Advances in sepsis-Associated liver dysfunction

Burns and Trauma

Volumn 2, Issue 3, 2014, Pages 97-105

  Wang, Dawei ^a,b   Yin, Yimei ^b   Yao, Yongming ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Weihai Municipal Hospital   (China)

Author keywords

dysfunction; inflammation; jaundice; liver; Sepsis

Indexed keywords

EID: 85014951807     PISSN: None     EISSN: 23213876     Source Type: Journal    
DOI: 10.4103/2321-3868.132689     Document Type: Review

References (66)

1. Angus DC, van der Poll T. Severe sepsis and septic shock. N Engl J Med 2013;369:840-51.
2. Marshall JC. New translational research provides insights into liver dysfunction in sepsis. PLoS Med 2012;9:e1001341.
3. Dahn MS, Lange P, Lobdell K, Hans B, Jacobs LA, Mitchell RA. Splanchnic and total body oxygen consumption differences in septic and injured patients. Surgery 1987;101:69-80.
4. Tamandl D, Jørgensen P, Gundersen Y, Fuegger R, Sautner T, Aasen AO, et al. Nitric oxide administration restores the hepatic artery buffer response during porcine endotoxemia. J Invest Surg 2008;21:183-94.
5. Spapen H. Liver perfusion in sepsis, septic shock, and multiorgan failure. Anat Rec (Hoboken) 2008;291:714-20.
6. La Mura V, Pasarín M, Meireles CZ, Miquel R, Rodríguez-Vilarrupla A, Hide D, et al. Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction. Hepatology 2013;57:1172-81.
7. Eum HA, Park SW, Lee SM. Role of nitric oxide in the expression of hepatic vascular stress genes in response to sepsis. Nitric Oxide 2007;17:126-33.
8. Lange M, Hamahata A, Traber DL, Nakano Y, Esechie A, Jonkam C, et al. Effects of early neuronal and delayed inducible nitric oxide synthase blockade on cardiovascular, renal, and hepatic function in ovine sepsis. Anesthesiology 2010;113:1376-84.
9. Norris EJ, Larion S, Culberson CR, Clemens MG. Hydrogen sulfide differentially affects the hepatic vasculature in response to phenylephrine and endothelin 1 during endotoxemia. Shock 2013;39:168-75.
10. Kolios G, Valatas V, Manousou P, Xidakis C, Notas G, Kouroumalis E. Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells. Mol Cell Biochem 2008;319:91-8.
11. Traeger T, Mikulcak M, Eipel C, Abshagen K, Diedrich S, Heidecke CD, et al. Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis. Eur J Gastroenterol Hepatol 2010;22:1039-49.
12. Jaeschke H, Farhood A, Cai SX, Tseng BY, Bajt ML. Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice. Toxicol Appl Pharmacol 2000;169:77-83.
13. Diao L, Li N, Brayman TG, Hotz KJ, Lai Y. Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflame matory cytokines TNF-?, IL-6, and IL-1?. J Biol Chem 2010;285:31185-92.
14. Streetz KL, Wöstefeld T, Klein C, Manns MP, Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol (Noisy-le-grand) 2001;47:661-73.
15. Tsutsui H, Matsui K, Kawada N, Hyodo Y, Hayashi N, Okamura H, et al. IL-18 accounts for both TNF-Alpha-and Fas ligand-mediated hepatotoxic pathways in endotoxininduced liver injury in mice. J Immunol 1997;159:3961-7.
16. Doi F, Goya T, Torisu M. Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis. Hepatology 1993;17:1086-94.
17. Lawson JA, Fisher MA, Simmons CA, Farhood A, Jaeschke H. Parenchymal cell apoptosis as a signal for sinusoidal sequestration and transendothelial migration of neutrophils in murine models of endotoxin and Fas-Antibody-induced liver injury. Hepatology 1998;28:761-7.
18. Ohira H, Abe K, Yokokawa J, Takiguchi J, Rai T, Shishido S, et al. Adhesion molecules and CXC chemokines in endotoxin-induced liver injury. Fukushima J Med Sci 2003;49:1-13.
19. Matesic LE, Niemitz EL, De Maio A, Reeves RH. Quantitative trait loci modulate neutrophil infiltration in the liver during LPS-induced inflammation. FASEB J 2000;14:2247-54.
20. Boehme MW, Galle P, Stremmel W. Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. Immunology 2002;107:340-9.
