메뉴 건너뛰기




Volumn 22, Issue 9, 2010, Pages 1039-1049

Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis

Author keywords

abdominal sepsis; bacterial infection; CASP; Kupffer cells; liver; mice; microcirculation

Indexed keywords

CLODRONIC ACID; INTERLEUKIN 10; INTERLEUKIN 6; LIPOSOME; TUMOR NECROSIS FACTOR;

EID: 77955467766     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32833847db     Document Type: Article
Times cited : (33)

References (53)
  • 3
    • 54049121020 scopus 로고    scopus 로고
    • Novel potential therapies for septic shock
    • Azevedo LC, Park M, Schettino GP. Novel potential therapies for septic shock. Shock 2008; 30 (Suppl 1):60-66.
    • (2008) Shock , vol.30 , Issue.SUPPL. 1 , pp. 60-66
    • Azevedo, L.C.1    Park, M.2    Schettino, G.P.3
  • 4
    • 59649126694 scopus 로고    scopus 로고
    • Rifle classification for predicting in-hospital mortality in critically ill sepsis patients
    • Chen YC, Jenq CC, Tian YC, Chang MY, Lin CY, Chang CC, et al. Rifle classification for predicting in-hospital mortality in critically ill sepsis patients. Shock 2009; 31:139-145.
    • (2009) Shock , vol.31 , pp. 139-145
    • Chen, Y.C.1    Jenq, C.C.2    Tian, Y.C.3    Chang, M.Y.4    Lin, C.Y.5    Chang, C.C.6
  • 5
    • 59649083965 scopus 로고    scopus 로고
    • Scoring systems for prediction of mortality in patients with intensive care unitacquired sepsis: A comparison of the Pitt bacteremia score and the acute physiology and chronic health evaluation II scoring systems
    • Rhee JY, Kwon KT, Ki HK, Shin SY, Jung DS, Chung DR, et al. Scoring systems for prediction of mortality in patients with intensive care unitacquired sepsis: a comparison of the Pitt bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems. Shock 2009; 31:146-150.
    • (2009) Shock , vol.31 , pp. 146-150
    • Rhee, J.Y.1    Kwon, K.T.2    Ki, H.K.3    Shin, S.Y.4    Jung, D.S.5    Chung, D.R.6
  • 6
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer M, Roggel F, Gerbes AL. Role of Kupffer cells in host defense and liver disease. Liver Int 2006; 26:1175-1186.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 7
    • 17844399568 scopus 로고    scopus 로고
    • Kupffer cell ablation improves hepatic microcirculation after trauma and sepsis
    • discussion 749-751
    • Keller SA, Paxian M, Ashburn JH, Clemens MG, Huynh T. Kupffer cell ablation improves hepatic microcirculation after trauma and sepsis. J Trauma 2005; 58:740-749. discussion 749-751.
    • (2005) J Trauma , vol.58 , pp. 740-749
    • Keller, S.A.1    Paxian, M.2    Ashburn, J.H.3    Clemens, M.G.4    Huynh, T.5
  • 8
    • 0033562174 scopus 로고    scopus 로고
    • Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis
    • Koo DJ, Chaudry IH, Wang P. Kupffer cells are responsible for producing inflammatory cytokines and hepatocellular dysfunction during early sepsis. J Surg Res 1999; 83:151-157.
    • (1999) J Surg Res , vol.83 , pp. 151-157
    • Koo, D.J.1    Chaudry, I.H.2    Wang, P.3
  • 9
    • 0030330332 scopus 로고    scopus 로고
    • Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats
    • Vollmar B, Ruttinger D,Wanner GA, Leiderer R, Menger MD. Modulation of Kupffer cell activity by gadolinium chloride in endotoxemic rats. Shock 1996; 6:434-441.
    • (1996) Shock , vol.6 , pp. 434-441
    • Vollmar, B.1    Ruttinger, D.2    Wanner, G.A.3    Leiderer, R.4    Menger, M.D.5
  • 10
    • 0031969250 scopus 로고    scopus 로고
    • Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival
    • Ruttinger D, Vollmar B, Kempter B, Messmer K. Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival. Langenbecks Arch Surg 1998; 383:75-80.
