메뉴 건너뛰기




Volumn 4, Issue , 2016, Pages

Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk

Author keywords

longitudinal data; Mahalanobis distance; mortality; physiological dysregulation; sex differences; stochastic process model

Indexed keywords


EID: 85015261884     PISSN: None     EISSN: 22962565     Source Type: Journal    
DOI: 10.3389/fpubh.2016.00003     Document Type: Article
Times cited : (36)

References (49)
  • 1
    • 69949102187 scopus 로고    scopus 로고
    • Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment
    • 19567825
    • Fried LP Xue Q-L Cappola AR Ferrucci L Chaves P Varadhan R et al. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci (2009) 64:1049–57.10.1093/gerona/glp07619567825
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 1049-1057
    • Fried, L.P.1    Xue, Q.-L.2    Cappola, A.R.3    Ferrucci, L.4    Chaves, P.5    Varadhan, R.6
  • 2
    • 51649087122 scopus 로고    scopus 로고
    • Biomarkers related to aging in human populations
    • 19004190
    • Crimmins E Vasunilashorn S Kim JK Alley D. Biomarkers related to aging in human populations. Adv Clin Chem (2008) 46:161–216.10.1016/s0065-2423(08)00405-819004190
    • (2008) Adv Clin Chem , vol.46 , pp. 161-216
    • Crimmins, E.1    Vasunilashorn, S.2    Kim, J.K.3    Alley, D.4
  • 3
    • 69949088072 scopus 로고    scopus 로고
    • Maintaining physiological state for exceptional survival: what is the normal level of blood glucose and does it change with age?
    • 19635493
    • Yashin AI Ukraintseva SV Arbeev KG Akushevich I Arbeeva LS Kulminski AM. Maintaining physiological state for exceptional survival: what is the normal level of blood glucose and does it change with age? Mech Ageing Dev (2009) 130:611–8.10.1016/j.mad.2009.07.00419635493
    • (2009) Mech Ageing Dev , vol.130 , pp. 611-618
    • Yashin, A.I.1    Ukraintseva, S.V.2    Arbeev, K.G.3    Akushevich, I.4    Arbeeva, L.S.5    Kulminski, A.M.6
  • 5
    • 84875050995 scopus 로고    scopus 로고
    • A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
    • 23376244
    • Cohen AA Milot E Yong J Seplaki CL Fueloep T Bandeen-Roche K et al. A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech Ageing Dev (2013) 134:110–7.10.1016/j.mad.2013.01.00423376244
    • (2013) Mech Ageing Dev , vol.134 , pp. 110-117
    • Cohen, A.A.1    Milot, E.2    Yong, J.3    Seplaki, C.L.4    Fueloep, T.5    Bandeen-Roche, K.6
  • 6
    • 84955344859 scopus 로고    scopus 로고
    • Complex systems dynamics in aging: new evidence, continuing questions
    • 25991473
    • Cohen AA. Complex systems dynamics in aging: new evidence, continuing questions. Biogerontology (2015).10.1007/s10522-015-9584-x25991473
    • (2015) Biogerontology
    • Cohen, A.A.1
  • 7
    • 84924347534 scopus 로고    scopus 로고
    • Detection of a novel, integrative aging process suggests complex physiological integration
    • Cohen AA Milot E Li Q Bergeron P Poirier R Dusseault-Belanger F et al. Detection of a novel, integrative aging process suggests complex physiological integration. PLoS One (2015) 10(3):e0116489.10.1371/journal.pone.0116489
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0116489
    • Cohen, A.A.1    Milot, E.2    Li, Q.3    Bergeron, P.4    Poirier, R.5    Dusseault-Belanger, F.6
  • 9
    • 63649098103 scopus 로고    scopus 로고
    • Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data
    • 19490866
    • Arbeev KG Akushevich I Kulminski AM Arbeeva LS Akushevich L Ukraintseva SV et al. Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data. J Theor Biol (2009) 258:103–11.10.1016/j.jtbi.2009.01.02319490866
    • (2009) J Theor Biol , vol.258 , pp. 103-111
    • Arbeev, K.G.1    Akushevich, I.2    Kulminski, A.M.3    Arbeeva, L.S.4    Akushevich, L.5    Ukraintseva, S.V.6
  • 10
    • 84863466422 scopus 로고    scopus 로고
    • The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span
