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Volumn 127, Issue 3, 2017, Pages 1019-1030

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; CD5 ANTIGEN; CD69 ANTIGEN; CLODRONIC ACID; FATTY ACID; LEUKOTRIENE B4; FAT INTAKE; LEUKOTRIENE B4 RECEPTOR; LTB4R1 PROTEIN, MOUSE;

EID: 85015850164     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI90350     Document Type: Article
Times cited : (101)

References (50)
  • 1
    • 85015886599 scopus 로고    scopus 로고
    • National Diabetes Statistics Report: Estimates of Diabetes and its Burden in the United States, 2014. Centers for Disease Control and Prevention.. Accessed December 29
    • National Diabetes Statistics Report: Estimates of Diabetes and its Burden in the United States, 2014. Centers for Disease Control and Prevention. https://www.cdc.gov/diabetes/pubs/statsreport14/national-diabetes-report-web.pdf. Accessed December 29, 2016.
    • (2016)
  • 2
    • 84973376090 scopus 로고    scopus 로고
    • Trends in obesity among adults in the United States, 2005 to 2014
    • Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in Obesity Among Adults in the United States, 2005 to 2014. JAMA. 2016;315(21):2284-2291.
    • (2016) JAMA , vol.315 , Issue.21 , pp. 2284-2291
    • Flegal, K.M.1    Kruszon-Moran, D.2    Carroll, M.D.3    Fryar, C.D.4    Ogden, C.L.5
  • 3
    • 30944451953 scopus 로고    scopus 로고
    • Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    • Wilson PW, D'Agostino RB, Parise H, Sullivan L, Meigs JB. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112(20):3066-3072.
    • (2005) Circulation , vol.112 , Issue.20 , pp. 3066-3072
    • Wilson, P.W.1    D'Agostino, R.B.2    Parise, H.3    Sullivan, L.4    Meigs, J.B.5
  • 4
    • 84864244872 scopus 로고    scopus 로고
    • Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets
    • Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation-mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012;32(8):1771-1776.
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , Issue.8 , pp. 1771-1776
    • Romeo, G.R.1    Lee, J.2    Shoelson, S.E.3
  • 5
    • 84874045511 scopus 로고    scopus 로고
    • The origins and drivers of insulin resistance
    • Johnson AM, Olefsky JM. The origins and drivers of insulin resistance. Cell. 2013;152(4):673-684.
    • (2013) Cell , vol.152 , Issue.4 , pp. 673-684
    • Johnson, A.M.1    Olefsky, J.M.2
  • 6
    • 33845881411 scopus 로고    scopus 로고
    • Mechanisms linking obesity to insulin resistance and type 2 diabetes
    • Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121):840-846.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 840-846
    • Kahn, S.E.1    Hull, R.L.2    Utzschneider, K.M.3
  • 7
    • 79955487247 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
    • Holland WL, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest. 2011;121(5):1858-1870.
    • (2011) J Clin Invest , vol.121 , Issue.5 , pp. 1858-1870
    • Holland, W.L.1
  • 8
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest. 1995;95(5):2409-2415.
    • (1995) J Clin Invest , vol.95 , Issue.5 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 9
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821-1830.
    • (2003) J Clin Invest , vol.112 , Issue.12 , pp. 1821-1830
    • Xu, H.1
  • 10
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science. 1996;271(5249):665-668.
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 11
    • 0346880505 scopus 로고    scopus 로고
    • Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity-and diet-induced insulin resistance
    • Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity-and diet-induced insulin resistance. Int J Obes Relat Metab Disord. 2003;27 Suppl 3:S49-S52.
    • (2003) Int J Obes Relat Metab Disord , vol.27 , pp. S49-S52
    • Shoelson, S.E.1    Lee, J.2    Yuan, M.3
  • 12
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007;56(1):16-23.
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 13
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009;15(8):914-920.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 914-920
    • Nishimura, S.1
  • 14
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009;15(8):921-929.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 921-929
    • Winer, S.1
  • 15
    • 84878800136 scopus 로고    scopus 로고
    • Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
    • Morris DL, et al. Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes. 2013;62(8):2762-2772.
