrinolytic inhibitor epsilon-aminocaproic acid on the incidence of deep-vein thrombosis after prostatectomy. Br J Surg 1972, 59:522-524.
39. Rybo G., Westerberg K. The effect of tranexamic acid (AMCA) on postoperative bleeding after conization. Acta Obstet Gynecol Scand 1972, 51:347-350.
40. Raymond G., Fournier P., Cazenave G. Action of tranexamic acid on pre and post-operative bleeding after prostatic adenomectomy (double blind study). J Urol Nephrol (Paris) 1973, 79:958-962. French.
41. Smart C.J., Turnbull A.R., Jenkins J.D. The use of frusemide and epsilon-amino-caproic-acid in transurethral prostatectomy. Br J Urol 1974, 46:521-525.
42. Landin L., Weiner E. Late bleeding after conization. The effect of tranexamic acid (Cyklokapron). Opusc Med 1975, 20:280-284.
43. Hayashi I., Yoshida K., Motomiya Y. Clinical effect of tranexamic acid to control hemorrhage during and following prostatectomy in prostatic hypertrophy: a study with a double blind method (Japanese). Acta Urol Jpn 1976, 22:793-807. Japanese.
44. Sinclair J., Forbes C.D., Prentice C.R., Scott R. The incidence of deep vein thrombosis in prostatectomised patients following the administration of the fibrinolytic inhibitor, aminocaproic acid (EACA). Urol Res 1976, 4:129-131.
45. Vecsey D., Bankuti P., Palfy A. Prevention of bleeding following prostatectomy by the use of AMCA. Med Welt 1977, 28:1100-1102. German.
46. Gamba G., Fornasari P.M., Grignani G., Dolci D., Colloi D. Haemostasis during transvesical prostatic adenomectomy. A controlled trial on the effect of drugs with antifibrinolytic and thrombin-like activities. Blut 1979, 39:89-98.
47. Miller R.A., May M.W., Hendry W.F., Whitfield H.N., Wickham J.E. The prevention of secondary haemorrhage after prostatectomy: the value of antifibrinolytic therapy. Br J Urol 1980, 52:26-28.
48. Grundsell H., Larsson G., Bekassy Z. Use of an antifibrinolytic agent (tranexamic acid) and lateral sutures with laser conization of the cervix. Obstet Gynecol 1984, 64:573-576.
49. Lundvall F., Nielsen N.C. The hemostatic effect of tranexamic acid in conisatio colli uteri. Acta Obstet Gynecol Scand 1984, 63:81-84.
50. Smith R.B., Riach P., Kaufman J.J. Epsilon aminocaproic acid and the control of post-prostatectomy bleeding: a prospective double-blind study. J Urol 1984, 131:1093-1095.
51. Flanigan R.C., Butler K.M., O'Neal W., et al. Comparison of epsilon aminocaproic acid and normal saline for postoperative bladder irrigation following transurethral resection of prostate. Urology 1985, 26:227-228.
52. Sharifi R., Lee M., Ray P., Millner S.N., Dupont P.F. Safety and efficacy of intravesical aminocaproic acid for bleeding after transurethral resection of prostate. Urology 1986, 27:214-219.
53. Gai M., Wu L., Su Q., Tatsumoto K. Clinical observation of blood loss reduced by tranexamic acid during and after caesarian section: a multi-center, randomized trial. Eur J Obstet Gynecol Reprod Biol 2004, 112:154-157.
54. Rannikko A., Petas A., Taari K. Tranexamic acid in control of primary hemorrhage during transurethral prostatectomy. Urology 2004, 64:955-958.
55. Celebi N., Celebioglu B., Selcuk M., Canbay O., Karagoz A.H., Aypar U. The role of antifibrinolytic agents in gynecologic cancer surgery. Saudi Med J 2006, 27:637-641.
56. Gohel M., Patel P., Gupta A., Desai P. Efficacy of tranexamic acid in decreasing blood loss during and after cesarean section: a randomized case controlled prospective study. J Obstet Gynecol India 2007, 57:227-230.
57. Caglar G.S., Tasci Y., Kayikcioglu F., Haberal A. Intravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study. Eur J Obstet Gynecol Reprod Biol 2008, 137:227-231.
58. Sekhavat L., Tabatabaii A., Dalili M., Farajkhoda T., Tafti A.D. Efficacy of tranexamic acid in reducing blood loss after cesarean section. J Matern Fetal Neonatal Med 2009, 22:72-75.
59. Crescenti A., Borghi G., Bignami E., et al. Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial. Br Med J 2011, 343:1-12.
60. Gungorduk K., Yildirim G., Asicioglu O., Gungorduk O., Sudolmus S., Ark C. Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study. Am J Perinatol 2011, 28:233-240.
61. Movafegh A., Eslamian L., Dorabadi A. Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery. Int J Gynaecol Obstet 2011, 115:224-226.
62. Ergun B., Bastu E., Ozsurmeli M., Celik C. Tranexamic acid: a potential adjunct to resectoscopic endometrial ablation. Int Surg 2012, 97:310-314.
63. Gupta K., Rastogi B., Krishan A., Gupta A., Singh V., Agarwal S. The prophylactic role of tranexamic acid to reduce blood loss during radical surgery: a prospective study. Anesth Essays Res 2012, 6:70-73.
64. Rashmi P., Sudha T., Prema P., Rajashri P., Vijayanath V. Role of tranexamic acid in reducing blood loss during and after cesarean section: a randomized case control prospective study. J Med Res Pract 2012, 1:40-43.
65. Abdel-Aleem H., Alhusani T., Abdel-Aleem M., Menoufy M., Gulmezoglu A. Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial. J Matern Fetal Neonatal Med 2013, 26:1705-1709.
66. Manizheh S., Elaheh O., Simin T., et al. The effect of intrauterine instillation of E-Aminocaproic Acid during hysteroscopic operations in the management of intractable uterine hemorrhage: a randomized clinical trial. Life Sci J 2013, 10:1369-1374.
67. Senturk M.B., Cakmak Y., Yildiz G., Yildiz P. Tranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial. Arch Gynecol Obstet 2013, 287:641-645.
68. Xu J., Gao W., Ju Y. Tranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial. Arch Gynecol Obstet 2013, 287:463-468.
69. Shahid A., Khan A. Tranexamic acid in decreasing blood loss during and after caesarean section. J Coll Physicians Surg Pak 2013, 23:459-462.
70. Schulz K.F., Altman D.G., Moher D. CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials. Br Med J 2010, 340:28-55. for the CONSORT Group.
71. von Elm E., Altman D.G., Egger M., et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol 2008, 61:344-349.
72. Ker K., Edwards P., Perel P., Shakur H., Roberts I. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. Br Med J 2012, 344:1-13.