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Volumn 19, Issue 4, 2017, Pages

Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure

Author keywords

Blood pressure; Diet; Gut microbiome; Hypertension; Nitrate; Nitric oxide; Nitrite

Indexed keywords

ANTIINFECTIVE AGENT; MOUTHWASH; NITRATE; NITRIC OXIDE; NITRITE; NITRIC ACID DERIVATIVE;

EID: 85016445394     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-017-0725-2     Document Type: Review
Times cited : (98)

References (79)
  • 1
    • 12344282783 scopus 로고    scopus 로고
    • Global burden of hypertension: analysis of worldwide data
    • PID: 15652604
    • Kearney PM, et al. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217–23.
    • (2005) Lancet , vol.365 , Issue.9455 , pp. 217-223
    • Kearney, P.M.1
  • 2
    • 84893651437 scopus 로고    scopus 로고
    • Heart disease and stroke statistics—2014 update: a report from the American Heart Association
    • PID: 24352519
    • Go AS, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28–e292.
    • (2014) Circulation , vol.129 , Issue.3 , pp. e28-e292
    • Go, A.S.1
  • 3
    • 0035000282 scopus 로고    scopus 로고
    • Anticonvulsant properties of the methanolic extract of Cyperus Articulatus (Cyperaceae)
    • COI: 1:STN:280:DC%2BD3MzitVSgsg%3D%3D, PID: 11390127
    • Bum EN, et al. Anticonvulsant properties of the methanolic extract of Cyperus Articulatus (Cyperaceae). J Ethnopharmacol. 2001;76(2):145–50.
    • (2001) J Ethnopharmacol , vol.76 , Issue.2 , pp. 145-150
    • Bum, E.N.1
  • 4
    • 0033304161 scopus 로고    scopus 로고
    • Cardiovascular risks related to increased diastolic, systolic and pulse pressure. An epidemiologist’s point of view
    • COI: 1:STN:280:DyaK1MvgtFaqsg%3D%3D
    • Franklin SS. Cardiovascular risks related to increased diastolic, systolic and pulse pressure. An epidemiologist’s point of view. Pathol Biol (Paris). 1999;47(6):594–603.
    • (1999) Pathol Biol (Paris) , vol.47 , Issue.6 , pp. 594-603
    • Franklin, S.S.1
  • 5
    • 0035105181 scopus 로고    scopus 로고
    • Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III
    • COI: 1:CAS:528:DC%2BD3MXitFegtLY%3D, PID: 11244010
    • Franklin SS, et al. Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension. 2001;37(3):869–74.
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 869-874
    • Franklin, S.S.1
  • 6
    • 0347423198 scopus 로고    scopus 로고
    • Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    • COI: 1:CAS:528:DC%2BD3sXpsVGisL4%3D, PID: 14656957
    • Chobanian AV, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6):1206–52.
    • (2003) Hypertension , vol.42 , Issue.6 , pp. 1206-1252
    • Chobanian, A.V.1
  • 7
    • 17644378057 scopus 로고    scopus 로고
    • Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease
    • PID: 15851645
    • Hsu CY, et al. Elevated blood pressure and risk of end-stage renal disease in subjects without baseline kidney disease. Arch Intern Med. 2005;165(8):923–8.
    • (2005) Arch Intern Med , vol.165 , Issue.8 , pp. 923-928
    • Hsu, C.Y.1
  • 8
    • 0030002580 scopus 로고    scopus 로고
    • The progression from hypertension to congestive heart failure
    • COI: 1:STN:280:DyaK283htlyquw%3D%3D, PID: 8622246
    • Levy D, et al. The progression from hypertension to congestive heart failure. JAMA. 1996;275(20):1557–62.
    • (1996) JAMA , vol.275 , Issue.20 , pp. 1557-1562
    • Levy, D.1
  • 9
    • 0035522330 scopus 로고    scopus 로고
    • Impact of high-normal blood pressure on the risk of cardiovascular disease
    • COI: 1:STN:280:DC%2BD38%2FmsFCrtg%3D%3D, PID: 11794147
    • Vasan RS, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001;345(18):1291–7.