    • (2013) Diabetes , vol.62 , Issue.8 , pp. 2762-2772
    • Morris, D.L.1
  • 16
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta D, et al. PPAR-is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012;486(7404):549-553.
    • (2012) Nature , vol.486 , Issue.7404 , pp. 549-553
    • Cipolletta, D.1
  • 17
    • 84856533216 scopus 로고    scopus 로고
    • Increased macrophage migration into adipose tissue in obese mice
    • Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM. Increased macrophage migration into adipose tissue in obese mice. Diabetes. 2012;61(2):346-354.
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 346-354
    • Oh, D.Y.1    Morinaga, H.2    Talukdar, S.3    Bae, E.J.4    Olefsky, J.M.5
  • 18
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009;15(8):930-939.
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 930-939
    • Feuerer, M.1
  • 19
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer DA, et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011;17(5):610-617.
    • (2011) Nat Med , vol.17 , Issue.5 , pp. 610-617
    • Winer, D.A.1
  • 20
    • 84875548030 scopus 로고    scopus 로고
    • B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
    • DeFuria J, et al. B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci USA. 2013;110(13):5133-5138.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.13 , pp. 5133-5138
    • DeFuria, J.1
  • 21
    • 84957586830 scopus 로고    scopus 로고
    • MiR-150 regulates obesity-associated insulin resistance by controlling B cell functions
    • Ying W, et al. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Sci Rep. 2016;6:20176.
    • (2016) Sci Rep , vol.6 , pp. 20176
    • Ying, W.1
  • 22
    • 0023177955 scopus 로고
    • Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
    • Samuelsson B, Dahlén SE, Lindgren JA, Rouzer CA, Serhan CN. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 1987;237(4819):1171-1176.
    • (1987) Science , vol.237 , Issue.4819 , pp. 1171-1176
    • Samuelsson, B.1    Dahlén, S.E.2    Lindgren, J.A.3    Rouzer, C.A.4    Serhan, C.N.5
  • 23
    • 10944253095 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis
    • Haeggström JZ. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. J Biol Chem. 2004;279(49):50639-50642.
    • (2004) J Biol Chem , vol.279 , Issue.49 , pp. 50639-50642
    • Haeggström, J.Z.1
  • 25
    • 0142092620 scopus 로고    scopus 로고
    • Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues
    • Goodarzi K, Goodarzi M, Tager AM, Luster AD, von Andrian UH. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat Immunol. 2003;4(10):965-973.
    • (2003) Nat Immunol , vol.4 , Issue.10 , pp. 965-973
    • Goodarzi, K.1    Goodarzi, M.2    Tager, A.M.3    Luster, A.D.4    Von Andrian, U.H.5
  • 26
    • 57749205363 scopus 로고    scopus 로고
    • Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis
    • Sánchez-Galán E, et al. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. Cardiovasc Res. 2009;81(1):216-225.
    • (2009) Cardiovasc Res , vol.81 , Issue.1 , pp. 216-225
    • Sánchez-Galán, E.1
  • 27
    • 0030976460 scopus 로고    scopus 로고
    • A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    • Yokomizo T, Izumi T, Chang K, Takuwa Y, Shimizu T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997;387(6633):620-624.
    • (1997) Nature , vol.387 , Issue.6633 , pp. 620-624
    • Yokomizo, T.1    Izumi, T.2    Chang, K.3    Takuwa, Y.4    Shimizu, T.5
  • 28
    • 5344263063 scopus 로고    scopus 로고
    • Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes
    • Huang L, et al. Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Arterioscler Thromb Vasc Biol. 2004;24(10):1783-1788.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , Issue.10 , pp. 1783-1788
    • Huang, L.1
  • 29
    • 84937634493 scopus 로고    scopus 로고
    • Leukotriene B4-neutrophil elastase axis drives neutrophil reverse transendothelial cell migration in vivo
    • Colom B, et al. Leukotriene B4-neutrophil elastase axis drives neutrophil reverse transendothelial cell migration in vivo. Immunity. 2015;42(6):1075-1086.