21. Koo DJ, Chaudry IH, Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res 1999;83:151-7.
22. Cai H, Song C, Lim IG, Krilis SA, Geczy CL, McNeil HP. Importance of C-reactive protein in regulating monocyte tissue factor expression in patients with inflammatory rheumatic diseases. J Rheumatol 2005;32:1224-31.
23. Rose S, Baumann H, Jahreis GP, Sayeed MM. Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis. Shock 1994;1:87-93.
24. Gonnert FA, Recknagel P, Hilger I, Claus RA, Bauer M, Kortgen A. Hepatic excretory function in sepsis: Implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model. Crit Care 2013;17:R67.
25. Bhogal HK, Sanyal AJ. The molecular pathogenesis of cholestasis in sepsis. Front Biosci (Elite Ed) 2013;5:87-96.
26. Lehmann GL, Marinelli RA. Peritoneal sepsis down regulates liver expression of Aquaporin-8: A water channel involved in bile secretion. Liver Int 2009;29:317-8.
27. Laschke MW, Menger MD, Wang Y, Lindell G, Jeppsson B, Thorlacius H. Sepsis-Associated cholestasis is critically dependent on P-selectin-dependent leukocyte recruitment in mice. Am J Physiol Gastrointest Liver Physiol 2007;292:G1396-402.
28. Han X, Fink MP, Uchiyama T, Yang R, Delude RL. Increased iNOS activity is essential for hepatic epithelial tight junction dysfunction in endotoxemic mice. Am J Physiol Gastrointest Liver Physiol 2004;286:G126-36.
29. Jacob A, Zhou M, Wu R, Wang P. The role of hepatic cytochrome P-450 in sepsis. Int J Clin Exp Med 2009;2:203-11.
30. Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, et al. Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: Experimental studies in rodent models of peritonitis. PLoS Med 2012;9:e1001338.
31. Carchman EH, Rao J, Loughran PA, Rosengart MR, Zuckerbraun BS. Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice. Hepatology 2011;53:2053-62.
32. Hutchins NA, Chung CS, Borgerding JN, Ayala CA, Ayala A. Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. Am J Pathol 2013;182:742-54.
33. Hutchins NA, Wang F, Wang Y, Chung CS, Ayala A. Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. J Leukoc Biol 2013;94:963-70.
34. Knolle PA, Löser E, Protzer U, Duchmann R, Schmitt E, zum Böschenfelde KH, et al. Regulation of endotoxininduced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10. Clin Exp Immunol 1997;107:555-61.
35. Cheluvappa R, Denning GM, Lau GW, Grimm MC, Hilmer SN, Le Couteur DG. Pathogenesis of the hyperlipidemia of Gramnegative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. Int J Infect Dis 2010;14:e857-67.
36. Gonnert FA, Kunisch E, Gajda M, Lambeck S, Weber M, Claus RA, et al. Hepatic fibrosis in a long-Term Murine model of sepsis. Shock 2012;37:399-407.
37. Bjerring PN, Eefsen M, Hansen BA, Larsen FS. The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. Metab Brain Dis 2009;24:5-14.
38. Munoz SJ. The hepatorenal syndrome. Med Clin North Am 2008;92:813-37, viii-ix.
39. Kobashi H, Toshimori J, Yamamoto K. Sepsis-Associated liver injury: Incidence, classification and the clinical significance. Hepatol Res 2013;43:255-66.
40. Riediger C, Sauer P, Matevossian E, Möller MW, Böchler P, Friess H. Herpes simplex virus sepsis and acute liver failure. Clin Transplant 2009;23 Suppl 21:37-41.
41. Henrion J. Hypoxic hepatitis. Liver Int 2012;32:1039-52.
42. Fuhrmann V, Jäger B, Zubkova A, Drolz A. Hypoxic hepatitisepidemiology, pathophysiology and clinical management. Wien Klin Wochenschr 2010;122:129-39.
43. Famularo G, De Simone C, Nicotra GC. Jaundice and the sepsis syndrome: A neglected link. Eur J Intern Med 2003;14:269-71.
44. Chand N, Sanyal AJ. Sepsis-induced cholestasis. Hepatology 2007;45:230-41.
45. Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, et al. Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 2003;31:834-40.
