DissolvIt: An in Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs

Assay and Drug Development Technologies

Volumn 15, Issue 2, 2017, Pages 77-88

  Gerde, Per ^a,b   Malmlöf, Maria ^a,b   Havsborn, Lina ^a   Sjöberg, Carl Olof ^c   Ewing, Pär ^d   Eirefelt, Stefan ^d,e   Ekelund, Katarina ^d,e  

^a Inhalation Sciences Sweden AB   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c Flexura AB   (Sweden)

^d ASTRAZENECA R AND D   (Sweden)

^e LEO PHARMA A S   (Denmark)

Author keywords

dry powder

Indexed keywords

BUDESONIDE; FLUTICASONE PROPIONATE; MACROGOL; POLYCARBONATE; BIOMIMETIC MATERIAL; POWDER;

AEROSOL; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG HALF LIFE; DRUG RETENTION; DRUG SOLUBILITY; DRY POWDER; DRY POWDER INHALER; IN VITRO STUDY; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; LUNG BLOOD FLOW; MAXIMUM PLASMA CONCENTRATION; MICROSCOPY; PLASMA CONCENTRATION-TIME CURVE; SCANNING ELECTRON MICROSCOPY; SIMULATION; SOLUTE; TIME TO MAXIMUM PLASMA CONCENTRATION; ABSORPTION; ADMINISTRATION AND DOSAGE; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; INHALATIONAL DRUG ADMINISTRATION; LUNG; MICROFLUIDICS; MUCUS; POWDER; RESPIRATORY FUNCTION; SOLUBILITY;

ABSORPTION, PHYSICOCHEMICAL; ADMINISTRATION, INHALATION; BIOMIMETIC MATERIALS; EQUIPMENT DESIGN; LUNG; MICROFLUIDICS; MUCUS; POWDERS; RESPIRATORY TRACT ABSORPTION; SOLUBILITY;

EID: 85016162712     PISSN: 1540658X     EISSN: 15578127     Source Type: Journal    
DOI: 10.1089/adt.2017.779     Document Type: Article

References (26)

1. Azarmi S, Roa W, Lobenberg R: Current perspectives in dissolution testing of conventional and novel dosage forms. Int J Pharm 2007;328:12-21.
2. Son YJ, McConville JT: Development of a standardized dissolution test method for inhaled pharmaceutical formulations. Int J Pharm 2009;382:15-22.
3. Davies NM, Feddah MR: A novel method for assessing dissolution of aerosol inhaler products. Int J Pharm 2003;255:175-187.
4. Franz TJ: Percutaneous absorption on the relevance of in vitro data. J Invest Dermatol 1975;64:190-195.
5. Arora D, Shah KA, Halquist MS, Sakagami M: In vitro aqueous fluid-capacity-limited dissolution testing of respirable aerosol drug particles generated from inhaler products. Pharm Res 2010;27:786-795.
6. Rohrschneider M, Bhagwat S, Krampe R, Michler V, Breitkreutz J, Hochhaus G: Evaluation of the transwell system for characterization of dissolution behavior of inhalation drugs: effects of membrane and surfactant. Mol Pharm 2015; 12:2618-2624.
7. Salama RO, Traini D, Chan HK, Young PM: Preparation and characterisation of controlled release co-spray dried drug-polymer microparticles for inhalation 2: evaluation of in vitro release profiling methodologies for controlled release respiratory aerosols. Eur J Pharm Biopharm 2008;70:145-152.
8. May S, Jensen B, Wolkenhauer M, Schneider M, Lehr CM: Dissolution techniques for in vitro testing of dry powders for inhalation. Pharm Res 2012;29:2157-2166.
9. Gerde P, Ewing P, Lastbom L, Ryrfeldt A, Waher J, Liden G: A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot. Inhal Toxicol 2004;16: 45-52.
10. Selg E, Ewing P, Acevedo F, Sjoberg CO, Ryrfeldt A, Gerde P: Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: the pulmonary pharmacokinetics of fluticasone furoate. J Aerosol Med Pulm Drug Deliv 2013;26:181-189.
11. Selg E, Acevedo F, Nybom R, Blomgren B, Ryrfeldt A, Gerde P: Delivering horseradish peroxidase as a respirable powder to the isolated, perfused, and ventilated lung of the rat: the pulmonary disposition of an inhaled model diopharmaceutical. J Aerosol Med Pulm Drug Deliv 2010;23: 273-284.
12. Gerde P; Inhalation Sciences Sweden AB, assignee: Device for studying interaction between particles and lungs. US Patent 8348673. 2013.
13. Gerde P, Ewing P, Låstbom L, Waher J, Lidén G, Ryrfeldt Å : A novel method to aerosolize powder for short inhalation exposures at high concentrations: isolated rat lungs exposed to respirable diesel soot. Inhal Toxicol 2004;16: 45-52.
14. Rubow KL, Marple VA, Olin J, McCawley MA: A personal cascade impactor: design, evaluation and calibration. Am Ind Hyg Assoc J 1987;48:532-538.
15. Laitinen A, Laitinen LA, Moss R, Widdicombe JG: Organisation and structure of the tracheal and bronchial blood vessels in the dog. J Anat 1989;165: 133-140.
16. Patton JS, Byron PR: Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 2007;6:67-74.
17. Shah S, Fung K, Brim S, Rubin BK: An in vitro evaluation of the effectiveness of endotracheal suction catheters. Chest 2005;128:3699-3704.
18. Gerde P, Scholander P: A mathematical model of the penetration of polycyclic aromatic hydrocarbons through the bronchial lining layer. Environ Res 1987; 44:321-334.
19. Joh S, Matsuura H, Kotani Y, et al.: Change in tracheal blood flow during endotracheal intubation. Acta Anesthesiol Scand 1987;31:300-304.
20. Mortimer KJ, Tattersfield AE, Tang Y, et al.: Plasma concentrations of fluticasone propionate and budesonide following inhalation: effect of induced bronchoconstriction. Br J Clin Pharmacol 2007;64:439-444.
21. Ewing P, Eirefelt SJ, Andersson P, Blomgren A, Ryrfeldt A, Gerde P: Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols; the detailed pharmacokinetics of budesonide, formoterol, and terbutaline. J Aerosol Med Pulm Drug Deliv 2008;21:169-180.
22. Gerde P, Muggenburg BA, Hoover MD, Henderson RF: Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the Beagle dog: I. The alveolar region. Toxicol Appl Pharmacol 1993;121:313-318.
23. Gerde P, Muggenburg BA, Thornton-Manning JR, Lewis JL, Pyon KH, Dahl AR: Benzo(a)pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium. Carcinogenesis 1997;18:1825-1832.
24. Ewing P, Eirefelt SJ, Andersson P, Blomgren A, Ryrfeldt A, Gerde P: Short inhalation exposures of the isolated and perfused rat lung to respirable dry particle aerosols; the detailed pharmacokinetics of budesonide, formoterol, and terbutaline. J Aerosol Med Pulm Drug Deliv 2008;21:169-180.
25. Gerde P, Scholander P: An experimental study on the penetration of polycyclic aromatic hydrocarbons through a model of the bronchial lining layer. Environ Res 1989;48:287-295.
26. Freiwald M, Valotis A, Kirschbaum A, et al.: Monitoring the initial pulmonary absorption of two different beclomethasone dipropionate aerosols employing a human lung reperfusion model. Respir Res 2005;6:21.