    • (1998) Langenbecks Arch Surg , vol.383 , pp. 75-80
    • Ruttinger, D.1    Vollmar, B.2    Kempter, B.3    Messmer, K.4
  • 12
    • 11444268282 scopus 로고    scopus 로고
    • Opposite effects of enhanced tumor necrosis factor-alpha production from Kupffer cells by gadolinium chloride on liver injury/mortality in endotoxemia of normal and partially hepatectomized mice
    • Kinoshita M, Uchida T, Nakashima H, Ono S, Seki S, Hiraide H. Opposite effects of enhanced tumor necrosis factor-alpha production from Kupffer cells by gadolinium chloride on liver injury/mortality in endotoxemia of normal and partially hepatectomized mice. Shock 2005; 23:65-72.
    • (2005) Shock , vol.23 , pp. 65-72
    • Kinoshita, M.1    Uchida, T.2    Nakashima, H.3    Ono, S.4    Seki, S.5    Hiraide, H.6
  • 13
    • 51549114943 scopus 로고    scopus 로고
    • Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice
    • Abraham S, Szabo A, Kaszaki J, Varga R, Eder K, Duda E, et al. Kupffer cell blockade improves the endotoxin-induced microcirculatory inflammatory response in obstructive jaundice. Shock 2008; 30:69-74.
    • (2008) Shock , vol.30 , pp. 69-74
    • Abraham, S.1    Szabo, A.2    Kaszaki, J.3    Varga, R.4    Eder, K.5    Duda, E.6
  • 14
    • 33746439457 scopus 로고    scopus 로고
    • The Kupffer cell protects against acute lung injury in a rat peritonitis model: Role of IL-10
    • Kono H, Fujii H, Hirai Y, Tsuchiya M, Amemiya H, Asakawa M, et al. The Kupffer cell protects against acute lung injury in a rat peritonitis model: role of IL-10. J Leukoc Biol 2006; 79:809-817.
    • (2006) J Leukoc Biol , vol.79 , pp. 809-817
    • Kono, H.1    Fujii, H.2    Hirai, Y.3    Tsuchiya, M.4    Amemiya, H.5    Asakawa, M.6
  • 15
    • 0032055225 scopus 로고    scopus 로고
    • Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alphainduced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model
    • Jaeschke H, Fisher MA, Lawson JA, Simmons CA, Farhood A, Jones DA. Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alphainduced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model. J Immunol 1998; 160:3480-3486.
    • (1998) J Immunol , vol.160 , pp. 3480-3486
    • Jaeschke, H.1    Fisher, M.A.2    Lawson, J.A.3    Simmons, C.A.4    Farhood, A.5    Jones, D.A.6
  • 16
    • 16644385124 scopus 로고    scopus 로고
    • Cecal ligation and puncture versus colon ascendens stent peritonitis: Two distinct animal models for polymicrobial sepsis
    • Maier S, Traeger T, Entleutner M, Westerholt A, Kleist B, Huser N, et al. Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 2004; 21:505-511.
    • (2004) Shock , vol.21 , pp. 505-511
    • Maier, S.1    Traeger, T.2    Entleutner, M.3    Westerholt, A.4    Kleist, B.5    Huser, N.6
  • 17
  • 20
    • 0036135609 scopus 로고    scopus 로고
    • Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver
    • Gregory SH, Cousens LP, van Rooijen N, Dopp EA, Carlos TM, Wing EJ. Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver. J Immunol 2002; 168:308-315.
    • (2002) J Immunol , vol.168 , pp. 308-315
    • Gregory, S.H.1    Cousens, L.P.2    Van Rooijen, N.3    Dopp, E.A.4    Carlos, T.M.5    Wing, E.J.6
  • 21
  • 22
    • 0031149344 scopus 로고    scopus 로고
    • Transient suppression of macrophage functions by liposome-encapsulated drugs
    • van Rooijen N, Bakker J, Sanders A. Transient suppression of macrophage functions by liposome-encapsulated drugs. Trends Biotechnol 1997; 15:178-185.
    • (1997) Trends Biotechnol , vol.15 , pp. 178-185
    • Van Rooijen, N.1    Bakker, J.2    Sanders, A.3
  • 23
    • 0028111256 scopus 로고
    • Liposome mediated depletion of macrophages: Mechanism of action, preparation of liposomes and applications
    • van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 1994; 174:83-93.
    • (1994) J Immunol Methods , vol.174 , pp. 83-93
    • Van Rooijen, N.1    Sanders, A.2
  • 24
    • 0027210471 scopus 로고
    • Microcirculation of the liver in hemorrhagic shock in the rat and its significance for energy metabolism and function
    • Vollmar B, Lang G, Post S, Menger MD, Messmer K. Microcirculation of the liver in hemorrhagic shock in the rat and its significance for energy metabolism and function. Zentralbl Chir 1993; 118:218-225.