    • (2001) N Engl J Med , vol.345 , Issue.18 , pp. 1291-1297
    • Vasan, R.S.1
  • 11
    • 84948439672 scopus 로고    scopus 로고
    • A randomized trial of intensive versus standard blood-pressure control
    • COI: 1:CAS:528:DC%2BC28XntVSku78%3D, PID: 26551272
    • Wright Jr JT, et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103–16.
    • (2015) N Engl J Med , vol.373 , Issue.22 , pp. 2103-2116
    • Wright, J.T.1
  • 12
    • 33846485050 scopus 로고    scopus 로고
    • Outpatient hypertension treatment, treatment intensification, and control in Western Europe and the United States
    • PID: 17242314
    • Wang YR, Alexander GC, Stafford RS. Outpatient hypertension treatment, treatment intensification, and control in Western Europe and the United States. Arch Intern Med. 2007;167(2):141–7.
    • (2007) Arch Intern Med , vol.167 , Issue.2 , pp. 141-147
    • Wang, Y.R.1    Alexander, G.C.2    Stafford, R.S.3
  • 13
    • 55949126144 scopus 로고    scopus 로고
    • Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988–1994 and 1999–2004
    • COI: 1:CAS:528:DC%2BD1cXht1GgtbjJ, PID: 18852389
    • Cutler JA, et al. Trends in hypertension prevalence, awareness, treatment, and control rates in United States adults between 1988–1994 and 1999–2004. Hypertension. 2008;52(5):818–27.
    • (2008) Hypertension , vol.52 , Issue.5 , pp. 818-827
    • Cutler, J.A.1
  • 14
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine
    • The original discovery of an endothelium derived relaxing factor that led to Nobel Prize
    • •• Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature. 1980;288(5789):373–6. The original discovery of an endothelium derived relaxing factor that led to Nobel Prize
    • (1980) Nature , vol.288 , Issue.5789 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 15
    • 0023505509 scopus 로고
    • Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
    • The identification of EDRF as nitric oxide which led to Nobel Prize for Dr. Ignarro
    • • Ignarro LJ, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987;84:9265–9. The identification of EDRF as nitric oxide which led to Nobel Prize for Dr. Ignarro
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 9265-9269
    • Ignarro, L.J.1
  • 16
    • 0023198721 scopus 로고
    • Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
    • First demonstration that EDRF is nitric oxide
    • • Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327(6122):524–6. First demonstration that EDRF is nitric oxide
    • (1987) Nature , vol.327 , Issue.6122 , pp. 524-526
    • Palmer, R.M.J.1    Ferrige, A.G.2    Moncada, S.3
  • 17
    • 34547144278 scopus 로고    scopus 로고
    • Blood pressure control and cardiovascular risk reduction
    • COI: 1:STN:280:DC%2BD1MvmvFShsw%3D%3D, PID: 19582204
    • Antonakoudis G, et al. Blood pressure control and cardiovascular risk reduction. Hippokratia. 2007;11(3):114–9.
    • (2007) Hippokratia , vol.11 , Issue.3 , pp. 114-119
    • Antonakoudis, G.1
  • 18
    • 0030330268 scopus 로고    scopus 로고
    • Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease
    • COI: 1:STN:280:DyaK2s7hvF2jtw%3D%3D, PID: 8960576
    • Lieberman EH, et al. Flow-induced vasodilation of the human brachial artery is impaired in patients <40 years of age with coronary artery disease. Am J Cardiol. 1996;78(11):1210–4.
    • (1996) Am J Cardiol , vol.78 , Issue.11 , pp. 1210-1214
    • Lieberman, E.H.1
  • 19
    • 0023028215 scopus 로고
    • Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
    • COI: 1:STN:280:DyaL2s%2FhsVKitw%3D%3D, PID: 3093861
    • Ludmer PL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med. 1986;315(17):1046–51.
    • (1986) N Engl J Med , vol.315 , Issue.17 , pp. 1046-1051
    • Ludmer, P.L.1
  • 20
    • 69949111623 scopus 로고    scopus 로고
    • Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases
    • COI: 1:CAS:528:DC%2BD1MXhtVOnt7nL, PID: 19727602
    • Napoli C, Ignarro LJ. Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Arch Pharm Res. 2009;32(8):1103–8.
    • (2009) Arch Pharm Res , vol.32 , Issue.8 , pp. 1103-1108
    • Napoli, C.1    Ignarro, L.J.2
  • 21
    • 0025307354 scopus 로고
    • Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans
    • COI: 1:CAS:528:DyaK3cXkvFGlu7k%3D, PID: 2195060
    • Creager MA, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990;86(1):228–34.