    • (2015) Immunity , vol.42 , Issue.6 , pp. 1075-1086
    • Colom, B.1
  • 30
    • 77951630780 scopus 로고    scopus 로고
    • 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity
    • Horrillo R, et al. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity. J Immunol. 2010;184(7):3978-3987.
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3978-3987
    • Horrillo, R.1
  • 31
    • 80051939276 scopus 로고    scopus 로고
    • Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity
    • Spite M, et al. Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol. 2011;187(4):1942-1949.
    • (2011) J Immunol , vol.187 , Issue.4 , pp. 1942-1949
    • Spite, M.1
  • 32
    • 84914696693 scopus 로고    scopus 로고
    • Leukotriene production is increased in abdominal obesity
    • Bäck M, et al. Leukotriene production is increased in abdominal obesity. PLoS One. 2014;9(12):e104593.
    • (2014) PLoS One , vol.9 , Issue.12 , pp. e104593
    • Bäck, M.1
  • 33
    • 84865497318 scopus 로고    scopus 로고
    • Adipocytes secrete leukotrienes: Contribution to obesity-associated inflammation and insulin resistance in mice
    • Mothe-Satney I, et al. Adipocytes secrete leukotrienes: contribution to obesity-associated inflammation and insulin resistance in mice. Diabetes. 2012;61(9):2311-2319.
    • (2012) Diabetes , vol.61 , Issue.9 , pp. 2311-2319
    • Mothe-Satney, I.1
  • 34
    • 84925485114 scopus 로고    scopus 로고
    • LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
    • Li P, et al. LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015;21(3):239-247.
    • (2015) Nat Med , vol.21 , Issue.3 , pp. 239-247
    • Li, P.1
  • 35
    • 73249123069 scopus 로고    scopus 로고
    • Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization
    • Sears DD, et al. Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization. Proc Natl Acad Sci USA. 2009;106(44):18745-18750.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.44 , pp. 18745-18750
    • Sears, D.D.1
  • 36
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
    • Kitamura D, Roes J, Kühn R, Rajewsky K. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 1991;350(6317):423-426.
    • (1991) Nature , vol.350 , Issue.6317 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 37
    • 41949133387 scopus 로고    scopus 로고
    • BAFF enhances chemotaxis of primary human B cells: A particular synergy between BAFF and CXCL13 on memory B cells
    • Badr G, et al. BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells. Blood. 2008;111(5):2744-2754.
    • (2008) Blood , vol.111 , Issue.5 , pp. 2744-2754
    • Badr, G.1
  • 38
    • 84868275745 scopus 로고    scopus 로고
    • Depletion and reconstitution of macrophages in mice
    • Weisser SB, van Rooijen N, Sly LM. Depletion and reconstitution of macrophages in mice. J Vis Exp. 2012;66(66):e4105.
    • (2012) J Vis Exp , vol.66 , Issue.66 , pp. e4105
    • Weisser, S.B.1    Van Rooijen, N.2    Sly, L.M.3
  • 39
    • 77950479716 scopus 로고    scopus 로고
    • Liposomes for specific depletion of macrophages from organs and tissues
    • van Rooijen N, Hendrikx E. Liposomes for specific depletion of macrophages from organs and tissues. Methods Mol Biol. 2010;605:189-203.
    • (2010) Methods Mol Biol , vol.605 , pp. 189-203
    • Van Rooijen, N.1    Hendrikx, E.2
  • 40
    • 84878122228 scopus 로고    scopus 로고
    • In vivo depletion of leukocytes and platelets following injection of T cell-specific antibodies into mice
    • Loubaki L, Tremblay T, Bazin R. In vivo depletion of leukocytes and platelets following injection of T cell-specific antibodies into mice. J Immunol Methods. 2013;393(1-2):38-44.