    • (1993) Zentralbl Chir , vol.118 , pp. 218-225
    • Vollmar, B.1    Lang, G.2    Post, S.3    Menger, M.D.4    Messmer, K.5
  • 25
    • 34548158792 scopus 로고    scopus 로고
    • Local interaction of apoptotic hepatocytes and Kupffer cells in a rat model of systemic endotoxemia
    • Eipel C, Hirschmann M, Abshagen K, Menger MD, Vollmar B. Local interaction of apoptotic hepatocytes and Kupffer cells in a rat model of systemic endotoxemia. Hepatol Res 2007; 37:863-871.
    • (2007) Hepatol Res , vol.37 , pp. 863-871
    • Eipel, C.1    Hirschmann, M.2    Abshagen, K.3    Menger, M.D.4    Vollmar, B.5
  • 26
    • 33745326435 scopus 로고    scopus 로고
    • Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury
    • Thorlacius K, Slotta JE, Laschke MW, Wang Y, Menger MD, Jeppsson B, Thorlacius H. Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury. J Leukoc Biol 2006; 79:923-931.
    • (2006) J Leukoc Biol , vol.79 , pp. 923-931
    • Thorlacius, K.1    Slotta, J.E.2    Laschke, M.W.3    Wang, Y.4    Menger, M.D.5    Jeppsson, B.6    Thorlacius, H.7
  • 28
    • 0033063209 scopus 로고    scopus 로고
    • Role of microcirculation in hepatic ischemia/reperfusion injury
    • Menger MD, Richter S, Yamauchi J, Vollmar B. Role of microcirculation in hepatic ischemia/reperfusion injury. Hepatogastroenterology 1999; 46 (Suppl 2):1452-1457.
    • (1999) Hepatogastroenterology , vol.46 , Issue.SUPPL. 2 , pp. 1452-1457
    • Menger, M.D.1    Richter, S.2    Yamauchi, J.3    Vollmar, B.4
  • 29
    • 10044267618 scopus 로고    scopus 로고
    • Staphylococcal enterotoxin A-induced hepatotoxicity is predominantly mediated by Fas ligand (CD95L)
    • discussion, 1072-11063
    • Klintman D, Li X, Sato T, Wang Y, Jeppsson B, Thorlacius H. Staphylococcal enterotoxin A-induced hepatotoxicity is predominantly mediated by Fas ligand (CD95L). Ann Surg 2004; 240:1065-1072. discussion 1072-11063
    • (2004) Ann Surg , vol.240 , pp. 1065-1072
    • Klintman, D.1    Li, X.2    Sato, T.3    Wang, Y.4    Jeppsson, B.5    Thorlacius, H.6
  • 30
    • 0031442582 scopus 로고    scopus 로고
    • Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: An intravital microscopic analysis of Kupffer cell and leukocyte response
    • Vollmar B, Messner S, Wanner GA, Hartung T, Menger MD. Immunomodulatory action of G-CSF in a rat model of endotoxin-induced liver injury: an intravital microscopic analysis of Kupffer cell and leukocyte response. J Leukoc Biol 1997; 62:710-718.
    • (1997) J Leukoc Biol , vol.62 , pp. 710-718
    • Vollmar, B.1    Messner, S.2    Wanner, G.A.3    Hartung, T.4    Menger, M.D.5
  • 31
    • 32444450374 scopus 로고    scopus 로고
    • Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN)induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage
    • Slotta JE, Scheuer C, Menger MD, Vollmar B. Immunostimulatory CpG-oligodeoxynucleotides (CpG-ODN) induce early hepatic injury, but provide a late window for protection against endotoxin-mediated liver damage. J Hepatol 2006; 44:576-585.
    • (2006) J Hepatol , vol.44 , pp. 576-585
    • Slotta, J.E.1    Scheuer, C.2    Menger, M.D.3    Vollmar, B.4
  • 33
    • 0347758631 scopus 로고    scopus 로고
    • Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice
    • Klintman D, Li X, Thorlacius H. Important role of P-selectin for leukocyte recruitment, hepatocellular injury, and apoptosis in endotoxemic mice. Clin Diagn Lab Immunol 2004; 11:56-62.
    • (2004) Clin Diagn Lab Immunol , vol.11 , pp. 56-62
    • Klintman, D.1    Li, X.2    Thorlacius, H.3
  • 35
    • 34249672873 scopus 로고    scopus 로고
    • Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide
    • Eipel C, Kidess E, Abshagen K, Leminh K, Menger MD, Burkhardt H, Vollmar B. Antileukoproteinase protects against hepatic inflammation, but not apoptosis in the response of D-galactosamine-sensitized mice to lipopolysaccharide. Br J Pharmacol 2007; 151:406-413.
