The effect of regular intake of dry‐cured ham rich in bioactive peptides on inflammation, platelet and monocyte activation markers in humans

Nutrients

Volumn 9, Issue 4, 2017, Pages

  Martínez Sánchez, Sara María ^a   Minguela, Alfredo ^b,c   Prieto Merino, David ^a   Zafrilla Rentero, María Pilar ^a   Abellán Alemán, José ^a   Montoro‐García, Silvia ^a  

^a CATHOLIC UNIVERSITY OF MURCIA   (Spain)

^b Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca IMIB Arrixaca   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LA ARRIXACA   (Spain)

Author keywords

Active biopeptides; Dry cured ham; Inflammation; Molecular markers; Monocyte; Platelet function

Indexed keywords

ADENOSINE DIPHOSPHATE; BIOLOGICAL MARKER; BIOPEPTIDE; CHEMOKINE RECEPTOR CXCR4; DUAL SPECIFICITY PHOSPHATASE 2; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1 RECEPTOR; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PADGEM PROTEIN; PEPTIDE; RECEPTOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CELL ADHESION MOLECULE; CXCR4 PROTEIN, HUMAN; SELP PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; BIOCHEMICAL ANALYSIS; BLOOD SAMPLING; CELL ADHESION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRY CURED HAM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; MALE; MONOCYTE; NORMAL HUMAN; PORK; PREHYPERTENSION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE ACTIVATION; ANIMAL; BLOOD; BLOOD CLOTTING PARAMETERS; DESICCATION; DIET; FEEDING BEHAVIOR; FOOD HANDLING; METABOLISM; MIDDLE AGED; PIG; PROCEDURES; RED MEAT; THROMBOCYTE;

ADENOSINE DIPHOSPHATE; ADULT; ANIMALS; BIOMARKERS; BLOOD PLATELETS; CELL ADHESION MOLECULES; DESICCATION; DIET; FEEDING BEHAVIOR; FEMALE; FOOD HANDLING; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MONOCYTES; P-SELECTIN; PEPTIDES; PLATELET FUNCTION TESTS; RECEPTORS, CXCR4; RED MEAT; SWINE; TOLL-LIKE RECEPTOR 4;

EID: 85016165357     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu9040321     Document Type: Article

References (29)

