The neurobiology of depression: An integrated view

Asian Journal of Psychiatry

Volumn 27, Issue , 2017, Pages 101-111

  Dean, Jason ^a   Keshavan, Matcheri ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Attachment; Biology; Depression; Inflammation; MDD; Neurobiology; Neurogenesis; Psychology; Serotonin; Stress

Indexed keywords

MONOAMINE;

CHRONIC STRESS; DEPRESSION; DISEASE PREDISPOSITION; ENDOPHENOTYPE; HUMAN; HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVOUS SYSTEM DEVELOPMENT; NEUROBIOLOGY; NEUROTRANSMISSION; NONHUMAN; PATHOPHYSIOLOGY; PSYCHOLOGICAL ASPECT; REVIEW; IMMUNOLOGY; METABOLISM;

DEPRESSIVE DISORDER; HUMANS;

EID: 85015641899     PISSN: 18762018     EISSN: 18762026     Source Type: Journal    
DOI: 10.1016/j.ajp.2017.01.025     Document Type: Review

References (69)

1. Acheson, A., Conover, J.C., Fandl, J.P., DeChiara, T.M., Russell, M., Thadani, A., Squinto, S.P., Yancopoulos, G.D., Lindsay, R.M., A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature, 1995.
2. Ahmad, A., Rasheed, N., Banu, N., Palit, G., Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress 13:4 (2010), 356–365.
3. Alfarez, D.N., Wiegert, O., Joels, M., Krugers, H.J., Corticosterone and stress reduce synaptic potentiation in mouse hippocampal slices with mild stimulation. Neuroscience 115:4 (2002), 1119–1126.
4. Banasr, M., Hery, M., Printemps, R., Daszuta, A., Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology 29:3 (2004), 450–460.
5. Beck, A.T., The evolution of the cognitive model of depression and its neurobiological correlates. Am. J. Psychiatry 165:August (8) (2008), 969–977.
6. Bell, C., Abrams, J., Nutt, D., Tryptophan depletion and its implications for psychiatry. Br. J. Psychiatry 178:5 (2001), 399–405.
7. Bibring, E., The Mechanism of Depression. 1953.
8. Black, P.H., The inflammatory response is an integral part of the stress response: implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav. Immun. 17:5 (2003), 350–364.
9. Bowlby, J., 1980. Loss: Sadness and Depression, 3, Basic Books.
10. Brady, R.O., Keshavan, M., Emergent treatments based on the pathophysiology of bipolar disorder: a selective review. Asian J. Psychiatry 18:December (2015), 15–21.
11. Brady, R. Jr., Öngür, D., Keshavan, M., Neurobiology of mood-state shifts in bipolar disorder: a selective review and a hypothesis. Harv. Rev. Psychiatry 22:January–February (1) (2014), 23–30.
12. Brezun, J.M., Daszuta, A., Serotonergic reinnervation reverses lesion-induced decreases in PSA-nCAM labeling and proliferation of hippocampal cells in adult rats. Hippocampus 10:1 (2000), 37–46.
13. Carlin, J.M., Ozaki, Y., Byrne, G.I., Brown, R.R., Borden, E.C., Interferons and indoleamine 2, 3-dioxygenase: role in antimicrobial and antitumor effects. Experientia 45:6 (1989), 535–541.
14. Caspi, A., Hariri, A.R., Holmes, A., Uher, R., Moffitt, T.E., Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Focus 8:July (3) (2010), 398–416.
15. Castrén, E., Rantamäki, T., The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity. Dev. Neurobiol. 70:5 (2010), 289–297.
16. Castrén, E., Neuronal network plasticity and recovery from depression. JAMA Psychiatry 70:9 (2013), 983–989.
17. Center for Disease Control and Prevention, Depression in the U.S. Household Population, 2009–2012. 2014 (Accessed 12 August 2016) http://www.cdc.gov/nchs/data/databriefs/db172.htm.
18. Cerqueira, J.J., Pêgo, J.M., Taipa, R., Bessa, J.M., Almeida, O.F., Sousa, N., Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors. J. Neurosci. 25:34 (2005), 7792–7800.
19. Drevets, W.C., Price, J.L., Simpson, J.R. Jr., Todd, R.D., Reich, T., Vannier, M., Raichle, M.E., Subgenual prefrontal cortex abnormalities in mood disorders. Nature(April (24)), 1997 386 (6627);824.
20. Duvarci, S., Paré, D., Glucocorticoids enhance the excitability of principal basolateral amygdala neurons. J. Neurosci. 27:16 (2007), 4482–4491.
21. El Mansari, M., Guiard, B.P., Chernoloz, O., Ghanbari, R., Katz, N., Blier, P., Relevance of norepinephrine–dopamine interactions in the treatment of major depressive disorder. CNS Neurosci. Ther. 16:3 (2010), e1–e17.
22. Fabbri, C., Marsano, A., Serretti, A., Genetics of serotonin receptors and depression: state of the art. Curr. Drug Targets 14:5 (2013), 531–548.
