-
1
-
-
25444441069
-
Progression in chronic kidney disease
-
Eddy AA. Progression in chronic kidney disease. Adv Chronic Kidney Dis 2005; 12:353-365.
-
(2005)
Adv Chronic Kidney Dis
, vol.12
, pp. 353-365
-
-
Eddy, A.A.1
-
2
-
-
84884002531
-
Physiology and molecular biology of the relaxin peptide family
-
Knobil E, Neill JD, editors, 3rd ed. New York: Elsevier;
-
Bathgate RAD, Hsueh AJ, Sherwood OD. Physiology and molecular biology of the relaxin peptide family. In: Knobil E, Neill JD, editors. Physiology of reproduction, 3rd ed. New York: Elsevier; 2006. pp. 679-770.
-
(2006)
Physiology of reproduction
, pp. 679-770
-
-
Bathgate, R.A.D.1
Hsueh, A.J.2
Sherwood, O.D.3
-
3
-
-
3042610399
-
Relaxin's physiological roles and other diverse actions
-
Sherwood OD. Relaxin's physiological roles and other diverse actions. Endocr Rev 2004; 25:205-234.
-
(2004)
Endocr Rev
, vol.25
, pp. 205-234
-
-
Sherwood, O.D.1
-
4
-
-
33748091739
-
Relaxin: A pleiotropic hormone and its emerging role for experimental and clinical therapeutics
-
Dschietzig T, Bartsch C, Baumann G, et al. Relaxin: a pleiotropic hormone and its emerging role for experimental and clinical therapeutics. Pharmacol Ther 2006; 112:38-56.
-
(2006)
Pharmacol Ther
, vol.112
, pp. 38-56
-
-
Dschietzig, T.1
Bartsch, C.2
Baumann, G.3
-
6
-
-
34247639085
-
Relaxin as a cardiovascular hormone: Physiology, pathophysiology and therapeutic promises
-
Nistri S, Bigazzi M, Bani D. Relaxin as a cardiovascular hormone: physiology, pathophysiology and therapeutic promises. Cardiovasc Hematol Agents Med Chem 2007; 5:101-108.
-
(2007)
Cardiovasc Hematol Agents Med Chem
, vol.5
, pp. 101-108
-
-
Nistri, S.1
Bigazzi, M.2
Bani, D.3
-
8
-
-
2442647519
-
Relaxin-1 -deficient mice develop an age related progression of renal fibrosis
-
Samuel CS, Zhao C, Bond CP, et al. Relaxin-1 -deficient mice develop an age related progression of renal fibrosis. Kidney Int 2004; 65:2054-2064.
-
(2004)
Kidney Int
, vol.65
, pp. 2054-2064
-
-
Samuel, C.S.1
Zhao, C.2
Bond, C.P.3
-
9
-
-
0037059750
-
Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family
-
Bathgate RA, Samuel CS, Burazin TC, et al. Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. J Biol Chem 2002; 277:1148-1157.
-
(2002)
J Biol Chem
, vol.277
, pp. 1148-1157
-
-
Bathgate, R.A.1
Samuel, C.S.2
Burazin, T.C.3
-
10
-
-
33846453635
-
-
• Hewitson TD, Mookerjee I, Masterson R, et al. Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis. Endocrinology 2007; 148:660-669. This study demonstrates that the absence of endogenous relaxin accelerates the progression of tubulointerstitial disease.
-
• Hewitson TD, Mookerjee I, Masterson R, et al. Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis. Endocrinology 2007; 148:660-669. This study demonstrates that the absence of endogenous relaxin accelerates the progression of tubulointerstitial disease.
-
-
-
-
11
-
-
33646522213
-
Relaxin in cardiovascular and renal disease
-
Samuel CS, Hewitson TD. Relaxin in cardiovascular and renal disease. Kidney Int 2006;69:1498-1502.
-
(2006)
Kidney Int
, vol.69
, pp. 1498-1502
-
-
Samuel, C.S.1
Hewitson, T.D.2
-
12
-
-
0037169071
-
Activation of orphan receptors by the hormone relaxin
-
Hsu SY, Nakabayashi K, Nishi S, et al. Activation of orphan receptors by the hormone relaxin. Science 2002; 295:671-674.
