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Volumn 8, Issue 9, 2016, Pages 297-305

Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease

Author keywords

Cardiovascular disease; Exosomes; Mesenchymal stem cells; Messenger RNA; MicroRNA; Stem cells

Indexed keywords


EID: 85015389636     PISSN: None     EISSN: 19480210     Source Type: Journal    
DOI: 10.4252/wjsc.v8.i9.297     Document Type: Short Survey
Times cited : (64)

References (79)
  • 1
    • 0036266426 scopus 로고    scopus 로고
    • Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects
    • discussion1926 PMID: 12078791
    • Shake JG, Gruber PJ, Baumgartner WA, Senechal G, Meyers J, Redmond JM, Pittenger MF, Martin BJ. Mesenchymal stem cell implantation in a swine myocardial infarct model: engraftment and functional effects. Ann Thorac Surg 2002; 73: 1919-1925; discussion1926 [PMID: 12078791 DOI: 10.1016/S0003-4975(02)03517-8]
    • (2002) Ann Thorac Surg , vol.73 , pp. 1919-1925
    • Shake, J.G.1    Gruber, P.J.2    Baumgartner, W.A.3    Senechal, G.4    Meyers, J.5    Redmond, J.M.6    Pittenger, M.F.7    Martin, B.J.8
  • 2
    • 0036142213 scopus 로고    scopus 로고
    • Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    • PMID: 11772882
    • Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002; 105: 93-98 [PMID:11772882 DOI: 10.1161/hc0102.101442]
    • (2002) Circulation , vol.105 , pp. 93-98
    • Toma, C.1    Pittenger, M.F.2    Cahill, K.S.3    Byrne, B.J.4    Kessler, P.D.5
  • 5
    • 3042662157 scopus 로고    scopus 로고
    • Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction
    • PMID: 15219514
    • Chen SL, Fang WW, Ye F, Liu YH, Qian J, Shan SJ, Zhang JJ, Chunhua RZ, Liao LM, Lin S, Sun JP. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute myocardial infarction. Am J Cardiol 2004; 94: 92-95 [PMID: 15219514 DOI: 10.1016/ j.amjcard.2004.03.034]
    • (2004) Am J Cardiol , vol.94 , pp. 92-95
    • Chen, S.L.1    Fang, W.W.2    Ye, F.3    Liu, Y.H.4    Qian, J.5    Shan, S.J.6    Zhang, J.J.7    Chunhua, R.Z.8    Liao, L.M.9    Lin, S.10    Sun, J.P.11
  • 11
    • 33646269967 scopus 로고    scopus 로고
    • A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction
    • PMID: 16510464
    • Freyman T, Polin G, Osman H, Crary J, Lu M, Cheng L, Palasis M, Wilensky RL. A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J 2006; 27: 1114-1122 [PMID: 16510464 DOI: 10.1093/eurheartj/ehi818]
    • (2006) Eur Heart J , vol.27 , pp. 1114-1122
    • Freyman, T.1    Polin, G.2    Osman, H.3    Crary, J.4    Lu, M.5    Cheng, L.6    Palasis, M.7    Wilensky, R.L.8
  • 12
    • 66249096305 scopus 로고    scopus 로고
    • Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect
    • PMID: 19099374
    • Fischer UM, Harting MT, Jimenez F, Monzon-Posadas WO, Xue H, Savitz SI, Laine GA, Cox CS. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 2009; 18: 683-692 [PMID: 19099374 DOI: 10.1089/ scd.2008.0253]
    • (2009) Stem Cells Dev , vol.18 , pp. 683-692
    • Fischer, U.M.1    Harting, M.T.2    Jimenez, F.3    Monzon-Posadas, W.O.4    Xue, H.5    Savitz, S.I.6    Laine, G.A.7    Cox, C.S.8
  • 14
    • 33646252939 scopus 로고    scopus 로고
    • Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cellmediated cardiac protection and functional improvement
    • PMID: 16581974
