Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

Human Molecular Genetics

Volumn 25, Issue 13, 2016, Pages 2853-2861

  Hunter, Gillian ^a,b   Powis, Rachael A ^b   Jones, Ross A ^b   Groen, Ewout J N ^b   Shorrock, Hannah K ^b   Lane, Fiona M ^b   Zheng, Yinan ^b   Sherman, Diane L ^b   Brophy, Peter J ^b   Gillingwater, Thomas H ^b  

^a GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SURVIVAL MOTOR NEURON PROTEIN 1; SMN1 PROTEIN, MOUSE; SMN2 PROTEIN, MOUSE; SURVIVAL MOTOR NEURON PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; GENE LOSS; GENE OVEREXPRESSION; GENOTYPE; HUMAN; IMMUNOHISTOCHEMISTRY; MOTONEURON; MOUSE; MYELINATION; NERVOUS SYSTEM DEVELOPMENT; NEUROMUSCULAR FUNCTION; NEUROMUSCULAR JUNCTION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SCHWANN CELL; SPINAL MUSCULAR ATROPHY; SURVIVAL; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; GENETICS; GLIA; METABOLISM; MYELIN SHEATH; NERVE DEGENERATION; NEUROMUSCULAR DISEASE; PATHOLOGY; SPINAL CORD; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCULAR ATROPHY, SPINAL; MYELIN SHEATH; NERVE DEGENERATION; NEUROGLIA; NEUROMUSCULAR DISEASES; NEUROMUSCULAR JUNCTION; SCHWANN CELLS; SPINAL CORD; SURVIVAL OF MOTOR NEURON 1 PROTEIN; SURVIVAL OF MOTOR NEURON 2 PROTEIN;

EID: 85016017024     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddw141     Document Type: Article

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