Acute lymphoblastic leukaemia cells produce large extracellular vesicles containing organelles and an active cytoskeleton

Journal of Extracellular Vesicles

Volumn 6, Issue 1, 2017, Pages

  Johnson, Suzanne M ^a   Dempsey, Clare ^a   Parker, Catriona ^a   Mironov, Aleksandr ^a   Bradley, Helen ^b,d   Saha, Vaskar ^a,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c Tata Medical Centre   (India)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Acute lymphoblastic leukaemia; Biomarker; Extracellular vesicles; Intercellular vesicle transfer

Indexed keywords

BETA3 INTEGRIN; CD19 ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1;

ACTIVE CYTOSKELETON; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA; CELL ORGANELLE; CELL SHAPE; CHILD; CONTROLLED STUDY; CYTOSKELETON; EXOSOME; EXTRACELLULAR FLUID; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LARGE EXTRACELLULAR VESICLE; LEUKEMIA CELL LINE; LYSOSOME; MESENCHYME CELL; MOUSE; NONHUMAN; PATIENT DERIVED XENOGRAFT; PHENOTYPE; PHENOTYPIC TRANSFORMATION; TUMOR XENOGRAFT;

EID: 85015685520     PISSN: None     EISSN: 20013078     Source Type: Journal    
DOI: 10.1080/20013078.2017.1294339     Document Type: Article

References (32)

1. Kalra H, Drummen GP, Mathivanan S. Focus on extracellular vesicles: introducing the next small big thing. Int J Mol Sci. 2016;17(2):170.
2. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J Cell Biol. 2013;200 (4):373-383.
3. György B, Szabó TG, Pásztói M, et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci. 2011;68(16):2667-2688.
4. Yáñez-Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066.
5. Di Vizio D, Morello M, Dudley AC, et al. Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol. 2012;181(5):1573-1584.
6. Minciacchi VR, You S, Spinelli C, et al. Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles. Oncotarget. 2015;6(13):11327-11341.
7. Johnson SM, Dempsey C, Chadwick A, et al. Metabolic reprogramming of bone marrow stromal cells by leukemic extracellular vesicles in acute lymphoblastic leukemia. Blood. 2016;128(3):453-456.
8. Liu J, Masurekar A, Johnson S, et al. Stromal cellmediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia. Oncotarget. 2015;6(40):43048-43064.
9. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012;9 (7):671-675.
10. Patel N, Krishnan S, Offman MN, et al. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase. J Clin Invest. 2009;119(7):1964-1973.
11. Sexton KB, Witte MD, Blum G, et al. Design of cellpermeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain. Bioorg Med Chem Lett. 2007;17 (3):649-653.
12. Headland SE, Jones HR, Asv D, et al. Cutting-edge analysis of extracellular microparticles using imagestreamx imaging flow cytometry. Sci Rep. 2014;4:5237.
13. Lawrie AS, Albanyan A, Cardigan RA, et al. Microparticle sizing by dynamic light scattering in fresh-frozen plasma. Vox Sanguinis. 2009;96(3):206-212.
14. Paluch EK, Raz E. The role and regulation of blebs in cell migration. Curr Opin Cell Biol. 2013;25(5):582-590.
15. Lorentzen A, Bamber J, Sadok A, et al. An ezrin-rich, rigid uropod-like structure directs movement of amoeboid blebbing cells. J Cell Sci. 2011;124(Pt 8):1256-1267.
16. Holland M, Castro FV, Alexander S, et al. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 2011;118(3):638-649.
17. Janmey PA, Lindberg U. Cytoskeletal regulation: rich in lipids. Nat Rev Mol Cell Biol. 2004;5(8):658-666.
18. Croisé P, Estay-Ahumada C, Gasman S, et al. Rho GTPases, phosphoinositides, and actin: A tripartite framework for efficient vesicular trafficking. Small Gtpases. 2014;5(2):e29469.
19. Zomer A, Maynard C, Verweij FJ, et al. In Vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior. Cell. 2015;161(5):1046-1057.
20. Carr JM, Dvorak AM, Dvorak HF. Circulating membrane vesicles in leukemic blood. Cancer Res. 1985;45 (11 Pt 2):5944-5951.
21. van der Meer W, MacKenzie MA, Dinnissen JWB, et al. Pseudoplatelets: a retrospective study of their incidence and interference with platelet counting. J Clin Pathol. 2003;56(10):772-774.
22. Rustom A, Saffrich R, Markovic I, et al. Nanotubular highways for intercellular organelle transport. Science. 2004;303(5660):1007-1010.
23. Lim YS, Tang BL. Intercellular organelle trafficking by membranous nanotube connections: a possible new role in cellular rejuvenation? Cell Commun Adhes. 2012;19 (3-4):39-44.
24. Spees JL, Olson SD, Whitney MJ, et al. Mitochondrial transfer between cells can rescue aerobic respiration. Proc Natl Acad Sci U S A. 2006;103(5):1283-1288.
25. Peinado H, Aleckovic M, Lavotshkin S, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18(6):883-891.
26. Costa-Silva B, Aiello NM, Ocean AJ, et al. Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nat Cell Biol. 2015;17(6):816-826.
27. Moorman AV, Enshaei A, Schwab C, et al. A novel integrated cytogenetic and genomic classification refines risk stratification in pediatric acute lymphoblastic leukemia. Blood. 2014;124(9):1434-1444.
28. Irving JA, Enshaei A, Parker CA, et al. Integration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemia. Blood. 2016;128(7):911-922.
29. Ma X, Edmonson M, Yergeau D, et al. Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia. Nat Commun. 2015;6:6604.
30. Haeno H, Gonen M, Davis Meghan B, et al. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell. 2012;148(1-2):362-375.
31. Topp MS, Gökbuget N, Zugmaier G, et al. Phase II trial of the anti-CD19 bispecific T cell-engager blinatumomab shows hematologic and molecular remissions in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia. J Clin Oncol. 2014;32 (36):4134-4140.
32. Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371(16):1507-1517.