    • Gnecchi M, He H, Noiseux N, Liang OD, Zhang L, Morello F, Mu H, Melo LG, Pratt RE, Ingwall JS, Dzau VJ. Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cellmediated cardiac protection and functional improvement. FASEB J 2006; 20: 661-669 [PMID: 16581974 DOI: 10.1096/fj.05-5211com]
    • (2006) FASEB J , vol.20 , pp. 661-669
    • Gnecchi, M.1    He, H.2    Noiseux, N.3    Liang, O.D.4    Zhang, L.5    Morello, F.6    Mu, H.7    Melo, L.G.8    Pratt, R.E.9    Ingwall, J.S.10    Dzau, V.J.11
  • 15
    • 33846845067 scopus 로고    scopus 로고
    • Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
    • PMID: 17251350
    • Mirotsou M, Zhang Z, Deb A, Zhang L, Gnecchi M, Noiseux N, Mu H, Pachori A, Dzau V. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc Natl Acad Sci USA 2007; 104: 1643-1648 [PMID: 17251350 DOI: 10.1073/pnas.0610024104]
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 1643-1648
    • Mirotsou, M.1    Zhang, Z.2    Deb, A.3    Zhang, L.4    Gnecchi, M.5    Noiseux, N.6    Mu, H.7    Pachori, A.8    Dzau, V.9
  • 16
    • 79958173698 scopus 로고    scopus 로고
    • Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy
    • PMID: 21493893
    • Jeong JO, Han JW, Kim JM, Cho HJ, Park C, Lee N, Kim DW, Yoon YS. Malignant tumor formation after transplantation of short-term cultured bone marrow mesenchymal stem cells in experimental myocardial infarction and diabetic neuropathy. Circ Res 2011; 108: 1340-1347 [PMID: 21493893 DOI: 10.1161/ CIRCRESAHA.110.239848]
    • (2011) Circ Res , vol.108 , pp. 1340-1347
    • Jeong, J.O.1    Han, J.W.2    Kim, J.M.3    Cho, H.J.4    Park, C.5    Lee, N.6    Kim, D.W.7    Yoon, Y.S.8
  • 17
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • PMID: 19498381
    • Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009; 9: 581-593 [PMID:19498381 DOI: 10.1038/nri2567]
    • (2009) Nat Rev Immunol , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 18
    • 84912080852 scopus 로고    scopus 로고
    • Pathologic function and therapeutic potential of exosomes in cardiovascular disease
    • PMID: 25463630
    • Ailawadi S, Wang X, Gu H, Fan GC. Pathologic function and therapeutic potential of exosomes in cardiovascular disease. Biochim Biophys Acta 2015; 1852: 1-11 [PMID: 25463630 DOI: 10.1016/ j.bbadis.2014.10.008]
    • (2015) Biochim Biophys Acta , vol.1852 , pp. 1-11
    • Ailawadi, S.1    Wang, X.2    Gu, H.3    Fan, G.C.4
  • 19
    • 84930345994 scopus 로고    scopus 로고
    • Isolation of extracellular vesicles: Determining the correct approach (Review)
    • PMID: 25902369
    • Szatanek R, Baran J, Siedlar M, Baj-Krzyworzeka M. Isolation of extracellular vesicles: Determining the correct approach (Review). Int J Mol Med 2015; 36: 11-17 [PMID: 25902369 DOI: 10.3892/ ijmm.2015.2194]
    • (2015) Int J Mol Med , vol.36 , pp. 11-17
    • Szatanek, R.1    Baran, J.2    Siedlar, M.3    Baj-Krzyworzeka, M.4
  • 20
    • 84926220052 scopus 로고    scopus 로고
    • Strategies for isolation of exosomes
    • PMID: 25834266
    • Zeringer E, Barta T, Li M, Vlassov AV. Strategies for isolation of exosomes. Cold Spring Harb Protoc 2015; 2015: 319-323 [PMID:25834266 DOI: 10.1101/pdb.top074476]
    • (2015) Cold Spring Harb Protoc , vol.2015 , pp. 319-323
    • Zeringer, E.1    Barta, T.2    Li, M.3    Vlassov, A.V.4
  • 21
    • 84955207408 scopus 로고    scopus 로고
    • Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles
    • PMID: 26564379