46. Patel JJ, Taneja A, Niccum D, Kumar G, Jacobs E, Nanchal R. The association of serum bilirubin levels on the outcomes of severe sepsis. J Intensive Care Med 2013.
47. Kimura S, Yoshioka T, Shibuya M, Sakano T, Tanaka R, Matsuyama S. Indocyanine green elimination rate detects hepatocellular dysfunction early in septic shock and correlates with survival. Crit Care Med 2001;29:1159-63.
48. Kawasaki T, Chaudry IH. The effects of estrogen on various organs: Therapeutic approach for sepsis, trauma, and reperfusion injury. Part 2: Liver, intestine, spleen, and kidney. J Anesth 2012;26:892-9.
49. Novotny AR, Emmanuel K, Maier S, Westerholt A, Weighardt H, Stadler J, et al. Cytochrome P450 activity mirrors nitric oxide levels in postoperative sepsis: Predictive indicators of lethal outcome. Surgery 2007;141:376-84.
50. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41:580-637.
51. Dzakovic A, Kaviani A, Eshach-Adiv O, Perez-Atayde A, Ling PR, Yu M, et al. Trophic enteral nutrition increases hepatic glutathione and protects against peroxidative damage after exposure to endotoxin. J Pediatr Surg 2003;38:844-7.
52. Huang YH, Yang YL, Tiao MM, Kuo HC, Huang LT, Chuang JH. Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice. Peptides 2012;35:212-7.
53. Montalto AS, Bitto A, Irrera N, Polito F, Rinaldi M, Antonuccio P, et al. CO2 pneumoperitoneum impact on early liver and lung cytokine expression in a rat model of abdominal sepsis. Surg Endosc 2012;26:984-9.
54. Uji Y, Yamamoto H, Maeda K, Tsuchihashi H, Akabori H, Shimizu T, et al. Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. J Surg Res 2010;161:301-11.
55. Tsao CM, Huang HC, Chen ZF, Liaw WJ, Lue WM, Chen A, et al. Beneficial effects of hyperoncotic albumin on liver injury and survival in peritonitis-induced sepsis rats. Shock 2011;35:210-6.
56. Mustafa SB, Olson MS. Effects of calcium channel antagonists on LPS-induced hepatic iNOS expression. Am J Physiol 1999;277:G351-60.
57. Mohamadin AM, Elberry AA, Elkablawy MA, Gawad HS, Al-Abbasi FA. Montelukast, a leukotriene receptor antagonist abrogates lipopolysaccharide-induced toxicity and oxidative stress in rat liver. Pathophysiology 2011;18:235-42.
58. Avila TV, Bastos Pereira AL, De Oliveira Christoff A, Da Silva Soley B, Queiroz Telles JE, Eler GJ, et al. Hepatic effects of flunixin-meglumin in LPS-induced sepsis. Fundam Clin Pharmacol 2010;24:759-69.
59. Fink T, Heymann P, Taha-Melitz S, Taha A, Wolf B, Rensing H, et al. Dobutamine pretreatment improves survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat. Shock 2013;40:129-35.
60. Sezer A, Memi? D, Usta U, Söt N. The effect of dexmedetomidine on liver histopathology in a rat sepsis model: An experimental pilot study. Ulus Travma Acil Cerrahi Derg 2010;16:108-12.
61. Freise H, Daudel F, Grosserichter C, Lauer S, Hinkelmann J, Van Aken HK, et al. Thoracic epidural anesthesia reverses sepsis-induced hepatic hyperperfusion and reduces leukocyte adhesion in septic rats. Crit Care 2009;13:R116.
62. Zhang F, Wu R, Qiang X, Zhou M, Wang P. Antagonism of alpha2A-Adrenoceptor: A novel approach to inhibit inflammatory responses in sepsis. J Mol Med (Berl) 2010;88:289-96.
63. Hayakawa M, Sawamura A, Yanagida Y, Sugano M, Hoshino H, Gando S. The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction. Shock 2008;30:649-52.
64. Wang YY, Ryg U, Dahle MK, Steffensen KR, Thiemermann C, Chaudry IH, et al. Liver X receptor protects against liver injury in sepsis caused by rodent cecal ligation and puncture. Surg Infect (Larchmt) 2011;12:283-9.
65. Lee JH, Kim K, Jo YH, Kim MA, Rim KP, Kang KW, et al. Therapeutic hypothermia attenuates liver injury in polymicrobial sepsis model of rats via Akt survival pathway. J Surg Res 2013;181:114-20.
66. Schilsky ML. Acute liver failure and liver assist devices. Transplant Proc 2011;43:879-83.