    • (1990) J Clin Invest , vol.86 , Issue.1 , pp. 228-234
    • Creager, M.A.1
  • 22
    • 0027367617 scopus 로고
    • Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults
    • COI: 1:STN:280:DyaK2c%2Fjslemtg%3D%3D, PID: 8222109
    • Celermajer DS, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88(5 Pt 1):2149–55.
    • (1993) Circulation , vol.88 , Issue.5 , pp. 2149-2155
    • Celermajer, D.S.1
  • 23
    • 77955282773 scopus 로고    scopus 로고
    • Nitric oxide and oxidative stress in vascular disease
    • PID: 20306272
    • Forstermann U. Nitric oxide and oxidative stress in vascular disease. Pflugers Arch. 2010;459(6):923–39.
    • (2010) Pflugers Arch , vol.459 , Issue.6 , pp. 923-939
    • Forstermann, U.1
  • 24
    • 84873846821 scopus 로고    scopus 로고
    • Linking the gut microbiota to human health
    • COI: 1:CAS:528:DC%2BC3sXhsFCgs7g%3D, PID: 23360877
    • Robles Alonso V, Guarner F. Linking the gut microbiota to human health. Br J Nutr. 2013;109(Suppl 2):S21–6.
    • (2013) Br J Nutr , vol.109 , pp. S21-S26
    • Robles Alonso, V.1    Guarner, F.2
  • 25
    • 38849162730 scopus 로고    scopus 로고
    • The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    • COI: 1:CAS:528:DC%2BD1cXhs1Khsrw%3D, PID: 18167491
    • Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov. 2008;7(8):156–67.
    • (2008) Nat Rev Drug Discov , vol.7 , Issue.8 , pp. 156-167
    • Lundberg, J.O.1    Weitzberg, E.2    Gladwin, M.T.3
  • 26
    • 3142748526 scopus 로고    scopus 로고
    • Nitrate, bacteria and human health
    • COI: 1:CAS:528:DC%2BD2cXkvVSqsrw%3D, PID: 15197394
    • Lundberg JO, et al. Nitrate, bacteria and human health. Nat Rev Microbiol. 2004a;2(7):593–602.
    • (2004) Nat Rev Microbiol , vol.2 , Issue.7 , pp. 593-602
    • Lundberg, J.O.1
  • 27
    • 84859918752 scopus 로고    scopus 로고
    • Survey of residual nitrite and nitrate in conventional and organic/natural/uncured/indirectly cured meats available at retail in the United States
    • Nunez De Gonzalez, M.T., et al., Survey of residual nitrite and nitrate in conventional and organic/natural/uncured/indirectly cured meats available at retail in the United States. J Agric Food Chem, 2012. 60(15): p. 3981–3990.
    • (2012) J Agric Food Chem , vol.60 , Issue.15 , pp. 3981-3990
    • Nunez De Gonzalez, M.T.1
  • 28
    • 84929128672 scopus 로고    scopus 로고
    • A survey of nitrate and nitrite concentrations in conventional and organic-labeled raw vegetables at retail
    • Nunez De Gonzalez, M.T., et al., A survey of nitrate and nitrite concentrations in conventional and organic-labeled raw vegetables at retail. J Food Sci, 2015. 80(5): p. C942–C949.
    • (2015) J Food Sci , vol.80 , Issue.5 , pp. C942-C949
    • Nunez De Gonzalez, M.T.1
  • 29
    • 0032899615 scopus 로고    scopus 로고
    • Nitric oxide metabolism and breakdown
    • COI: 1:CAS:528:DyaK1MXjsF2qtr0%3D, PID: 10320663
    • Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta. 1999;1411:273–89.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 273-289
    • Kelm, M.1
  • 30
    • 33644829863 scopus 로고    scopus 로고
    • Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    • Report showing evidence that nitrite acts as a signaling molecule independent of its reduction to nitric oxide
    • • Bryan NS, et al. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol. 2005;1(5):290–7. Report showing evidence that nitrite acts as a signaling molecule independent of its reduction to nitric oxide
    • (2005) Nat Chem Biol , vol.1 , Issue.5 , pp. 290-297
    • Bryan, N.S.1
  • 31
    • 0029114339 scopus 로고
    • Enzyme-independent formation of nitric oxide in biological tissues
    • COI: 1:CAS:528:DyaK2MXnt1ynu7g%3D, PID: 7585184
    • Zweier JL, et al. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med. 1995;1(8):804–9.
