Disruption of pathogenic cellular networks by IL-21 blockade leads to disease amelioration in murine lupus

Journal of Immunology

Volumn 198, Issue 7, 2017, Pages 2578-2588

  Choi, Jin Young ^a   Seth, Abhinav ^a   Kashgarian, Michael ^a   Terrillon, Sonia ^b   Fung, Emma ^b   Huang, Lili ^b   Wang, Li Chun ^b   Craft, Joe ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ABBVIE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD40 LIGAND; GAMMA INTERFERON; IMMUNOGLOBULIN; IMMUNOGLOBULIN G2C; INTERLEUKIN 21; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4H11 B4; SYNDECAN 1; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL INTERACTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; FOLLICULAR TH CELL; GERMINAL CENTER; GLOMERULONEPHRITIS; HELPER CELL; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOPATHOGENESIS; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PLASMABLAST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TH1 CELL; ANIMAL; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; IMMUNOLOGY; MUTANT MOUSE STRAIN;

ANIMALS; AUTOIMMUNITY; B-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ENZYME-LINKED IMMUNOSPOT ASSAY; FLOW CYTOMETRY; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICE, MUTANT STRAINS; RECEPTOR CROSS-TALK; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 85016314546     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1601687     Document Type: Article

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