    • (2007) Br J Pharmacol , vol.151 , pp. 406-413
    • Eipel, C.1    Kidess, E.2    Abshagen, K.3    Leminh, K.4    Menger, M.D.5    Burkhardt, H.6    Vollmar, B.7
  • 36
    • 34447294258 scopus 로고    scopus 로고
    • Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice
    • Le Minh K, Klemm K, Abshagen K, Eipel C, Menger MD,Vollmar B. Attenuation of inflammation and apoptosis by pre- and posttreatment of darbepoetin-alpha in acute liver failure of mice. Am J Pathol 2007; 170:1954-1963.
    • (2007) Am J Pathol , vol.170 , pp. 1954-1963
    • Le Minh, K.1    Klemm, K.2    Abshagen, K.3    Eipel, C.4    Menger, M.D.5    Vollmar, B.6
  • 37
    • 54049158480 scopus 로고    scopus 로고
    • Experimental models of sepsis and their clinical relevance
    • Poli-de-Figueiredo LF, Garrido AG, Nakagawa N, Sannomiya P. Experimental models of sepsis and their clinical relevance. Shock 2008; 30 (Suppl 1):53-59.
    • (2008) Shock , vol.30 , Issue.SUPPL. 1 , pp. 53-59
    • Poli-De-Figueiredo, L.F.1    Garrido, A.G.2    Nakagawa, N.3    Sannomiya, P.4
  • 38
    • 0036698294 scopus 로고    scopus 로고
    • Neutrophil-Kupffer cell interaction: A critical component of host defenses to systemic bacterial infections
    • Gregory SH, Wing EJ. Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J Leukoc Biol 2002; 72:239-248.
    • (2002) J Leukoc Biol , vol.72 , pp. 239-248
    • Gregory, S.H.1    Wing, E.J.2
  • 39
    • 33749627330 scopus 로고    scopus 로고
    • How to modulate inflammatory cytokines in liver diseases
    • Tilg H, Kaser A, Moschen AR. How to modulate inflammatory cytokines in liver diseases. Liver Int 2006; 26:1029-1039.
    • (2006) Liver Int , vol.26 , pp. 1029-1039
    • Tilg, H.1    Kaser, A.2    Moschen, A.R.3
  • 40
    • 28244467218 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase-dependent chemokine production, leukocyte recruitment, and hepatocellular apoptosis in endotoxemic liver injury
    • discussion, 838-839
    • Klintman D, Li X, Santen S, Schramm R, Jeppsson B, Thorlacius H. p38 mitogen-activated protein kinase-dependent chemokine production, leukocyte recruitment, and hepatocellular apoptosis in endotoxemic liver injury. Ann Surg 2005; 242:830-838. discussion 838-839.
    • (2005) Ann Surg , vol.242 , pp. 830-838
    • Klintman, D.1    Li, X.2    Santen, S.3    Schramm, R.4    Jeppsson, B.5    Thorlacius, H.6
  • 41
    • 56349159142 scopus 로고    scopus 로고
    • Hepatocellular apoptosis is mediated by TNF alpha-dependent Fas/ FasLigand cytotoxicity in a murine model of acute liver failure
    • Kuhla A, Eipel C, Siebert N, Abshagen K, Menger MD, Vollmar B. Hepatocellular apoptosis is mediated by TNF alpha-dependent Fas/ FasLigand cytotoxicity in a murine model of acute liver failure. Apoptosis 2008; 13:1427-1438.
    • (2008) Apoptosis , vol.13 , pp. 1427-1438
    • Kuhla, A.1    Eipel, C.2    Siebert, N.3    Abshagen, K.4    Menger, M.D.5    Vollmar, B.6
  • 42
    • 36349035436 scopus 로고    scopus 로고
    • FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts
    • Miyagawa-Hayashino A, Tsuruyama T, Egawa H, Haga H, Sakashita H,Okuno T, et al. FasL expression in hepatic antigen-presenting cells and phagocytosis of apoptotic T cells by FasL+ Kupffer cells are indicators of rejection activity in human liver allografts. Am J Pathol 2007; 171:1499-1508.