    • van der Pol E, Böing AN, Gool EL, Nieuwland R. Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J Thromb Haemost 2016; 14: 48-56 [PMID: 26564379 DOI: 10.1111/jth.13190]
    • (2016) J Thromb Haemost , vol.14 , pp. 48-56
    • van der Pol, E.1    Böing, A.N.2    Gool, E.L.3    Nieuwland, R.4
  • 22
    • 84899624274 scopus 로고    scopus 로고
    • Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes
    • PMID: 24740901
    • Kastelowitz N, Yin H. Exosomes and microvesicles: identification and targeting by particle size and lipid chemical probes. Chembiochem 2014; 15: 923-928 [PMID: 24740901 DOI: 10.1002/ cbic.201400043]
    • (2014) Chembiochem , vol.15 , pp. 923-928
    • Kastelowitz, N.1    Yin, H.2
  • 23
    • 84937977362 scopus 로고    scopus 로고
    • Exosomes and exosomal miRNAs in cardiovascular protection and repair
    • PMID: 25869502
    • Emanueli C, Shearn AI, Angelini GD, Sahoo S. Exosomes and exosomal miRNAs in cardiovascular protection and repair. Vascul Pharmacol 2015; 71: 24-30 [PMID: 25869502 DOI: 10.1016/ j.vph.2015.02.008]
    • (2015) Vascul Pharmacol , vol.71 , pp. 24-30
    • Emanueli, C.1    Shearn, A.I.2    Angelini, G.D.3    Sahoo, S.4
  • 24
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: A compendium of exosomal proteins and RNA
    • PMID: 19810033
    • Mathivanan S, Simpson RJ. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics 2009; 9: 4997-5000 [PMID: 19810033 DOI: 10.1002/pmic.200900351]
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 26
    • 84859515309 scopus 로고    scopus 로고
    • The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities
    • PMID: 22230477
    • Pant S, Hilton H, Burczynski ME. The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol 2012; 83: 1484-1494 [PMID: 22230477 DOI: 10.1016/ j.bcp.2011.12.037]
    • (2012) Biochem Pharmacol , vol.83 , pp. 1484-1494
    • Pant, S.1    Hilton, H.2    Burczynski, M.E.3
  • 27
    • 84874355076 scopus 로고    scopus 로고
    • Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies
    • PMID: 23456661
    • Akers JC, Gonda D, Kim R, Carter BS, Chen CC. Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies. J Neurooncol 2013; 113: 1-11 [PMID:23456661 DOI: 10.1007/s11060-013-1084-8]
    • (2013) J Neurooncol , vol.113 , pp. 1-11
    • Akers, J.C.1    Gonda, D.2    Kim, R.3    Carter, B.S.4    Chen, C.C.5
  • 28
    • 84904657288 scopus 로고    scopus 로고
    • Biogenesis and secretion of exosomes
    • PMID: 24959705
    • Kowal J, Tkach M, Théry C. Biogenesis and secretion of exosomes. Curr Opin Cell Biol 2014; 29: 116-125 [PMID: 24959705 DOI: 10.1016/j.ceb.2014.05.004]
    • (2014) Curr Opin Cell Biol , vol.29 , pp. 116-125
    • Kowal, J.1    Tkach, M.2    Théry, C.3
  • 29
  • 31
    • 72049088519 scopus 로고    scopus 로고
    • TI-VAMP/ VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways
    • PMID: 19781582
    • Fader CM, Sánchez DG, Mestre MB, Colombo MI. TI-VAMP/ VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways. Biochim Biophys Acta 2009; 1793: 1901-1916 [PMID: 19781582 DOI: 10.1016/j.bbamcr.2009.09.011]
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1901-1916
    • Fader, C.M.1    Sánchez, D.G.2    Mestre, M.B.3    Colombo, M.I.4
  • 32
    • 0037096162 scopus 로고    scopus 로고
    • The exosome pathway in K562 cells is regulated by Rab11
    • PMID: 12045221
    • Savina A, Vidal M, Colombo MI. The exosome pathway in K562 cells is regulated by Rab11. J Cell Sci 2002; 115: 2505-2515 [PMID: 12045221]