1. Eussen, S.R.; Verhagen, H.; Klungel, O.H.; Garssen, J.; van Loveren, H.; van Kranen, H.J.; Rompelberg, C. J. Functional foods and dietary supplements: Products at the interface between pharma and nutrition. Eur. J. Pharmacol. 2011, 668 (Suppl. S1), 2–9.
2. Aihara, K.; Osaka, M.; Yoshida, M. Oral administration of the milk casein‐derived tripeptide Val‐Pro‐Pro attenuates high‐fat diet‐induced adipose tissue inflammation in mice. Br. J. Nutr. 2014, 112, 513–519.
3. Bjørndal, B.; Berge, C.; Ramsvik, M.S.; Svardal, A.; Bohov, P.; Skorve, J.; Berge, R.K. A fish protein hydrolysate alters fatty acid composition in liver and adipose tissue and increases plasma carnitine levels in a mouse model of chronic inflammation. Lipids Health Dis. 2013, 12, 143.
4. Girgih, A.T.; Alashi, A.M.; He, R.; Malomo, S.A.; Raj, P.; Netticadan, T.; Aluko, R.E. A novel hemp seed meal protein hydrolysate reduces oxidative stress factors in spontaneously hypertensive rats. Nutrients 2014, 6, 5652–5266.
5. Borissoff, J.I.; Spronk, H.M.; ten Cate, H. The hemostatic system as a modulator of atherosclerosis. N. Engl. J. Med. 2011, 364, 1746–1760.
6. Passacquale, G.; Vamadevan, P.; Pereira, L.; Hamid, C.; Corrigall, V.; Ferro, A. Monocyte‐platelet interaction induces a pro‐inflammatory phenotype in circulating monocytes. PLoS ONE 2011, 6, e25595.
7. Ed Rainger, G.; Chimen, M.; Harrison, M.J.; Yates, C.M.; Harrison, P.; Watson, S.P.; Lordkipanizdé, M.; Nash, G.B. The role of platelets in the recruitment of leukocytes during vascular disease. Platelets 2015, 26, 507–520.
8. Chen, M.; Ye, X.; Ming, X.; Chen, Y.; Wang, Y.; Su, X.; Kong, Y. A Novel Direct Factor Xa Inhibitory Peptide with Anti‐Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates. Sci. Rep. 2015, 5, 10846.
9. Majumder, K.; Chakrabarti, S.; Davidge, S.T.; Wu, J. Structure and activity study of egg protein ovotransferrin derived peptides (IRW and IQW) on endothelial inflammatory response and oxidative stress. J. Agric. Food Chem. 2013, 61, 2120–2129.
10. Qin, L.Q.; Xu, J.Y.; Dong, J.Y.; Zhao, Y.; van Bladeren, P.; Zhang, W. Lactotripeptides intake and blood pressure management: A meta‐analysis of randomised controlled clinical trials. Nutr. Metab. Cardiovasc. Dis. 2013, 23, 395–402.
11. Bähr, M.; Fechner, A.; Kiehntopf, M.; Jahreis, G. Consuming a mixed diet enriched with lupin protein beneficially affects plasma lipids in hypercholesterolemic subjects: A randomized controlled trial. Clin. Nutr. 2015, 34, 7–14.
12. Majumder, K.; Wu, J. Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension. Int. J. Mol. Sci. 2014, 16, 256–283.
13. Ryan, J.T.; Ross, R.P.; Bolton, D.; Fitzgerald, G.F.; Stanton, C. Bioactive peptides from muscle sources: Meat and fish. Nutrients 2011, 3, 765–791.
14. Escudero, E.; Mora, L.; Fraser, P.D.; Aristoy, M.C.; Arihara, K.; Toldrá, F. Purification and Identification of antihypertensive peptides in Spanish dry‐cured ham. J. Proteom. 2013, 78, 499–507.
15. Mora, L.; Gallego, M.; Escudero, E.; Reig, M.; Aristoy, M.C.; Toldrá, F. Small peptides hydrolysis in dry-cured meats. Int. J. Food Microbiol. 2015, 212, 9–15.
16. Escudero, E.; Aristoy, M.C.; Nishimura, H.; Arihara, K.; Toldrá, F. Antihypertensive effect and antioxidant activity of peptide fractions extracted from Spanish dry‐cured ham. Meat Sci. 2012, 91, 306–311.
17. Escudero, E.; Mora, L.; Toldrá, F. Stability of ACE inhibitory ham peptides against heat treatment and in vitro digestion. Food Chem. 2014, 161, 305–311.
18. Jiménez-Colmenero, F.; Ventanas, J.; Toldrá, F. Nutritional composition of dry‐cured ham and its role in a healthy diet. Meat Sci. 2010, 84, 585–593.
19. Gallego, M.; Mora, L.; Toldrá, F. Peptidomics as a tool for quality control in dry‐cured ham processing. J Proteom. 2016, 147, 98–107.
20. Montoro-Garcia, S.; Shantsila, E.; Hernandez-Romero, D.; Jover, E.; Valdes, M.; Marin, F.; Lip, G.Y. Small-size platelet microparticles trigger platelet and monocyte functionality and modulate thrombogenesis via P‐selectin. Br. J. Haematol. 2014, 166, 571–580.
21. Shantsila, E.; Tapp, L.D.; Wrigley, B.J.; Pamukcu, B.; Apostolakis, S.; Montoro‐Garcia, S.; Lip, G.Y. Monocyte subsets in coronary artery disease and their associations with markers of inflammation and fibrinolysis. Atherosclerosis 2014, 234, 4–10.
22. Micha, R.; Michas, G.; Mozaffarian, D. Unprocessed red and processed meats and risk of coronary artery disease and type 2 diabetes—An updated review of the evidence. Curr. Atheroscler. Rep. 2012, 14, 515–24.
23. Gallego, M.; Aristoy, M.C.; Toldrá, F. Dipeptidyl peptidase IV inhibitory peptides generated in Spanish dry‐cured ham. Meat Sci. 2014, 96, 757–761.
24. Escudero, E.; Mora, L.; Fraser, P.D.; Aristoy, M.C.; Toldrá, F. Identification of novel antioxidant peptides generated in Spanish dry‐cured ham. Food Chem. 2013, 138, 1282–1288.
25. Blann, A.D.; Nadar, S.K.; Lip GY. The adhesion molecule P‐selectin and cardiovascular disease. Eur. Heart J. 2003, 24, 2166–2179.
26. Kling, D.; Stucki, C.; Kronenberg, S.; Tuerck, D.; Rhéaume, E.; Tardif, J.C.; Gaudreault, J.; Schmit, C. Pharmacological control of platelet‐leukocyte interactions by the human anti‐P‐selectin antibody inclacumab—Preclinical and clinical studies. Thromb. Res. 2013, 131, 401–410.
27. Konić-Ristić, A.; Srdić-Rajić, T.; Kardum, N.; Aleksić-Veličković, V.; Kroon, P.A.; Hollands, W.J.; Needs, P. W.; Boyko, N.; Hayran, O.; Jorjadze, M.; et al. Effects of bioactive‐rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation. J. Sci. Food. Agric. 2013, 93, 3581–3587.
28. Shantsila, E.; Wrigley, B.; Tapp, L.; Apostolakis, S.; Montoro‐Garcia, S.; Drayson, M.T.; Lip, G.Y.Immunophenotypic characterization of human monocyte subsets: Possible implications for cardiovascular disease pathophysiology. J. Thromb. Haemost. 2011, 9, 1056–1066.
29. Canton, J.; Neculai, D.; Grinstein, S. Scavenger receptors in homeostasis and immunity. Nat. Rev. Immunol. 2013, 13, 621–634.