    • Yashin AI Arbeev KG Akushevich I Kulminski A Ukraintseva SV Stallard E et al. The quadratic hazard model for analyzing longitudinal data on aging, health, and the life span. Phys Life Rev (2012) 9:177–88.10.1016/j.plrev.2012.05.002
    • (2012) Phys Life Rev , vol.9 , pp. 177-188
    • Yashin, A.I.1    Arbeev, K.G.2    Akushevich, I.3    Kulminski, A.4    Ukraintseva, S.V.5    Stallard, E.6
  • 11
    • 0029975330 scopus 로고    scopus 로고
    • The aging process: physiologic changes and pharmacologic implications
    • 8650079
    • Troncale JA. The aging process: physiologic changes and pharmacologic implications. Postgrad Med (1996) 99(111–114):120–2.8650079
    • (1996) Postgrad Med , vol.99 , Issue.111–114 , pp. 120-122
    • Troncale, J.A.1
  • 12
    • 0033902016 scopus 로고    scopus 로고
    • Aging reduces adaptive capacity and stress protein expression in the liver after heat stress
    • 10926662
    • Hall DM Xu L Drake VJ Oberley LW Oberley TD Moseley PL et al. Aging reduces adaptive capacity and stress protein expression in the liver after heat stress. J Appl Physiol (2000) 89:749–59.10926662
    • (2000) J Appl Physiol , vol.89 , pp. 749-759
    • Hall, D.M.1    Xu, L.2    Drake, V.J.3    Oberley, L.W.4    Oberley, T.D.5    Moseley, P.L.6
  • 13
    • 0037218317 scopus 로고    scopus 로고
    • The concept of allostasis in biology and biomedicine
    • 12614627
    • McEwen BS Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav (2003) 43:2–15.10.1016/s0018-506x(02)00024-712614627
    • (2003) Horm Behav , vol.43 , pp. 2-15
    • McEwen, B.S.1    Wingfield, J.C.2
  • 14
    • 66649128739 scopus 로고    scopus 로고
    • Adaptive beta-cell proliferation is severely restricted with advanced age
    • 19265026
    • Rankin MM Kushner JA. Adaptive beta-cell proliferation is severely restricted with advanced age. Diabetes (2009) 58:1365–72.10.2337/db08-119819265026
    • (2009) Diabetes , vol.58 , pp. 1365-1372
    • Rankin, M.M.1    Kushner, J.A.2
  • 15
    • 77949320611 scopus 로고    scopus 로고
    • Mitochondria, cellular stress resistance, somatic cell depletion and lifespan
    • 20021396
    • Robb EL Page MM Stuart JA. Mitochondria, cellular stress resistance, somatic cell depletion and lifespan. Curr Aging Sci (2009) 2:12–27.10.2174/187460981090201001220021396
    • (2009) Curr Aging Sci , vol.2 , pp. 12-27
    • Robb, E.L.1    Page, M.M.2    Stuart, J.A.3
  • 19
    • 84893960255 scopus 로고    scopus 로고
    • A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation
    • Milot E Cohen AA Vezina F Buehler DM Matson KD Piersma T. A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods Ecol Evol (2014) 5:146–55.10.1111/2041-210X.12145
    • (2014) Methods Ecol Evol , vol.5 , pp. 146-155
    • Milot, E.1    Cohen, A.A.2    Vezina, F.3    Buehler, D.M.4    Matson, K.D.5    Piersma, T.6
  • 20
    • 84949116267 scopus 로고    scopus 로고
    • Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations
    • Milot E Morissette-Thomas V Li Q Fried LP Ferrucci L Cohen AA. Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech Ageing Dev (2014) 141:56–63.10.1016/j.mad.2014.10.001
    • (2014) Mech Ageing Dev , vol.141 , pp. 56-63
    • Milot, E.1    Morissette-Thomas, V.2    Li, Q.3    Fried, L.P.4    Ferrucci, L.5    Cohen, A.A.6
  • 23
    • 39749119242 scopus 로고    scopus 로고
    • What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: findings from the NLTCS-medicare data
    • 18242665
    • Yashin AI Arbeev KG Kulminski A Akushevich I Akushevich L Ukraintseva SV. What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: findings from the NLTCS-medicare data. Mech Ageing Dev (2008) 129:191–200.10.1016/j.mad.2007.12.00518242665
    • (2008) Mech Ageing Dev , vol.129 , pp. 191-200
    • Yashin, A.I.1    Arbeev, K.G.2    Kulminski, A.3    Akushevich, I.4    Akushevich, L.5    Ukraintseva, S.V.6
  • 24
    • 77954819683 scopus 로고    scopus 로고
    • Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data