23. Felger, J.C., Lotrich, F.E., Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications. Neuroscience 246 (2013), 199–229.
24. Fisher, M., Mellon, S.H., Wolkowitz, O., Vinogradov, S., Neuroscience-informed auditory training in schizophrenia: a final report of the effects on cognition and serum brain-derived neurotrophic factor. Schizophr. Res.: Cognit. 3 (2016), 1–7.
25. Freud, S., Mourning and Melancholia. Standard Edition, vol. 14, 1917, 237–258.
26. Greenberg, P.E., Kessler, R.C., Birnbaum, H.G., Leong, S.A., Lowe, S.W., Berglund, P.A., Corey-Lisle, P.K., The economic burden of depression in the United States: how did it change between 1990 and 2000?. J. Clin. Psychiatry 64:12 (2003), 1465–1475.
27. Hanson, J.L., Knodt, A.R., Brigidi, B.D., Hariri, A.R., Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress. Dev. Psychopathol. 27:4 pt 2 (2015), 1611–1619.
28. Holmes, J., An attachment model of depression: integrating findings from the mood disorder laboratory. Psychiatry 76:1 (2013), 68–86.
29. Iadarola, N.D., Niciu, M.J., Richards, E.M., Voort, J.L.V., Ballard, E.D., Lundin, N.B., Nugent, A.C., Machado-Vieira, R., Zarate, C.A., Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther. Adv. Chronic Dis., 2015 p. 2040622315579059.
30. Kendler, K.S., Karkowski, L.M., Prescott, C.A., Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry, 1999.
31. Kendler, K.S., Toward a philosophical structure for psychiatry. Am. J. Psychiatry, 2005.
32. Kernberg, O.F., An integrated theory of depression. Neuropsychoanalysis 11:1 (2009), 76–80.
33. Klein, M., Mourning and its relation to manic-depressive states. Int. J. Psycho-Anal., 21, 1940, p.125.
34. Leonard, B.E., Stress, norepinephrine and depression. J. Psychiatry Neurosci., 26(Suppl), 2001, S11.
35. Machado-Vieira, R., Salvadore, G., DiazGranados, N., Ibrahim, L., Latov, D., Wheeler-Castillo, C., Baumann, J., Henter, I.D., Zarate, C.A., New therapeutic targets for mood disorders. Sci. World J. 10 (2010), 713–726.
36. Mayberg, H.S., Positron emission tomography imaging in depression: a neural systems perspective. Neuroimag. Clin. N. Am. 13:November (4) (2003), 805–815.
37. Molteni, R., Calabrese, F., Bedogni, F., Tongiorgi, E., Fumagalli, F., Racagni, G., Riva, M.A., Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions. Int. J. Neuropsychopharmacol. 9:03 (2006), 307–317.
38. Monteleone, P., Serritella, C., Martiadis, V., Maj, M., Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders. Bipolar Disord. 10:1 (2008), 95–100.
39. Müller, N., Schwarz, M.J., The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression. Mol. Psychiatry 12:11 (2007), 988–1000.
40. Myers, B., McKlveen, J.M., Herman, J.P., Glucocorticoid actions on synapses, circuits, and behavior: implications for the energetics of stress. Front. Neuroendocrinol. 35:2 (2014), 180–196.
41. Nestler, E.J., Carlezon, W.A., The mesolimbic dopamine reward circuit in depression. Biol. Psychiatry 59:12 (2006), 1151–1159.
42. Pasco, J.A., Nicholson, G.C., Williams, L.J., Jacka, F.N., Henry, M.J., Kotowicz, M.A., Schneider, H.G., Leonard, B.E., Berk, M., Association of high-sensitivity C-reactive protein with de novo major depression. Br. J. Psychiatry 197:5 (2010), 372–377.
43. Pechtel, P., Pizzagalli, D.A., Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology (Berl.) 214:1 (2011), 55–70.
44. Pruessner, M., Hellhammer, D.H., Pruessner, J.C., Lupien, S.J., Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening. Psychosom. Med. 65:1 (2003), 92–99.
45. Richelson, E., Pharmacology of antidepressants. May (5) Mayo Clinic Proceedings, 76, 2001, Elsevier, 511–527.
46. Rocha, R.B., Dondossola, E.R., Grande, A.J., Colonetti, T., Ceretta, L.B., Passos, I.C., Quevedo, J., da Rosa, M.I., Increased BDNF levels after electroconvulsive therapy in patients with major depressive disorder: a meta-analysis study. J. Psychiatr. Res. 83 (2016), 47–53.
47. Rosenblat, J.D., Cha, D.S., Mansur, R.B., McIntyre, R.S., Inflamed moods: a review of the interactions between inflammation and mood disorders. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 53 (2014), 23–34.