    • (1995) Nat Med , vol.1 , Issue.8 , pp. 804-809
    • Zweier, J.L.1
  • 32
    • 0028143644 scopus 로고
    • Intragastric nitric oxide production in humans: measurements in expelled air
    • COI: 1:STN:280:DyaK2M7ivF2mtA%3D%3D, PID: 7828969
    • Lundberg JO, et al. Intragastric nitric oxide production in humans: measurements in expelled air. Gut. 1994;35(11):1543–6.
    • (1994) Gut , vol.35 , Issue.11 , pp. 1543-1546
    • Lundberg, J.O.1
  • 33
    • 0028767323 scopus 로고
    • Stomach NO synthesis
    • COI: 1:STN:280:DyaK2c7oslyksA%3D%3D, PID: 8139683
    • Benjamin N, et al. Stomach NO synthesis. Nature. 1994;368(6471):502.
    • (1994) Nature , vol.368 , Issue.6471 , pp. 502
    • Benjamin, N.1
  • 34
    • 84938603438 scopus 로고    scopus 로고
    • Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients
    • Comprehensive human evidence presented for establishment of dietary guidelines for nitrite and nitrate
    • • Bryan NS, Ivy JL. Inorganic nitrite and nitrate: evidence to support consideration as dietary nutrients. Nutr Res. 2015;35(8):643–54. Comprehensive human evidence presented for establishment of dietary guidelines for nitrite and nitrate
    • (2015) Nutr Res , vol.35 , Issue.8 , pp. 643-654
    • Bryan, N.S.1    Ivy, J.L.2
  • 35
    • 80755151739 scopus 로고    scopus 로고
    • Nitrite and nitrate in human health and disease
    • Humana Press, First edited book on the therapeutic and safety profile of nitrite and nitrate
    • • Bryan NS, Loscalzo J. Nitrite and nitrate in human health and disease. In: Bendich A, editor. Nutrition and health. New York: Humana Press; 2011. First edited book on the therapeutic and safety profile of nitrite and nitrate
    • (2011) Nutrition and health. New York
    • Bryan, N.S.1    Loscalzo, J.2    Bendich, A.3
  • 36
    • 0029075644 scopus 로고
    • Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate
    • First demonstration that inorganic nitrate could be metabolized to nitrite and nitric oxide by oral nitrate reducing bacteria
    • •• Duncan C, et al. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1995a;1(6):546–51. First demonstration that inorganic nitrate could be metabolized to nitrite and nitric oxide by oral nitrate reducing bacteria
    • (1995) Nat Med , vol.1 , Issue.6 , pp. 546-551
    • Duncan, C.1
  • 37
    • 3042667643 scopus 로고    scopus 로고
    • Inorganic nitrate is a possible source for systemic generation of nitric oxide
    • COI: 1:CAS:528:DC%2BD2cXltF2rtrk%3D, PID: 15223073
    • Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004;37(3):395–400.
    • (2004) Free Radic Biol Med , vol.37 , Issue.3 , pp. 395-400
    • Lundberg, J.O.1    Govoni, M.2
  • 38
    • 0017046438 scopus 로고
    • Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds
    • COI: 1:CAS:528:DyaE2sXhtlygtbk%3D, PID: 1017769
    • Spiegelhalder B, Eisenbrand G, Preussmann R. Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet Toxicol. 1976;14(6):545–8.
    • (1976) Food Cosmet Toxicol , vol.14 , Issue.6 , pp. 545-548
    • Spiegelhalder, B.1    Eisenbrand, G.2    Preussmann, R.3
  • 39
    • 68349130367 scopus 로고    scopus 로고
    • Bioavailability of sodium nitrite from an aqueous solution in healthy adults
    • COI: 1:CAS:528:DC%2BD1MXhtVSgtbnE, PID: 19576277
    • Hunault CC, et al. Bioavailability of sodium nitrite from an aqueous solution in healthy adults. Toxicol Lett. 2009;190(1):48–53.
