Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Greenblatt, Matthew B ^a   Vbranac, Vladimir ^b   Tivey, Trevor ^b   Tsang, Kelly ^a   Tager, Andrew M ^b   Aliprantis, Antonios O ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; INTERLEUKIN 2 RECEPTOR GAMMA;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW DISEASE; CD4+ T LYMPHOCYTE; CELL INFILTRATION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIGESTIVE SYSTEM INFLAMMATION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; GASTROINTESTINAL DISEASE; GASTROINTESTINAL TRACT SCLEROSIS; GENETIC ANALYSIS; GENETIC RISK; GRAFT VERSUS HOST REACTION; HLA SYSTEM; IMMUNE SYSTEM; INCIDENCE; LIVER DISEASE; LUNG FIBROSIS; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PAROTID GLAND; PAROTID GLAND DISEASE; PAROTID GLAND INFLAMMATION; PAROTID GLAND SCLEROSIS; PHENOTYPE; PNEUMONIA; SCID MOUSE; SCLERODERMA; SCLEROSIS; SKIN INFLAMMATION; TH1 CELL; THYMUS DISEASE;

ANIMALS; BONE MARROW; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; DISEASE MODELS, ANIMAL; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; INTERLEUKIN-2; LIVER; MACROPHAGES; MICE; MICE, INBRED NOD; MICE, SCID; RISK; SKIN; SPLEEN; THYMUS GLAND;

ANIMALIA; MURINAE; MUS;

EID: 84866034943     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044664     Document Type: Article

References (45)

1. Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, et al. (2009) Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol 83: 7305-7321.
2. Denton PW, Garcia JV, (2011) Humanized mouse models of HIV infection. AIDS Rev 13: 135-148.
3. Shultz LD, Ishikawa F, Greiner DL, (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7: 118-130.
4. Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, et al. (2002) NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100: 3175-3182.
5. Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, et al. (2004) Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304: 104-107.
6. Melkus MW, Estes JD, Padgett-Thomas A, Gatlin J, Denton PW, et al. (2006) Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med 12: 1316-1322.
7. Tonomura N, Habiro K, Shimizu A, Sykes M, Yang YG, (2008) Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood 111: 4293-4296.
8. Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, et al. (2012) Interspecies Comparison of Human and Murine Scleroderma Reveals IL-13 and CCL2 as Disease Subset-Specific Targets. Am J Pathol.
9. Tsiakalou V, Tsangaridou E, Polioudaki H, Nifli AP, Koulentaki M, et al. (2006) Optimized detection of circulating anti-nuclear envelope autoantibodies by immunofluorescence. BMC Immunol 7: 20.
10. Ruzek MC, Jha S, Ledbetter S, Richards SM, Garman RD, (2004) A modified model of graft-versus-host-induced systemic sclerosis (scleroderma) exhibits all major aspects of the human disease. Arthritis Rheum 50: 1319-1331.
11. Kawase T, Morishima Y, Matsuo K, Kashiwase K, Inoko H, et al. (2007) High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood 110: 2235-2241.
12. Sasazuki T, Juji T, Morishima Y, Kinukawa N, Kashiwabara H, et al. (1998) Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. N Engl J Med 339: 1177-1185.
13. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, et al. (1992) Cloning of the gamma chain of the human IL-2 receptor. Science 257: 379-382.
14. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, et al. (2001) Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol 167: 1-5.
15. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, et al. (1993) Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 262: 1877-1880.
16. Ito M, Kobayashi K, Nakahata T, (2008) NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. Curr Top Microbiol Immunol 324: 53-76.
17. Zimmermann N, Doepker MP, Witte DP, Stringer KF, Fulkerson PC, et al. (2005) Expression and regulation of small proline-rich protein 2 in allergic inflammation. Am J Respir Cell Mol Biol 32: 428-435.
18. Martinez FO, Helming L, Gordon S, (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27: 451-483.
19. Saenz SA, Siracusa MC, Perrigoue JG, Spencer SP, Urban JF, et al. (2010) IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464: 1362-1366.
20. Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464: 1367-1370.
21. Sun Z, Denton PW, Estes JD, Othieno FA, Wei BL, et al. (2007) Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med 204: 705-714.
22. Olesen R, Wahl A, Denton PW, Garcia JV, (2011) Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection. J Reprod Immunol 88: 195-203.
23. Kalscheuer H, Danzl N, Onoe T, Faust T, Winchester R, et al. (2012) A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med 4: 125ra130.
24. Gallina G, Dolcetti L, Serafini P, De Santo C, Marigo I, et al. (2006) Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116: 2777-2790.
25. Wynn TA, (2004) Fibrotic disease and the T(H)1/T(H)2 paradigm. Nat Rev Immunol 4: 583-594.
26. Farina G, Lafyatis D, Lemaire R, Lafyatis R, (2010) A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum 62: 580-588.
27. Juchem KW, Anderson BE, Zhang C, McNiff JM, Demetris AJ, et al. (2011) A repertoire-independent and cell-intrinsic defect in murine GVHD induction by effector memory T cells. Blood 118: 6209-6219.
28. Murphy WJ, Welniak LA, Taub DD, Wiltrout RH, Taylor PA, et al. (1998) Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest 102: 1742-1748.
29. Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M, (1998) Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest 102: 2126-2135.
30. Papp G, Horvath IF, Barath S, Gyimesi E, Vegh J, et al. (2012) Immunomodulatory effects of extracorporeal photochemotherapy in systemic sclerosis. Clin Immunol 142: 150-159.
31. Wynn TA, (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210.
32. Hoffmann KF, Cheever AW, Wynn TA, (2000) IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis. J Immunol 164: 6406-6416.
33. Aguet M, Dembic Z, Merlin G, (1988) Molecular cloning and expression of the human interferon-gamma receptor. Cell 55: 273-280.
34. Kim EY, Battaile JT, Patel AC, You Y, Agapov E, et al. (2008) Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med 14: 633-640.
35. Littera R, Orru N, Caocci G, Sanna M, Mulargia M, et al. (2012) Interactions between killer immunoglobulin-like receptors and their human leucocyte antigen Class I ligands influence the outcome of unrelated haematopoietic stem cell transplantation for thalassaemia: a novel predictive algorithm. Br J Haematol 156: 118-128.
36. Petersdorf EW, Malkki M, (2006) Genetics of risk factors for graft-versus-host disease. Semin Hematol 43: 11-23.
37. Gregoire-Gauthier J, Selleri S, Fontaine F, Dieng MM, Patey N, et al. (2011) Therapeutic Efficacy of Cord Blood-Derived Mesenchymal Stromal Cells for the Prevention of Acute Graft-Versus-Host Disease in a Xenogenic Mouse Model. Stem Cells Dev.
38. Cao T, Soto A, Zhou W, Wang W, Eck S, et al. (2009) Ex vivo expanded human CD4+CD25+Foxp3+ regulatory T cells prevent lethal xenogenic graft versus host disease (GVHD). Cell Immunol 258: 65-71.
39. Verlinden SF, Mulder AH, de Leeuw JP, van Bekkum DW, (1998) T lymphocytes determine the development of xeno GVHD and of human hemopoiesis in NOD/SCID mice following human umbilical cord blood transplantation. Stem Cells 16Suppl 1: 205-217.
40. Ito R, Katano I, Kawai K, Hirata H, Ogura T, et al. (2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 87: 1654-1658.
41. Zhang B, Duan Z, Zhao Y, (2009) Mouse models with human immunity and their application in biomedical research. J Cell Mol Med 13: 1043-1058.
42. Denton CP, Merkel PA, Furst DE, Khanna D, Emery P, et al. (2007) Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: a multicenter, randomized, placebo-controlled phase I/II trial of CAT-192. Arthritis Rheum 56: 323-333.
43. Khanna D, Clements PJ, Furst DE, Korn JH, Ellman M, et al. (2009) Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60: 1102-1111.
44. Sora F, Antinori A, Piccirillo N, De Luca A, Chiusolo P, et al. (2002) Highly active antiretroviral therapy and allogeneic CD34(+) peripheral blood progenitor cells transplantation in an HIV/HCV coinfected patient with acute myeloid leukemia. Exp Hematol 30: 279-284.
45. Gupta V, Tomblyn M, Pedersen TL, Atkins HL, Battiwalla M, et al. (2009) Allogeneic hematopoietic cell transplantation in human immunodeficiency virus-positive patients with hematologic disorders: a report from the center for international blood and marrow transplant research. Biol Blood Marrow Transplant 15: 864-871.