Sulforaphane, a dietary isothiocyanate, induces G2/M arrest in cervical cancer cells through cyclinB1 downregulation and GADD45β/CDC2 association

International Journal of Molecular Sciences

Volumn 17, Issue 9, 2016, Pages

  Cheng, Ya Min ^a,b   Tsai, Ching Chou ^c   Hsu, Yi Chiang ^d  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

Author keywords

Cervical cancer cells; Cyclin B1 CDC2; G2 M arrest; Growth arrest and DNA damage 45 (GADD45); Sulforaphane

Indexed keywords

CASPASE 3; CYCLIN B1; SULFORAPHANE; ANTINEOPLASTIC AGENT; CCNB1 PROTEIN, HUMAN; CDK1 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; DIFFERENTIATION ANTIGEN; GADD45B PROTEIN, HUMAN; ISOTHIOCYANIC ACID DERIVATIVE; SULFORAFAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION ASSAY; CELL SURVIVAL; DNA DAMAGE; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE; G2 PHASE CELL CYCLE CHECKPOINT; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HYSTERECTOMY; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING; CELL PROLIFERATION; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HELA CELL LINE; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

ANTICARCINOGENIC AGENTS; ANTIGENS, DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B1; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; ISOTHIOCYANATES; UTERINE CERVICAL NEOPLASMS;

EID: 85016406884     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17091530     Document Type: Article

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