    • (2007) Am J Pathol , vol.171 , pp. 1499-1508
    • Miyagawa-Hayashino, A.1    Tsuruyama, T.2    Egawa, H.3    Haga, H.4    Sakashita, H.5    Okuno, T.6
  • 43
    • 4143103526 scopus 로고    scopus 로고
    • Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species
    • Uchikura K, Wada T, Hoshino S, Nagakawa Y, Aiko T, Bulkley GB, et al. Lipopolysaccharides induced increases in Fas ligand expression by Kupffer cells via mechanisms dependent on reactive oxygen species. Am J Physiol Gastrointest Liver Physiol 2004; 287:G620-G626.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Uchikura, K.1    Wada, T.2    Hoshino, S.3    Nagakawa, Y.4    Aiko, T.5    Bulkley, G.B.6
  • 45
    • 33646102220 scopus 로고    scopus 로고
    • Leukocyteendothelial interactions via ICAM-1 are detrimental in polymicrobial sepsis
    • Van Griensven M, Probst C, Muller K, Hoevel P, Pape HC. Leukocyteendothelial interactions via ICAM-1 are detrimental in polymicrobial sepsis. Shock 2006; 25:254-259.
    • (2006) Shock , vol.25 , pp. 254-259
    • Van Griensven, M.1    Probst, C.2    Muller, K.3    Hoevel, P.4    Pape, H.C.5
  • 46
    • 33748307666 scopus 로고    scopus 로고
    • Role of neutrophils in acute inflammatory liver injury
    • Jaeschke H, Hasegawa T. Role of neutrophils in acute inflammatory liver injury. Liver Int 2006; 26:912-919.
    • (2006) Liver Int , vol.26 , pp. 912-919
    • Jaeschke, H.1    Hasegawa, T.2
  • 47
    • 44449096726 scopus 로고    scopus 로고
    • IL-10: The master regulator of immunity to infection
    • Couper KN, Blount DG, Riley EM. IL-10: the master regulator of immunity to infection. J Immunol 2008; 180:5771-5777.
    • (2008) J Immunol , vol.180 , pp. 5771-5777
    • Couper, K.N.1    Blount, D.G.2    Riley, E.M.3
  • 48
    • 0028845021 scopus 로고
    • Immunosuppressive and anti-inflammatory properties of interleukin 10
    • De Vries JE. Immunosuppressive and anti-inflammatory properties of interleukin 10. Ann Med 1995; 27:537-541.
    • (1995) Ann Med , vol.27 , pp. 537-541
    • De Vries, J.E.1
  • 49
    • 0028815553 scopus 로고
    • Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance
    • Berg DJ, Kuhn R, Rajewsky K, Muller W, Menon S, Davidson N, et al. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest 1995; 96:2339-2347.
    • (1995) J Clin Invest , vol.96 , pp. 2339-2347
    • Berg, D.J.1    Kuhn, R.2    Rajewsky, K.3    Muller, W.4    Menon, S.5    Davidson, N.6
  • 50
    • 33750297077 scopus 로고    scopus 로고
    • Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production
    • Gomes RN, Figueiredo RT, Bozza FA, Pacheco P, Amancio RT, Laranjeira AP, et al. Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production. Shock 2006; 26:457-463.
    • (2006) Shock , vol.26 , pp. 457-463
    • Gomes, R.N.1    Figueiredo, R.T.2    Bozza, F.A.3    Pacheco, P.4    Amancio, R.T.5    Laranjeira, A.P.6
  • 51
    • 33846164128 scopus 로고    scopus 로고
    • Interleukin- 10 gene transfer: Prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis
    • Kabay B, Kocaefe C, Baykal A, Ozden H, Baycu C, Oner Z, et al. Interleukin- 10 gene transfer: prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis. World J Surg 2007; 31:105-115.
    • (2007) World J Surg , vol.31 , pp. 105-115
    • Kabay, B.1    Kocaefe, C.2    Baykal, A.3    Ozden, H.4    Baycu, C.5    Oner, Z.6
  • 52
    • 0029076291 scopus 로고
    • Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection
    • Salkowski CA, Neta R,Wynn TA, Strassmann G, van Rooijen N, Vogel SN. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol 1995; 155:3168-3179.
    • (1995) J Immunol , vol.155 , pp. 3168-3179
    • Salkowski, C.A.1    Neta, R.2    Wynn, T.A.3    Strassmann, G.4    Van Rooijen, N.5    Vogel, S.N.6
  • 53
    • 0025240113 scopus 로고
    • Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate
    • van Rooijen N, Kors N, vd Ende M, Dijkstra CD. Depletion and repopulation of macrophages in spleen and liver of rat after intravenous treatment with liposome-encapsulated dichloromethylene diphosphonate. Cell Tissue Res 1990; 260:215-222.
    • (1990) Cell Tissue Res , vol.260 , pp. 215-222
    • Van Rooijen, N.1    Kors N. Vd Ende, M.2    Dijkstra, C.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.