    • (2002) J Cell Sci , vol.115 , pp. 2505-2515
    • Savina, A.1    Vidal, M.2    Colombo, M.I.3
  • 35
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calcium-dependent mechanism in K562 cells
    • PMID: 12639953
    • Savina A, Furlán M, Vidal M, Colombo MI. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem 2003; 278: 20083-20090 [PMID: 12639953 DOI: 10.1074/jbc. M301642200]
    • (2003) J Biol Chem , vol.278 , pp. 20083-20090
    • Savina, A.1    Furlán, M.2    Vidal, M.3    Colombo, M.I.4
  • 36
    • 79951838013 scopus 로고    scopus 로고
    • Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine
    • PMID: 21242526
    • Chen T, Guo J, Yang M, Zhu X, Cao X. Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine. J Immunol 2011; 186: 2219-2228 [PMID: 21242526 DOI: 10.4049/ jimmunol.1002991]
    • (2011) J Immunol , vol.186 , pp. 2219-2228
    • Chen, T.1    Guo, J.2    Yang, M.3    Zhu, X.4    Cao, X.5
  • 37
    • 84900549711 scopus 로고    scopus 로고
    • WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells
    • PMID: 24766647
    • Ekström EJ, Bergenfelz C, von Bülow V, Serifler F, Carlemalm E, Jönsson G, Andersson T, Leandersson K. WNT5A induces release of exosomes containing pro-angiogenic and immunosuppressive factors from malignant melanoma cells. Mol Cancer 2014; 13: 88 [PMID:24766647 DOI: 10.1186/1476-4598-13-88]
    • (2014) Mol Cancer , vol.13 , pp. 88
    • Ekström, E.J.1    Bergenfelz, C.2    von Bülow, V.3    Serifler, F.4    Carlemalm, E.5    Jönsson, G.6    Andersson, T.7    Leandersson, K.8
  • 38
    • 84894239930 scopus 로고    scopus 로고
    • Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles
    • PMID: 24440457
    • Giricz Z, Varga ZV, Baranyai T, Sipos P, Pálóczi K, Kittel á, Buzás EI, Ferdinandy P. Cardioprotection by remote ischemic preconditioning of the rat heart is mediated by extracellular vesicles. J Mol Cell Cardiol 2014; 68: 75-78 [PMID: 24440457 DOI: 10.1016/ j.yjmcc.2014.01.004]
    • (2014) J Mol Cell Cardiol , vol.68 , pp. 75-78
    • Giricz, Z.1    Varga, Z.V.2    Baranyai, T.3    Sipos, P.4    Pálóczi, K.5    Kittel, Á.6    Buzás, E.I.7    Ferdinandy, P.8
  • 39
    • 84899948104 scopus 로고    scopus 로고
    • Regulation of exosome release by glycosphingolipids and flotillins
    • PMID: 24605801
    • Phuyal S, Hessvik NP, Skotland T, Sandvig K, Llorente A. Regulation of exosome release by glycosphingolipids and flotillins. FEBS J 2014; 281: 2214-2227 [PMID: 24605801 DOI: 10.1111/ febs.12775]
    • (2014) FEBS J , vol.281 , pp. 2214-2227
    • Phuyal, S.1    Hessvik, N.P.2    Skotland, T.3    Sandvig, K.4    Llorente, A.5
  • 41
    • 0038312168 scopus 로고    scopus 로고
    • Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules
    • PMID: 12743365
    • Hwang I, Shen X, Sprent J. Direct stimulation of naive T cells by membrane vesicles from antigen-presenting cells: distinct roles for CD54 and B7 molecules. Proc Natl Acad Sci USA 2003; 100: 6670-6675 [PMID: 12743365 DOI: 10.1073/pnas.1131852100]
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6670-6675
    • Hwang, I.1    Shen, X.2    Sprent, J.3
  • 43
    • 76749106591 scopus 로고    scopus 로고
    • Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosomeinduced endothelial cell activation
    • PMID: 20124479
