Inhibition of miR-203 Reduces Spontaneous Recurrent Seizures in Mice

Molecular Neurobiology

Volumn 54, Issue 5, 2017, Pages 3300-3308

  Lee, Soon Tae ^a,b   Jeon, Daejong ^a,c   Chu, Kon ^a,b   Jung, Keun Hwa ^a,b   Moon, Jangsup ^a,b   Sunwoo, Junsang ^a,b,d   Park, Dong Kyu ^a   Yang, Hyunwoo ^e   Park, Ji Hyun ^a   Kim, Manho ^a,b   Roh, Jae Kyu ^a,f   Lee, Sang Kun ^a,b  

^a Seoul National University Hospital   (South Korea)

^b Seoul National University   (South Korea)

^c Advanced Neural Technologies Co   (South Korea)

^d Soonchunhyang University   (South Korea)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^f The Armed Forces Capital Hospital   (South Korea)

Author keywords

Antagomir; Epilepsy; Glycine receptor beta; microRNA; Spontaneous recurrent seizure

Indexed keywords

AM 203; ANTAGOMIR; GLYCINE RECEPTOR; GLYCINE RECEPTOR BETA; MICRORNA; MICRORNA 203; UNCLASSIFIED DRUG; MIRN203 MICRORNA, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; EPILEPSY; EPILEPTIC STATE; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MOUSE; NONHUMAN; TISSUE DISTRIBUTION; UPREGULATION; ANIMAL; C57BL MOUSE; CHRONIC DISEASE; GENETICS; METABOLISM; PATHOLOGY; PROTEIN SUBUNIT; RECURRENT DISEASE; SEIZURE;

ANIMALS; CHRONIC DISEASE; EPILEPSY; MALE; MICE, INBRED C57BL; MICRORNAS; PROTEIN SUBUNITS; RECEPTORS, GLYCINE; RECURRENCE; SEIZURES; UP-REGULATION;

EID: 84966460595     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-9901-7     Document Type: Article

References (39)

