Benzo[a]pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium

Carcinogenesis

Volumn 18, Issue 9, 1997, Pages 1825-1832

  Gerde, Per ^a,b   Muggenburg, Bruce A ^a   Thornton Manning, Janice R ^a   Lewis, Johnnye L ^a   Pyon, Kee H ^a   Dahl, Alan R ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; POLYCYCLIC AROMATIC HYDROCARBON; SODIUM CHLORIDE; TOBACCO SMOKE;

AIR POLLUTANT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AZYGOS VEIN; CONTROLLED STUDY; DOG; ENVIRONMENTAL EXPOSURE; LIPOPHILICITY; LUNG CARCINOGENESIS; NONHUMAN; PRIORITY JOURNAL; TRACHEA MUCOSA;

ABSORPTION; ANIMALS; AUTORADIOGRAPHY; BENZO(A)PYRENE; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; EPITHELIUM; LUNG NEOPLASMS; RADIOMETRY; TRACHEA;

EID: 0031428102     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/18.9.1825     Document Type: Article

References (45)

1. Shopland, D.R. (1995) Tobacco use and its contribution to early cancer mortality with special emphasis on cigarette smoking. Environ. Health Perspect., 103 (Suppl. 8), 131-141.
2. Mills, C.A. and Mills Porter, M. (1950) Tobacco smoking habits and cancer of the mouth and respiratory system. Cancer Res., 10, 539-542.
3. Wynder, E.L. and Graham, E.A. (1950) Tobacco smoking as a possible etiologic factor in bronchiogenic carcinoma. J. Am. Med. Assoc., 143, 329-336.
4. Blacklock, J.W.S. (1957) The production of lung tumours in rats by 3:4 benzopyrene, methylcholanthrene and the condensate from cigarette smoke. Br. J. Cancer, 11, 181-191.
5. Grimmer, G., Brune, H., Dettbarn, G., Naujack, K.-W., Mohr, U. and Wenzel-Hartung, R. (1988) Contribution of polycyclic aromatic compounds to the carcinogenicity of sidestream smoke of cigarettes evaluated by implantation into the lungs of rats. Cancer Lett., 43, 173-177.
6. Wynder, E.L. and Hoffmann, D. (1959) A study of tobacco carcinogenesis. VII. The role of higher polycyclic hydrocarbons. Cancer, 12(6), 1079-1086.
7. Henry, M.C., Port, C.D., Bates, R.R. and Kaufman, D.G. (1975) Respiratory tract tumors in hamsters induced by benzo[a]pyrene. Cancer Res., 33, 1585-1592.
8. Saffiotti, U., Cefis, F. and Kolb, L.H. (1968) A method for the experimental induction of bronchogenic carcinoma. Cancer Res., 28, 104-124.
9. Shabad, L.M. (1962) Experimental cancer of the lung. J. Natl Cancer Inst., 28(6), 1305-1317.
10. Sun, J.D., Wolff, R.K. and Kanapilly, G.M. (1982) Deposition, retention, and biological fate of inhaled benzo[a]pyrene adsorbed onto ultrafine particles and as a pure aerosol. Toxicol. Appl. Pharmacol., 65, 231-244.
11. Weyand, E.H. and Bevan, D.R. (1987) Species differences in disposition of benzo[a]pyrene. Drug Metab. Dispos., 15(4), 442-448.
12. Hecht, S.S., Morse, M.A., Amin, S., Stoner, G.D., Jordan, K.G., Choi, C.-I. and Chung, F.-L. (1989) Rapid single-dose model for lung tumor induction in A/J mice by 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet. Carcinogenesis, 10(10), 1901-1904.
13. Loeb, L.A., Ernster, V.L., Warner, K.E., Abbotts, J. and Laszlo, J. (1984) Smoking and lung cancer: An overview. Cancer Res., 44, 5940-5958.
14. Hoffmann, D., Rivenson, A., Murphy, S.E., Chung, F.-L., Amin, S. and Hecht, S.S. (1993) Cigarette smoking and adenocarcinoma of the lung: The relevance of nicotine-derived N-nitrosamines. J. Smok.-Rel. Dis., 4(3), 165-189.
15. Miller, E.C. and Miller, J.A. (1981) Mechanisms of chemical carcinogenesis. Cancer, 47 (Suppl.), 1055-1064.
16. Wall, K.L., Gao, W., Koppele, J.M., Kwei, G.Y., Kauffman, F.C. and Thurman, R.G. (1991) The liver plays a central role in the mechanism of chemical carcinogenesis due to polycyclic aromatic hydrocarbons. Carcinogenesis, 17(5), 783-786.
17. Wiersman, D.A. and Roth, R.A. (1983) The prediction of benzo[a]pyrene clearance by rat liver and lung from enzyme kinetic data. Mol. Pharmacol., 24, 300-308.
18. Wynder, E.L. and Hoffmann, D. (1994) Smoking and lung cancer: Scientific challenges and opportunities. Cancer Res., 54, 5284-5295.
19. Mackay, D., Shiu, W.Y. and Ma, K.C. (1992) Illustrated Handbook of Physical-Chemical Properties and Environmental Fate for Organic Chemicals. Lewis Publishers, Boca Raton, FL.
20. Gerde, P., Medinsky, M.A. and Bond, J.A. (1991) Particle-associated polycyclic aromatic hydrocarbons - a reappraisal of their possible role in pulmonary carcinogenesis. Toxicol. Appl. Pharmacol., 108, 1-13.
21. Gerde, P. and Scholander, P. (1987) A mathematical model of the penetration of polycyclic aromatic hydrocarbons through the bronchial lining layer. Environ. Res., 44, 321-334.
