A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

Blood

Volumn 129, Issue 8, 2017, Pages 959-969

  Yu, Hua ^a   Borsotti, Chiara ^b,e   Schickel, Jean Nicolas ^a,f   Zhu, Shu ^a   Strowig, Till ^a,g   Eynon, Elizabeth E ^a   Frleta, Davor ^c   Gurer, Cagan ^c   Murphy, Andrew J ^c   Yancopoulos, George D ^c   Meffre, Eric ^a   Manz, Markus G ^b   Flavell, Richard A ^a,d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c REGENERON PHARMACEUTICALS INC   (United States)

^d YALE UNIVERSITY   (United States)

^e UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^f Adimab   (United States)

^g HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; IMMUNOGLOBULIN G; INTERLEUKIN 6; OVALBUMIN; IL6 PROTEIN, HUMAN;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; FETUS; GENE LOCUS; GENE REARRANGEMENT; HEMATOPOIESIS; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOGLOBULIN BLOOD LEVEL; MEMORY CELL; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; T LYMPHOCYTE; THYMOPOIESIS; ANIMAL; B LYMPHOCYTE; CHICKEN; CYTOLOGY; GENE EXPRESSION; GENE TARGETING; GENETICS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; PROCEDURES;

ADAPTIVE IMMUNITY; ANIMALS; ANTIBODY FORMATION; B-LYMPHOCYTES; CHICKENS; GENE EXPRESSION; GENE KNOCK-IN TECHNIQUES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; INTERLEUKIN-6; MICE; OVALBUMIN; T-LYMPHOCYTES;

EID: 85014930838     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2016-04-709584     Document Type: Article

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