    • (2009) Toxicol Lett , vol.190 , Issue.1 , pp. 48-53
    • Hunault, C.C.1
  • 40
    • 0029075644 scopus 로고
    • Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate
    • COI: 1:CAS:528:DyaK2MXmtFegtb0%3D, PID: 7585121
    • Duncan C, et al. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate. Nat Med. 1995b;1(6):546–51.
    • (1995) Nat Med , vol.1 , Issue.6 , pp. 546-551
    • Duncan, C.1
  • 41
    • 3142748526 scopus 로고    scopus 로고
    • Nitrate, bacteria, and human health
    • COI: 1:CAS:528:DC%2BD2cXkvVSqsrw%3D, PID: 15197394
    • Lundberg J, et al. Nitrate, bacteria, and human health. Nat Rev Microbiol. 2004b;2:593–602.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 593-602
    • Lundberg, J.1
  • 42
    • 14644394290 scopus 로고    scopus 로고
    • Evaluation of bacterial nitrate reduction in the human oral cavity
    • COI: 1:CAS:528:DC%2BD2MXis1Kltrs%3D, PID: 15693824
    • Doel J, et al. Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci. 2005;113:14–9.
    • (2005) Eur J Oral Sci , vol.113 , pp. 14-19
    • Doel, J.1
  • 43
    • 84899897939 scopus 로고    scopus 로고
    • Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis
    • PID: 24670812
    • Hyde ER, et al. Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis. PLoS One. 2014;9(3):e88645.
    • (2014) PLoS One , vol.9 , Issue.3
    • Hyde, E.R.1
  • 44
    • 37649023552 scopus 로고    scopus 로고
    • Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
    • Study showing dietary nitrite and nitrate could protect the heart from injury from heart attack
    • • Bryan NS, et al. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A. 2007;104(48):19144–9. Study showing dietary nitrite and nitrate could protect the heart from injury from heart attack
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.48 , pp. 19144-19149
    • Bryan, N.S.1
  • 45
    • 46649108907 scopus 로고    scopus 로고
    • Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
    • COI: 1:CAS:528:DC%2BD1cXosFWntLs%3D, PID: 18501719
    • Bryan NS, et al. Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Free Radic Biol Med. 2008;45(4):468–74.
    • (2008) Free Radic Biol Med , vol.45 , Issue.4 , pp. 468-474
    • Bryan, N.S.1
  • 46
    • 39749182795 scopus 로고    scopus 로고
    • Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
    • COI: 1:CAS:528:DC%2BD1cXhvVemsLc%3D, PID: 18250365
    • Webb AJ, et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008;51(3):784–90.
    • (2008) Hypertension , vol.51 , Issue.3 , pp. 784-790
    • Webb, A.J.1
  • 47
    • 78049238308 scopus 로고    scopus 로고
    • Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice
    • COI: 1:CAS:528:DC%2BC3cXhtlals73K, PID: 20876122
    • Carlstrom M, et al. Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. PNAS. 2010;107(41):17716–20.
    • (2010) PNAS , vol.107 , Issue.41 , pp. 17716-17720
    • Carlstrom, M.1
  • 48
    • 79551495798 scopus 로고    scopus 로고
    • Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension
    • PID: 21097806
    • Carlstrom M, et al. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res. 2011;89(3):574–85.
    • (2011) Cardiovasc Res , vol.89 , Issue.3 , pp. 574-585
    • Carlstrom, M.1
  • 49
    • 10744229717 scopus 로고    scopus 로고
    • Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    • COI: 1:CAS:528:DC%2BD3sXosVKnsLw%3D, PID: 14583343
    • Kleinbongard P, et al. Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med. 2003;35(7):790–6.
    • (2003) Free Radic Biol Med , vol.35 , Issue.7 , pp. 790-796
    • Kleinbongard, P.1
  • 50
    • 33746701292 scopus 로고    scopus 로고
    • Nitrite in nitric oxide biology: cause or consequence? A systems-based review
    • COI: 1:CAS:528:DC%2BD28XotVyqsb4%3D, PID: 16895789
    • Bryan NS. Nitrite in nitric oxide biology: cause or consequence? A systems-based review. Free Radic Biol Med. 2006;41(5):691–701.