1. Thurman DJ, Beghi E, Begley CE, Berg AT, Buchhalter JR, Ding D, Hesdorffer DC, Hauser WA (2011) Standards for epidemiologic studies and surveillance of epilepsy. Epilepsia 52(Suppl 7):2–26
2. Moshe SL, Perucca E, Ryvlin P, Tomson T (2015) Epilepsy: new advances. Lancet 385:884–898
3. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL et al (2012) Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia 53:571–582
4. Dutertre S, Becker CM, Betz H (2012) Inhibitory glycine receptors: an update. J Biol Chem 287:40216–40223
5. Davies JS, Chung SK, Thomas RH, Robinson A, Hammond CL, Mullins JG, Carta E, Pearce BR et al (2010) The glycinergic system in human startle disease: a genetic screening approach. Front Mol Neurosci 3:8
6. Trapani G, Latrofa A, Franco M, Carrieri A, Cellamare S, Serra M, Sanna E, Biggio G et al (2003) Alpidem analogues containing a GABA or glycine moiety as new anticonvulsant agents. Eur J Pharm Sci 18:231–240
7. Mohammadi B, Krampfl K, Cetinkaya C, Wolfes H, Dengler R, Bufler J (2005) Interaction of topiramate with glycine receptor channels. Pharmacol Res 51:587–592
8. Kim VN, Han J, Siomi MC (2009) Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 10:126–139
9. Lee ST, Chu K, Jung KH, Yoon HJ, Jeon D, Kang KM, Park KH, Bae EK et al (2010) MicroRNAs induced during ischemic preconditioning. Stroke 41:1646–1651
10. Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A (2007) A microRNA feedback circuit in midbrain dopamine neurons. Science 317:1220–1224
11. Lee ST, Chu K, Jung KH, Kim JH, Huh JY, Yoon H, Park DK, Lim JY et al (2012) miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol 72:269–277
12. Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G et al (2010) Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 30:92–101
13. Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan RC, Mouri G, Tanaka K, Sano T et al (2011) miRNA Expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. Am J Pathol 179:2519–2532
14. Hu K, Xie YY, Zhang C, Ouyang DS, Long HY, Sun DN, Long LL, Feng L et al (2012) MicroRNA expression profile of the hippocampus in a rat model of temporal lobe epilepsy and miR-34a-targeted neuroprotection against hippocampal neurone cell apoptosis post-status epilepticus. BMC Neurosci 13:115
15. Aronica E, Fluiter K, Iyer A, Zurolo E, Vreijling J, van Vliet EA, Baayen JC, Gorter JA (2010) Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Eur J Neurosci 31:1100–1107
16. Sun Z, Yu JT, Jiang T, Li MM, Tan L, Zhang Q, Tan L (2013) Genome-wide microRNA profiling of rat hippocampus after status epilepticus induced by amygdala stimulation identifies modulators of neuronal apoptosis. PLoS One 8:e78375
17. Kan AA, van Erp S, Derijck AA, de Wit M, Hessel EV, O’Duibhir E, de Jager W, Van Rijen PC et al (2012) Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cell Mol Life Sci 69:3127–3145
18. McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C et al (2012) Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis. PLoS One 7:e35921
19. Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O’Tuathaigh C et al (2012) Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 18:1087–1094
20. McKiernan RC, Jimenez-Mateos EM, Sano T, Bray I, Stallings RL, Simon RP, Henshall DC (2012) Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Exp Neurol 237:346–354
21. Harvey RJ, Yee BK (2013) Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov 12:866–885
22. Weltzien F, Puller C, O’Sullivan GA, Paarmann I, Betz H (2012) Distribution of the glycine receptor beta-subunit in the mouse CNS as revealed by a novel monoclonal antibody. J Comp Neurol 520:3962–3681
23. Treiman DM (2001) GABAergic mechanisms in epilepsy. Epilepsia 42(Suppl 3):8–12
24. Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32:281–294
25. Jeon D, Chu K, Lee ST, Jung KH, Kang KM, Ban JJ, Kim S, Seo JS et al (2011) A cell-free extract from human adipose stem cells protects mice against epilepsy. Epilepsia 52:1617–1626
26. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15–20
27. Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I et al (2005) Combinatorial microRNA target predictions. Nat Genet 37:495–500
28. Kiriakidou M, Nelson PT, Kouranov A, Fitziev P, Bouyioukos C, Mourelatos Z, Hatzigeorgiou A (2004) A combined computational-experimental approach predicts human microRNA targets. Genes Dev 18:1165–1178
29. Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Ørum H (2010) Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327:198–201
30. Zhao C, Huang C, Weng T, Xiao X, Ma H, Liu L (2012) Computational prediction of MicroRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor. BMC Res Notes 5:91
31. Dhuria SV, Hanson LR, Frey WH 2nd (2010) Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J Pharm Sci 99:1654–1673
32. Reger MA, Watson GS, Green PS, Wilkinson CW, Baker LD, Cholerton B, Fishel MA, Plymate SR et al (2008) Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 70:440–448
33. Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E (2010) miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2:415–431
34. Sonkoly E, Stahle M, Pivarcsi A (2008) MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation. Semin Cancer Biol 18:131–140
35. Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM (2008) Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 76:582–588
36. Monk CE, Hutvagner G, Arthur JS (2010) Regulation of miRNA transcription in macrophages in response to Candida albicans. PLoS One 5:e13669
37. Redell JB, Zhao J, Dash PK (2011) Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J Neurosci Res 89:212–221
38. Nudelman AS, DiRocco DP, Lambert TJ, Garelick MG, Le J, Nathanson NM, Storm DR (2010) Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus 20:492–498
39. Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK et al (2013) Treatment of HCV infection by targeting microRNA. N Engl J Med 368:1685–1694