    • Yashin AI Arbeev KG Akushevich I Ukraintseva SV Kulminski A Arbeeva LS et al. Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data. Biogerontology (2010) 11:257–65.10.1007/s10522-009-9243-1
    • (2010) Biogerontology , vol.11 , pp. 257-265
    • Yashin, A.I.1    Arbeev, K.G.2    Akushevich, I.3    Ukraintseva, S.V.4    Kulminski, A.5    Arbeeva, L.S.6
  • 25
    • 84876175996 scopus 로고    scopus 로고
    • Effect of the APOE polymorphism and age trajectories of physiological variables on mortality: application of genetic stochastic process model of aging
    • 23682334
    • Arbeev KG Ukraintseva SV Kulminski AM Akushevich I Arbeeva LS Culminskaya IV et al. Effect of the APOE polymorphism and age trajectories of physiological variables on mortality: application of genetic stochastic process model of aging. Scientifica (Cairo) (2012) 2012:568628.10.6064/2012/56862823682334
    • (2012) Scientifica (Cairo) , vol.2012 , pp. 568628
    • Arbeev, K.G.1    Ukraintseva, S.V.2    Kulminski, A.M.3    Akushevich, I.4    Arbeeva, L.S.5    Culminskaya, I.V.6
  • 26
    • 84875695734 scopus 로고    scopus 로고
    • Patterns of aging related changes on the way to 100: an approach to studying aging, mortality, and longevity from longitudinal data
    • Yashin AI Arbeev KG Ukraintseva SV Akushevich I Kulminski A. Patterns of aging related changes on the way to 100: an approach to studying aging, mortality, and longevity from longitudinal data. N Am Actuar J (2012) 16:403–33.10.1080/10920277.2012.10597640
    • (2012) N Am Actuar J , vol.16 , pp. 403-433
    • Yashin, A.I.1    Arbeev, K.G.2    Ukraintseva, S.V.3    Akushevich, I.4    Kulminski, A.5
  • 27
    • 84876175611 scopus 로고    scopus 로고
    • How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data
    • 23346098
    • Yashin AI Arbeev KG Wu D Arbeeva LS Kulminski A Akushevich I et al. How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data. Front Genetics (2013) 4:3.10.3389/fgene.2013.0000323346098
    • (2013) Front Genetics , vol.4 , pp. 3
    • Yashin, A.I.1    Arbeev, K.G.2    Wu, D.3    Arbeeva, L.S.4    Kulminski, A.5    Akushevich, I.6
  • 28
    • 0017459630 scopus 로고
    • A random-walk model of human mortality and aging
    • Woodbury MA Manton KG. A random-walk model of human mortality and aging. Theor Popul Biol (1977) 11:37–48.10.1016/0040-5809(77)90005-3
    • (1977) Theor Popul Biol , vol.11 , pp. 37-48
    • Woodbury, M.A.1    Manton, K.G.2
  • 29
    • 0026951142 scopus 로고
    • Projecting the future size and health status of the United States elderly population
    • Manton KG Stallard E Singer B. Projecting the future size and health status of the United States elderly population. Int J Forecast (1992) 8:433–58.10.1016/0169-2070(92)90057-g
    • (1992) Int J Forecast , vol.8 , pp. 433-458
    • Manton, K.G.1    Stallard, E.2    Singer, B.3
  • 30
    • 0007171750 scopus 로고
    • Survival functions induced by stochastic covariate processes
    • Myers LE. Survival functions induced by stochastic covariate processes. J Appl Probab (1981) 18:523–9.10.2307/3213300
    • (1981) J Appl Probab , vol.18 , pp. 523-529
    • Myers, L.E.1
  • 31
    • 0024652107 scopus 로고
    • The propagation of uncertainty in human mortality processes operating in stochastic environments
    • 2727949
    • Yashin AI Manton KG Stallard E. The propagation of uncertainty in human mortality processes operating in stochastic environments. Theor Popul Biol (1989) 35:119–41.10.1016/0040-5809(89)90013-02727949
    • (1989) Theor Popul Biol , vol.35 , pp. 119-141
    • Yashin, A.I.1    Manton, K.G.2    Stallard, E.3
  • 32
    • 0002671404 scopus 로고
    • Dynamics in survival analysis: conditional Gaussian property vs. Cameron-Martin formula
    • Krylov N.V., Lipster R.S., Novikov A.A., (eds), New York, Springer, In:, editors., :, p
    • Yashin AI. Dynamics in survival analysis: conditional Gaussian property vs. Cameron-Martin formula. In: Krylov NV Lipster RS Novikov AA, editors. Statistics and Control of Stochastic Processes. New York: Springer (1985). p. 446–75.