    • (2006) Free Radic Biol Med , vol.41 , Issue.5 , pp. 691-701
    • Bryan, N.S.1
  • 51
    • 33744832041 scopus 로고    scopus 로고
    • An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
    • COI: 1:CAS:528:DC%2BD28XlvFChtrg%3D, PID: 16717191
    • Angelo M, Singel DJ, Stamler JS. An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate. Proc Natl Acad Sci U S A. 2006;103(22):8366–71.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.22 , pp. 8366-8371
    • Angelo, M.1    Singel, D.J.2    Stamler, J.S.3
  • 52
    • 84918258075 scopus 로고
    • Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs
    • COI: 1:CAS:528:DyaG3sXlvFCruw%3D%3D, PID: 13062084
    • Furchgott RF, Bhadrakom S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther. 1953;108(2):129–43.
    • (1953) J Pharmacol Exp Ther , vol.108 , Issue.2 , pp. 129-143
    • Furchgott, R.F.1    Bhadrakom, S.2
  • 53
    • 10744220361 scopus 로고    scopus 로고
    • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    • COI: 1:CAS:528:DC%2BD3sXpt1Gksr0%3D, PID: 14595407
    • Cosby K, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003a;9:1498–505.
    • (2003) Nat Med , vol.9 , pp. 1498-1505
    • Cosby, K.1
  • 54
    • 84959839939 scopus 로고
    • Nitrite in human saliva. Its possible relationship to nitrosamine formation
    • COI: 1:CAS:528:DyaE2MXhsVCjsA%3D%3D, PID: 4835100
    • Tannenbaum SR, et al. Nitrite in human saliva. Its possible relationship to nitrosamine formation. J Natl Cancer Inst. 1974;53(1):79–84.
    • (1974) J Natl Cancer Inst , vol.53 , Issue.1 , pp. 79-84
    • Tannenbaum, S.R.1
  • 55
    • 0030475455 scopus 로고    scopus 로고
    • Modulation of nitrate-nitrite conversion in the oral cavity
    • PID: 8939344
    • van Maanen JM, van Geel AA, Kleinjans JC. Modulation of nitrate-nitrite conversion in the oral cavity. Cancer Detect Prev. 1996;20(6):590–6.
    • (1996) Cancer Detect Prev , vol.20 , Issue.6 , pp. 590-596
    • van Maanen, J.M.1    van Geel, A.A.2    Kleinjans, J.C.3
  • 56
    • 0014194438 scopus 로고
    • Nitrite metabolism by skeletal muscle mitochondria in relation to haem pigments
    • COI: 1:CAS:528:DyaF2sXkvFKku7g%3D, PID: 4292888
    • Walters CL, Casselden RJ, Taylor AM. Nitrite metabolism by skeletal muscle mitochondria in relation to haem pigments. Biochim Biophys Acta. 1967;143(2):310–8.
    • (1967) Biochim Biophys Acta , vol.143 , Issue.2 , pp. 310-318
    • Walters, C.L.1    Casselden, R.J.2    Taylor, A.M.3
  • 57
    • 0033035767 scopus 로고    scopus 로고
    • Nitrite reductase activity is a novel function of mammalian mitochondria
    • COI: 1:CAS:528:DyaK1MXks1Crtbk%3D, PID: 10413109
    • Kozlov AV, Staniek K, Nohl H. Nitrite reductase activity is a novel function of mammalian mitochondria. FEBS Lett. 1999;454(1–2):127–30.
    • (1999) FEBS Lett , vol.454 , Issue.1-2 , pp. 127-130
    • Kozlov, A.V.1    Staniek, K.2    Nohl, H.3
  • 58
    • 10744220361 scopus 로고    scopus 로고
    • Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    • COI: 1:CAS:528:DC%2BD3sXpt1Gksr0%3D, PID: 14595407
    • Cosby K, et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003b;9(12):1498–505.
    • (2003) Nat Med , vol.9 , Issue.12 , pp. 1498-1505
    • Cosby, K.1
  • 59
    • 2342436130 scopus 로고    scopus 로고
    • Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation
    • COI: 1:CAS:528:DC%2BD2cXjt1Ggs7k%3D, PID: 14766900
    • Li H, et al. Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation. J Biol Chem. 2004;279(17):16939–46.