-
(2002)
Science
, vol.295
, pp. 671-674
-
-
Hsu, S.Y.1
Nakabayashi, K.2
Nishi, S.3
-
13
-
-
1342285008
-
Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro
-
Masterson R, Hewitson TD, Kelynack K, et al. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol Dial Transplant 2004; 19:544-552.
-
(2004)
Nephrol Dial Transplant
, vol.19
, pp. 544-552
-
-
Masterson, R.1
Hewitson, T.D.2
Kelynack, K.3
-
14
-
-
2442704145
-
Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease
-
Hocher B, Ziebig R, Krause R, et al. Relaxin is an independent risk factor predicting death in male patients with end-stage kidney disease. Circulation 2004; 109:2266-2268.
-
(2004)
Circulation
, vol.109
, pp. 2266-2268
-
-
Hocher, B.1
Ziebig, R.2
Krause, R.3
-
15
-
-
33751520386
-
The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs
-
Lekgabe ED, Royce SG, Hewitson TD, et al. The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs. Endocrinology 2006; 147:5575-5583.
-
(2006)
Endocrinology
, vol.147
, pp. 5575-5583
-
-
Lekgabe, E.D.1
Royce, S.G.2
Hewitson, T.D.3
-
16
-
-
0028053857
-
Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor
-
Baylis C. Age-dependent glomerular damage in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest 1994; 94:1823-1829.
-
(1994)
J Clin Invest
, vol.94
, pp. 1823-1829
-
-
Baylis, C.1
-
17
-
-
0032894945
-
Sex hormones and gender-related differences: Their influence on chronic renal allograft rejection
-
Muller V, Szabo A, Viklicky O, et al. Sex hormones and gender-related differences: their influence on chronic renal allograft rejection. Kidney Int 1999; 55:2011-2020.
-
(1999)
Kidney Int
, vol.55
, pp. 2011-2020
-
-
Muller, V.1
Szabo, A.2
Viklicky, O.3
-
18
-
-
0035096195
-
Relaxin decreases renal interstitial fibrosis and slows progression of renal disease
-
Garber SL, Mirochnik Y, Brecklin CS, et al. Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. Kidney Int 2001; 59:876-882.
-
(2001)
Kidney Int
, vol.59
, pp. 876-882
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.S.3
-
19
-
-
0037210131
-
Effect of relaxin in two models of renal mass reduction
-
Garber SL, Mirochnik Y, Brecklin C, et al. Effect of relaxin in two models of renal mass reduction. Am J Nephrol 2003; 23:8-12.
-
(2003)
Am J Nephrol
, vol.23
, pp. 8-12
-
-
Garber, S.L.1
Mirochnik, Y.2
Brecklin, C.3
-
20
-
-
0038721960
-
Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo
-
McDonald GA, Sarkar P, Rennke H, et al. Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo. Am J Physiol Renal Physiol 2003; 285:F59-67.
-
(2003)
Am J Physiol Renal Physiol
, vol.285
-
-
McDonald, G.A.1
Sarkar, P.2
Rennke, H.3
-
21
-
-
23244443050
-
Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats
-
Lekgabe ED, Kiriazis H, Zhao C, et al. Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension 2005; 46:412-418.
-
(2005)
Hypertension
, vol.46
, pp. 412-418
-
-
Lekgabe, E.D.1
Kiriazis, H.2
Zhao, C.3
-
22
-
-
33646359679
-
Relaxin improves renal function and histology in aging Munich Wistar rats
-
Danielson LA, Welford A, Harris A. Relaxin improves renal function and histology in aging Munich Wistar rats. J Am Soc Nephrol 2006; 17:1325-1333.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1325-1333
-
-
Danielson, L.A.1
Welford, A.2
Harris, A.3
-
23
-
-
24944542890
-
The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
-
Heeg MH, Koziolek MJ, Vasko R, et al. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int 2005; 68:96-109.