    • Nazarenko I, Rana S, Baumann A, McAlear J, Hellwig A, Trendelenburg M, Lochnit G, Preissner KT, Zöller M. Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosomeinduced endothelial cell activation. Cancer Res 2010; 70: 1668-1678 [PMID: 20124479 DOI: 10.1158/0008-5472.CAN-09-2470]
    • (2010) Cancer Res , vol.70 , pp. 1668-1678
    • Nazarenko, I.1    Rana, S.2    Baumann, A.3    McAlear, J.4    Hellwig, A.5    Trendelenburg, M.6    Lochnit, G.7    Preissner, K.T.8    Zöller, M.9
  • 45
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • PMID: 17486113
    • Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-659 [PMID: 17486113 DOI: 10.1038/ncb1596]
    • (2007) Nat Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 46
    • 85009840654 scopus 로고    scopus 로고
    • Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells
    • [PMID 24009880]
    • Ekström K, Valadi H, Sjöstrand M, Malmhäll C, Bossios A, Eldh M, Lötvall J. Characterization of mRNA and microRNA in human mast cell-derived exosomes and their transfer to other mast cells and blood CD34 progenitor cells. J Extracell Vesicles 2012; 1 [PMID: 24009880 DOI: 10.3402/jev.v1i0.18389]
    • (2012) J Extracell Vesicles , vol.1
    • Ekström, K.1    Valadi, H.2    Sjöstrand, M.3    Malmhäll, C.4    Bossios, A.5    Eldh, M.6    Lötvall, J.7
  • 47
    • 84904768520 scopus 로고    scopus 로고
    • Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells
    • PMID: 24825548
    • Wang X, Huang W, Liu G, Cai W, Millard RW, Wang Y, Chang J, Peng T, Fan GC. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. J Mol Cell Cardiol 2014; 74: 139-150 [PMID:24825548 DOI: 10.1016/j.yjmcc.2014.05.001]
    • (2014) J Mol Cell Cardiol , vol.74 , pp. 139-150
    • Wang, X.1    Huang, W.2    Liu, G.3    Cai, W.4    Millard, R.W.5    Wang, Y.6    Chang, J.7    Peng, T.8    Fan, G.C.9
  • 50
    • 0035958546 scopus 로고    scopus 로고
    • Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I
    • PMID: 11511343
    • Katzmann DJ, Babst M, Emr SD. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 2001; 106: 145-155 [PMID: 11511343 DOI: 10.1016/S0092-8674(01)00434-2]
    • (2001) Cell , vol.106 , pp. 145-155
    • Katzmann, D.J.1    Babst, M.2    Emr, S.D.3
  • 51
    • 40049084797 scopus 로고    scopus 로고
    • Cell biology No ESCRTs for exosomes
    • PMID: 18309064
    • Marsh M, van Meer G. Cell biology. No ESCRTs for exosomes. Science 2008; 319: 1191-1192 [PMID: 18309064 DOI: 10.1126/ science.1155750]
    • (2008) Science , vol.319 , pp. 1191-1192
    • Marsh, M.1    van Meer, G.2
  • 53
    • 84873919177 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury
    • PMID: 23399448
    • Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP. Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res 2013; 10: 301-312 [PMID: 23399448 DOI: 10.1016/j.scr.2013.01.002]
    • (2013) Stem Cell Res , vol.10 , pp. 301-312
    • Arslan, F.1    Lai, R.C.2    Smeets, M.B.3    Akeroyd, L.4    Choo, A.5    Aguor, E.N.6    Timmers, L.7    van Rijen, H.V.8    Doevendans, P.A.9    Pasterkamp, G.10    Lim, S.K.11    de Kleijn, D.P.12
  • 54
    • 84898461927 scopus 로고    scopus 로고
    • Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
    • PMID: 24337504
    • Bian S, Zhang L, Duan L, Wang X, Min Y, Yu H. Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model. J Mol Med (Berl) 2014; 92: 387-397 [PMID: 24337504 DOI: 10.1007/ s00109-013-1110-5]
