MiR-134 blockade prevents status epilepticus like-activity and is neuroprotective in cultured hippocampal neurons

Neuroscience Letters

Volumn 572, Issue , 2014, Pages 20-25

  Wang, Xiao Mu ^a   Jia, Rui Hua ^b   Wei, Dong ^a   Cui, Wei Yun ^c   Jiang, Wen ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Department of Neurology People's Liberation Army 457th Hospital   (China)

^c Tianjin Neurological Institute   (China)

Author keywords

Hippocampal cultures; Lentivirus; MiR 134; Status epilepticus

Indexed keywords

LIM KINASE 1; MAGNESIUM; MICRORNA; MICRORNA 134; UNCLASSIFIED DRUG; LIM KINASE; LIMK1 PROTEIN, RAT; MIRN134 MICRORNA, RAT;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BINDING SITE; CONTROLLED STUDY; ELECTROGRAPHY; EPILEPTIC STATE; GENE EXPRESSION; HIPPOCAMPAL NEURONAL CULTURE; LENTIVIRINAE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; GENETICS; HIPPOCAMPUS; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIMARY CELL CULTURE; SPRAGUE DAWLEY RAT;

ANIMALS; HIPPOCAMPUS; LENTIVIRUS; LIM KINASES; MICRORNAS; NEURONS; PRIMARY CELL CULTURE; RATS, SPRAGUE-DAWLEY; STATUS EPILEPTICUS;

EID: 84901947365     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.04.049     Document Type: Article

References (22)

1. DeLorenzo R.J., Pellock J.M., Towne A.R., Boggs J.G. Epidemiology of status epilepticus. J. Clin. Neurophysiol. 1995, 12:316-325.
2. DeLorenzo R.J. Epidemiology and clinical presentation of status epilepticus. Adv. Neurol. 2006, 97:199-215.
3. Li J.M., Chen L., Zhou B., Zhu Y., Zhou D. Convulsive status epilepticus in adults and adolescents of southwest China: mortality, etiology, and predictors of death. Epilepsy Behav. 2009, 14:146-149.
4. Kosik K.S. The neuronal microRNA system. Nat. Rev. Neurosci. 2006, 7:911-920.
5. Dogini D.B., Avansini S.H., Vieira A.S., Lopes-Cendes I. MicroRNA regulation and dysregulation in epilepsy. Front. Cell. Neurosci. 2013, 7:172.
6. Henshall D.C. MicroRNA and epilepsy: profiling, functions and potential clinical applications. Curr. Opin. Neurol. 2014, 27:199-205.
7. Ma Y., Ramachandran A., Ford N., Parada I., Prince D.A. Remodeling of dendrites and spines in the C1q knockout model of genetic epilepsy. Epilepsia 2013, 54:1232-1239.
8. Swann J.W., Al-Noori S., Jiang M., Lee C.L. Spine loss and other dendritic abnormalities in epilepsy. Hippocampus 2000, 10:617-625.
9. Jimenez-Mateos E.M., Engel T., Merino-Serrais P., McKiernan R.C., Tanaka K., Mouri G., Sano T., O'Tuathaigh C., Waddington J.L., Prenter S., Delanty N., Farrell M.A., O'Brien D.F., Conroy R.M., Stallings R.L., DeFelipe J., Henshall D.C. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat. Med. 2012, 18:1087-1094.
10. Schratt G.M., Tuebing F., Nigh E.A., Kane C.G., Sabatini M.E., Kiebler M., Greenberg M.E. A brain-specific microRNA regulates dendritic spine development. Nature 2006, 439:283-289.
11. Fiore R., Khudayberdiev S., Christensen M., Siegel G., Flavell S.W., Kim T.K., Greenberg M.E., Schratt G. Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009, 28:697-710.
12. Gao J., Wang W.Y., Mao Y.W., Graff J., Guan J.S., Pan L., Mak G., Kim D., Su S.C., Tsai L.H. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature 2010, 466:1105-1109.
13. Gaughwin P., Ciesla M., Yang H., Lim B., Brundin P. Stage-specific modulation of cortical neuronal development by Mmu-miR-134. Cerebr. Cortex 2011, 21:1857-1869.
14. Delorenzo R.J., Sun D.A., Deshpande L.S. Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy. Pharmacol. Ther. 2005, 105:229-266.
15. Mangan P.S., Kapur J. Factors underlying bursting behavior in a network of cultured hippocampal neurons exposed to zero magnesium. J. Neurophysiol. 2004, 91:946-957.
16. Sombati S., Delorenzo R.J. Recurrent spontaneous seizure activity in hippocampal neuronal networks in culture. J. Neurophysiol. 1995, 73:1706-1711.
17. Chiang C.W., Chen Y.C., Lu J.C., Hsiao Y.T., Chang C.W., Huang P.C., Chang Y.T., Chang P.Y., Wang C.T. Synaptotagmin I regulates patterned spontaneous activity in the developing rat retina via calcium binding to the C2AB domains. PLoS ONE 2012, 7:e47465.
18. Drislane F.W. Presentation, evaluation, and treatment of nonconvulsive status epilepticus. Epilepsy Behav. 2000, 1:301-314.
19. Duncan J.S. Seizure-induced neuronal injury: human data. Neurology 2002, 59:S15-S20.
20. Fujikawa D.G. Prolonged seizures and cellular injury: understanding the connection. Epilepsy Behav. 2005, 7(Suppl. 3):S3-S11.
21. Lowenstein D.H., Alldredge B.K. Status epilepticus. N. Engl. J. Med. 1998, 338:970-976.
22. Deshpande L.S., Lou J.K., Mian A., Blair R.E., Sombati S., DeLorenzo R.J. In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Res. 2007, 75:171-179.