22. Hoover, M.D., Harkema, J.R., Muggenburg, B.A., Spoo, J.W., Gerde, P., Staller, H.J. and Hotchkiss, J.A. (1993) A microspray nozzle for local administration of liquids or suspensions to lung airways via bronchoscopy. J. Aerosol Med., 6(2), 67-72.
23. Plopper, C.G., Mariassy, A.T. and Lollini, L.O. (1983) Structure as revealed by airway dissection. A comparison of mammalian lungs. Am. Rev. Respir. Dis., 128 (Suppl.), S4-S7.
24. Dahl, A.R., Benson, J.M., Hanson, R.L. and Rothenberg, S.J. (1984) The fractionation of environmental samples according to volatility by vacuum line-cryogenic distillation. Am. Ind. Hyg. Assoc. J., 45(3), 193-198.
25. Knoche, H.W. and Bell, R.M. (1965) Tritium assay by combustion with a novel oxygen train and liquid scintillation techniques. Anal. Biochem., 12(1), 49-59.
26. Barman, S.A., Ardell, J.L., Parker, J.C., Perry, M.L. and Taylor, A.E. (1988) Pulmonary and systemic blood flow contributions to upper airways in canine lung. Am. J. Physiol., 255, H1130-H1135.
27. Gerde, P., Muggenburg, B.A., Hoover, M.D. and Henderson, R.F. (1993) Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog: I. The alveolar region. Toxicol. Appl. Pharmacol., 121, 313-318.
28. DHEW (1979) Smoking and Health: A Report of the Surgeon General. DHEW Publications, Washington, DC.
29. Hinds, W., First, M.W., Huber, G.L. and Shea, J.W. (1983) A method for measuring respiratory deposition of cigarette smoke during smoking. Am. Ind. Hyg. Assoc. J., 44(2), 113-118.
30. Weibel, E.R. (1963) Morphometry of the Human Lung. Springer-Verlag, Berlin.
31. Miller, M.E., Christensen, G.C. and Evans, H.E. (1964) The venous system. In Anatomy of the Dog. W.B. Saunders, Philadelphia, PA, pp. 389-429.
32. Gerde, P., Muggenburg, B.A., Sabourin, P.J., Harkema, J.R., Hotchkiss, J.A., Hoover, M.D. and Henderson, R.F. (1993) Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog: II. The conducting airways. Toxicol. Appl. Pharmacol., 121, 319-327.
33. Farr, S.J., Kellaway, I.W., Parry-Jones, D.R. and Woolfrey, S.G. (1985) 99m-Technetium as a marker of liposomal deposition and clearance in the human lung. Int. J. Pharmaceutics, 26, 303-316.
34. Morimoto, Y. and Adachi, Y. (1982) Pulmonary uptake of liposomal phosphatidylcholine upon intratracheal administration to rats. Chem. Pharm. Bull., 30(6), 2248-2251.
35. Cuddihy, R.G., Hall, R.P., Hobbs, C.H., Boecker, B.B. and Muggenburg, B.A. (1972) Tissue blood volumes and weights in adult beagle dogs. LF-45, UC-48, US Atomic Energy Commission.
36. Obana, H., Hori, S., Kashimoto, T. and Kunita, N. (1981) Polycyclic aromatic hydrocarbons in human fat and liver. Bull. Environ. Contam. Toxicol., 27, 23-27.
37. Gerde, P., Medinsky, M.A. and Bond, J.A. (1991) The retention of polycyclic aromatic hydrocarbons in the bronchial airways and in the alveolar region - a theoretical comparison. Toxicol. Appl. Pharmacol., 107, 239-252.
38. Dahl, A.R. (1995) Metabolic characteristics of the respiratory tract. In McClellan, R.O. and Henderson, R.F. (eds) Concepts in Inhalation Toxicology. Taylor and Francis, Washington, DC, pp. 175-190.
39. Gerde, P., Muggenburg, B.A. and Henderson, R.F. (1993) Disposition of polycyclic aromatic hydrocarbons in the respiratory tract of the beagle dog: III. Mechanisms of the dosimetry. Toxicol. Appl. Pharmacol., 121, 328-334.
40. Pott, F. (1989) A hypothesis for explaining the syncarcinogenic effect of cigarette smoke and asbestos. In Wehner, A.P. and Felton, D.-L. (eds) Biological Interactions of Inhaled Mineral Fibers and Cigarette Smoke. Battelle Press, Columbus, OH, pp. 52-62.
41. Bond, J.A., Harkema, J.R. and Russell, V.I. (1988) Regional distribution of xenobiotic metabolizing enzymes in respiratory airways of dogs. Drug Metab. Dispos., 16(1), 116-124.
42. Anttila, S., Hirvonen, A., Vainio, H., Husgafvel-Pursiainen, K., Hayes, J.D. and Ketterer, B. (1993) Immunohistochemical localization of glutathione S-transferase in human lung. Cancer Res., 53, 5643-5648.
43. Baron, J. and Voight, J.M. (1990) Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmacol. Ther., 47, 419-445.
44. McCoy, G.D., Rosenkrantz, H.S. and Klopman, G. (1990) Non-mutagenic carcinogens are primarily hydrophobic. Carcinogenesis, 11(7), 1111-1117.
45. Denissenko, M.F., Pao, A., Tang, M. and Pfeifer, G.P. (1996) Preferential formation of benzo[o]pyrene adducts at lung cancer mutational hotspots in p53. Science, 274, 430-432.