Dry powder inhalation exposures of the endotracheally intubated rat lung, ex vivo and in vivo: The pulmonary pharmacokinetics of fluticasone furoate

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 26, Issue 4, 2013, Pages 181-189

  Selg, Ewa ^a   Ewing, Pär ^b   Acevedo, Fernando ^a   Sjöberg, Carl Olof ^c   Ryrfeldt, Åke ^d   Gerde, Per ^a,d  

^a Inhalation Sciences Sweden AB   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Karolinska Institutet ^*  (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

corticosteroid; dry powder aerosol; endotracheally intubated rat; fluticasone furoate; inhalation; isolated perfused lung; pharmacokinetics; PK

Indexed keywords

FLUTICASONE FUROATE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG RETENTION; DRUG TISSUE LEVEL; DRY POWDER; DRY POWDER INHALER; ENDOTRACHEAL INTUBATION; FEMALE; ISOLATED LUNG; NONHUMAN; PARTICLE SIZE; RAT; TIDAL VOLUME; TIME TO MAXIMUM PLASMA CONCENTRATION; VENOUS BLOOD;

EID: 84880884209     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2012.0971     Document Type: Article

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