Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy

Molecular Therapy Nucleic Acids

Volumn 6, Issue , 2017, Pages 45-56

  Reschke, Cristina R ^a   Silva, Luiz F Almeida ^a   Norwood, Braxton A ^b,c   Senthilkumar, Ketharini ^a,d   Morris, Gareth ^e   Sanz Rodriguez, Amaya ^a   Conroy, Ronán M ^a   Costard, Lara ^b   Neubert, Valentin ^b   Bauer, Sebastian ^b,c   Farrell, Michael A ^f   O'Brien, Donncha F ^f   Delanty, Norman ^f   Schorge, Stephanie ^e   Pasterkamp, R Jeroen ^d   Rosenow, Felix ^b,c   Henshall, David C ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f BEAUMONT HOSPITAL   (Ireland)

Author keywords

anti epileptic drug; chemoconvulsant; epileptogenesis; hippocampal sclerosis; noncoding RNA; status epilepticus; temporal lobe epilepsy

Indexed keywords

ANTAGOMIR; LOCKED NUCLEIC ACID; LORAZEPAM; MESSENGER RNA; MICRORNA; MICRORNA 134; MOLECULAR MARKER; PENTETRAZOLE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ELECTROGRAPHY; EPILEPSY; EPILEPTIC DISCHARGE; EPILEPTIC STATE; EX VIVO STUDY; GENE SILENCING; HIPPOCAMPAL SLICE; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; PENTYLENETETRAZOLE-INDUCED SEIZURE; PRIORITY JOURNAL; RAT; TONIC CLONIC SEIZURE;

EID: 85015651505     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1016/j.omtn.2016.11.002     Document Type: Article

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