Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

Cell Reports

Volumn 18, Issue 13, 2017, Pages 3192-3203

  Traub, Shuyang ^a,b   Meier, Daniel T ^a,b   Schulze, Friederike ^a,b   Dror, Erez ^a,b   Nordmann, Thierry M ^a,b   Goetz, Nicole ^a,b   Koch, Norina ^a,b   Dalmas, Elise ^a,b   Stawiski, Marc ^a,b   Makshana, Valmir ^a,b   Thorel, Fabrizio ^c   Herrera, Pedro L ^c   Böni Schnetzler, Marianne ^a,b   Donath, Marc Y ^a,b  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

diabetes; DPP 4; GLP 1; glucagon; glucose homeostasis; insulin; islet; paracrine; sitagliptin; cell; cell

Indexed keywords

DIPHTHERIA TOXIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; INSULIN; RNA; SITAGLIPTIN; GLUCOSE; SERINE PROTEINASE;

ADAPTATION; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HUMAN; HUMAN TISSUE; ILEUM; IMMUNOHISTOCHEMISTRY; INSULIN RELEASE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; MALE; METABOLIC STRESS; MOUSE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; RAT; SECRETION (PROCESS);

ADAPTATION, PHYSIOLOGICAL; AGING; ANIMALS; DIET, HIGH-FAT; DIPHTHERIA TOXIN; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-SECRETING CELLS; GLUCOSE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; PROPROTEIN CONVERTASES; RATS; STRESS, PHYSIOLOGICAL;

EID: 85016328608     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.03.005     Document Type: Article

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