48. Sale, A., Vetencourt, J.F.M., Medini, P., Cenni, M.C., Baroncelli, L., De Pasquale, R., Maffei, L., Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition. Nat. Neurosci. 10:6 (2007), 679–681.
49. Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C., Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:5634 (2003), 805–809.
50. Scher, C.D., Ingram, R.E., Segal, Z.V., Cognitive reactivity and vulnerability: empirical evaluation of construct activation and cognitive diatheses in unipolar depression. Clin. Psychol. Rev. 25:4 (2005), 487–510.
51. Schwabe, L., Tegenthoff, M., Höffken, O., Wolf, O.T., Mineralocorticoid receptor blockade prevents stress-induced modulation of multiple memory systems in the human brain. Biol. Psychiatry 74:11 (2013), 801–808.
52. Sekar, A., Bialas, A.R., de Rivera, H., Davis, A., Hammond, T.R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., Genovese, G., Schizophrenia risk from complex variation of complement component 4. Nature 530:7589 (2016), 177–183.
53. Shang, Y., Wang, X., Shang, X., Zhang, H., Liu, Z., Yin, T., Zhang, T., Repetitive transcranial magnetic stimulation effectively facilitates spatial cognition and synaptic plasticity associated with increasing the levels of BDNF and synaptic proteins in Wistar rats. Neurobiol. Learn. Mem. 134 (2016), 369–378.
54. Sheline, Y.I., Neuroimaging studies of mood disorder effects on the brain. Biol. Psychiatry 54:August (3) (2003), 338–352.
55. Singh, R.B., Gupta, S., Dherange, P., De Meester, F., Wilczynska, A., Alam, S.E., Pella, D., Wilson, D.W., Metabolic syndrome: a brain disease. Can. J. Physiol. Pharmacol. 90:9 (2012), 1171–1183.
56. Smyth, G.P., Stapleton, P.P., Freeman, T.A., Concannon, E.M., Mestre, J.R., Duff, M., Maddali, S., Daly, J.M., Glucocorticoid pretreatment induces cytokine overexpression and nuclear factor-κB activation in macrophages. J. Surg. Res. 116:2 (2004), 253–261.
57. Sorrells, S.F., Caso, J.R., Munhoz, C.D., Sapolsky, R.M., The stressed CNS: when glucocorticoids aggravate inflammation. Neuron 64:1 (2009), 33–39.
58. Steptoe, A., Hamer, M., Chida, Y., The effects of acute psychological stress on circulating inflammatory factors in humans: a review and meta-analysis. Brain Behav. Immun. 21:7 (2007), 901–912.
59. Straub, R.H., Cutolo, M., Buttgereit, F., Pongratz, G., Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases. J. Intern. Med. 267:6 (2010), 543–560.
60. Taliaz, D., Stall, N., Dar, D.E., Zangen, A., Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol. Psychiatry 15:1 (2010), 80–92.
61. Taylor, W.D., Aizenstein, H.J., Alexopoulos, G.S., The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol. Psychiatry 18:9 (2013), 963–974.
62. Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., Cella, D., Etanercept and clinical outcomes, fatigue, and depression in psoriasis: double-blind placebo-controlled randomised phase III trial. Lancet 367:9504 (2006), 29–35.
63. Vetencourt, J.F.M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., O'Leary, O.F., Castrén, E., Maffei, L., The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science 320:5874 (2008), 385–388.
64. Watt, D.F., Panksepp, J., Depression: an evolutionarily conserved mechanism to terminate separation distress? A review of aminergic, peptidergic, and neural network perspectives. Neuropsychoanalysis 11:1 (2009), 7–51.
65. Weiss, G., Murr, C., Zoller, H., Haun, M., Widner, B., Ludescher, C., Fuchs, D., Modulation of neopterin formation and tryptophan degradation by Th1-and Th2-derived cytokines in human monocytic cells. Clin. Exp. Immunol. 116:3 (1999), 435–440.
66. Wichers, M.C., Kenis, G., Koek, G.H., Robaeys, G., Nicolson, N.A., Maes, M., Interferon-α-induced depressive symptoms are related to changes in the cytokine network but not to cortisol. J. Psychosom. Res. 62:2 (2007), 207–214.
67. Willner, P., Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52:2 (2005), 90–110.
68. World Health Organization, Investing In Mental Health. 2003 (Accessed 30 March 2016) http://www.who.int/mental_health/media/investing_mnh.pdf.
69. Wright, C.E., Strike, P.C., Brydon, L., Steptoe, A., Acute inflammation and negative mood: mediation by cytokine activation. Brain Behav. Immun. 19:4 (2005), 345–350.