    • (1985) Statistics and Control of Stochastic Processes , pp. 446-475
    • Yashin, A.I.1
  • 33
    • 21144470123 scopus 로고
    • An extension of the Cameron-Martin result
    • Yashin AI. An extension of the Cameron-Martin result. J Appl Probab (1993) 30:247–51.10.2307/3214636
    • (1993) J Appl Probab , vol.30 , pp. 247-251
    • Yashin, A.I.1
  • 34
    • 84928795150 scopus 로고    scopus 로고
    • Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition
    • Cohen AA Li Q Milot E Leroux M Faucher S Morissette-Thomas V et al. Statistical distance as a measure of physiological dysregulation is largely robust to variation in its biomarker composition. PLoS One (2015) 10(4):e0122541.10.1371/journal.pone.0122541
    • (2015) PLoS One , vol.10 , Issue.4 , pp. e0122541
    • Cohen, A.A.1    Li, Q.2    Milot, E.3    Leroux, M.4    Faucher, S.5    Morissette-Thomas, V.6
  • 36
    • 0028359036 scopus 로고
    • Time-varying covariates in models of human mortality and aging: multidimensional generalizations of the Gompertz
    • 8014388
    • Manton KG Stallard E Woodbury MA Dowd JE. Time-varying covariates in models of human mortality and aging: multidimensional generalizations of the Gompertz. J Gerontol (1994) 49:B169–90.10.1093/geronj/49.4.B1698014388
    • (1994) J Gerontol , vol.49 , pp. B169-B190
    • Manton, K.G.1    Stallard, E.2    Woodbury, M.A.3    Dowd, J.E.4
  • 37
    • 0142011017 scopus 로고    scopus 로고
    • Imputation of missing longitudinal data: a comparison of methods
    • 14568628
    • Engels JM Diehr P. Imputation of missing longitudinal data: a comparison of methods. J Clin Epidemiol (2003) 56:968–76.10.1016/s0895-4356(03)00170-714568628
    • (2003) J Clin Epidemiol , vol.56 , pp. 968-976
    • Engels, J.M.1    Diehr, P.2
  • 38
    • 29344473757 scopus 로고    scopus 로고
    • Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality
    • 16398907
    • Mitnitski A Song X Skoog I Broe GA Cox JL Grunfeld E et al. Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality. J Am Geriatr Soc (2005) 53:2184–9.10.1111/j.1532-5415.2005.00506.x16398907
    • (2005) J Am Geriatr Soc , vol.53 , pp. 2184-2189
    • Mitnitski, A.1    Song, X.2    Skoog, I.3    Broe, G.A.4    Cox, J.L.5    Grunfeld, E.6
  • 39
    • 14544279446 scopus 로고    scopus 로고
    • Sex differences in the risk of frailty for mortality independent of disability and chronic diseases
    • 15667374
    • Puts MT Lips P Deeg DJ. Sex differences in the risk of frailty for mortality independent of disability and chronic diseases. J Am Geriatr Soc (2005) 53:40–7.10.1111/j.1532-5415.2005.53008.x15667374
    • (2005) J Am Geriatr Soc , vol.53 , pp. 40-47
    • Puts, M.T.1    Lips, P.2    Deeg, D.J.3
  • 41
    • 0020422225 scopus 로고
    • Sex differentials in health
    • 6750677
    • Verbrugge LM. Sex differentials in health. Public Health Rep (1982) 97:417–37.6750677
    • (1982) Public Health Rep , vol.97 , pp. 417-437
    • Verbrugge, L.M.1
  • 42
    • 0023465080 scopus 로고
    • Sex differentials in health and mortality
