Delivering horseradish peroxidase as a respirable powder to the isolated, perfused, and ventilated lung of the rat: The pulmonary disposition of an inhaled model biopharmaceutical

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue 5, 2010, Pages 273-284

  Selg, Ewa ^a   Acevedo, Fernando ^a   Nybom, Rolf ^b   Blomgren, Bo ^c   Ryrfeldt, Ãke ^b   Gerde, Per ^a,b  

^a Inhalation Sciences Sweden AB   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

biologics; dry powder aerosol; inhalation exposure; pharmacokinetics

Indexed keywords

HORSERADISH PEROXIDASE; POLYARGININE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISPOSITION; DRUG EFFECT; DRUG EXPOSURE; DRUG MEGADOSE; FEMALE; LOW DRUG DOSE; LUNG ALVEOLUS EPITHELIUM; LUNG PERFUSION; LUNG VENTILATION; NEBULIZATION; NONHUMAN; RAT;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; EPITHELIAL CELLS; EXCIPIENTS; FEMALE; HORSERADISH PEROXIDASE; LUNG; NEBULIZERS AND VAPORIZERS; PEPTIDES; POWDERS; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; TIGHT JUNCTIONS; TISSUE DISTRIBUTION;

EID: 77958139123     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2009.0790     Document Type: Article

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