Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study

Multiple Sclerosis

Volumn 23, Issue 3, 2017, Pages 442-446

  Buscarinu, Maria Chiara ^a   Cerasoli, Benedetta ^a   Annibali, Viviana ^a   Policano, Claudia ^a   Lionetto, Luana ^b   Capi, Matilde ^c   Mechelli, Rosella ^a   Romano, Silvia ^a   Fornasiero, Arianna ^a   Mattei, Gianluca ^a   Piras, Eleonora ^d   Angelini, Daniela Francesca ^d   Battistini, Luca ^d   Simmaco, Maurizio ^c   Umeton, Renato ^a   Salvetti, Marco ^a   Ristori, Giovanni ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b LABORATORIO DI PATOLOGIA VASCOLARE   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

Biomarkers; gut absorption; intestinal permeability; microbiota; relapsing remitting; twins

Indexed keywords

LACTULOSE; MANNITOL; GASTROINTESTINAL AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE DURATION; EXPANDED DISABILITY STATUS SCALE; FEMALE; HUMAN; INTESTINE ABSORPTION; INTESTINE MUCOSA PERMEABILITY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PILOT STUDY; RELAPSE; URINE LEVEL; DRUG EFFECTS; INTESTINE FLORA; PERMEABILITY; PHYSIOLOGY;

ADULT; FEMALE; GASTROINTESTINAL AGENTS; GASTROINTESTINAL MICROBIOME; HUMANS; LACTULOSE; MANNITOL; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PERMEABILITY; PILOT PROJECTS;

EID: 85014829081     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458516652498     Document Type: Article

References (19)

1. Ascherio A, Munger K,. EBV and autoimmunity. Curr Top Microbiol Immunol 2015; 390: 365-385.
2. Bashinskaya VV, Kulakova OG, Boyko AN, et al. A review of genome-wide association studies for multiple sclerosis: Classical and hypothesis-driven approaches. Hum Genet 2015; 134: 1143-1162.
3. Bordi I, Ricigliano VA, Umeton R, et al. Noise in multiple sclerosis: Unwanted and necessary. Ann Clin Transl Neurol 2014; 1: 502-511.
4. Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, et al. Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site. Immunity 2015; 43: 343-353.
5. Annibali V, Ristori G, Angelini DF, et al. CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis. Brain 2011; 134: 542-554.
6. Held K, Bhonsle-Deeng L, Siewert K, et al. αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm 2015; 2: e107.
7. Godfrey DI, Uldrich AP, McCluskey J, et al. The burgeoning family of unconventional T cells. Nat Immunol 2015; 16: 1114-1123.
8. Berer K, Mues M, Koutrolos M, et al. Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011; 479: 538-541.
9. Ochoa-Repáraz J, Mielcarz DW, Ditrio LE, et al. Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis. J Immunol 2009; 183: 6041-6050.
10. Yokote H, Miyake S, Croxford JL, et al. NKT cell-dependent amelioration of a mouse model of multiple sclerosis by altering gut flora. Am J Pathol 2008; 173: 1714-1723.
11. Yang Y, Torchinsky MB, Gobert M, et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature 2014; 510: 152-156.
12. Haghikia A, Jörg S, Duscha A, et al. Dietary fatty acids directly impact central nervous system autoimmunity via the small intestine. Immunity 2015; 43: 817-829.
13. Nouri M, Bredberg A, Weström B, et al. Intestinal barrier dysfunction develops at the onset of experimental autoimmune encephalomyelitis, and can be induced by adoptive transfer of auto-reactive T cells. PLoS ONE 2014; 9: e106335.
14. Polman CH, Reingold SC, Banwell. B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011; 69: 292-302.
15. Lostia AM, Lionetto L, Principessa L, et al. A liquid chromatography/mass spectrometry method for the evaluation of intestinal permeability. Clin Biochem 2008; 41: 887-892.
16. Marsilio R, D'Antiga L, Zancan L, et al. Simultaneous HPLC determination with light scattering detection of lactulose and mannitol in studies of intestinal permeability in pediatrics. Clin Chem 1998; 44: 81685-81691.
17. Yacyshyn B, Meddings J, Sadowski D, et al. Multiple sclerosis patients have peripheral blood CD45RO + B cells and increased intestinal permeability. Dig Dis Sci 1996; 41: 2493.
18. Joscelyn J, Kasper LH,. Digesting the emerging role for the gut microbiome in central nervous system demyelination. Mult Scler 2014; 20: 1553-1559.
19. Spadoni I, Zagato E, Bertocchi A, et al. A gut-vascular barrier controls the systemic dissemination of bacteria. Science 2015; 350: 830-834.