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 16939-16946
    • Li, H.1
  • 60
    • 4544378255 scopus 로고    scopus 로고
    • Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    • COI: 1:CAS:528:DC%2BD2cXnvFehsL0%3D, PID: 15347817
    • Webb A, et al. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci U S A. 2004a;101(37):13683–8.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.37 , pp. 13683-13688
    • Webb, A.1
  • 61
    • 1642447134 scopus 로고    scopus 로고
    • Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo
    • COI: 1:CAS:528:DC%2BD2cXivFartbo%3D, PID: 15014175
    • Bryan NS, et al. Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proc Natl Acad Sci U S A. 2004;101(12):4308–13.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.12 , pp. 4308-4313
    • Bryan, N.S.1
  • 62
    • 20944446791 scopus 로고    scopus 로고
    • Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    • COI: 1:CAS:528:DC%2BD2MXktFSkt7o%3D, PID: 15841216
    • Duranski MR, et al. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005;115(5):1232–40.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1232-1240
    • Duranski, M.R.1
  • 63
    • 15044344420 scopus 로고    scopus 로고
    • Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage
    • COI: 1:CAS:528:DC%2BD2MXis1Crsbg%3D, PID: 15784871
    • Pluta RM, et al. Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA. 2005;293(12):1477–84.
    • (2005) JAMA , vol.293 , Issue.12 , pp. 1477-1484
    • Pluta, R.M.1
  • 64
    • 7044250715 scopus 로고    scopus 로고
    • Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
    • COI: 1:CAS:528:DC%2BD2cXnvFyntbo%3D, PID: 15361865
    • Hunter CJ, et al. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med. 2004;10:1122–7.
    • (2004) Nat Med , vol.10 , pp. 1122-1127
    • Hunter, C.J.1
  • 65
    • 0035057940 scopus 로고    scopus 로고
    • A novel method for the delivery of nitric oxide therapy to the skin of human subjects using a semi-permeable membrane
    • COI: 1:CAS:528:DC%2BD3MXjs12hsbk%3D
    • Hardwick JB, et al. A novel method for the delivery of nitric oxide therapy to the skin of human subjects using a semi-permeable membrane. Clin Sci (Lond). 2001;100(4):395–400.
    • (2001) Clin Sci (Lond) , vol.100 , Issue.4 , pp. 395-400
    • Hardwick, J.B.1
  • 66
    • 85047693682 scopus 로고    scopus 로고
    • Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
    • Bjorne HH, et al. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest. 2004;113(1):106–14.
    • (2004) J Clin Invest , vol.113 , Issue.1 , pp. 106-114
    • Bjorne, H.H.1
  • 67
    • 20944449213 scopus 로고    scopus 로고
    • Nitrite is an alternative source of NO in vivo
    • COI: 1:CAS:528:DC%2BD2MXktlSht78%3D, PID: 15626692
    • Tsuchiya K, et al. Nitrite is an alternative source of NO in vivo. Am J Physiol Heart Circ Physiol. 2005;288(5):H2163–70.
    • (2005) Am J Physiol Heart Circ Physiol , vol.288 , Issue.5 , pp. H2163-H2170
    • Tsuchiya, K.1
  • 68
    • 30344474311 scopus 로고    scopus 로고
    • Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
    • COI: 1:CAS:528:DC%2BD28XksVehtQ%3D%3D, PID: 16413411
    • Kleinbongard P, et al. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med. 2006;40(2):295–302.
    • (2006) Free Radic Biol Med , vol.40 , Issue.2 , pp. 295-302
    • Kleinbongard, P.1
  • 69
    • 63049130956 scopus 로고    scopus 로고
    • Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash
    • COI: 1:CAS:528:DC%2BD1MXkt1ShtL0%3D, PID: 19439233
    • Petersson J, et al. Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med. 2009;46(8):1068–75.
    • (2009) Free Radic Biol Med , vol.46 , Issue.8 , pp. 1068-1075
    • Petersson, J.1
  • 70
    • 4544378255 scopus 로고    scopus 로고
    • Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    • Webb, A., et al. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci USA. 2004b. 101(13683–13688).
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13683-13688
    • Webb, A.1
  • 71
    • 84867572397 scopus 로고    scopus 로고
    • Dietary nitrate supplementation improves revascularization in chronic ischemia
    • COI: 1:CAS:528:DC%2BC38XhsFSgtLnL, PID: 22992322
    • Hendgen-Cotta UB, et al. Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation. 2012;126(16):1983–92.
