Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling

Oncotarget

Volumn 8, Issue 13, 2017, Pages 21044-21053

  Chen, Lei ^a   Sha, Ming Lei ^a   Li, Deng ^a   Zhu, Yi Ping ^a   Wang, Xing Jie ^a   Jiang, Chen Yi ^a   Xia, Shu Jie ^a   Shao, Yi ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Macrophage polarization; Relaxin; Renal fibrosis; Toll like receptor 4

Indexed keywords

FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 23; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MYELOID DIFFERENTIATION FACTOR 88; RELAXIN; RESATORVID; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; ETHYL 6-(N-(2-CHLORO-4-FLUOROPHENYL)SULFAMOYL)CYCLOHEX-1-ENE-1-CARBOXYLATE; RECOMBINANT PROTEIN; RLN2 PROTEIN, HUMAN; SULFONAMIDE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; IN VITRO STUDY; KIDNEY FIBROSIS; MACROPHAGE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PROTEIN EXPRESSION; RAW 264.7 CELL LINE; TREATMENT OUTCOME; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL POLARITY; DISEASE MODEL; DRUG EFFECTS; FIBROSIS; HUMAN; KIDNEY; MALE; MOUSE; PATHOLOGY; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; TUMOR CELL LINE; URETER OBSTRUCTION;

ANIMALS; CELL LINE, TUMOR; CELL POLARITY; DISEASE MODELS, ANIMAL; FIBROSIS; HUMANS; KIDNEY; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; RELAXIN; RENAL INSUFFICIENCY, CHRONIC; SIGNAL TRANSDUCTION; SULFONAMIDES; TOLL-LIKE RECEPTOR 4; URETERAL OBSTRUCTION;

EID: 85016438054     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.15483     Document Type: Article

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