    • (2014) J Mol Med (Berl) , vol.92 , pp. 387-397
    • Bian, S.1    Zhang, L.2    Duan, L.3    Wang, X.4    Min, Y.5    Yu, H.6
  • 55
    • 84897808834 scopus 로고    scopus 로고
    • Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22
    • PMID: 24558412
    • Feng Y, Huang W, Wani M, Yu X, Ashraf M. Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One 2014; 9: e88685 [PMID: 24558412 DOI: 10.1371/journal. pone.0088685]
    • (2014) PLoS One , vol.9
    • Feng, Y.1    Huang, W.2    Wani, M.3    Yu, X.4    Ashraf, M.5
  • 56
    • 84947201437 scopus 로고    scopus 로고
    • Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection
    • PMID: 25590961
    • Yu B, Kim HW, Gong M, Wang J, Millard RW, Wang Y, Ashraf M, Xu M. Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection. Int J Cardiol 2015; 182: 349-360 [PMID: 25590961 DOI: 10.1016/j.ijcard.2014.12.043]
    • (2015) Int J Cardiol , vol.182 , pp. 349-360
    • Yu, B.1    Kim, H.W.2    Gong, M.3    Wang, J.4    Millard, R.W.5    Wang, Y.6    Ashraf, M.7    Xu, M.8
  • 57
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • PMID: 23963371
    • Xin H, Li Y, Cui Y, Yang JJ, Zhang ZG, Chopp M. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J Cereb Blood Flow Metab 2013; 33: 1711-1715 [PMID:23963371 DOI: 10.1038/jcbfm.2013.152]
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1711-1715
    • Xin, H.1    Li, Y.2    Cui, Y.3    Yang, J.J.4    Zhang, Z.G.5    Chopp, M.6
  • 58
    • 84883382523 scopus 로고    scopus 로고
    • MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles
    • PMID: 23630198
    • Xin H, Li Y, Liu Z, Wang X, Shang X, Cui Y, Zhang ZG, Chopp M. MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles. Stem Cells 2013; 31: 2737-2746 [PMID: 23630198 DOI: 10.1002/ stem.1409]
    • (2013) Stem Cells , vol.31 , pp. 2737-2746
    • Xin, H.1    Li, Y.2    Liu, Z.3    Wang, X.4    Shang, X.5    Cui, Y.6    Zhang, Z.G.7    Chopp, M.8
  • 60
    • 84873713781 scopus 로고    scopus 로고
    • Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury
    • PMID: 23318173
    • Chen L, Wang Y, Pan Y, Zhang L, Shen C, Qin G, Ashraf M, Weintraub N, Ma G, Tang Y. Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury. Biochem Biophys Res Commun 2013; 431: 566-571 [PMID:23318173 DOI: 10.1016/j.bbrc.2013.01.015]
    • (2013) Biochem Biophys Res Commun , vol.431 , pp. 566-571
    • Chen, L.1    Wang, Y.2    Pan, Y.3    Zhang, L.4    Shen, C.5    Qin, G.6    Ashraf, M.7    Weintraub, N.8    Ma, G.9    Tang, Y.10
  • 61
    • 84907337461 scopus 로고    scopus 로고
    • Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction
    • PMID: 25016614
    • Barile L, Lionetti V, Cervio E, Matteucci M, Gherghiceanu M, Popescu LM, Torre T, Siclari F, Moccetti T, Vassalli G. Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction. Cardiovasc Res 2014; 103: 530-541 [PMID: 25016614 DOI: 10.1093/cvr/cvu167]
    • (2014) Cardiovasc Res , vol.103 , pp. 530-541
    • Barile, L.1    Lionetti, V.2    Cervio, E.3    Matteucci, M.4    Gherghiceanu, M.5    Popescu, L.M.6    Torre, T.7    Siclari, F.8    Moccetti, T.9    Vassalli, G.10
  • 62
    • 84899980641 scopus 로고    scopus 로고
    • Exosomes as critical agents of cardiac regeneration triggered by cell therapy
    • PMID: 24936449
    • Ibrahim AG, Cheng K, Marbán E. Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Reports 2014; 2: 606-619 [PMID: 24936449 DOI: 10.1016/ j.stemcr.2014.04.006]