    • (2013) J Immunol Methods , vol.393 , Issue.1-2 , pp. 38-44
    • Loubaki, L.1    Tremblay, T.2    Bazin, R.3
  • 41
    • 0034667933 scopus 로고    scopus 로고
    • Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis
    • Grcevi D, Lee SK, Marusi A, Lorenzo JA. Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25-dihydroxyvitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis. J Immunol. 2000;165(8):4231-4238.
    • (2000) J Immunol , vol.165 , Issue.8 , pp. 4231-4238
    • Grcevi, D.1    Lee, S.K.2    Marusi, A.3    Lorenzo, J.A.4
  • 42
    • 85060903811 scopus 로고    scopus 로고
    • Investigation of macrophage polarization using bone marrow derived macrophages
    • Ying W, Cheruku PS, Bazer FW, Safe SH, Zhou B. Investigation of macrophage polarization using bone marrow derived macrophages. J Vis Exp. 2013;76(76):e50323.
    • (2013) J Vis Exp , vol.76 , Issue.76 , pp. e50323
    • Ying, W.1    Cheruku, P.S.2    Bazer, F.W.3    Safe, S.H.4    Zhou, B.5
  • 43
    • 84946779883 scopus 로고    scopus 로고
    • MicroRNA-223 is a crucial mediator of PPARregulated alternative macrophage activation
    • Ying W, et al. MicroRNA-223 is a crucial mediator of PPARregulated alternative macrophage activation. J Clin Invest. 2015;125(11):4149-4159.
    • (2015) J Clin Invest , vol.125 , Issue.11 , pp. 4149-4159
    • Ying, W.1
  • 44
    • 38449104856 scopus 로고    scopus 로고
    • Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions
    • Peres CM, Aronoff DM, Serezani CH, Flamand N, Faccioli LH, Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol. 2007;179(8):5454-5461.
    • (2007) J Immunol , vol.179 , Issue.8 , pp. 5454-5461
    • Peres, C.M.1    Aronoff, D.M.2    Serezani, C.H.3    Flamand, N.4    Faccioli, L.H.5    Peters-Golden, M.6
  • 45
    • 59849118736 scopus 로고    scopus 로고
    • Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP
    • Lee SP, Serezani CH, Medeiros AI, Ballinger MN, Peters-Golden M. Crosstalk between prostaglandin E2 and leukotriene B4 regulates phagocytosis in alveolar macrophages via combinatorial effects on cyclic AMP. J Immunol. 2009;182(1):530-537.
    • (2009) J Immunol , vol.182 , Issue.1 , pp. 530-537
    • Lee, S.P.1    Serezani, C.H.2    Medeiros, A.I.3    Ballinger, M.N.4    Peters-Golden, M.5
  • 46
    • 84866983794 scopus 로고    scopus 로고
    • Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice
    • Aeffner F, Davis IC. Respiratory syncytial virus reverses airway hyperresponsiveness to methacholine in ovalbumin-sensitized mice. PLoS One. 2012;7(10):e46660.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e46660
    • Aeffner, F.1    Davis, I.C.2
  • 47
    • 84940104544 scopus 로고    scopus 로고
    • Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases?
    • Tsai S, Clemente-Casares X, Revelo XS, Winer S, Winer DA. Are obesity-related insulin resistance and type 2 diabetes autoimmune diseases? Diabetes. 2015;64(6):1886-1897.
    • (2015) Diabetes , vol.64 , Issue.6 , pp. 1886-1897
    • Tsai, S.1    Clemente-Casares, X.2    Revelo, X.S.3    Winer, S.4    Winer, D.A.5
  • 49
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest. 2006;116(6):1494-1505.
    • (2006) J Clin Invest , vol.116 , Issue.6 , pp. 1494-1505
    • Kanda, H.1
  • 50
    • 84962026512 scopus 로고    scopus 로고
    • Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice
    • Morinaga H, et al. Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice. Diabetes. 2015;64(4):1120-1130.
    • (2015) Diabetes , vol.64 , Issue.4 , pp. 1120-1130
    • Morinaga, H.1


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