    • Verbrugge LM Wingard DL. Sex differentials in health and mortality. Women Health (1987) 12:103–45.10.1300/J013v12n02_07
    • (1987) Women Health , vol.12 , pp. 103-145
    • Verbrugge, L.M.1    Wingard, D.L.2
  • 43
    • 56649112851 scopus 로고    scopus 로고
    • Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time
    • 18835429
    • Kulminski AM Culminskaya IV Ukraintseva SV Arbeev KG Land KC Yashin AI. Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time. Exp Gerontol (2008) 43:1052–7.10.1016/j.exger.2008.09.00718835429
    • (2008) Exp Gerontol , vol.43 , pp. 1052-1057
    • Kulminski, A.M.1    Culminskaya, I.V.2    Ukraintseva, S.V.3    Arbeev, K.G.4    Land, K.C.5    Yashin, A.I.6
  • 44
    • 84902687035 scopus 로고    scopus 로고
    • Cross-population validation of statistical distance as a measure of physiological dysregulation during aging
    • 24802990
    • Cohen AA Milot E Li Q Legault V Fried LP Ferrucci L. Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Exp Gerontol (2014) 57:203–10.10.1016/j.exger.2014.04.01624802990
    • (2014) Exp Gerontol , vol.57 , pp. 203-210
    • Cohen, A.A.1    Milot, E.2    Li, Q.3    Legault, V.4    Fried, L.P.5    Ferrucci, L.6
  • 45
    • 0001296914 scopus 로고    scopus 로고
    • Accumulation of deficits as a proxy measure of aging
    • 12806071
    • Mitnitski AB Mogilner AJ Rockwood K. Accumulation of deficits as a proxy measure of aging. ScientificWorldJournal (2001) 1:323–36.10.1100/tsw.2001.5812806071
    • (2001) ScientificWorldJournal , vol.1 , pp. 323-336
    • Mitnitski, A.B.1    Mogilner, A.J.2    Rockwood, K.3
  • 46
    • 33846887182 scopus 로고    scopus 로고
    • Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the national long term care survey
    • 17223183
    • Kulminski A Yashin A Arbeev K Akushevich I Ukraintseva S Land K et al. Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the national long term care survey. Mech Ageing Dev (2007) 128:250–8.10.1016/j.mad.2006.12.00417223183
    • (2007) Mech Ageing Dev , vol.128 , pp. 250-258
    • Kulminski, A.1    Yashin, A.2    Arbeev, K.3    Akushevich, I.4    Ukraintseva, S.5    Land, K.6
  • 47
    • 84954374841 scopus 로고    scopus 로고
    • Homeostatic dysregulation proceeds in parallel in multiple physiological systems
    • 26416593
    • Li Q Wang S Milot E Bergeron P Ferrucci L Fried LP et al. Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell (2015) 14:1103–12.10.1111/acel.1240226416593
    • (2015) Aging Cell , vol.14 , pp. 1103-1112
    • Li, Q.1    Wang, S.2    Milot, E.3    Bergeron, P.4    Ferrucci, L.5    Fried, L.P.6
  • 48
    • 0035885366 scopus 로고    scopus 로고
    • How individual age-associated changes may influence human morbidity and mortality patterns
    • 11470132
    • Ukraintseva SV Yashin AI. How individual age-associated changes may influence human morbidity and mortality patterns. Mech Ageing Dev (2001) 122:1447–60.10.1016/S0047-6374(01)00277-911470132
    • (2001) Mech Ageing Dev , vol.122 , pp. 1447-1460
    • Ukraintseva, S.V.1    Yashin, A.I.2
  • 49


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.