    • (2014) Stem Cell Reports , vol.2 , pp. 606-619
    • Ibrahim, A.G.1    Cheng, K.2    Marbán, E.3
  • 69
    • 41149172340 scopus 로고    scopus 로고
    • Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer
    • PMID: 18362931
    • Dai S, Wei D, Wu Z, Zhou X, Wei X, Huang H, Li G. Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer. Mol Ther 2008; 16: 782-790 [PMID: 18362931 DOI: 10.1038/mt.2008.1]
    • (2008) Mol Ther , vol.16 , pp. 782-790
    • Dai, S.1    Wei, D.2    Wu, Z.3    Zhou, X.4    Wei, X.5    Huang, H.6    Li, G.7
  • 70
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • PMID: 21423189
    • Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011; 29: 341-345 [PMID:21423189 DOI: 10.1038/nbt.1807]
    • (2011) Nat Biotechnol , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 74
    • 84896700643 scopus 로고    scopus 로고
    • Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice
    • PMID: 24565517
    • Zhang Y, Li L, Yu J, Zhu D, Zhang Y, Li X, Gu H, Zhang CY, Zen K. Microvesicle-mediated delivery of transforming growth factor β1 siRNA for the suppression of tumor growth in mice. Biomaterials 2014; 35: 4390-4400 [PMID: 24565517 DOI: 10.1016/j.biomaterials. 2014.02.003]
    • (2014) Biomaterials , vol.35 , pp. 4390-4400
    • Zhang, Y.1    Li, L.2    Yu, J.3    Zhu, D.4    Zhang, Y.5    Li, X.6    Gu, H.7    Zhang, C.Y.8    Zen, K.9
  • 75
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • PMID: 20571541
    • Sun D, Zhuang X, Xiang X, Liu Y, Zhang S, Liu C, Barnes S, Grizzle W, Miller D, Zhang HG. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol Ther 2010; 18: 1606-1614 [PMID:20571541 DOI: 10.1038/mt.2010.105]
    • (2010) Mol Ther , vol.18 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.2    Xiang, X.3    Liu, Y.4    Zhang, S.5    Liu, C.6    Barnes, S.7    Grizzle, W.8    Miller, D.9    Zhang, H.G.10
  • 76
    • 80053574021 scopus 로고    scopus 로고
    • Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain
    • PMID: 21915101
    • Zhuang X, Xiang X, Grizzle W, Sun D, Zhang S, Axtell RC, Ju S, Mu J, Zhang L, Steinman L, Miller D, Zhang HG. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain. Mol Ther 2011; 19: 1769-1779 [PMID: 21915101 DOI: 10.1038/mt.2011.164]
    • (2011) Mol Ther , vol.19 , pp. 1769-1779
    • Zhuang, X.1    Xiang, X.2    Grizzle, W.3    Sun, D.4    Zhang, S.5    Axtell, R.C.6    Ju, S.7    Mu, J.8    Zhang, L.9    Steinman, L.10    Miller, D.11    Zhang, H.G.12
  • 78
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • PMID: 24345736
    • Tian Y, Li S, Song J, Ji T, Zhu M, Anderson GJ, Wei J, Nie G. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 2014; 35: 2383-2390 [PMID: 24345736 DOI: 10.1016/j.biomaterials.2013.11.0 83]
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3    Ji, T.4    Zhu, M.5    Anderson, G.J.6    Wei, J.7    Nie, G.8
  • 79
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • PMID: 22055459
    • Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X, Wang M, Qian H, Xu W. Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett 2012; 315: 28-37 [PMID: 22055459 DOI: 10.1016/j.canlet.2011.10.002]
    • (2012) Cancer Lett , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4    Gu, J.5    Yan, Y.6    Xu, X.7    Wang, M.8    Qian, H.9    Xu, W.10


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