    • (2012) Circulation , vol.126 , Issue.16 , pp. 1983-1992
    • Hendgen-Cotta, U.B.1
  • 72
    • 84956741143 scopus 로고    scopus 로고
    • A stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load
    • COI: 1:CAS:528:DC%2BC28XhvVOhsb4%3D, PID: 26778277
    • Woessner M, et al. A stepwise reduction in plasma and salivary nitrite with increasing strengths of mouthwash following a dietary nitrate load. Nitric Oxide. 2016;54:1–7.
    • (2016) Nitric Oxide , vol.54 , pp. 1-7
    • Woessner, M.1
  • 73
    • 33845877743 scopus 로고    scopus 로고
    • Effects of dietary nitrate on blood pressure in healthy volunteers
    • COI: 1:CAS:528:DC%2BD2sXhslGjtA%3D%3D, PID: 17192551
    • Larsen FJ, et al. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med. 2006;355(26):2792–3.
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2792-2793
    • Larsen, F.J.1
  • 74
    • 84871394316 scopus 로고    scopus 로고
    • Physiological role for nitrate-reducing oral bacteria in blood pressure control
    • •• Kapil V, et al. Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med. 2013;55:93–100. Study demonstrating that oral nitrate reducing bacteria can affect systemic blood pressure
    • (2013) Free Radic Biol Med , vol.55 , pp. 93-100
    • Kapil, V.1
  • 75
    • 84986325268 scopus 로고    scopus 로고
    • The effects of chronic nitrate supplementation and the use of strong and weak antibacterial agents on plasma nitrite concentration and exercise blood pressure
    • COI: 1:CAS:528:DC%2BC2MXitVansLbJ, PID: 26332900
    • McDonagh ST, et al. The effects of chronic nitrate supplementation and the use of strong and weak antibacterial agents on plasma nitrite concentration and exercise blood pressure. Int J Sports Med. 2015;36(14):1177–85.
    • (2015) Int J Sports Med , vol.36 , Issue.14 , pp. 1177-1185
    • McDonagh, S.T.1
  • 76
    • 84993965180 scopus 로고    scopus 로고
    • Oral nitrite circumvents antiseptic mouthwash-induced disruption of enterosalivary circuit of nitrate and promotes nitrosation and blood pressure lowering effect
    • COI: 1:CAS:528:DC%2BC28XhslOqsLjK, PID: 27769921
    • Pinheiro LC, et al. Oral nitrite circumvents antiseptic mouthwash-induced disruption of enterosalivary circuit of nitrate and promotes nitrosation and blood pressure lowering effect. Free Radic Biol Med. 2016;101:226–35.
    • (2016) Free Radic Biol Med , vol.101 , pp. 226-235
    • Pinheiro, L.C.1
  • 77
    • 0034585248 scopus 로고    scopus 로고
    • Strength of evidence linking oral conditions and systemic disease
    • quiz 65
    • Joshipura K, Ritchie C, Douglass C. Strength of evidence linking oral conditions and systemic disease. Compend Contin Educ Dent Suppl. 2000;30:12–23. quiz 65
    • (2000) Compend Contin Educ Dent Suppl , vol.30 , pp. 12-23
    • Joshipura, K.1    Ritchie, C.2    Douglass, C.3
  • 78
    • 84855403751 scopus 로고    scopus 로고
    • Nitric oxide and geriatrics: implications in diagnostics and treatment of the elderly
    • COI: 1:CAS:528:DC%2BC38XlvVGqu7Y%3D, PID: 22783310
    • Torregrossa AC, Aranke M, Bryan NS. Nitric oxide and geriatrics: implications in diagnostics and treatment of the elderly. J Geriatr Cardiol. 2011;8:230–42.
    • (2011) J Geriatr Cardiol , vol.8 , pp. 230-242
    • Torregrossa, A.C.1    Aranke, M.2    Bryan, N.S.3
  • 79
    • 63849246674 scopus 로고    scopus 로고
    • Discovery of the nitric oxide signaling pathway and targets for drug development
    • COI: 1:CAS:528:DC%2BD1MXltFejsrs%3D
    • Bryan NS, Bian K, Murad F. Discovery of the nitric oxide signaling pathway and targets for drug development. Front Biosci. 2009;14:1–18.
    • (2009) Front Biosci , vol.14 , pp. 1-18
    • Bryan, N.S.1    Bian, K.2    Murad, F.3


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