-
(2005)
Kidney Int
, vol.68
, pp. 96-109
-
-
Heeg, M.H.1
Koziolek, M.J.2
Vasko, R.3
-
24
-
-
4344606223
-
Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo
-
Samuel CS, Unemori EN, Mookerjee I, et al. Relaxin modulates cardiac fibroblast proliferation, differentiation and collagen production and reverses cardiac fibrosis in vivo. Endocrinology 2004; 145:4125-4133.
-
(2004)
Endocrinology
, vol.145
, pp. 4125-4133
-
-
Samuel, C.S.1
Unemori, E.N.2
Mookerjee, I.3
-
27
-
-
34547625988
-
Renal function during normal pregnancy and preeclampsia
-
Jeyabalan A, Conrad KP. Renal function during normal pregnancy and preeclampsia. Front Biosci 2007; 12:2425-2437.
-
(2007)
Front Biosci
, vol.12
, pp. 2425-2437
-
-
Jeyabalan, A.1
Conrad, K.P.2
-
28
-
-
0037428061
-
Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: Attenuation of endothelin-1 -mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB
-
Dschietzig T, Bartsch C, Richter C, et al. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1 -mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 2003; 92:32-40.
-
(2003)
Circ Res
, vol.92
, pp. 32-40
-
-
Dschietzig, T.1
Bartsch, C.2
Richter, C.3
-
29
-
-
33845909264
-
-
•• Jeyabalan A, Novak J, Doty KD, et al. Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin. Endocrinology 2007; 148:189-197. This study demonstrates the significance of the relaxin-mediated promotion of gelatinase activity to its vasodilatory effects in the kidney.
-
•• Jeyabalan A, Novak J, Doty KD, et al. Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin. Endocrinology 2007; 148:189-197. This study demonstrates the significance of the relaxin-mediated promotion of gelatinase activity to its vasodilatory effects in the kidney.
-
-
-
-
30
-
-
0033037935
-
Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women
-
Unemori EN, Erikson ME, Rocco SE, et al. Relaxin stimulates expression of vascular endothelial growth factor in normal human endometrial cells in vitro and is associated with menometrorrhagia in women. Hum Reprod 1999; 14:800-806.
-
(1999)
Hum Reprod
, vol.14
, pp. 800-806
-
-
Unemori, E.N.1
Erikson, M.E.2
Rocco, S.E.3
-
31
-
-
0033673465
-
Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites
-
Unemori EN, Lewis M, Constant J, et al. Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites. Wound Repair Regen 2000; 8:361-370.
-
(2000)
Wound Repair Regen
, vol.8
, pp. 361-370
-
-
Unemori, E.N.1
Lewis, M.2
Constant, J.3
-
32
-
-
35649009903
-
-
• Formigli L, Perna AM, Meacci E, et al. Paracrine effects of transplanted myoblasts and relaxin on postinfarction heart remodelling J. Cell Mol Med 2007; 11:1087-1100. This study is the first to demonstrate the complementary effects of relaxin to stem cell-based therapies in the setting of ischemic heart disease.
-
• Formigli L, Perna AM, Meacci E, et al. Paracrine effects of transplanted myoblasts and relaxin on postinfarction heart remodelling J. Cell Mol Med 2007; 11:1087-1100. This study is the first to demonstrate the complementary effects of relaxin to stem cell-based therapies in the setting of ischemic heart disease.
-
-
-
-
33
-
-
0034917262
-
Impaired angiogenesis in the remnant kidney model. II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function
-
Kang DH, Hughes J, Mazzali M, et al. Impaired angiogenesis in the remnant kidney model. II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001; 12:1448-1457.
-
(2001)
J Am Soc Nephrol
, vol.12
, pp. 1448-1457
-
-
Kang, D.H.1
Hughes, J.2
Mazzali, M.3
-
34
-
-
33750731616
-
Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers
-
Smith MC, Danielson LA, Conrad KP, et al. Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. J Am Soc Nephrol 2006; 17:3192-3197.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 3192-3197
-
-
Smith, M.C.1
Danielson, L.A.2
Conrad, K.P.3
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